| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 258 | 725 | 2.81 | 114 | 44.19% | 58 | 22.48% | 86 | 33.33% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 17 | 11 | 3 | 3 | 37 | 20 | +17 | 36 | WWWX | 11 | 8 | 2 | 1 | 25 | 10 | 6 | 3 | 1 | 2 | 12 | 10 | ||
| 2 | 1 | Tampa Bay Rowdies | 17 | 11 | 0 | 6 | 24 | 15 | +9 | 33 | WWLW | 10 | 8 | 0 | 2 | 18 | 7 | 7 | 3 | 0 | 4 | 6 | 8 | |
| 3 | 1 | Pittsburgh Riverhounds | 18 | 10 | 3 | 5 | 28 | 21 | +7 | 33 | LWWW | 8 | 4 | 1 | 3 | 10 | 8 | 10 | 6 | 2 | 2 | 18 | 13 | |
| 4 | Birmingham Legion | 17 | 10 | 2 | 5 | 23 | 18 | +5 | 32 | WLWX | 8 | 5 | 1 | 2 | 13 | 8 | 9 | 5 | 1 | 3 | 10 | 10 | ||
| 5 | Miami FC | 18 | 9 | 3 | 6 | 28 | 25 | +3 | 30 | WXWL | 9 | 6 | 0 | 3 | 15 | 13 | 9 | 3 | 3 | 3 | 13 | 12 | ||
| 6 | Hartford Athletic | 16 | 7 | 3 | 6 | 28 | 22 | +6 | 24 | LLXL | 7 | 3 | 3 | 1 | 15 | 6 | 9 | 4 | 0 | 5 | 13 | 16 | ||
| 7 | 1 | Charleston Battery | 16 | 7 | 3 | 6 | 26 | 24 | +2 | 24 | WLLW | 9 | 5 | 2 | 2 | 16 | 11 | 7 | 2 | 1 | 4 | 10 | 13 | |
| 8 | 2 | Charlotte Independence | 16 | 7 | 2 | 7 | 22 | 21 | +1 | 23 | WOWL | 6 | 4 | 1 | 1 | 12 | 6 | 10 | 3 | 1 | 6 | 10 | 15 | |
| 9 | 4 | Atlanta United 2 | 19 | 5 | 7 | 7 | 30 | 28 | +2 | 22 | XWLX | 12 | 4 | 5 | 3 | 24 | 16 | 7 | 1 | 2 | 4 | 6 | 12 | |
| 10 | 1 | OKC Energy | 18 | 5 | 7 | 6 | 20 | 21 | -1 | 22 | XWLO | 9 | 2 | 4 | 3 | 9 | 9 | 9 | 3 | 3 | 3 | 11 | 12 | |
| 11 | 4 | FC Tulsa | 16 | 7 | 1 | 8 | 25 | 29 | -4 | 22 | WLLL | 7 | 4 | 0 | 3 | 15 | 13 | 9 | 3 | 1 | 5 | 10 | 16 | |
| 12 | Memphis 901 | 15 | 5 | 5 | 5 | 16 | 20 | -4 | 20 | XLWW | 5 | 2 | 1 | 2 | 5 | 5 | 10 | 3 | 4 | 3 | 11 | 15 | ||
| 13 | 2 | Indy Eleven | 16 | 5 | 4 | 7 | 19 | 24 | -5 | 19 | LWLX | 8 | 1 | 2 | 5 | 6 | 10 | 8 | 4 | 2 | 2 | 13 | 14 | |
| 14 | Sporting Kansas City 2 | 19 | 3 | 5 | 11 | 23 | 38 | -15 | 14 | LLLL | 8 | 1 | 2 | 5 | 10 | 16 | 11 | 2 | 3 | 6 | 13 | 22 | ||
| 15 | New York Red Bulls 2 | 17 | 3 | 4 | 10 | 22 | 38 | -16 | 13 | LLLL | 10 | 1 | 2 | 7 | 11 | 19 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 17 | 2 | 1 | 14 | 15 | 35 | -20 | 7 | LOLL | 9 | 1 | 1 | 7 | 10 | 21 | 8 | 1 | 0 | 7 | 5 | 14 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | El Paso Locomotive | 16 | 11 | 4 | 1 | 26 | 10 | +16 | 37 | WWWW | 9 | 7 | 2 | 0 | 16 | 4 | 7 | 4 | 2 | 1 | 10 | 6 | ||
| 2 | Phoenix Rising | 16 | 11 | 3 | 2 | 38 | 13 | +25 | 36 | XWWW | 8 | 7 | 1 | 0 | 28 | 5 | 8 | 4 | 2 | 2 | 10 | 8 | ||
| 3 | RGV Toros | 17 | 8 | 4 | 5 | 25 | 19 | +6 | 28 | LWLX | 9 | 5 | 1 | 3 | 12 | 10 | 8 | 3 | 3 | 2 | 13 | 9 | ||
| 4 | Orange County SC | 17 | 7 | 4 | 6 | 26 | 21 | +5 | 25 | LWLX | 8 | 2 | 3 | 3 | 10 | 12 | 9 | 5 | 1 | 3 | 16 | 9 | ||
| 5 | Colorado Springs | 17 | 7 | 4 | 6 | 33 | 29 | +4 | 25 | XWLW | 9 | 4 | 2 | 3 | 19 | 16 | 8 | 3 | 2 | 3 | 14 | 13 | ||
| 6 | 3 | San Antonio | 17 | 6 | 6 | 5 | 25 | 20 | +5 | 24 | WLWL | 8 | 3 | 3 | 2 | 13 | 8 | 9 | 3 | 3 | 3 | 12 | 12 | |
| 7 | 1 | San Diego Loyal | 17 | 7 | 3 | 7 | 21 | 23 | -2 | 24 | LWLL | 8 | 5 | 1 | 2 | 10 | 7 | 9 | 2 | 2 | 5 | 11 | 16 | |
| 8 | 1 | Austin Bold | 16 | 6 | 5 | 5 | 15 | 18 | -3 | 23 | LWLX | 7 | 3 | 1 | 3 | 8 | 9 | 9 | 3 | 4 | 2 | 7 | 9 | |
