| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 208 | 567 | 2.72 | 107 | 51.44% | 67 | 32.21% | 34 | 16.35% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York Red Bulls | 22 | 9 | 4 | 9 | 36 | 28 | +8 | 31 | WXWO | 11 | 8 | 1 | 2 | 23 | 10 | 11 | 1 | 3 | 7 | 13 | 18 | |
| 2 | 1 | Philadelphia Union | 21 | 8 | 6 | 7 | 35 | 33 | +2 | 30 | LXWL | 11 | 7 | 3 | 1 | 25 | 14 | 10 | 1 | 3 | 6 | 10 | 19 | |
| 3 | Montréal Impact | 20 | 7 | 8 | 5 | 35 | 30 | +5 | 29 | WLXX | 10 | 5 | 3 | 2 | 22 | 15 | 10 | 2 | 5 | 3 | 13 | 15 | ||
| 4 | Toronto FC | 20 | 7 | 6 | 7 | 25 | 23 | +2 | 27 | WLXW | 8 | 4 | 3 | 1 | 12 | 7 | 12 | 3 | 3 | 6 | 13 | 16 | ||
| 5 | New England Revolution | 21 | 6 | 8 | 7 | 27 | 33 | -6 | 26 | WOWL | 11 | 5 | 4 | 2 | 15 | 11 | 10 | 1 | 4 | 5 | 12 | 22 | ||
| 6 | 1 | Orlando City | 20 | 4 | 11 | 5 | 32 | 35 | -3 | 23 | XXLO | 10 | 3 | 7 | 0 | 19 | 14 | 10 | 1 | 4 | 5 | 13 | 21 | |
| 7 | 1 | D.C. United | 20 | 5 | 7 | 8 | 19 | 25 | -6 | 22 | LXLX | 9 | 4 | 1 | 4 | 12 | 9 | 11 | 1 | 6 | 4 | 7 | 16 | |
| 8 | Columbus Crew | 20 | 3 | 10 | 7 | 26 | 32 | -6 | 19 | XXXL | 11 | 3 | 7 | 1 | 19 | 17 | 9 | 0 | 3 | 6 | 7 | 15 | ||
| 9 | Chicago Fire | 19 | 4 | 5 | 10 | 17 | 25 | -8 | 17 | LLWL | 9 | 4 | 3 | 2 | 10 | 8 | 10 | 0 | 2 | 8 | 7 | 17 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 23 | 12 | 5 | 6 | 35 | 31 | +4 | 41 | XWLW | 11 | 8 | 3 | 0 | 23 | 7 | 12 | 4 | 2 | 6 | 12 | 24 | ||
| 2 | Colorado Rapids | 20 | 10 | 8 | 2 | 23 | 14 | +9 | 38 | XWXO | 11 | 8 | 3 | 0 | 14 | 5 | 9 | 2 | 5 | 2 | 9 | 9 | ||
| 3 | LA Galaxy | 20 | 9 | 8 | 3 | 34 | 19 | +15 | 35 | WWWW | 10 | 6 | 4 | 0 | 21 | 8 | 10 | 3 | 4 | 3 | 13 | 11 | ||
| 4 | 3 | Sporting Kansas City | 23 | 9 | 4 | 10 | 27 | 25 | +2 | 31 | WLLW | 12 | 7 | 1 | 4 | 20 | 14 | 11 | 2 | 3 | 6 | 7 | 11 | |
| 5 | 1 | Real Salt Lake | 21 | 8 | 7 | 6 | 30 | 31 | -1 | 31 | XOLX | 10 | 5 | 5 | 0 | 13 | 8 | 11 | 3 | 2 | 6 | 17 | 23 | |
| 6 | 1 | Vancouver Whitecaps | 22 | 8 | 6 | 8 | 33 | 35 | -2 | 30 | OXWX | 12 | 5 | 5 | 2 | 19 | 13 | 10 | 3 | 1 | 6 | 14 | 22 | |
| 7 | 1 | Portland Timbers | 22 | 7 | 8 | 7 | 33 | 33 | +0 | 29 | LWXO | 12 | 7 | 2 | 3 | 24 | 18 | 10 | 0 | 6 | 4 | 9 | 15 | |
| 8 | San Jose Earthquakes | 20 | 6 | 8 | 6 | 22 | 23 | -1 | 26 | XWLL | 10 | 6 | 3 | 1 | 13 | 6 | 10 | 0 | 5 | 5 | 9 | 17 | ||
| 9 | Seattle Sounders | 20 | 6 | 2 | 12 | 20 | 27 | -7 | 20 | LLWL | 10 | 5 | 0 | 5 | 12 | 8 | 10 | 1 | 2 | 7 | 8 | 19 | ||
