Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 314 | 884 | 2.81 | 156 | 49.68% | 100 | 31.85% | 58 | 18.47% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 32 | 14 | 9 | 9 | 56 | 42 | +14 | 51 | WWXX | 16 | 12 | 2 | 2 | 33 | 15 | 16 | 2 | 7 | 7 | 23 | 27 | ||
| 2 | Toronto FC | 32 | 13 | 10 | 9 | 46 | 35 | +11 | 49 | LOXX | 16 | 7 | 6 | 3 | 25 | 15 | 16 | 6 | 4 | 6 | 21 | 20 | ||
| 3 | 2 | D.C. United | 32 | 10 | 13 | 9 | 48 | 42 | +6 | 43 | WWWX | 16 | 8 | 4 | 4 | 32 | 17 | 16 | 2 | 9 | 5 | 16 | 25 | |
| 4 | 1 | Philadelphia Union | 32 | 11 | 9 | 12 | 52 | 51 | +1 | 42 | LXLX | 15 | 8 | 4 | 3 | 30 | 20 | 17 | 3 | 5 | 9 | 22 | 31 | |
| 5 | 1 | Montréal Impact | 31 | 10 | 11 | 10 | 46 | 48 | -2 | 41 | WLLX | 16 | 7 | 4 | 5 | 29 | 27 | 15 | 3 | 7 | 5 | 17 | 21 | |
| 6 | New England Revolution | 32 | 10 | 9 | 13 | 40 | 52 | -12 | 39 | WLWW | 16 | 8 | 4 | 4 | 23 | 19 | 16 | 2 | 5 | 9 | 17 | 33 | ||
| 7 | 1 | Columbus Crew | 31 | 8 | 11 | 12 | 45 | 49 | -4 | 35 | WLWW | 17 | 6 | 8 | 3 | 31 | 25 | 14 | 2 | 3 | 9 | 14 | 24 | |
| 8 | 1 | Orlando City | 31 | 7 | 14 | 10 | 49 | 57 | -8 | 35 | OLLL | 15 | 5 | 7 | 3 | 27 | 25 | 16 | 2 | 7 | 7 | 22 | 32 | |
| 9 | Chicago Fire | 31 | 6 | 9 | 16 | 36 | 52 | -16 | 27 | LLLX | 15 | 5 | 7 | 3 | 22 | 18 | 16 | 1 | 2 | 13 | 14 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 32 | 16 | 8 | 8 | 48 | 39 | +9 | 56 | WOXL | 16 | 11 | 4 | 1 | 31 | 11 | 16 | 5 | 4 | 7 | 17 | 28 | ||
| 2 | Colorado Rapids | 30 | 13 | 12 | 5 | 33 | 27 | +6 | 51 | WXOW | 15 | 10 | 5 | 0 | 17 | 5 | 15 | 3 | 7 | 5 | 16 | 22 | ||
| 3 | LA Galaxy | 32 | 11 | 15 | 6 | 53 | 39 | +14 | 48 | LLXW | 16 | 8 | 7 | 1 | 32 | 18 | 16 | 3 | 8 | 5 | 21 | 21 | ||
| 4 | Real Salt Lake | 32 | 12 | 9 | 11 | 43 | 44 | -1 | 45 | LOLL | 16 | 8 | 7 | 1 | 22 | 14 | 16 | 4 | 2 | 10 | 21 | 30 | ||
| 5 | Sporting Kansas City | 32 | 12 | 7 | 13 | 40 | 41 | -1 | 43 | LWXX | 16 | 9 | 3 | 4 | 28 | 19 | 16 | 3 | 4 | 9 | 12 | 22 | ||
| 6 | 1 | Seattle Sounders | 30 | 12 | 5 | 13 | 39 | 39 | +0 | 41 | WWWX | 15 | 9 | 1 | 5 | 20 | 11 | 15 | 3 | 4 | 8 | 19 | 28 | |
| 7 | 1 | Portland Timbers | 32 | 11 | 8 | 13 | 46 | 49 | -3 | 41 | LLWW | 16 | 11 | 2 | 3 | 34 | 21 | 16 | 0 | 6 | 10 | 12 | 28 | |
| 8 | 1 | San Jose Earthquakes | 31 | 8 | 13 | 10 | 31 | 36 | -5 | 37 | WLLO | 16 | 7 | 6 | 3 | 18 | 12 | 15 | 1 | 7 | 7 | 13 | 24 | |
| 9 | 1 | Vancouver Whitecaps | 31 | 9 | 8 | 14 | 40 | 49 | -9 | 35 | XLWL | 15 | 5 | 6 | 4 | 23 | 19 | 16 | 4 | 2 | 10 | 17 | 30 | |
