| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 235 | 649 | 2.76 | 120 | 51.06% | 77 | 32.77% | 38 | 16.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | New York Red Bulls | 25 | 10 | 6 | 9 | 43 | 33 | +10 | 36 | WXXW | 12 | 9 | 1 | 2 | 26 | 11 | 13 | 1 | 5 | 7 | 17 | 22 | |
| 2 | 1 | Toronto FC | 23 | 10 | 6 | 7 | 33 | 24 | +9 | 36 | WWWW | 11 | 7 | 3 | 1 | 20 | 8 | 12 | 3 | 3 | 6 | 13 | 16 | |
| 3 | 1 | Philadelphia Union | 24 | 9 | 7 | 8 | 42 | 37 | +5 | 34 | WXLL | 12 | 7 | 3 | 2 | 26 | 16 | 12 | 2 | 4 | 6 | 16 | 21 | |
| 4 | 2 | Montréal Impact | 23 | 8 | 9 | 6 | 38 | 34 | +4 | 33 | LWXW | 11 | 6 | 3 | 2 | 23 | 15 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 5 | 2 | D.C. United | 23 | 6 | 9 | 8 | 24 | 28 | -4 | 27 | WXXL | 12 | 5 | 3 | 4 | 17 | 12 | 11 | 1 | 6 | 4 | 7 | 16 | |
| 6 | 1 | New England Revolution | 24 | 6 | 8 | 10 | 29 | 44 | -15 | 26 | LLLW | 12 | 5 | 4 | 3 | 15 | 15 | 12 | 1 | 4 | 7 | 14 | 29 | |
| 7 | 1 | Orlando City | 22 | 5 | 11 | 6 | 36 | 39 | -3 | 26 | LWXX | 12 | 4 | 7 | 1 | 23 | 18 | 10 | 1 | 4 | 5 | 13 | 21 | |
| 8 | Columbus Crew | 22 | 3 | 11 | 8 | 29 | 38 | -9 | 20 | XLXX | 12 | 3 | 8 | 1 | 22 | 20 | 10 | 0 | 3 | 7 | 7 | 18 | ||
| 9 | Chicago Fire | 21 | 4 | 6 | 11 | 20 | 30 | -10 | 18 | LXLL | 10 | 4 | 4 | 2 | 12 | 10 | 11 | 0 | 2 | 9 | 8 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | FC Dallas | 25 | 13 | 6 | 6 | 39 | 33 | +6 | 45 | XWXW | 13 | 9 | 4 | 0 | 27 | 9 | 12 | 4 | 2 | 6 | 12 | 24 | ||
| 2 | Colorado Rapids | 23 | 11 | 9 | 3 | 27 | 20 | +7 | 42 | XWLX | 12 | 9 | 3 | 0 | 16 | 5 | 11 | 2 | 6 | 3 | 11 | 15 | ||
| 3 | 1 | LA Galaxy | 23 | 9 | 11 | 3 | 38 | 23 | +15 | 38 | XXXW | 12 | 6 | 6 | 0 | 24 | 11 | 11 | 3 | 5 | 3 | 14 | 12 | |
| 4 | 1 | Real Salt Lake | 24 | 10 | 7 | 7 | 35 | 34 | +1 | 37 | WLWX | 11 | 6 | 5 | 0 | 16 | 9 | 13 | 4 | 2 | 7 | 19 | 25 | |
| 5 | Sporting Kansas City | 26 | 10 | 5 | 11 | 30 | 30 | +0 | 35 | XLWW | 13 | 8 | 1 | 4 | 21 | 14 | 13 | 2 | 4 | 7 | 9 | 16 | ||
| 6 | 1 | Portland Timbers | 25 | 8 | 8 | 9 | 36 | 36 | +0 | 32 | LWLL | 13 | 8 | 2 | 3 | 27 | 18 | 12 | 0 | 6 | 6 | 9 | 18 | |
| 7 | 1 | San Jose Earthquakes | 23 | 7 | 10 | 6 | 25 | 25 | +0 | 31 | WOXX | 11 | 6 | 4 | 1 | 13 | 6 | 12 | 1 | 6 | 5 | 12 | 19 | |
| 8 | 2 | Vancouver Whitecaps | 25 | 8 | 6 | 11 | 34 | 41 | -7 | 30 | LLLO | 13 | 5 | 5 | 3 | 20 | 15 | 12 | 3 | 1 | 8 | 14 | 26 | |
| 9 | Seattle Sounders | 22 | 7 | 3 | 12 | 24 | 29 | -5 | 24 | WXLL | 11 | 5 | 1 | 5 | 13 | 9 | 11 | 2 | 2 | 7 | 11 | 20 | ||