| 10 | Houston Dynamo | 20 | 4 | 7 | 9 | 23 | 26 | -3 | 19 | OLOW | 9 | 4 | 4 | 1 | 14 | 8 | 11 | 0 | 3 | 8 | 9 | 18 | ||
| 13 | David VILLA (New York City, 3p) | |
| 12 | +1 | Ignacio PIATTI (Montréal Impact, 2p) |
| 11 | +2 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| +3 | Sebastian GIOVINCO (Toronto FC, 2p) | |
| 10 | Fanendo ADI (Portland Timbers, 1p) | |
| +2 | Dominic DWYER (Sporting Kansas City) | |
| +1 | Ola KAMARA (Columbus Crew, 1p) | |
| +1 | Cyle LARIN (Orlando City) | |
| 9 | Diego VALERI (Portland Timbers, 3p) | |
| 8 | Kei KAMARA (New England Revolution, 1p) | |
| +1 | Chris PONTIUS (Philadelphia Union) | |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| +3 | Didier DROGBA (Montréal Impact, 1p) | |
| 7 | +1 | Robbie KEANE (LA Galaxy, 2p) |
| Jordan MORRIS (Seattle Sounders) | ||
| +1 | Kevin MOLINO (Orlando City, 1p) | |
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| GIOVANI dos Santos (LA Galaxy) | ||
| 6 | Mike GRELLA (New York Red Bulls) | |
| Roland ALBERG (Philadelphia Union, 3p) | ||
| Michael BARRIOS (FC Dallas) | ||
| C.J. SAPONG (Philadelphia Union, 1p) | ||
| Pedro MORALES (Vancouver Whitecaps, 5p) | ||
| Juan MARTÍNEZ (Real Salt Lake) |
| Friday, 22 July 2016 | |||||
| Real Salt Lake | 1-1 | San Jose Earthquakes | |||
| 64 | Mulholland | 9 | Wondolowski | ||
| Saturday, 23 July 2016 | |||||
| Houston Dynamo | 0-0 | Vancouver Whitecaps | |||
| Colorado Rapids | 1-1 | FC Dallas | |||
| 44 | Hairston | 82 | Ulloa | ||
| Columbus Crew | 2-2 | Orlando City | |||
| 20 | Tchani | 65 | Molino | ||
| 45(p) | Kamara | 70 | Larin | ||
| New England Revolution | 1-0 | Chicago Fire | |||
| 85 | Watson | ||||
| Montréal Impact | 5-1 | Philadelphia Union | |||
| 19 | Drogba | 72 | Pontius | ||
| 42 | Drogba | ||||
| 52 | Drogba | ||||
| 87 | Piatti | ||||
| 90 | Mancosu | ||||
| Portland Timbers | 1-2 | LA Galaxy | |||
| 41 | Valentin | 7 | Keane | ||
| 11 | Zardes | ||||
| Toronto FC | 4-1 | D.C. United | |||
| 21 | Giovinco | 24 | Jeffrey | ||
| 29 | Delgado | ||||
| 39 | Giovinco | ||||
| 90 | Giovinco | ||||
| Sunday, 24 July 2016 | |||||
| New York Red Bulls | 4-1 | New York City | |||
| 20 | Wright-Phillips | 43 | McNamara | ||
| 23 | Zubar | ||||
| 41(p) | Kljestan | ||||
| 70 | Wright-Phillips | ||||
| Sporting Kansas City | 3-0 | Seattle Sounders | |||
| 21 | Dwyer | ||||
| 45 | Peterson | ||||
| 79 | Dwyer | ||||