| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 247 | 686 | 2.77 | 109 | 44.13% | 55 | 22.27% | 83 | 33.60% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 17 | 11 | 3 | 3 | 37 | 20 | +17 | 36 | WWWX | 11 | 8 | 2 | 1 | 25 | 10 | 6 | 3 | 1 | 2 | 12 | 10 | ||
| 2 | Pittsburgh Riverhounds | 17 | 10 | 3 | 4 | 26 | 18 | +8 | 33 | WWWW | 7 | 4 | 1 | 2 | 8 | 5 | 10 | 6 | 2 | 2 | 18 | 13 | ||
| 3 | 1 | Tampa Bay Rowdies | 16 | 10 | 0 | 6 | 23 | 15 | +8 | 30 | WLWL | 9 | 7 | 0 | 2 | 17 | 7 | 7 | 3 | 0 | 4 | 6 | 8 | |
| 4 | 1 | Birmingham Legion | 16 | 9 | 2 | 5 | 19 | 16 | +3 | 29 | LWXW | 7 | 4 | 1 | 2 | 9 | 6 | 9 | 5 | 1 | 3 | 10 | 10 | |
| 5 | Miami FC | 17 | 8 | 3 | 6 | 25 | 23 | +2 | 27 | XWLW | 9 | 6 | 0 | 3 | 15 | 13 | 8 | 2 | 3 | 3 | 10 | 10 | ||
| 6 | Hartford Athletic | 15 | 7 | 3 | 5 | 28 | 21 | +7 | 24 | LXLW | 7 | 3 | 3 | 1 | 15 | 6 | 8 | 4 | 0 | 4 | 13 | 15 | ||
| 7 | 4 | FC Tulsa | 16 | 7 | 1 | 8 | 25 | 29 | -4 | 22 | WLLL | 7 | 4 | 0 | 3 | 15 | 13 | 9 | 3 | 1 | 5 | 10 | 16 | |
| 8 | 1 | Charleston Battery | 15 | 6 | 3 | 6 | 25 | 24 | +1 | 21 | LLWW | 8 | 4 | 2 | 2 | 15 | 11 | 7 | 2 | 1 | 4 | 10 | 13 | |
| 9 | 4 | OKC Energy | 17 | 5 | 6 | 6 | 18 | 19 | -1 | 21 | WLOW | 9 | 2 | 4 | 3 | 9 | 9 | 8 | 3 | 2 | 3 | 9 | 10 | |
| 10 | 2 | Charlotte Independence | 15 | 6 | 2 | 7 | 19 | 19 | +0 | 20 | OWLX | 6 | 4 | 1 | 1 | 12 | 6 | 9 | 2 | 1 | 6 | 7 | 13 | |
| 11 | 2 | Indy Eleven | 15 | 5 | 4 | 6 | 17 | 18 | -1 | 19 | WLXX | 8 | 1 | 2 | 5 | 6 | 10 | 7 | 4 | 2 | 1 | 11 | 8 | |
| 12 | 2 | Memphis 901 | 14 | 5 | 4 | 5 | 15 | 19 | -4 | 19 | LWWX | 4 | 2 | 0 | 2 | 4 | 4 | 10 | 3 | 4 | 3 | 11 | 15 | |
| 13 | 1 | Atlanta United 2 | 17 | 4 | 6 | 7 | 22 | 24 | -2 | 18 | LXWL | 10 | 3 | 4 | 3 | 16 | 12 | 7 | 1 | 2 | 4 | 6 | 12 | |
| 14 | Sporting Kansas City 2 | 18 | 3 | 5 | 10 | 21 | 34 | -13 | 14 | LLLO | 8 | 1 | 2 | 5 | 10 | 16 | 10 | 2 | 3 | 5 | 11 | 18 | ||
| 15 | New York Red Bulls 2 | 16 | 3 | 4 | 9 | 20 | 35 | -15 | 13 | LLLX | 9 | 1 | 2 | 6 | 9 | 16 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 16 | 2 | 1 | 13 | 15 | 34 | -19 | 7 | OLLL | 9 | 1 | 1 | 7 | 10 | 21 | 7 | 1 | 0 | 6 | 5 | 13 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | El Paso Locomotive | 16 | 11 | 4 | 1 | 26 | 10 | +16 | 37 | WWWW | 9 | 7 | 2 | 0 | 16 | 4 | 7 | 4 | 2 | 1 | 10 | 6 | |
| 2 | 1 | Phoenix Rising | 16 | 11 | 3 | 2 | 38 | 13 | +25 | 36 | XWWW | 8 | 7 | 1 | 0 | 28 | 5 | 8 | 4 | 2 | 2 | 10 | 8 | |
| 3 | RGV Toros | 16 | 8 | 4 | 4 | 24 | 17 | +7 | 28 | WLXW | 8 | 5 | 1 | 2 | 11 | 8 | 8 | 3 | 3 | 2 | 13 | 9 | ||
| 4 | Orange County SC | 17 | 7 | 4 | 6 | 26 | 21 | +5 | 25 | LWLX | 8 | 2 | 3 | 3 | 10 | 12 | 9 | 5 | 1 | 3 | 16 | 9 | ||
| 5 | 4 | Colorado Springs | 16 | 7 | 3 | 6 | 32 | 28 | +4 | 24 | WLWX | 9 | 4 | 2 | 3 | 19 | 16 | 7 | 3 | 1 | 3 | 13 | 12 | |
| 6 | 1 | San Diego Loyal | 17 | 7 | 3 | 7 | 21 | 23 | -2 | 24 | LWLL | 8 | 5 | 1 | 2 | 10 | 7 | 9 | 2 | 2 | 5 | 11 | 16 | |
| 7 | 1 | Austin Bold | 16 | 6 | 5 | 5 | 15 | 18 | -3 | 23 | LWLX | 7 | 3 | 1 | 3 | 8 | 9 | 9 | 3 | 4 | 2 | 7 | 9 | |
