| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 354 | 1,009 | 2.85 | 159 | 44.92% | 83 | 23.45% | 112 | 31.64% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 23 | 16 | 1 | 6 | 38 | 15 | +23 | 49 | WWWW | 13 | 11 | 0 | 2 | 29 | 7 | 10 | 5 | 1 | 4 | 9 | 8 | ||
| 2 | Pittsburgh Riverhounds | 25 | 14 | 5 | 6 | 42 | 26 | +16 | 47 | WXWW | 12 | 7 | 2 | 3 | 20 | 9 | 13 | 7 | 3 | 3 | 22 | 17 | ||
| 3 | Louisville City | 23 | 13 | 5 | 5 | 45 | 27 | +18 | 44 | XWLL | 13 | 9 | 2 | 2 | 27 | 12 | 10 | 4 | 3 | 3 | 18 | 15 | ||
| 4 | 1 | Miami FC | 23 | 12 | 5 | 6 | 37 | 27 | +10 | 41 | WXWW | 11 | 8 | 0 | 3 | 20 | 13 | 12 | 4 | 5 | 3 | 17 | 14 | |
| 5 | 1 | Birmingham Legion | 23 | 12 | 4 | 7 | 31 | 26 | +5 | 40 | XLWW | 10 | 6 | 1 | 3 | 16 | 11 | 13 | 6 | 3 | 4 | 15 | 15 | |
| 6 | FC Tulsa | 23 | 12 | 2 | 9 | 37 | 36 | +1 | 38 | XWWW | 11 | 7 | 1 | 3 | 23 | 17 | 12 | 5 | 1 | 6 | 14 | 19 | ||
| 7 | Charlotte Independence | 22 | 10 | 4 | 8 | 35 | 28 | +7 | 34 | WWXL | 10 | 6 | 3 | 1 | 20 | 11 | 12 | 4 | 1 | 7 | 15 | 17 | ||
| 8 | 3 | Hartford Athletic | 23 | 9 | 3 | 11 | 36 | 36 | +0 | 30 | WLLL | 11 | 5 | 3 | 3 | 23 | 14 | 12 | 4 | 0 | 8 | 13 | 22 | |
| 9 | 1 | OKC Energy | 24 | 7 | 9 | 8 | 25 | 28 | -3 | 30 | XLWW | 12 | 3 | 6 | 3 | 12 | 11 | 12 | 4 | 3 | 5 | 13 | 17 | |
| 10 | 1 | Atlanta United 2 | 24 | 7 | 8 | 9 | 38 | 37 | +1 | 29 | XWLL | 13 | 4 | 6 | 3 | 25 | 17 | 11 | 3 | 2 | 6 | 13 | 20 | |
| 11 | 1 | Charleston Battery | 21 | 8 | 5 | 8 | 31 | 30 | +1 | 29 | XLOW | 11 | 5 | 3 | 3 | 16 | 12 | 10 | 3 | 2 | 5 | 15 | 18 | |
| 12 | Indy Eleven | 23 | 8 | 5 | 10 | 27 | 33 | -6 | 29 | WLLW | 12 | 4 | 2 | 6 | 11 | 12 | 11 | 4 | 3 | 4 | 16 | 21 | ||
| 13 | Memphis 901 | 21 | 6 | 7 | 8 | 21 | 28 | -7 | 25 | LWLO | 9 | 3 | 2 | 4 | 9 | 11 | 12 | 3 | 5 | 4 | 12 | 17 | ||
| 14 | Sporting Kansas City 2 | 25 | 4 | 7 | 14 | 28 | 45 | -17 | 19 | LWLO | 13 | 2 | 4 | 7 | 15 | 22 | 12 | 2 | 3 | 7 | 13 | 23 | ||
| 15 | New York Red Bulls 2 | 23 | 4 | 4 | 15 | 27 | 53 | -26 | 16 | LLWL | 13 | 2 | 2 | 9 | 16 | 24 | 10 | 2 | 2 | 6 | 11 | 29 | ||
| 16 | Loudoun United | 22 | 3 | 2 | 17 | 20 | 49 | -29 | 11 | LLXL | 12 | 2 | 1 | 9 | 14 | 29 | 10 | 1 | 1 | 8 | 6 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 23 | 15 | 5 | 3 | 54 | 24 | +30 | 50 | WWWW | 12 | 9 | 3 | 0 | 36 | 9 | 11 | 6 | 2 | 3 | 18 | 15 | ||
| 2 | El Paso Locomotive | 22 | 13 | 7 | 2 | 35 | 16 | +19 | 46 | OWXL | 11 | 9 | 2 | 0 | 21 | 5 | 11 | 4 | 5 | 2 | 14 | 11 | ||