| 10 | Houston Dynamo | 30 | 7 | 11 | 12 | 36 | 40 | -4 | 32 | LWWX | 15 | 5 | 7 | 3 | 21 | 17 | 15 | 2 | 4 | 9 | 15 | 23 | ||
| 21 | +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| +2 | David VILLA (New York City, 4p) | |
| 16 | +1 | Dominic DWYER (Sporting Kansas City) |
| Sebastian GIOVINCO (Toronto FC, 3p) | ||
| 15 | Fanendo ADI (Portland Timbers, 1p) | |
| +1 | Ignacio PIATTI (Montréal Impact, 2p) | |
| Ola KAMARA (Columbus Crew, 2p) | ||
| 14 | Cyle LARIN (Orlando City) | |
| GIOVANI dos Santos (LA Galaxy, 1p) | ||
| 13 | Diego VALERI (Portland Timbers, 3p) | |
| 12 | +1 | Chris PONTIUS (Philadelphia Union) |
| Frank LAMPARD (New York City, 1p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| 11 | +1 | Kei KAMARA (New England Revolution, 1p) |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| 10 | Robbie KEANE (LA Galaxy, 3p) | |
| Kevin MOLINO (Orlando City, 1p) | ||
| Didier DROGBA (Montréal Impact, 2p) | ||
| 9 | +3 | Lamar NEAGLE (D.C. United, 2p) |
| Roland ALBERG (Philadelphia Union, 4p) | ||
| Michael BARRIOS (FC Dallas) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| +1 | Jozy ALTIDORE (Toronto FC) | |
| Joao PLATA (Real Salt Lake, 2p) |
| Wednesday, 28 September 2016 | |||||
| D.C. United | 3-0 | Columbus Crew | |||
| 71 | Sam | ||||
| 86 | Neagle | ||||
| 90 | Saborio | ||||
| Montréal Impact | 3-1 | San Jose Earthquakes | |||
| 22 | Oduro | 62 | Wondolowski | ||
| 32 | Piatti | ||||
| 90 | Venegas | ||||
| Seattle Sounders | 1-0 | Chicago Fire | |||
| 24 | Marshall | ||||
| Toronto FC | 0-0 | Orlando City | |||
| Friday, 30 September 2016 | |||||
| Houston Dynamo | 0-2 | New York City | |||
| 52 | Villa | ||||
| 90 | Villa | ||||
| Saturday, 1 October 2016 | |||||
| FC Dallas | 1-0 | LA Galaxy | |||
| 39 | Zimmerman | ||||
| Colorado Rapids | 1-0 | Portland Timbers | |||
| 63 | Le Toux | ||||
| New York Red Bulls | 3-2 | Philadelphia Union | |||
| 44 | Kljestan | 15 | Herbers | ||
| 47 | Wright-Phillips | 55 | Pontius | ||
| 66 | McCarty | ||||
| Columbus Crew | 3-0 | Chicago Fire | |||
| 8 | Afful | ||||
| 50 | Meram | ||||
| 59 | Duka | ||||
| New England Revolution | 3-1 | Sporting Kansas City | |||
| 4 | Kamara | 49 | Dwyer | ||
| 75(og) | Ellis | ||||
| 83 | Agudelo | ||||
| Toronto FC | 1-2 | D.C. United | |||
| 36 | Altidore | 39 | Neagle | ||
| 58 | Neagle | ||||
| San Jose Earthquakes | 2-1 | Real Salt Lake | |||
| 34 | Dawkins | 40 | Glad | ||
| 72 | Alashe | ||||
