| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 132 | 368 | 2.78 | 69 | 52.27% | 39 | 29.55% | 24 | 18.18% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 13 | 5 | 5 | 3 | 18 | 14 | +4 | 20 | XXWX | 6 | 4 | 2 | 0 | 11 | 4 | 7 | 1 | 3 | 3 | 7 | 10 | ||
| 2 | New York Red Bulls | 14 | 6 | 1 | 7 | 24 | 20 | +4 | 19 | WWWL | 7 | 5 | 0 | 2 | 15 | 9 | 7 | 1 | 1 | 5 | 9 | 11 | ||
| 3 | 1 | Montréal Impact | 13 | 5 | 4 | 4 | 22 | 20 | +2 | 19 | WLXX | 6 | 3 | 2 | 1 | 11 | 7 | 7 | 2 | 2 | 3 | 11 | 13 | |
| 4 | 2 | D.C. United | 13 | 4 | 4 | 5 | 14 | 14 | +0 | 16 | WLWL | 7 | 3 | 1 | 3 | 10 | 7 | 6 | 1 | 3 | 2 | 4 | 7 | |
| 5 | 2 | Toronto FC | 13 | 4 | 4 | 5 | 14 | 15 | -1 | 16 | LOXL | 4 | 1 | 2 | 1 | 5 | 5 | 9 | 3 | 2 | 4 | 9 | 10 | |
| 6 | 1 | New England Revolution | 14 | 3 | 7 | 4 | 19 | 25 | -6 | 16 | WLWL | 8 | 3 | 4 | 1 | 11 | 9 | 6 | 0 | 3 | 3 | 8 | 16 | |
| 7 | 2 | Orlando City | 12 | 3 | 6 | 3 | 21 | 19 | +2 | 15 | XWLX | 7 | 2 | 5 | 0 | 14 | 10 | 5 | 1 | 1 | 3 | 7 | 9 | |
| 8 | Columbus Crew | 12 | 3 | 5 | 4 | 16 | 18 | -2 | 14 | WOXX | 6 | 3 | 2 | 1 | 14 | 12 | 6 | 0 | 3 | 3 | 2 | 6 | ||
| 9 | Chicago Fire | 12 | 2 | 5 | 5 | 10 | 14 | -4 | 11 | XWLL | 7 | 2 | 3 | 2 | 8 | 8 | 5 | 0 | 2 | 3 | 2 | 6 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Colorado Rapids | 14 | 8 | 4 | 2 | 17 | 10 | +7 | 28 | XWXW | 7 | 6 | 1 | 0 | 10 | 3 | 7 | 2 | 3 | 2 | 7 | 7 | ||
| 2 | FC Dallas | 15 | 8 | 3 | 4 | 23 | 21 | +2 | 27 | OWWW | 7 | 5 | 2 | 0 | 13 | 5 | 8 | 3 | 1 | 4 | 10 | 16 | ||
| 3 | 1 | Vancouver Whitecaps | 15 | 6 | 3 | 6 | 23 | 25 | -2 | 21 | XLWW | 8 | 4 | 3 | 1 | 12 | 7 | 7 | 2 | 0 | 5 | 11 | 18 | |
| 4 | 1 | Real Salt Lake | 12 | 6 | 2 | 4 | 20 | 19 | +1 | 20 | LWLL | 4 | 4 | 0 | 0 | 6 | 2 | 8 | 2 | 2 | 4 | 14 | 17 | |
| 5 | LA Galaxy | 12 | 5 | 5 | 2 | 27 | 16 | +11 | 20 | LXXW | 6 | 4 | 2 | 0 | 18 | 8 | 6 | 1 | 3 | 2 | 9 | 8 | ||
| 6 | San Jose Earthquakes | 13 | 5 | 5 | 3 | 16 | 15 | +1 | 20 | OXWL | 7 | 5 | 2 | 0 | 10 | 3 | 6 | 0 | 3 | 3 | 6 | 12 | ||
| 7 | Sporting Kansas City | 15 | 5 | 2 | 8 | 14 | 18 | -4 | 17 | LLWL | 8 | 3 | 1 | 4 | 9 | 11 | 7 | 2 | 1 | 4 | 5 | 7 | ||
| 8 | 1 | Portland Timbers | 14 | 4 | 4 | 6 | 22 | 25 | -3 | 16 | XWLL | 7 | 4 | 1 | 2 | 15 | 12 | 7 | 0 | 3 | 4 | 7 | 13 | |
| 9 | 1 | Seattle Sounders | 12 | 4 | 1 | 7 | 11 | 15 | -4 | 13 | LLLW | 7 | 4 | 0 | 3 | 7 | 5 | 5 | 0 | 1 | 4 | 4 | 10 | |
