| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 272 | 755 | 2.77 | 137 | 50.37% | 87 | 31.99% | 48 | 17.65% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York Red Bulls | 28 | 12 | 7 | 9 | 47 | 35 | +12 | 43 | WWXW | 13 | 10 | 1 | 2 | 27 | 11 | 15 | 2 | 6 | 7 | 20 | 24 | |
| 2 | 1 | Toronto FC | 27 | 12 | 7 | 8 | 39 | 28 | +11 | 43 | LWWX | 12 | 7 | 3 | 2 | 20 | 9 | 15 | 5 | 4 | 6 | 19 | 19 | |
| 3 | Philadelphia Union | 28 | 11 | 7 | 10 | 47 | 44 | +3 | 40 | LWWL | 14 | 8 | 3 | 3 | 29 | 19 | 14 | 3 | 4 | 7 | 18 | 25 | ||
| 4 | Montréal Impact | 27 | 9 | 10 | 8 | 41 | 42 | -1 | 37 | LWXL | 14 | 6 | 4 | 4 | 25 | 23 | 13 | 3 | 6 | 4 | 16 | 19 | ||
| 5 | 1 | Orlando City | 27 | 7 | 13 | 7 | 45 | 45 | +0 | 34 | WWLO | 14 | 5 | 7 | 2 | 26 | 21 | 13 | 2 | 6 | 5 | 19 | 24 | |
| 6 | 1 | D.C. United | 27 | 7 | 11 | 9 | 35 | 36 | -1 | 32 | LWXX | 14 | 6 | 4 | 4 | 25 | 16 | 13 | 1 | 7 | 5 | 10 | 20 | |
| 7 | New England Revolution | 28 | 7 | 9 | 12 | 31 | 47 | -16 | 30 | WLOL | 14 | 6 | 4 | 4 | 17 | 17 | 14 | 1 | 5 | 8 | 14 | 30 | ||
| 8 | 1 | Chicago Fire | 26 | 6 | 8 | 12 | 32 | 40 | -8 | 26 | WLXW | 13 | 5 | 6 | 2 | 19 | 14 | 13 | 1 | 2 | 10 | 13 | 26 | |
| 9 | 1 | Columbus Crew | 26 | 5 | 11 | 10 | 35 | 42 | -7 | 26 | LWLW | 14 | 4 | 8 | 2 | 25 | 22 | 12 | 1 | 3 | 8 | 10 | 20 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 28 | 15 | 6 | 7 | 45 | 36 | +9 | 51 | WWLX | 14 | 10 | 4 | 0 | 30 | 10 | 14 | 5 | 2 | 7 | 15 | 26 | ||
| 2 | Real Salt Lake | 28 | 12 | 8 | 8 | 42 | 40 | +2 | 44 | XWWL | 14 | 8 | 6 | 0 | 22 | 13 | 14 | 4 | 2 | 8 | 20 | 27 | ||
| 3 | 1 | LA Galaxy | 28 | 10 | 14 | 4 | 45 | 30 | +15 | 44 | XWOX | 14 | 7 | 7 | 0 | 26 | 12 | 14 | 3 | 7 | 4 | 19 | 18 | |
| 4 | 1 | Colorado Rapids | 26 | 11 | 10 | 5 | 28 | 24 | +4 | 43 | LLOX | 13 | 9 | 4 | 0 | 16 | 5 | 13 | 2 | 6 | 5 | 12 | 19 | |
| 5 | Sporting Kansas City | 28 | 11 | 5 | 12 | 32 | 32 | +0 | 38 | LWXL | 14 | 9 | 1 | 4 | 23 | 14 | 14 | 2 | 4 | 8 | 9 | 18 | ||
| 6 | Portland Timbers | 28 | 9 | 8 | 11 | 42 | 44 | -2 | 35 | LWLL | 14 | 9 | 2 | 3 | 31 | 20 | 14 | 0 | 6 | 8 | 11 | 24 | ||
| 7 | San Jose Earthquakes | 26 | 7 | 11 | 8 | 26 | 29 | -3 | 32 | LOLW | 13 | 6 | 5 | 2 | 14 | 8 | 13 | 1 | 6 | 6 | 12 | 21 | ||
| 8 | Seattle Sounders | 26 | 9 | 4 | 13 | 32 | 36 | -4 | 31 | LXWW | 13 | 7 | 1 | 5 | 18 | 11 | 13 | 2 | 3 | 8 | 14 | 25 | ||