| 3 | Colorado Springs | 24 | 10 | 7 | 7 | 50 | 39 | +11 | 37 | OXWL | 13 | 6 | 4 | 3 | 26 | 18 | 11 | 4 | 3 | 4 | 24 | 21 | ||
| 4 | 1 | San Antonio | 23 | 10 | 7 | 6 | 35 | 27 | +8 | 37 | WWLX | 11 | 5 | 4 | 2 | 19 | 12 | 12 | 5 | 3 | 4 | 16 | 15 | |
| 5 | 1 | Orange County SC | 23 | 9 | 7 | 7 | 34 | 28 | +6 | 34 | WXOW | 11 | 3 | 4 | 4 | 15 | 17 | 12 | 6 | 3 | 3 | 19 | 11 | |
| 6 | 2 | San Diego Loyal | 23 | 10 | 4 | 9 | 35 | 31 | +4 | 34 | OWWL | 12 | 7 | 1 | 4 | 21 | 14 | 11 | 3 | 3 | 5 | 14 | 17 | |
| 7 | 2 | Austin Bold | 22 | 8 | 8 | 6 | 21 | 25 | -4 | 32 | WWLX | 12 | 5 | 4 | 3 | 13 | 12 | 10 | 3 | 4 | 3 | 8 | 13 | |
| 8 | RGV Toros | 23 | 8 | 7 | 8 | 32 | 32 | +0 | 31 | XXLL | 11 | 5 | 2 | 4 | 15 | 16 | 12 | 3 | 5 | 4 | 17 | 16 | ||
| 9 | 2 | Tacoma Defiance | 21 | 8 | 6 | 7 | 27 | 28 | -1 | 30 | LLWL | 10 | 6 | 3 | 1 | 16 | 9 | 11 | 2 | 3 | 6 | 11 | 19 | |
| 10 | New Mexico United | 22 | 7 | 7 | 8 | 27 | 27 | +0 | 28 | LWLX | 10 | 5 | 4 | 1 | 15 | 8 | 12 | 2 | 3 | 7 | 12 | 19 | ||
| 11 | 2 | Oakland Roots | 22 | 7 | 6 | 9 | 24 | 31 | -7 | 27 | WOWL | 10 | 4 | 3 | 3 | 12 | 10 | 12 | 3 | 3 | 6 | 12 | 21 | |
| 12 | 1 | Sacramento Republic | 22 | 6 | 8 | 8 | 27 | 31 | -4 | 26 | LWXL | 10 | 3 | 2 | 5 | 14 | 17 | 12 | 3 | 6 | 3 | 13 | 14 | |
| 13 | 1 | LA Galaxy 2 | 22 | 6 | 5 | 11 | 39 | 46 | -7 | 23 | LLXW | 12 | 2 | 5 | 5 | 23 | 21 | 10 | 4 | 0 | 6 | 16 | 25 | |
| 14 | Las Vegas Lights | 25 | 5 | 2 | 18 | 31 | 60 | -29 | 17 | LLLL | 12 | 3 | 2 | 7 | 16 | 21 | 13 | 2 | 0 | 11 | 15 | 39 | ||
| 15 | Real Monarchs | 23 | 4 | 4 | 15 | 20 | 40 | -20 | 16 | LLLL | 11 | 3 | 2 | 6 | 12 | 18 | 12 | 1 | 2 | 9 | 8 | 22 | ||
| 21 | Hadji BARRY (Colorado Springs, 6p) | |
| 14 | +1 | Russell CICERONE (Pittsburgh Riverhounds, 3p) |
| 12 | +2 | SANTI Moar (Phoenix Rising, 2p) |
| +1 | Ronaldo DAMUS (Orange County SC) | |
| Cameron LANCASTER (Louisville City, 4p) | ||
| Neco BRETT (Birmingham Legion, 4p) | ||
| +2 | Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | |
| 11 | Kyle MURPHY (Memphis 901, 1p) | |
| Preston JUDD (LA Galaxy 2) | ||
| 10 | Villyan BIJEV (OKC Energy, 3p) | |
| Jorge HERNÁNDEZ (LA Galaxy 2, 3p) | ||
| 9 | Irvin PARRA (Charlotte Independence, 1p) | |
| 8 | Tumi MOSHOBANE (San Diego Loyal) | |
| NATHAN Uilian (San Antonio, 3p) | ||
| Michee NGALINA (Colorado Springs, 1p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Elvis AMOH (RGV Toros, 1p) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| Alex DIXON (Pittsburgh Riverhounds) | ||
| +1 | Darío SUÁREZ (FC Tulsa, 3p) | |
| 7 | +2 | Christiano FRANÇOIS (Miami FC) |