| 10 | Houston Dynamo | 13 | 3 | 3 | 7 | 19 | 21 | -2 | 12 | XLWL | 6 | 3 | 2 | 1 | 13 | 8 | 7 | 0 | 1 | 6 | 6 | 13 | ||
| 8 | Fanendo ADI (Portland Timbers, 1p) | |
| +1 | Ignacio PIATTI (Montréal Impact) | |
| +3 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) | |
| David VILLA (New York City, 2p) | ||
| Sebastian GIOVINCO (Toronto FC, 2p) | ||
| 7 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| +1 | Cyle LARIN (Orlando City) | |
| 6 | Dominic DWYER (Sporting Kansas City) | |
| +1 | GIOVANI dos Santos (LA Galaxy) | |
| +1 | Pedro MORALES (Vancouver Whitecaps, 5p) | |
| 5 | Kei KAMARA (New England Revolution, 1p) | |
| +1 | Kevin MOLINO (Orlando City, 1p) | |
| +1 | Mike MAGEE (LA Galaxy) | |
| Michael BARRIOS (FC Dallas) | ||
| +2 | Diego VALERI (Portland Timbers, 1p) | |
| C.J. SAPONG (Philadelphia Union) | ||
| Tesho AKINDELE (FC Dallas, 2p) | ||
| +1 | Didier DROGBA (Montréal Impact, 1p) | |
| +1 | Joao PLATA (Real Salt Lake, 1p) |
| Sunday, 22 May 2016 | |||||
| LA Galaxy | 1-1 | San Jose Earthquakes | |||
| 83(og) | Wynne | 87 | Alashe | ||
| Portland Timbers | 4-2 | Vancouver Whitecaps | |||
| 4(p) | Valeri | 49 | Manneh | ||
| 29 | McInerney | 84(p) | Morales | ||
| 78(p) | Asprilla | ||||
| 82 | Nagbe | ||||
| Wednesday, 25 May 2016 | |||||
| Orlando City | 2-2 | Philadelphia Union | |||
| 68 | Molino | 52 | Barnetta | ||
| 71 | Larin | 75 | Tribbett | ||
| Friday, 27 May 2016 | |||||
| Sporting Kansas City | 0-1 | D.C. United | |||
| 86 | Kamara | ||||
| Saturday, 28 May 2016 | |||||
| Colorado Rapids | 1-1 | Philadelphia Union | |||
| 87 | Cronin | 90 | Carroll | ||
| New York Red Bulls | 3-0 | Toronto FC | |||
| 4 | Wright-Phillips | ||||
| 25 | Wright-Phillips | ||||
| 27 | Wright-Phillips | ||||
| Columbus Crew | 4-3 | Real Salt Lake | |||
| 17 | Kamara | 13 | Mulholland | ||
| 20(og) | Glad | 78 | Allen | ||
| 64 | Kamara | 83 | Plata | ||
| 74 | Kamara | ||||
| New England Revolution | 2-1 | Seattle Sounders | |||
| 24(p) | Nguyen | 7 | Kovar | ||
| 80 | Hollinger-Janzen | ||||
| Chicago Fire | 1-1 | Portland Timbers | |||
| 20 | Accam | 18 | Valeri | ||
| Vancouver Whitecaps | 1-1 | Houston Dynamo | |||
| 52 | Rivero | 20 | Beasley | ||
| Montréal Impact | 3-2 | LA Galaxy | |||
| 26 | Piatti | 8 | Giovani | ||
| 56 | Ontivero | 58 | Magee | ||
| 90 | Drogba | ||||
| San Jose Earthquakes | 0-0 | FC Dallas | |||