| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 180 | 491 | 2.72 | 92 | 51.11% | 56 | 31.11% | 32 | 17.78% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 19 | 8 | 5 | 6 | 32 | 26 | +6 | 29 | WLLW | 10 | 7 | 2 | 1 | 23 | 12 | 9 | 1 | 3 | 5 | 9 | 14 | ||
| 2 | Montréal Impact | 17 | 6 | 7 | 4 | 28 | 25 | +3 | 25 | XWXO | 8 | 4 | 3 | 1 | 16 | 11 | 9 | 2 | 4 | 3 | 12 | 14 | ||
| 3 | New York Red Bulls | 18 | 7 | 2 | 9 | 28 | 25 | +3 | 23 | LXLW | 8 | 6 | 0 | 2 | 17 | 9 | 10 | 1 | 2 | 7 | 11 | 16 | ||
| 4 | 1 | Toronto FC | 17 | 6 | 5 | 6 | 19 | 19 | +0 | 23 | WXLW | 7 | 3 | 3 | 1 | 8 | 6 | 10 | 3 | 2 | 5 | 11 | 13 | |
| 5 | 2 | New England Revolution | 19 | 5 | 7 | 7 | 26 | 33 | -7 | 22 | WLLL | 10 | 4 | 4 | 2 | 14 | 11 | 9 | 1 | 3 | 5 | 12 | 22 | |
| 6 | 2 | D.C. United | 18 | 5 | 6 | 7 | 17 | 20 | -3 | 21 | LXWO | 9 | 4 | 1 | 4 | 12 | 9 | 9 | 1 | 5 | 3 | 5 | 11 | |
| 7 | 1 | Orlando City | 17 | 4 | 9 | 4 | 28 | 29 | -1 | 21 | OLWX | 10 | 3 | 7 | 0 | 19 | 14 | 7 | 1 | 2 | 4 | 9 | 15 | |
| 8 | Columbus Crew | 17 | 3 | 7 | 7 | 22 | 28 | -6 | 16 | LLXO | 8 | 3 | 4 | 1 | 15 | 13 | 9 | 0 | 3 | 6 | 7 | 15 | ||
| 9 | Chicago Fire | 16 | 3 | 5 | 8 | 15 | 21 | -6 | 14 | LWLL | 8 | 3 | 3 | 2 | 9 | 8 | 8 | 0 | 2 | 6 | 6 | 13 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | FC Dallas | 20 | 11 | 4 | 5 | 31 | 24 | +7 | 37 | WWWL | 10 | 7 | 3 | 0 | 20 | 6 | 10 | 4 | 1 | 5 | 11 | 18 | |
| 2 | 1 | Colorado Rapids | 18 | 9 | 7 | 2 | 21 | 13 | +8 | 34 | XOOW | 9 | 7 | 2 | 0 | 12 | 4 | 9 | 2 | 5 | 2 | 9 | 9 | |
| 3 | Real Salt Lake | 18 | 8 | 5 | 5 | 29 | 28 | +1 | 29 | XXLW | 8 | 5 | 3 | 0 | 12 | 7 | 10 | 3 | 2 | 5 | 17 | 21 | ||
| 4 | 3 | LA Galaxy | 18 | 7 | 8 | 3 | 31 | 18 | +13 | 29 | WWXO | 9 | 5 | 4 | 0 | 20 | 8 | 9 | 2 | 4 | 3 | 11 | 10 | |
| 5 | 1 | Sporting Kansas City | 19 | 7 | 4 | 8 | 21 | 22 | -1 | 25 | WXWO | 10 | 5 | 1 | 4 | 14 | 13 | 9 | 2 | 3 | 4 | 7 | 9 | |
| 6 | 1 | Vancouver Whitecaps | 19 | 7 | 4 | 8 | 29 | 33 | -4 | 25 | XLWL | 10 | 4 | 4 | 2 | 15 | 11 | 9 | 3 | 0 | 6 | 14 | 22 | |
| 7 | 1 | Portland Timbers | 18 | 6 | 6 | 6 | 28 | 29 | -1 | 24 | OWXW | 9 | 6 | 1 | 2 | 19 | 14 | 9 | 0 | 5 | 4 | 9 | 15 | |
| 8 | San Jose Earthquakes | 18 | 5 | 7 | 6 | 19 | 21 | -2 | 22 | LLXX | 9 | 5 | 3 | 1 | 11 | 5 | 9 | 0 | 4 | 5 | 8 | 16 | ||
