Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 129 | 313 | 2.42 | 63 | 48.84% | 32 | 24.81% | 34 | 26.36% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 17 | 10 | 4 | 3 | 25 | 13 | +12 | 34 | WWLO | 10 | 8 | 0 | 2 | 16 | 6 | 7 | 2 | 4 | 1 | 9 | 7 | ||
| 2 | New York Red Bulls | 16 | 8 | 2 | 6 | 18 | 19 | -1 | 26 | LOXW | 8 | 5 | 1 | 2 | 9 | 7 | 8 | 3 | 1 | 4 | 9 | 12 | ||
| 3 | Toronto FC | 16 | 6 | 5 | 5 | 19 | 18 | +1 | 23 | XLWX | 9 | 5 | 4 | 0 | 12 | 4 | 7 | 1 | 1 | 5 | 7 | 14 | ||
| 4 | Chicago Fire | 14 | 4 | 5 | 5 | 18 | 19 | -1 | 17 | LLWX | 7 | 2 | 3 | 2 | 9 | 8 | 7 | 2 | 2 | 3 | 9 | 11 | ||
| 5 | Kansas City Wizards | 16 | 4 | 4 | 8 | 13 | 20 | -7 | 16 | XWLL | 8 | 3 | 2 | 3 | 9 | 8 | 8 | 1 | 2 | 5 | 4 | 12 | ||
| 6 | Philadelphia Union | 14 | 4 | 2 | 8 | 18 | 26 | -8 | 14 | WLXW | 5 | 3 | 1 | 1 | 10 | 7 | 9 | 1 | 1 | 7 | 8 | 19 | ||
| 7 | New England Revolution | 15 | 4 | 2 | 9 | 15 | 26 | -11 | 14 | WLLL | 8 | 3 | 2 | 3 | 11 | 11 | 7 | 1 | 0 | 6 | 4 | 15 | ||
| 8 | D.C. United | 17 | 3 | 3 | 11 | 12 | 28 | -16 | 12 | LLOX | 9 | 2 | 1 | 6 | 6 | 13 | 8 | 1 | 2 | 5 | 6 | 15 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 18 | 12 | 4 | 2 | 29 | 10 | +19 | 40 | XWLW | 8 | 6 | 2 | 0 | 17 | 6 | 10 | 6 | 2 | 2 | 12 | 4 | ||
| 2 | Real Salt Lake | 17 | 9 | 4 | 4 | 29 | 14 | +15 | 31 | XLWW | 9 | 6 | 3 | 0 | 21 | 6 | 8 | 3 | 1 | 4 | 8 | 8 | ||
| 3 | FC Dallas | 16 | 6 | 8 | 2 | 20 | 14 | +6 | 26 | XWXW | 8 | 4 | 3 | 1 | 11 | 6 | 8 | 2 | 5 | 1 | 9 | 8 | ||
| 4 | 1 | San Jose Earthquakes | 15 | 6 | 5 | 4 | 20 | 18 | +2 | 23 | XWXO | 7 | 3 | 2 | 2 | 11 | 9 | 8 | 3 | 3 | 2 | 9 | 9 | |
| 5 | 1 | Colorado Rapids | 16 | 6 | 5 | 5 | 18 | 16 | +2 | 23 | LXLX | 7 | 3 | 3 | 1 | 9 | 6 | 9 | 3 | 2 | 4 | 9 | 10 | |
| 6 | 1 | Seattle Sounders | 18 | 6 | 4 | 8 | 20 | 25 | -5 | 22 | WWXL | 10 | 4 | 2 | 4 | 12 | 12 | 8 | 2 | 2 | 4 | 8 | 13 | |
| 7 | 1 | Houston Dynamo | 17 | 5 | 4 | 8 | 21 | 25 | -4 | 19 | LOXX | 9 | 4 | 2 | 3 | 14 | 9 | 8 | 1 | 2 | 5 | 7 | 16 | |
| 8 | Chivas USA | 16 | 4 | 3 | 9 | 18 | 22 | -4 | 15 | XWXL | 7 | 2 | 1 | 4 | 8 | 10 | 9 | 2 | 2 | 5 | 10 | 12 | ||
| 12 | +2 | Edson BUDDLE (LA Galaxy) |
| 9 | Juan Pablo ÁNGEL (New York Red Bulls, 1p) | |
| 8 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| 7 | Álvaro SABORIO (Real Salt Lake) | |
| +2 | Steve ZAKUANI (Seattle Sounders) | |
| Sébastien LE TOUX (Philadelphia Union, 1p) | ||
| Conor CASEY (Colorado Rapids, 3p) | ||
| 6 | Kei KAMARA (Kansas City Wizards) | |
| Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| Justin BRAUN (Chivas USA) | ||
| Marco PAPPA (Chicago Fire) | ||
| 5 | Danny MWANGA (Philadelphia Union) | |
| Guillermo BARROS SCHELOTTO (Columbus Crew, 2p) | ||
| Chad BARRETT (Toronto FC) | ||
| +1 | Omar CUMMINGS (Colorado Rapids) | |
| Zack SCHILAWSKI (New England Revolution) | ||
| 4 | Brek SHEA (FC Dallas) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Brian McBRIDE (Chicago Fire, 1p) | ||
| David FERREIRA (FC Dallas, 2p) | ||
| +1 | Jesus PADILLA (Chivas USA) | |
| Javier MORALES (Real Salt Lake) | ||
| +1 | Emilio RENTERÍA (Columbus Crew) | |
| Jeff CUNNINGHAM (FC Dallas, 2p) |
| Sunday, 18 July 2010 | |||||
| D.C. United | 1-2 | LA Galaxy | |||
| 54 | Najar | 38 | Buddle | ||
| 58(p) | Donovan | ||||
| Thursday, 22 July 2010 | |||||
| LA Galaxy | 2-2 | San Jose Earthquakes | |||
| 59 | Buddle | 2 | Convey | ||
| 90 | Donovan | 72 | McDonald | ||
| Saturday, 24 July 2010 | |||||
| Columbus Crew | 3-0 | Houston Dynamo | |||
| 34 | Rentería | ||||
| 84 | Iro | ||||
| 90 | Griffit | ||||
| Real Salt Lake | 1-1 | Chivas USA | |||
| 65 | Grabavoy | 70 | Padilla | ||
| Toronto FC | 1-1 | FC Dallas | |||
| 61 | Maicon Carioca | 77 | Rodríguez | ||
| Sunday, 25 July 2010 | |||||
| Seattle Sounders | 2-1 | Colorado Rapids | |||
| 8 | Zakuani | 9 | Cummings | ||
| 17 | Zakuani | ||||
