| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 496 | 1,426 | 2.87 | 230 | 46.37% | 116 | 23.39% | 150 | 30.24% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 32 | 23 | 2 | 7 | 55 | 23 | +32 | 71 | WWWX | 16 | 13 | 1 | 2 | 37 | 10 | 16 | 10 | 1 | 5 | 18 | 13 | ||
| 2 | 1 | Louisville City | 32 | 18 | 7 | 7 | 61 | 37 | +24 | 61 | WWLL | 16 | 12 | 2 | 2 | 37 | 17 | 16 | 6 | 5 | 5 | 24 | 20 | |
| 3 | 1 | Birmingham Legion | 32 | 18 | 6 | 8 | 51 | 31 | +20 | 60 | LWOW | 16 | 10 | 2 | 4 | 31 | 16 | 16 | 8 | 4 | 4 | 20 | 15 | |
| 4 | Charlotte Independence | 32 | 18 | 5 | 9 | 57 | 36 | +21 | 59 | XWWW | 16 | 12 | 3 | 1 | 36 | 14 | 16 | 6 | 2 | 8 | 21 | 22 | ||
| 5 | Pittsburgh Riverhounds | 32 | 17 | 7 | 8 | 52 | 34 | +18 | 58 | OWWW | 16 | 9 | 4 | 3 | 27 | 13 | 16 | 8 | 3 | 5 | 25 | 21 | ||
| 6 | Miami FC | 32 | 16 | 6 | 10 | 55 | 40 | +15 | 54 | WLWL | 16 | 11 | 1 | 4 | 32 | 18 | 16 | 5 | 5 | 6 | 23 | 22 | ||
| 7 | Memphis 901 | 32 | 14 | 8 | 10 | 47 | 42 | +5 | 50 | WWLW | 16 | 9 | 3 | 4 | 26 | 18 | 16 | 5 | 5 | 6 | 21 | 24 | ||
| 8 | FC Tulsa | 32 | 14 | 5 | 13 | 49 | 48 | +1 | 47 | WLXW | 16 | 9 | 1 | 6 | 30 | 23 | 16 | 5 | 4 | 7 | 19 | 25 | ||
| 9 | Hartford Athletic | 32 | 12 | 5 | 15 | 50 | 50 | +0 | 41 | OWLW | 16 | 7 | 3 | 6 | 29 | 20 | 16 | 5 | 2 | 9 | 21 | 30 | ||
| 10 | OKC Energy | 32 | 8 | 13 | 11 | 30 | 38 | -8 | 37 | LLOX | 16 | 4 | 8 | 4 | 15 | 13 | 16 | 4 | 5 | 7 | 15 | 25 | ||
| 11 | Charleston Battery | 32 | 10 | 7 | 15 | 49 | 60 | -11 | 37 | LLLW | 16 | 7 | 3 | 6 | 26 | 25 | 16 | 3 | 4 | 9 | 23 | 35 | ||
| 12 | Indy Eleven | 32 | 9 | 8 | 15 | 32 | 47 | -15 | 35 | LXWL | 16 | 5 | 4 | 7 | 14 | 16 | 16 | 4 | 4 | 8 | 18 | 31 | ||
| 13 | Atlanta United 2 | 32 | 7 | 10 | 15 | 44 | 57 | -13 | 31 | LLLX | 16 | 4 | 7 | 5 | 26 | 24 | 16 | 3 | 3 | 10 | 18 | 33 | ||
| 14 | New York Red Bulls 2 | 32 | 7 | 7 | 18 | 42 | 67 | -25 | 28 | WLWX | 16 | 3 | 3 | 10 | 22 | 30 | 16 | 4 | 4 | 8 | 20 | 37 | ||
| 15 | Sporting Kansas City 2 | 32 | 5 | 8 | 19 | 34 | 61 | -27 | 23 | LLWL | 16 | 3 | 5 | 8 | 17 | 24 | 16 | 2 | 3 | 11 | 17 | 37 | ||
| 16 | Loudoun United | 32 | 4 | 3 | 25 | 31 | 78 | -47 | 15 | LLLL | 16 | 3 | 1 | 12 | 20 | 39 | 16 | 1 | 2 | 13 | 11 | 39 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 32 | 20 | 7 | 5 | 68 | 35 | +33 | 67 | XXWL | 16 | 11 | 5 | 0 | 41 | 12 | 16 | 9 | 2 | 5 | 27 | 23 | ||
| 2 | El Paso Locomotive | 32 | 18 | 10 | 4 | 56 | 34 | +22 | 64 | LWWL | 16 | 13 | 3 | 0 | 36 | 10 | 16 | 5 | 7 | 4 | 20 | 24 | ||