| 9 | 1 | Houston Dynamo | 18 | 4 | 6 | 8 | 23 | 25 | -2 | 18 | OWLO | 8 | 4 | 3 | 1 | 14 | 8 | 10 | 0 | 3 | 7 | 9 | 17 | |
| 10 | 1 | Seattle Sounders | 17 | 5 | 2 | 10 | 14 | 21 | -7 | 17 | LXLL | 9 | 4 | 0 | 5 | 7 | 8 | 8 | 1 | 2 | 5 | 7 | 13 | |
| 12 | David VILLA (New York City, 3p) | |
| 10 | Ignacio PIATTI (Montréal Impact, 2p) | |
| 9 | Fanendo ADI (Portland Timbers, 1p) | |
| Bradley WRIGHT-PHILLIPS (New York Red Bulls) | ||
| 8 | +1 | Kei KAMARA (New England Revolution, 1p) |
| Dominic DWYER (Sporting Kansas City) | ||
| +1 | Ola KAMARA (Columbus Crew) | |
| Cyle LARIN (Orlando City) | ||
| Sebastian GIOVINCO (Toronto FC, 2p) | ||
| 7 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| +1 | Yura MOVSISYAN (Real Salt Lake, 2p) | |
| Diego VALERI (Portland Timbers, 3p) | ||
| GIOVANI dos Santos (LA Galaxy) | ||
| 6 | Chris PONTIUS (Philadelphia Union) | |
| +2 | Robbie KEANE (LA Galaxy, 2p) | |
| Jordan MORRIS (Seattle Sounders) | ||
| Mike GRELLA (New York Red Bulls) | ||
| +1 | Roland ALBERG (Philadelphia Union, 3p) | |
| Kevin MOLINO (Orlando City, 1p) | ||
| +1 | Michael BARRIOS (FC Dallas) | |
| Pedro MORALES (Vancouver Whitecaps, 5p) | ||
| Juan MARTÍNEZ (Real Salt Lake) |
| Monday, 4 July 2016 | |||||
| FC Dallas | 4-0 | Orlando City | |||
| 11 | Zimmerman | ||||
| 21 | Barrios | ||||
| 61 | Hedges | ||||
| 90 | Castillo | ||||
| Colorado Rapids | 0-0 | Portland Timbers | |||
| LA Galaxy | 2-0 | Vancouver Whitecaps | |||
| 12 | Keane | ||||
| 47 | Larentowicz | ||||
| Wednesday, 6 July 2016 | |||||
| New England Revolution | 0-1 | New York City | |||
| 58 | Lampard | ||||
| Friday, 8 July 2016 | |||||
| San Jose Earthquakes | 0-1 | FC Dallas | |||
| 51 | Urruti | ||||
| Orlando City | 0-0 | Houston Dynamo | |||
| Saturday, 9 July 2016 | |||||
| New England Revolution | 3-1 | Columbus Crew | |||
| 3 | Nguyen | 42 | Kamara | ||
| 34(og) | Trapp | ||||
| 71 | Kamara | ||||
| Vancouver Whitecaps | 2-2 | Colorado Rapids | |||
| 10 | Waston | 59 | Doyle | ||
| 87(p) | Techera | 90 | Sjöberg | ||
| Seattle Sounders | 0-1 | LA Galaxy | |||
| 15 | Keane | ||||
| Real Salt Lake | 1-1 | Montréal Impact | |||
| 79(p) | Movsisyan | 8 | Shipp | ||
| Toronto FC | 1-0 | Chicago Fire | |||
| 9 | Morrow | ||||
| Philadelphia Union | 3-0 | D.C. United | |||
| 20(p) | Alberg | ||||
| 37(p) | Ilsinho | ||||
| 47 | Ilsinho | ||||