| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 56 | 147 | 2.62 | 33 | 58.93% | 9 | 16.07% | 14 | 25.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 7 | 5 | 0 | 2 | 8 | 8 | +0 | 15 | LWWW | 3 | 3 | 0 | 0 | 5 | 2 | 4 | 2 | 0 | 2 | 3 | 6 | ||
| 2 | Columbus Crew | 5 | 3 | 2 | 0 | 9 | 5 | +4 | 11 | WXWX | 3 | 3 | 0 | 0 | 6 | 2 | 2 | 0 | 2 | 0 | 3 | 3 | ||
| 3 | 3 | Toronto FC | 7 | 3 | 0 | 4 | 11 | 13 | -2 | 9 | WLWL | 3 | 3 | 0 | 0 | 8 | 2 | 4 | 0 | 0 | 4 | 3 | 11 | |
| 4 | 1 | Chicago Fire | 7 | 2 | 2 | 3 | 9 | 10 | -1 | 8 | LXWW | 3 | 1 | 1 | 1 | 4 | 3 | 4 | 1 | 1 | 2 | 5 | 7 | |
| 5 | Kansas City Wizards | 6 | 2 | 1 | 3 | 6 | 6 | +0 | 7 | LLOL | 3 | 2 | 1 | 0 | 5 | 0 | 3 | 0 | 0 | 3 | 1 | 6 | ||
| 6 | 2 | New England Revolution | 8 | 2 | 1 | 5 | 10 | 14 | -4 | 7 | LLXL | 4 | 1 | 1 | 2 | 6 | 8 | 4 | 1 | 0 | 3 | 4 | 6 | |
| 7 | Philadelphia Union | 6 | 1 | 0 | 5 | 6 | 14 | -8 | 3 | LLLL | 1 | 1 | 0 | 0 | 3 | 2 | 5 | 0 | 0 | 5 | 3 | 12 | ||
| 8 | D.C. United | 7 | 1 | 0 | 6 | 4 | 15 | -11 | 3 | LWLL | 4 | 1 | 0 | 3 | 2 | 7 | 3 | 0 | 0 | 3 | 2 | 8 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 8 | 7 | 1 | 0 | 15 | 2 | +13 | 22 | WWWO | 4 | 4 | 0 | 0 | 8 | 2 | 4 | 3 | 1 | 0 | 7 | 0 | ||
| 2 | Houston Dynamo | 8 | 4 | 1 | 3 | 11 | 7 | +4 | 13 | WLWL | 5 | 3 | 0 | 2 | 8 | 4 | 3 | 1 | 1 | 1 | 3 | 3 | ||
| 3 | 2 | San Jose Earthquakes | 6 | 4 | 0 | 2 | 11 | 7 | +4 | 12 | WWLW | 4 | 3 | 0 | 1 | 7 | 3 | 2 | 1 | 0 | 1 | 4 | 4 | |
| 4 | 2 | Real Salt Lake | 7 | 3 | 1 | 3 | 12 | 8 | +4 | 10 | WWLL | 3 | 2 | 1 | 0 | 7 | 3 | 4 | 1 | 0 | 3 | 5 | 5 | |
| 5 | 3 | FC Dallas | 7 | 2 | 4 | 1 | 9 | 8 | +1 | 10 | WWXX | 4 | 1 | 3 | 0 | 6 | 5 | 3 | 1 | 1 | 1 | 3 | 3 | |
| 6 | 3 | Colorado Rapids | 7 | 3 | 1 | 3 | 8 | 7 | +1 | 10 | LLWW | 3 | 1 | 1 | 1 | 5 | 4 | 4 | 2 | 0 | 2 | 3 | 3 | |
| 7 | Chivas USA | 8 | 3 | 1 | 4 | 10 | 11 | -1 | 10 | LWXW | 4 | 2 | 0 | 2 | 5 | 5 | 4 | 1 | 1 | 2 | 5 | 6 | ||
| 8 | 4 | Seattle Sounders | 8 | 2 | 3 | 3 | 8 | 12 | -4 | 9 | LXLX | 5 | 2 | 1 | 2 | 4 | 6 | 3 | 0 | 2 | 1 | 4 | 6 | |
| 9 | Edson BUDDLE (LA Galaxy) | |
| 6 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| 4 | +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 1p) |
| Sébastien LE TOUX (Philadelphia Union) | ||
| Zack SCHILAWSKI (New England Revolution) | ||
| Juan Pablo ÁNGEL (New York Red Bulls, 1p) | ||
| +1 | Jeff CUNNINGHAM (FC Dallas, 2p) | |
| 3 | +1 | Kei KAMARA (Kansas City Wizards) |
| +1 | Brad DAVIS (Houston Dynamo, 2p) | |
| Guillermo BARROS SCHELOTTO (Columbus Crew, 1p) | ||
| +2 | Jesus PADILLA (Chivas USA) | |
| Steve ZAKUANI (Seattle Sounders) | ||
| Javier MORALES (Real Salt Lake) | ||
| Conor CASEY (Colorado Rapids, 3p) |
| Wednesday, 5 May 2010 | |||||
| D.C. United | 2-1 | Kansas City Wizards | |||
| 12 | Allsopp | 90 | Kamara | ||
| 34 | Allsopp | ||||
| Houston Dynamo | 0-1 | FC Dallas | |||
| 79 | Ihemelu | ||||
| Colorado Rapids | 0-1 | LA Galaxy | |||
| 21 | Gordon | ||||
| New England Revolution | 0-4 | Chivas USA | |||
| 26 | Padilla | ||||
| 33 | Braun | ||||
| 48 | Padilla | ||||
| 81 | Gavin | ||||
| Saturday, 8 May 2010 | |||||
| FC Dallas | 1-0 | D.C. United | |||
| 68 | Cunningham | ||||
| Columbus Crew | 3-2 | New England Revolution | |||
| 31 | Gaven | 29 | Boggs | ||
| 35(og) | Gibbs | 40 | Boggs | ||
| 90 | Rogers | ||||
| Seattle Sounders | 0-4 | LA Galaxy | |||
| 22 | Kirovski | ||||
| 52 | González | ||||
| 57 | Dunivant | ||||
| 67 | Donovan | ||||
| Real Salt Lake | 3-0 | Philadelphia Union | |||
| 27 | Beckerman | ||||
| 51 | Olave | ||||
| 70 | Saborio | ||||
| Chivas USA | 0-2 | Houston Dynamo | |||
| 4 | Davis | ||||
| 8 | Serioux | ||||
| Toronto FC | 4-1 | Chicago Fire | |||
| 24 | Labrocca | 50 | Pause | ||
| 47 | White | ||||
| 66 | Barrett | ||||
| 69 | Barrett | ||||
| San Jose Earthquakes | 4-0 | New York Red Bulls | |||
| 44 | Johnson | ||||
| 54 | Gjertsen | ||||
| 77 | Wondolowski | ||||
| 85 | Burling | ||||