| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 246 | 674 | 2.73 | 124 | 50.41% | 80 | 32.52% | 42 | 17.07% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Toronto FC | 25 | 11 | 7 | 7 | 37 | 26 | +11 | 40 | WXWW | 11 | 7 | 3 | 1 | 20 | 8 | 14 | 4 | 4 | 6 | 17 | 18 | |
| 2 | 1 | New York Red Bulls | 25 | 10 | 6 | 9 | 43 | 33 | +10 | 36 | WXXW | 12 | 9 | 1 | 2 | 26 | 11 | 13 | 1 | 5 | 7 | 17 | 22 | |
| 3 | Philadelphia Union | 25 | 9 | 7 | 9 | 43 | 40 | +3 | 34 | LWXL | 13 | 7 | 3 | 3 | 27 | 19 | 12 | 2 | 4 | 6 | 16 | 21 | ||
| 4 | Montréal Impact | 24 | 8 | 9 | 7 | 38 | 37 | +1 | 33 | LLWX | 12 | 6 | 3 | 3 | 23 | 18 | 12 | 2 | 6 | 4 | 15 | 19 | ||
| 5 | 2 | Orlando City | 24 | 5 | 13 | 6 | 38 | 41 | -3 | 28 | OXLW | 12 | 4 | 7 | 1 | 23 | 18 | 12 | 1 | 6 | 5 | 15 | 23 | |
| 6 | 1 | D.C. United | 23 | 6 | 9 | 8 | 24 | 28 | -4 | 27 | WXXL | 12 | 5 | 3 | 4 | 17 | 12 | 11 | 1 | 6 | 4 | 7 | 16 | |
| 7 | 1 | New England Revolution | 25 | 6 | 8 | 11 | 29 | 46 | -17 | 26 | LLLL | 13 | 5 | 4 | 4 | 15 | 17 | 12 | 1 | 4 | 7 | 14 | 29 | |
| 8 | Columbus Crew | 23 | 4 | 11 | 8 | 31 | 38 | -7 | 23 | WXLX | 12 | 3 | 8 | 1 | 22 | 20 | 11 | 1 | 3 | 7 | 9 | 18 | ||
| 9 | Chicago Fire | 23 | 5 | 7 | 11 | 25 | 32 | -7 | 22 | WXLX | 11 | 4 | 5 | 2 | 14 | 12 | 12 | 1 | 2 | 9 | 11 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 26 | 13 | 6 | 7 | 39 | 34 | +5 | 45 | LXWX | 13 | 9 | 4 | 0 | 27 | 9 | 13 | 4 | 2 | 7 | 12 | 25 | ||
| 2 | Colorado Rapids | 24 | 11 | 10 | 3 | 27 | 20 | +7 | 43 | OXWL | 13 | 9 | 4 | 0 | 16 | 5 | 11 | 2 | 6 | 3 | 11 | 15 | ||
| 3 | 1 | Real Salt Lake | 26 | 11 | 7 | 8 | 37 | 36 | +1 | 40 | WLWL | 12 | 7 | 5 | 0 | 17 | 9 | 14 | 4 | 2 | 8 | 20 | 27 | |
| 4 | 1 | Sporting Kansas City | 27 | 11 | 5 | 11 | 32 | 30 | +2 | 38 | WXLW | 14 | 9 | 1 | 4 | 23 | 14 | 13 | 2 | 4 | 7 | 9 | 16 | |
| 5 | 2 | LA Galaxy | 24 | 9 | 11 | 4 | 38 | 24 | +14 | 38 | LXXX | 12 | 6 | 6 | 0 | 24 | 11 | 12 | 3 | 5 | 4 | 14 | 13 | |
| 6 | Portland Timbers | 25 | 8 | 8 | 9 | 36 | 36 | +0 | 32 | LWLL | 13 | 8 | 2 | 3 | 27 | 18 | 12 | 0 | 6 | 6 | 9 | 18 | ||
| 7 | San Jose Earthquakes | 24 | 7 | 10 | 7 | 26 | 27 | -1 | 31 | LWOX | 12 | 6 | 4 | 2 | 14 | 8 | 12 | 1 | 6 | 5 | 12 | 19 | ||
| 8 | Vancouver Whitecaps | 26 | 8 | 6 | 12 | 34 | 43 | -9 | 30 | LLLL | 13 | 5 | 5 | 3 | 20 | 15 | 13 | 3 | 1 | 9 | 14 | 28 | ||