| 9 | Vancouver Whitecaps | 28 | 8 | 7 | 13 | 34 | 44 | -10 | 31 | LOLL | 14 | 5 | 5 | 4 | 20 | 16 | 14 | 3 | 2 | 9 | 14 | 28 | ||
| 10 | Houston Dynamo | 26 | 5 | 10 | 11 | 29 | 34 | -5 | 25 | LXWX | 13 | 4 | 7 | 2 | 18 | 14 | 13 | 1 | 3 | 9 | 11 | 20 | ||
| 17 | +1 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| +1 | David VILLA (New York City, 4p) | |
| 16 | Sebastian GIOVINCO (Toronto FC, 3p) | |
| 14 | Ignacio PIATTI (Montréal Impact, 2p) | |
| 13 | Fanendo ADI (Portland Timbers, 1p) | |
| Cyle LARIN (Orlando City) | ||
| 12 | Dominic DWYER (Sporting Kansas City) | |
| +3 | GIOVANI dos Santos (LA Galaxy) | |
| 11 | +2 | Frank LAMPARD (New York City, 1p) |
| +1 | Diego VALERI (Portland Timbers, 3p) | |
| 10 | Chris PONTIUS (Philadelphia Union) | |
| Ola KAMARA (Columbus Crew, 1p) | ||
| 9 | Kei KAMARA (New England Revolution, 1p) | |
| Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| Roland ALBERG (Philadelphia Union, 4p) | ||
| Kevin MOLINO (Orlando City, 1p) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| +1 | Didier DROGBA (Montréal Impact, 1p) | |
| +2 | Joao PLATA (Real Salt Lake, 2p) | |
| 8 | Clint DEMPSEY (Seattle Sounders, 2p) | |
| Michael BARRIOS (FC Dallas) | ||
| +2 | KAKÁ (Orlando City, 4p) |
| Thursday, 1 September 2016 | |||||
| New York City | 3-2 | D.C. United | |||
| 79 | Villa | 36 | Sam | ||
| 85 | Lampard | 90 | Neagle | ||
| 90 | Lampard | ||||
| Saturday, 3 September 2016 | |||||
| FC Dallas | 3-1 | Portland Timbers | |||
| 14(p) | Díaz | 87 | Valeri | ||
| 45 | Ulloa | ||||
| 53 | Zimmerman | ||||
| New England Revolution | 2-0 | Colorado Rapids | |||
| 12 | Agudelo | ||||
| 49 | Tierney | ||||
| LA Galaxy | 2-1 | Columbus Crew | |||
| 78 | Husidić | 90 | Jahn | ||
| 82 | Giovani | ||||
| Chicago Fire | 3-0 | Philadelphia Union | |||
| 22(og) | Alberg | ||||
| 71 | De Leeuw | ||||
| 90 | Álvarez | ||||
| Vancouver Whitecaps | 0-1 | New York Red Bulls | |||
| 50 | Wright-Phillips | ||||
| Wednesday, 7 September 2016 | |||||
| Montréal Impact | 1-4 | Orlando City | |||
| 2 | Drogba | 4 | Shea | ||
| 36 | Kaká | ||||
| 54(p) | Kaká | ||||
| 77 | Rivas | ||||
| Real Salt Lake | 3-3 | LA Galaxy | |||
| 53(p) | Plata | 6 | Boateng | ||
| 67 | Plata | 57 | Giovani | ||
| 90 | Martínez | 64 | Giovani | ||