| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 198 | 536 | 2.70 | 102 | 51.52% | 63 | 31.82% | 33 | 16.67% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 20 | 8 | 6 | 6 | 34 | 28 | +6 | 30 | XWLL | 11 | 7 | 3 | 1 | 25 | 14 | 9 | 1 | 3 | 5 | 9 | 14 | ||
| 2 | New York Red Bulls | 21 | 8 | 4 | 9 | 32 | 27 | +5 | 28 | XWOL | 10 | 7 | 1 | 2 | 19 | 9 | 11 | 1 | 3 | 7 | 13 | 18 | ||
| 3 | Montréal Impact | 19 | 6 | 8 | 5 | 30 | 29 | +1 | 26 | LXXW | 9 | 4 | 3 | 2 | 17 | 14 | 10 | 2 | 5 | 3 | 13 | 15 | ||
| 4 | Toronto FC | 19 | 6 | 6 | 7 | 21 | 22 | -1 | 24 | LXWX | 7 | 3 | 3 | 1 | 8 | 6 | 12 | 3 | 3 | 6 | 13 | 16 | ||
| 5 | New England Revolution | 20 | 5 | 8 | 7 | 26 | 33 | -7 | 23 | OWLL | 10 | 4 | 4 | 2 | 14 | 11 | 10 | 1 | 4 | 5 | 12 | 22 | ||
| 6 | D.C. United | 19 | 5 | 7 | 7 | 18 | 21 | -3 | 22 | XLXW | 9 | 4 | 1 | 4 | 12 | 9 | 10 | 1 | 6 | 3 | 6 | 12 | ||
| 7 | Orlando City | 19 | 4 | 10 | 5 | 30 | 33 | -3 | 22 | XLOL | 10 | 3 | 7 | 0 | 19 | 14 | 9 | 1 | 3 | 5 | 11 | 19 | ||
| 8 | 1 | Columbus Crew | 19 | 3 | 9 | 7 | 24 | 30 | -6 | 18 | XXLL | 10 | 3 | 6 | 1 | 17 | 15 | 9 | 0 | 3 | 6 | 7 | 15 | |
| 9 | 1 | Chicago Fire | 18 | 4 | 5 | 9 | 17 | 24 | -7 | 17 | LWLW | 9 | 4 | 3 | 2 | 10 | 8 | 9 | 0 | 2 | 7 | 7 | 16 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 22 | 12 | 4 | 6 | 34 | 30 | +4 | 40 | WLWW | 11 | 8 | 3 | 0 | 23 | 7 | 11 | 4 | 1 | 6 | 11 | 23 | ||
| 2 | Colorado Rapids | 19 | 10 | 7 | 2 | 22 | 13 | +9 | 37 | WXOO | 10 | 8 | 2 | 0 | 13 | 4 | 9 | 2 | 5 | 2 | 9 | 9 | ||
| 3 | 1 | LA Galaxy | 19 | 8 | 8 | 3 | 32 | 18 | +14 | 32 | WWWX | 10 | 6 | 4 | 0 | 21 | 8 | 9 | 2 | 4 | 3 | 11 | 10 | |
| 4 | 1 | Real Salt Lake | 20 | 8 | 6 | 6 | 29 | 30 | -1 | 30 | OLXX | 9 | 5 | 4 | 0 | 12 | 7 | 11 | 3 | 2 | 6 | 17 | 23 | |
| 5 | 1 | Vancouver Whitecaps | 21 | 8 | 5 | 8 | 33 | 35 | -2 | 29 | XWXL | 12 | 5 | 5 | 2 | 19 | 13 | 9 | 3 | 0 | 6 | 14 | 22 | |
| 6 | 1 | Portland Timbers | 21 | 7 | 8 | 6 | 32 | 31 | +1 | 29 | WXOO | 11 | 7 | 2 | 2 | 23 | 16 | 10 | 0 | 6 | 4 | 9 | 15 | |
| 7 | 2 | Sporting Kansas City | 22 | 8 | 4 | 10 | 24 | 25 | -1 | 28 | LLWW | 11 | 6 | 1 | 4 | 17 | 14 | 11 | 2 | 3 | 6 | 7 | 11 | |
| 8 | San Jose Earthquakes | 19 | 6 | 7 | 6 | 21 | 22 | -1 | 25 | WLLX | 10 | 6 | 3 | 1 | 13 | 6 | 9 | 0 | 4 | 5 | 8 | 16 | ||