| 9 | Seattle Sounders | 23 | 8 | 3 | 12 | 26 | 30 | -4 | 27 | WWXL | 12 | 6 | 1 | 5 | 15 | 10 | 11 | 2 | 2 | 7 | 11 | 20 | ||
| 10 | Houston Dynamo | 24 | 5 | 9 | 10 | 27 | 30 | -3 | 24 | WXLX | 11 | 4 | 6 | 1 | 16 | 10 | 13 | 1 | 3 | 9 | 11 | 20 | ||
| 16 | +1 | David VILLA (New York City, 4p) |
| +1 | Sebastian GIOVINCO (Toronto FC, 3p) | |
| 14 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) | |
| 13 | Ignacio PIATTI (Montréal Impact, 2p) | |
| 12 | Dominic DWYER (Sporting Kansas City) | |
| +1 | Cyle LARIN (Orlando City) | |
| 11 | Fanendo ADI (Portland Timbers, 1p) | |
| 10 | Chris PONTIUS (Philadelphia Union) | |
| Ola KAMARA (Columbus Crew, 1p) | ||
| Diego VALERI (Portland Timbers, 3p) | ||
| 9 | Kei KAMARA (New England Revolution, 1p) | |
| Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | ||
| Frank LAMPARD (New York City, 1p) | ||
| Kevin MOLINO (Orlando City, 1p) | ||
| 8 | +1 | Jordan MORRIS (Seattle Sounders) |
| Roland ALBERG (Philadelphia Union, 4p) | ||
| GIOVANI dos Santos (LA Galaxy) | ||
| Didier DROGBA (Montréal Impact, 1p) | ||
| 7 | Maximiliano URRUTI (FC Dallas) | |
| Robbie KEANE (LA Galaxy, 2p) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| C.J. SAPONG (Philadelphia Union, 1p) | ||
| +1 | Joao PLATA (Real Salt Lake, 1p) |
| Sunday, 14 August 2016 | |||||
| Houston Dynamo | 1-1 | Toronto FC | |||
| 8 | Maidana | 24 | Altidore | ||
| Chicago Fire | 2-2 | Orlando City | |||
| 6 | Goossens | 9 | Larin | ||
| 78 | Cociș | 32 | Kaká | ||
| Seattle Sounders | 2-1 | Real Salt Lake | |||
| 24 | Lodeiro | 62 | Plata | ||
| 37 | Morris | ||||
| Friday, 19 August 2016 | |||||
| San Jose Earthquakes | 1-2 | Houston Dynamo | |||
| 54 | Bernárdez | 6 | Clark | ||
| 50 | Horst | ||||
| Saturday, 20 August 2016 | |||||
| Colorado Rapids | 0-0 | Orlando City | |||
| New England Revolution | 0-2 | Columbus Crew | |||
| 8 | Finlay | ||||
| 49 | Higuaín | ||||
| Sporting Kansas City | 2-0 | Vancouver Whitecaps | |||
| 39 | Peterson | ||||
| 64(p) | Feilhaber | ||||
| Montréal Impact | 0-3 | Chicago Fire | |||
| 15 | Solignac | ||||
| 73 | Accam | ||||
| 89 | Polster | ||||
| Real Salt Lake | 1-0 | FC Dallas | |||
| 78 | Olave | ||||
| Philadelphia Union | 1-3 | Toronto FC | |||
| 24 | Tribbett | 18 | Giovinco | ||
| 30 | Moor | ||||
| 44 | Altidore | ||||
| New York City | 1-0 | LA Galaxy | |||
| 6 | Villa | ||||