| 3 | 1 | San Antonio | 32 | 14 | 10 | 8 | 50 | 38 | +12 | 52 | WOLX | 16 | 7 | 6 | 3 | 27 | 16 | 16 | 7 | 4 | 5 | 23 | 22 | |
| 4 | 1 | Orange County SC | 32 | 15 | 7 | 10 | 44 | 37 | +7 | 52 | WWWW | 16 | 7 | 4 | 5 | 21 | 20 | 16 | 8 | 3 | 5 | 23 | 17 | |
| 5 | 2 | Colorado Springs | 32 | 13 | 10 | 9 | 60 | 50 | +10 | 49 | LXWL | 16 | 8 | 5 | 3 | 31 | 20 | 16 | 5 | 5 | 6 | 29 | 30 | |
| 6 | San Diego Loyal | 32 | 14 | 6 | 12 | 51 | 43 | +8 | 48 | XLLX | 16 | 9 | 2 | 5 | 28 | 20 | 16 | 5 | 4 | 7 | 23 | 23 | ||
| 7 | 1 | RGV Toros | 32 | 13 | 8 | 11 | 49 | 42 | +7 | 47 | WWWL | 16 | 9 | 2 | 5 | 28 | 21 | 16 | 4 | 6 | 6 | 21 | 21 | |
| 8 | 1 | New Mexico United | 32 | 12 | 10 | 10 | 44 | 40 | +4 | 46 | WLWX | 16 | 9 | 6 | 1 | 29 | 15 | 16 | 3 | 4 | 9 | 15 | 25 | |
| 9 | Austin Bold | 32 | 10 | 12 | 10 | 32 | 42 | -10 | 42 | XOLL | 16 | 6 | 7 | 3 | 18 | 16 | 16 | 4 | 5 | 7 | 14 | 26 | ||
| 10 | 2 | Oakland Roots | 32 | 11 | 8 | 13 | 36 | 43 | -7 | 41 | WWOL | 16 | 7 | 4 | 5 | 19 | 16 | 16 | 4 | 4 | 8 | 17 | 27 | |
| 11 | 1 | LA Galaxy 2 | 32 | 11 | 6 | 15 | 55 | 57 | -2 | 39 | LLLW | 16 | 4 | 5 | 7 | 31 | 25 | 16 | 7 | 1 | 8 | 24 | 32 | |
| 12 | 1 | Tacoma Defiance | 32 | 10 | 9 | 13 | 37 | 41 | -4 | 39 | XWOO | 16 | 8 | 4 | 4 | 24 | 16 | 16 | 2 | 5 | 9 | 13 | 25 | |
| 13 | Sacramento Republic | 32 | 8 | 12 | 12 | 36 | 42 | -6 | 36 | XXOX | 16 | 4 | 5 | 7 | 19 | 23 | 16 | 4 | 7 | 5 | 17 | 19 | ||
| 14 | Real Monarchs | 32 | 5 | 7 | 20 | 28 | 56 | -28 | 22 | LLXW | 16 | 4 | 5 | 7 | 18 | 25 | 16 | 1 | 2 | 13 | 10 | 31 | ||
| 15 | Las Vegas Lights | 32 | 6 | 3 | 23 | 41 | 77 | -36 | 21 | LLLW | 16 | 3 | 2 | 11 | 22 | 34 | 16 | 3 | 1 | 12 | 19 | 43 | ||
| 25 | Hadji BARRY (Colorado Springs, 6p) | |
| 21 | Sebastián GUENZATTI (Tampa Bay Rowdies, 5p) | |
| 20 | +2 | Kyle MURPHY (Memphis 901, 3p) |
| Cameron LANCASTER (Louisville City, 6p) | ||
| 18 | Neco BRETT (Birmingham Legion, 4p) | |
| 17 | Preston JUDD (LA Galaxy 2) | |
| 16 | SANTI Moar (Phoenix Rising, 2p) | |
| Russell CICERONE (Pittsburgh Riverhounds, 4p) | ||
| 14 | +2 | Chris WEHAN (New Mexico United, 1p) |
| Ronaldo DAMUS (Orange County SC) | ||
| 13 | +1 | Samuel ADENIRAN (Tacoma Defiance, 1p) |
| Jorge HERNÁNDEZ (LA Galaxy 2, 3p) | ||
| 12 | Villyan BIJEV (OKC Energy, 3p) | |
| 11 | NATHAN Uilian (San Antonio, 4p) | |
