| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 139 | 387 | 2.78 | 71 | 51.08% | 42 | 30.22% | 26 | 18.71% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 14 | 6 | 5 | 3 | 21 | 16 | +5 | 23 | WXXW | 7 | 5 | 2 | 0 | 14 | 6 | 7 | 1 | 3 | 3 | 7 | 10 | ||
| 2 | New York Red Bulls | 14 | 6 | 1 | 7 | 24 | 20 | +4 | 19 | WWWL | 7 | 5 | 0 | 2 | 15 | 9 | 7 | 1 | 1 | 5 | 9 | 11 | ||
| 3 | Montréal Impact | 13 | 5 | 4 | 4 | 22 | 20 | +2 | 19 | WLXX | 6 | 3 | 2 | 1 | 11 | 7 | 7 | 2 | 2 | 3 | 11 | 13 | ||
| 4 | 1 | Toronto FC | 13 | 4 | 4 | 5 | 14 | 15 | -1 | 16 | LOXL | 4 | 1 | 2 | 1 | 5 | 5 | 9 | 3 | 2 | 4 | 9 | 10 | |
| 5 | 1 | D.C. United | 14 | 4 | 4 | 6 | 14 | 16 | -2 | 16 | LWLW | 8 | 3 | 1 | 4 | 10 | 9 | 6 | 1 | 3 | 2 | 4 | 7 | |
| 6 | 1 | Orlando City | 13 | 3 | 7 | 3 | 23 | 21 | +2 | 16 | XXWL | 7 | 2 | 5 | 0 | 14 | 10 | 6 | 1 | 2 | 3 | 9 | 11 | |
| 7 | 1 | New England Revolution | 14 | 3 | 7 | 4 | 19 | 25 | -6 | 16 | WLWL | 8 | 3 | 4 | 1 | 11 | 9 | 6 | 0 | 3 | 3 | 8 | 16 | |
| 8 | Columbus Crew | 13 | 3 | 5 | 5 | 18 | 21 | -3 | 14 | LWOX | 6 | 3 | 2 | 1 | 14 | 12 | 7 | 0 | 3 | 4 | 4 | 9 | ||
| 9 | Chicago Fire | 12 | 2 | 5 | 5 | 10 | 14 | -4 | 11 | XWLL | 7 | 2 | 3 | 2 | 8 | 8 | 5 | 0 | 2 | 3 | 2 | 6 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Colorado Rapids | 14 | 8 | 4 | 2 | 17 | 10 | +7 | 28 | XWXW | 7 | 6 | 1 | 0 | 10 | 3 | 7 | 2 | 3 | 2 | 7 | 7 | ||
| 2 | FC Dallas | 16 | 8 | 4 | 4 | 24 | 22 | +2 | 28 | XOWW | 8 | 5 | 3 | 0 | 14 | 6 | 8 | 3 | 1 | 4 | 10 | 16 | ||
| 3 | 1 | Real Salt Lake | 13 | 7 | 2 | 4 | 23 | 21 | +2 | 23 | WLWL | 4 | 4 | 0 | 0 | 6 | 2 | 9 | 3 | 2 | 4 | 17 | 19 | |
| 4 | 1 | Vancouver Whitecaps | 15 | 6 | 3 | 6 | 23 | 25 | -2 | 21 | XLWW | 8 | 4 | 3 | 1 | 12 | 7 | 7 | 2 | 0 | 5 | 11 | 18 | |
| 5 | LA Galaxy | 13 | 5 | 6 | 2 | 27 | 16 | +11 | 21 | OLXX | 7 | 4 | 3 | 0 | 18 | 8 | 6 | 1 | 3 | 2 | 9 | 8 | ||
| 6 | San Jose Earthquakes | 14 | 5 | 5 | 4 | 16 | 16 | +0 | 20 | LOXW | 7 | 5 | 2 | 0 | 10 | 3 | 7 | 0 | 3 | 4 | 6 | 13 | ||
| 7 | 1 | Portland Timbers | 15 | 5 | 4 | 6 | 23 | 25 | -2 | 19 | WXWL | 8 | 5 | 1 | 2 | 16 | 12 | 7 | 0 | 3 | 4 | 7 | 13 | |
| 8 | 1 | Sporting Kansas City | 16 | 5 | 3 | 8 | 14 | 18 | -4 | 18 | OLLW | 8 | 3 | 1 | 4 | 9 | 11 | 8 | 2 | 2 | 4 | 5 | 7 | |
| 9 | Seattle Sounders | 13 | 5 | 1 | 7 | 13 | 15 | -2 | 16 | WLLL | 7 | 4 | 0 | 3 | 7 | 5 | 6 | 1 | 1 | 4 | 6 | 10 | ||
| 10 | Houston Dynamo | 14 | 3 | 4 | 7 | 20 | 22 | -2 | 13 | XXLW | 6 | 3 | 2 | 1 | 13 | 8 | 8 | 0 | 2 | 6 | 7 | 14 | ||
| 10 | +2 | David VILLA (New York City, 3p) |
| 8 | Fanendo ADI (Portland Timbers, 1p) | |
| Ignacio PIATTI (Montréal Impact) | ||
| Bradley WRIGHT-PHILLIPS (New York Red Bulls) | ||
| Sebastian GIOVINCO (Toronto FC, 2p) | ||
| 7 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| Cyle LARIN (Orlando City) | ||
| 6 | Dominic DWYER (Sporting Kansas City) | |
| +1 | Kevin MOLINO (Orlando City, 1p) | |
| GIOVANI dos Santos (LA Galaxy) | ||
| Pedro MORALES (Vancouver Whitecaps, 5p) | ||
| 5 | Kei KAMARA (New England Revolution, 1p) | |
| +1 | Chris PONTIUS (Philadelphia Union) | |
| +1 | Jordan MORRIS (Seattle Sounders) | |
| Mike MAGEE (LA Galaxy) | ||
| Michael BARRIOS (FC Dallas) | ||
| Diego VALERI (Portland Timbers, 1p) | ||
| C.J. SAPONG (Philadelphia Union) | ||
| Tesho AKINDELE (FC Dallas, 2p) | ||
| Didier DROGBA (Montréal Impact, 1p) | ||
| Joao PLATA (Real Salt Lake, 1p) |
| Sunday, 29 May 2016 | |||||
| New York City | 2-2 | Orlando City | |||
| 42 | Brillant | 72 | Júlio Baptista | ||
| 66 | Villa | 90 | Molino | ||
| Wednesday, 1 June 2016 | |||||
| D.C. United | 0-2 | Seattle Sounders | |||
| 79 | Morris | ||||
| 83 | Jones | ||||
| Portland Timbers | 1-0 | San Jose Earthquakes | |||
| 11 | Ridgewell | ||||
| Philadelphia Union | 3-2 | Columbus Crew | |||
| 21 | Pontius | 14 | Kamara | ||
| 57 | Nogueira | 90 | Martinez | ||
| 84 | Herbers | ||||
| Thursday, 2 June 2016 | |||||
| FC Dallas | 1-1 | Houston Dynamo | |||
| 23 | Hollingshead | 51 | Clark | ||
| LA Galaxy | 0-0 | Sporting Kansas City | |||
| New York City | 2-3 | Real Salt Lake | |||
| 56 | Harrison | 59 | Movsisyan | ||
| 87(p) | Villa | 67 | Martínez | ||
| 74(og) | Brillant | ||||