| 9 | Seattle Sounders | 19 | 6 | 2 | 11 | 20 | 24 | -4 | 20 | LWLX | 10 | 5 | 0 | 5 | 12 | 8 | 9 | 1 | 2 | 6 | 8 | 16 | ||
| 10 | Houston Dynamo | 19 | 4 | 6 | 9 | 23 | 26 | -3 | 18 | LOWL | 8 | 4 | 3 | 1 | 14 | 8 | 11 | 0 | 3 | 8 | 9 | 18 | ||
| 13 | +1 | David VILLA (New York City, 3p) |
| 11 | Ignacio PIATTI (Montréal Impact, 2p) | |
| 10 | +1 | Fanendo ADI (Portland Timbers, 1p) |
| 9 | +1 | Ola KAMARA (Columbus Crew) |
| +1 | Cyle LARIN (Orlando City) | |
| Bradley WRIGHT-PHILLIPS (New York Red Bulls) | ||
| +2 | Diego VALERI (Portland Timbers, 3p) | |
| 8 | Kei KAMARA (New England Revolution, 1p) | |
| Dominic DWYER (Sporting Kansas City) | ||
| Sebastian GIOVINCO (Toronto FC, 2p) | ||
| 7 | +1 | Chris PONTIUS (Philadelphia Union) |
| Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| GIOVANI dos Santos (LA Galaxy) | ||
| 6 | Robbie KEANE (LA Galaxy, 2p) | |
| Mike GRELLA (New York Red Bulls) | ||
| Roland ALBERG (Philadelphia Union, 3p) | ||
| Kevin MOLINO (Orlando City, 1p) | ||
| Michael BARRIOS (FC Dallas) | ||
| +1 | C.J. SAPONG (Philadelphia Union, 1p) | |
| Pedro MORALES (Vancouver Whitecaps, 5p) | ||
| Juan MARTÍNEZ (Real Salt Lake) |
| Friday, 15 July 2016 | |||||
| LA Galaxy | 1-0 | Houston Dynamo | |||
| 66 | Gerrard | ||||
| Saturday, 16 July 2016 | |||||
| FC Dallas | 3-1 | Chicago Fire | |||
| 23 | Urruti | 90 | Álvarez | ||
| 41 | Díaz | ||||
| 90 | Rosales | ||||
| Colorado Rapids | 1-0 | Sporting Kansas City | |||
| 78 | Hairston | ||||
| Columbus Crew | 1-1 | D.C. United | |||
| 63 | Kamara | 89 | Espíndola | ||
| Vancouver Whitecaps | 2-2 | Orlando City | |||
| 35 | Mezquida | 14 | Júlio Baptista | ||
| 43 | Kudo | 50 | Larin | ||
| Real Salt Lake | 0-0 | New England Revolution | |||
| San Jose Earthquakes | 2-1 | Toronto FC | |||
| 30 | Amarikwa | 44 | Morrow | ||
| 70 | Dawkins | ||||
| Sunday, 17 July 2016 | |||||
| Montréal Impact | 1-3 | New York City | |||
| 55 | Shipp | 35 | Villa | ||
| 45 | Harrison | ||||
| 85 | Lampard | ||||
| Portland Timbers | 3-1 | Seattle Sounders | |||
| 44 | Valeri | 59 | Marshall | ||
| 50 | Valeri | ||||
| 64 | Adi | ||||
| Philadelphia Union | 2-2 | New York Red Bulls | |||
| 67(p) | Sapong | 27 | Kljestan | ||
| 68 | Pontius | 44 | Kljestan | ||