| 10 | Houston Dynamo | 22 | 4 | 8 | 10 | 24 | 28 | -4 | 20 | LXOL | 10 | 4 | 5 | 1 | 15 | 9 | 12 | 0 | 3 | 9 | 9 | 19 | ||
| 15 | +2 | David VILLA (New York City, 4p) |
| Sebastian GIOVINCO (Toronto FC, 3p) | ||
| 14 | +2 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) |
| 13 | +1 | Ignacio PIATTI (Montréal Impact, 2p) |
| 12 | +2 | Dominic DWYER (Sporting Kansas City) |
| 11 | +1 | Fanendo ADI (Portland Timbers, 1p) |
| Cyle LARIN (Orlando City) | ||
| 10 | +1 | Chris PONTIUS (Philadelphia Union) |
| Ola KAMARA (Columbus Crew, 1p) | ||
| +1 | Diego VALERI (Portland Timbers, 3p) | |
| 9 | Kei KAMARA (New England Revolution, 1p) | |
| Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | ||
| +1 | Frank LAMPARD (New York City, 1p) | |
| Kevin MOLINO (Orlando City, 1p) | ||
| 8 | +1 | Roland ALBERG (Philadelphia Union, 4p) |
| +1 | GIOVANI dos Santos (LA Galaxy) | |
| Didier DROGBA (Montréal Impact, 1p) | ||
| 7 | +1 | Maximiliano URRUTI (FC Dallas) |
| Robbie KEANE (LA Galaxy, 2p) | ||
| Jordan MORRIS (Seattle Sounders) | ||
| Yura MOVSISYAN (Real Salt Lake, 2p) | ||
| +1 | C.J. SAPONG (Philadelphia Union, 1p) |
| Sunday, 7 August 2016 | |||||
| LA Galaxy | 2-2 | New York Red Bulls | |||
| 80 | Magee | 68 | Veron | ||
| 89 | Cole | 74 | Davis | ||
| Portland Timbers | 3-0 | Sporting Kansas City | |||
| 65 | Valeri | ||||
| 87 | Jewsbury | ||||
| 90 | Adi | ||||
| Orlando City | 1-3 | Seattle Sounders | |||
| 7 | Hines | 14 | Dempsey | ||
| 37 | Dempsey | ||||
| 48 | Dempsey | ||||
| Friday, 12 August 2016 | |||||
| Vancouver Whitecaps | 1-2 | San Jose Earthquakes | |||
| 90 | Mezquida | 14 | Amarikwa | ||
| 60 | Dawkins | ||||
| Saturday, 13 August 2016 | |||||
| D.C. United | 2-0 | Portland Timbers | |||
| 7 | Birnbaum | ||||
| 29 | Acosta | ||||
| FC Dallas | 2-2 | Sporting Kansas City | |||
| 66 | Akindele | 68 | Dwyer | ||
| 76 | Urruti | 73 | Dwyer | ||
| New York Red Bulls | 3-1 | Montréal Impact | |||
| 22 | Wright-Phillips | 21 | Piatti | ||
| 41 | Wright-Phillips | ||||
| 46 | Davis | ||||
| Columbus Crew | 3-3 | New York City | |||
| 49 | Meram | 41 | Lampard | ||
| 80(p) | Finlay | 83 | Villa | ||
| 90 | Finlay | 90(p) | Villa | ||
| New England Revolution | 0-4 | Philadelphia Union | |||
| 2 | Sapong | ||||
| 51 | Pontius | ||||
| 54 | Marquez | ||||
| 90 | Alberg | ||||
| LA Galaxy | 1-1 | Colorado Rapids | |||
| 62 | Giovani | 51 | Gashi | ||