| Christiano FRANÇOIS (Miami FC, 1p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Irvin PARRA (Charlotte Independence, 1p) | ||
| Elvis AMOH (RGV Toros, 1p) | ||
| Dane KELLY (Charlotte Independence, 2p) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) | ||
| 10 | Tumi MOSHOBANE (San Diego Loyal) | |
| Aarón GÓMEZ (El Paso Locomotive) | ||
| Juan OBREGÓN (Hartford Athletic) | ||
| Manuel ARTEAGA (Indy Eleven, 1p) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| +2 | DUBA (Tampa Bay Rowdies) |
| Wednesday, 27 October 2021 | |||||
| Charlotte Independence | 1-0 | Loudoun United | |||
| 38 | Martínez | ||||
| Real Monarchs | 1-3 | RGV Toros | |||
| 41(og) | Diz | 16 | Sorto | ||
| 62 | Fjeldberg | ||||
| 66 | López | ||||
| Miami FC | 0-1 | Pittsburgh Riverhounds | |||
| Completion of previously abandoned game. 24 minutes played. | |||||
| Memphis 901 | 3-2 | FC Tulsa | |||
| 24 | Fortune | 8(p) | Marlon | ||
| 33 | Segbers | 74(og) | Logue | ||
| 75 | Murphy | ||||
| Saturday, 30 October 2021 | |||||
| Charleston Battery | 0-4 | Miami FC | |||
| 17 | Martínez | ||||
| 34 | Pérez | ||||
| 81 | Reid | ||||
| 83 | Reid | ||||
| Pittsburgh Riverhounds | 0-0 | Hartford Athletic | |||
| San Antonio | 3-0 | Colorado Springs | |||
| 5(og) | Edwards | ||||
| 46 | Gallegos | ||||
| 68 | Ford | ||||
| Phoenix Rising | 1-1 | Tacoma Defiance | |||
| 70 | Rodríguez | 30 | Adeniran | ||
| Sacramento Republic | 1-1 | San Diego Loyal | |||
| 77 | Iwasa | 67 | Guido | ||
| LA Galaxy 2 | 0-1 | Orange County SC | |||
| 90 | Enevoldsen | ||||
| FC Tulsa | 2-0 | OKC Energy | |||
| 11 | Rivas | ||||
| 82 | Marlon | ||||
| RGV Toros | 4-1 | El Paso Locomotive | |||
| 7(p) | López | 52 | Herrera | ||
| 45 | Edwards | ||||
| 59 | Edwards | ||||
| 79 | Ycaza | ||||
| Las Vegas Lights | 1-2 | Tampa Bay Rowdies | |||
| 24 | Trejo | 12 | Duba | ||
| 61 | Duba | ||||
| Birmingham Legion | 0-1 | Louisville City | |||
| 82 | Hoppenot | ||||
| Austin Bold | 1-1 | Charlotte Independence | |||
| 63 | Avila | 79 | Obertan | ||
| Memphis 901 | 3-0 | Indy Eleven | |||
| 12 | Lamah | ||||
| 32 | Murphy | ||||
| 56 | Fortune | ||||
| New Mexico United | 3-1 | Real Monarchs | |||
| 17 | Wehan | 40 | Mata | ||
| 45(p) | Wehan | ||||
| 81 | Bruce | ||||
| Loudoun United | 1-4 | New York Red Bulls 2 | |||
| 7 | Hopkins | 5 | Sowe | ||
| 26 | Rafanello | ||||
| 73 | Edelman | ||||
| 90 | Rafanello | ||||
| Oakland Roots | 1-0 | Sporting Kansas City 2 | |||
| 2 | Enríquez | ||||