| +1 | Juan OBREGÓN (Hartford Athletic) | |
| Manuel ARTEAGA (Indy Eleven, 1p) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Aiden McFADDEN (Atlanta United 2) | ||
| MARLON dos Santos (FC Tulsa) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Dane KELLY (Charlotte Independence, 1p) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Friday, 10 September 2021 | |||||
| Austin Bold | 1-0 | New Mexico United | |||
| 78(p) | Báez | ||||
| Saturday, 11 September 2021 | |||||
| Pittsburgh Riverhounds | 5-0 | Loudoun United | |||
| 20 | Wharton | ||||
| 58 | Forbes | ||||
| 75 | Cicerone | ||||
| 80 | Williamson | ||||
| 82 | Forbes | ||||
| Tampa Bay Rowdies | 6-0 | New York Red Bulls 2 | |||
| 12 | Fernandes | ||||
| 36 | Guenzatti | ||||
| 39 | Fernandes | ||||
| 49 | Guenzatti | ||||
| 58 | Ekra | ||||
| 69 | Ekra | ||||
| Orange County SC | 3-0 | Las Vegas Lights | |||
| 45 | Kiernan | ||||
| 84(p) | Enevoldsen | ||||
| 89 | Damus | ||||
| Indy Eleven | 1-0 | Sporting Kansas City 2 | |||
| 77 | Wild | ||||
| LA Galaxy 2 | 3-4 | Phoenix Rising | |||
| 12 | Cabral | 21(p) | Quinn | ||
| 27 | Vázquez | 31 | Lambert | ||
| 86 | Perez | 35 | Santi | ||
| 90(og) | Vázquez | ||||
| FC Tulsa | 1-1 | Birmingham Legion | |||
| 29(p) | Suárez | 80 | Williams | ||
| Charlotte Independence | 2-0 | Hartford Athletic | |||
| 36 | Marveaux | ||||
| 54 | Marveaux | ||||
| Colorado Springs | 1-1 | RGV Toros | |||
| 90 | Mahoney | 80 | López | ||
| Real Monarchs | 0-1 | San Antonio | |||
| 80 | Epps | ||||
| El Paso Locomotive | 2-0 | Sacramento Republic | |||
| 7 | Gómez | ||||
| 56 | Borelli | ||||
| Memphis 901 | 0-2 | Miami FC | |||
| 32 | François | ||||
| 50 | François | ||||
| Oakland Roots | 0-0 | San Diego Loyal | |||
| Sunday, 12 September 2021 | |||||
| OKC Energy | 1-1 | Louisville City | |||
| 25 | Ellis-Hayden | 45 | Delpiccolo | ||
| Wednesday, 15 September 2021 | |||||
| Phoenix Rising | 4-1 | Las Vegas Lights | |||
| 2 | Quinn | 27 | Vazquez | ||
| 17 | Santi | ||||
| 29 | Rodríguez | ||||
| 82 | Bakero | ||||
| Colorado Springs | 0-0 | El Paso Locomotive | |||
| New York Red Bulls 2 | 1-2 | San Antonio | |||
| 55 | Zajec | 33 | Gallegos | ||
| 48(og) | Joseph | ||||
| Atlanta United 2 | 1-1 | Charleston Battery | |||
| 11 | Conway | 60 | Crawford | ||
| Hartford Athletic | 2-0 | Real Monarchs | |||
| 30 | Obregón | ||||
| 83(og) | Flores | ||||
| Oakland Roots | 3-1 | Tacoma Defiance | |||
| 10 | Mfeka | 32 | Serrano | ||
| 40 | Fall | ||||
| 53 | Mfeka | ||||