| 9 | 1 | New Mexico United | 16 | 6 | 4 | 6 | 19 | 18 | +1 | 22 | OOLW | 7 | 4 | 2 | 1 | 10 | 4 | 9 | 2 | 2 | 5 | 9 | 14 | |
| 10 | 1 | Tacoma Defiance | 15 | 5 | 6 | 4 | 17 | 17 | +0 | 21 | WXOW | 8 | 5 | 3 | 0 | 13 | 5 | 7 | 0 | 3 | 4 | 4 | 12 | |
| 11 | 1 | LA Galaxy 2 | 17 | 5 | 4 | 8 | 27 | 31 | -4 | 19 | WLWL | 10 | 2 | 4 | 4 | 17 | 14 | 7 | 3 | 0 | 4 | 10 | 17 | |
| 12 | Sacramento Republic | 16 | 4 | 6 | 6 | 18 | 21 | -3 | 18 | OXWX | 8 | 2 | 2 | 4 | 11 | 13 | 8 | 2 | 4 | 2 | 7 | 8 | ||
| 13 | Las Vegas Lights | 16 | 5 | 2 | 9 | 23 | 34 | -11 | 17 | XWLL | 8 | 3 | 2 | 3 | 12 | 11 | 8 | 2 | 0 | 6 | 11 | 23 | ||
| 14 | Real Monarchs | 18 | 4 | 4 | 10 | 18 | 30 | -12 | 16 | WLLW | 10 | 3 | 2 | 5 | 12 | 17 | 8 | 1 | 2 | 5 | 6 | 13 | ||
| 15 | Oakland Roots | 13 | 1 | 4 | 8 | 8 | 22 | -14 | 7 | OLLL | 5 | 0 | 2 | 3 | 1 | 6 | 8 | 1 | 2 | 5 | 7 | 16 | ||
| 16 | +1 | Hadji BARRY (Colorado Springs, 5p) |
| 11 | +1 | Neco BRETT (Birmingham Legion, 4p) |
| 9 | +2 | Villyan BIJEV (OKC Energy, 3p) |
| +1 | Kyle MURPHY (Memphis 901, 1p) | |
| Ronaldo DAMUS (Orange County SC) | ||
| Cameron LANCASTER (Louisville City, 4p) | ||
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| 8 | SANTI Moar (Phoenix Rising, 1p) | |
| Russell CICERONE (Pittsburgh Riverhounds, 2p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| Preston JUDD (LA Galaxy 2) | ||
| 7 | +2 | NATHAN Uilian (San Antonio, 3p) |
| Dane KELLY (Charlotte Independence, 1p) | ||
| Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | ||
| 6 | +2 | Omar SOWE (New York Red Bulls 2) |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Aiden McFADDEN (Atlanta United 2) | ||
| Alex DIXON (Pittsburgh Riverhounds) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Sunday, 8 August 2021 | |||||
| Tacoma Defiance | 3-1 | Oakland Roots | |||
| 25 | Adeniran | 55 | Fall | ||
| 45 | Alvarez | ||||
| 45(p) | Adeniran | ||||
| RGV Toros | 1-2 | San Antonio | |||
| 35 | Azocár | 18(p) | Nathan | ||
| 58 | Nathan | ||||
| Atlanta United 2 | 6-2 | Indy Eleven | |||
| 1 | Wolff | 51 | Moon | ||
| 6 | Wolff | 61 | Vassell | ||
| 50 | Wolff | ||||
| 53 | Matheus | ||||
| 58 | Diop | ||||
| 90 | Mejia | ||||
| Tuesday, 10 August 2021 | |||||
| New York Red Bulls 2 | 2-3 | Charlotte Independence | |||
| 19 | Sowe | 13 | Palomino | ||
| 46 | Sowe | 25 | Martínez | ||
| 61 | Marveaux | ||||
| Memphis 901 | 1-1 | Colorado Springs | |||
| 84(p) | Murphy | 35(p) | Barry | ||
| Wednesday, 11 August 2021 | |||||
| Pittsburgh Riverhounds | 2-3 | Miami FC | |||
| 40 | Williamson | 52 | François | ||
| 50 | Forbes | 53 | Williams | ||
| 82(p) | Williams | ||||
| Atlanta United 2 | 2-2 | OKC Energy | |||
| 67 | Mertz | 39(p) | Bijev | ||
| 90 | Mejia | 76 | Bijev | ||
| Birmingham Legion | 4-2 | Sporting Kansas City 2 | |||
| 7 | Brett | 4 | Čuić | ||
| 70 | Williams | 74 | Roberts | ||
| 81 | Flemmings | ||||
| 90 | Asiedu | ||||
| Oakland Roots | 0-0 | Sacramento Republic | |||
| Friday, 13 August 2021 | |||||
| Charleston Battery | 1-0 | Loudoun United | |||
| 79 | Crawford | ||||
| Tampa Bay Rowdies | 1-0 | Hartford Athletic | |||
| 85 | Adebayo-Smith | ||||