| 8 | 1 | New Mexico United | 16 | 6 | 4 | 6 | 19 | 18 | +1 | 22 | OOLW | 7 | 4 | 2 | 1 | 10 | 4 | 9 | 2 | 2 | 5 | 9 | 14 | |
| 9 | 1 | San Antonio | 16 | 5 | 6 | 5 | 23 | 19 | +4 | 21 | LWLW | 8 | 3 | 3 | 2 | 13 | 8 | 8 | 2 | 3 | 3 | 10 | 11 | |
| 10 | 2 | LA Galaxy 2 | 17 | 5 | 4 | 8 | 27 | 31 | -4 | 19 | WLWL | 10 | 2 | 4 | 4 | 17 | 14 | 7 | 3 | 0 | 4 | 10 | 17 | |
| 11 | 1 | Tacoma Defiance | 14 | 4 | 6 | 4 | 14 | 16 | -2 | 18 | XOWX | 7 | 4 | 3 | 0 | 10 | 4 | 7 | 0 | 3 | 4 | 4 | 12 | |
| 12 | 1 | Sacramento Republic | 15 | 4 | 5 | 6 | 18 | 21 | -3 | 17 | XWXW | 8 | 2 | 2 | 4 | 11 | 13 | 7 | 2 | 3 | 2 | 7 | 8 | |
| 13 | Las Vegas Lights | 16 | 5 | 2 | 9 | 23 | 34 | -11 | 17 | XWLL | 8 | 3 | 2 | 3 | 12 | 11 | 8 | 2 | 0 | 6 | 11 | 23 | ||
| 14 | Real Monarchs | 18 | 4 | 4 | 10 | 18 | 30 | -12 | 16 | WLLW | 10 | 3 | 2 | 5 | 12 | 17 | 8 | 1 | 2 | 5 | 6 | 13 | ||
| 15 | Oakland Roots | 11 | 1 | 3 | 7 | 7 | 19 | -12 | 6 | LLLL | 4 | 0 | 1 | 3 | 1 | 6 | 7 | 1 | 2 | 4 | 6 | 13 | ||
| 15 | +1 | Hadji BARRY (Colorado Springs, 4p) |
| 10 | +1 | Neco BRETT (Birmingham Legion, 4p) |
| 9 | +1 | Ronaldo DAMUS (Orange County SC) |
| +1 | Cameron LANCASTER (Louisville City, 4p) | |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| 8 | +1 | SANTI Moar (Phoenix Rising, 1p) |
| +1 | Russell CICERONE (Pittsburgh Riverhounds, 2p) | |
| +1 | Kyle MURPHY (Memphis 901) | |
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| +1 | Preston JUDD (LA Galaxy 2) | |
| 7 | +1 | Villyan BIJEV (OKC Energy, 2p) |
| Dane KELLY (Charlotte Independence, 1p) | ||
| Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | ||
| 6 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| Aiden McFADDEN (Atlanta United 2) | ||
| +2 | Alex DIXON (Pittsburgh Riverhounds) | |
| +1 | Enoch MUSHAGALUSA (Sporting Kansas City 2) | |
| Cal JENNINGS (Las Vegas Lights, 1p) | ||
| 5 | NATHAN Uilian (San Antonio, 2p) | |
| +1 | Michee NGALINA (Colorado Springs, 1p) | |
| Tucker BONE (Sacramento Republic) | ||
| Joaquín RIVAS (FC Tulsa, 1p) | ||
| Irvin PARRA (Charlotte Independence, 1p) | ||
| Nicque DALEY (Charleston Battery) | ||
| Diego LUNA (El Paso Locomotive) | ||
| Kyle GREIG (Louisville City) | ||
| Santiago PATIÑO (San Antonio) | ||
| Preston TABORTETAKA (Hartford Athletic) |
| Thursday, 5 August 2021 | |||||
| Tacoma Defiance | 1-1 | Sacramento Republic | |||
| 82 | Mendoza | 18 | Kiesewetter | ||
| Friday, 6 August 2021 | |||||
| Charleston Battery | 2-3 | Pittsburgh Riverhounds | |||
| 20 | Gdula | 24(p) | Cicerone | ||
| 47 | Piggott | 45 | Dixon | ||
| 64 | Dixon | ||||
| New York Red Bulls 2 | 1-2 | Tampa Bay Rowdies | |||
| 9 | Lacava | 33 | Adebayo-Smith | ||
| 47 | Lachowecki | ||||
| Loudoun United | 0-0 | Charlotte Independence | |||
| Saturday, 7 August 2021 | |||||
| Orange County SC | 2-3 | LA Galaxy 2 | |||
| 30 | Wehan | 45 | Judd | ||
| 67 | Damus | 62 | Harvey | ||
| 87 | Aguirre | ||||
| OKC Energy | 4-1 | Memphis 901 | |||
| 40 | Daniels | 49 | Murphy | ||
| 45 | Daniels | ||||
| 73 | Bijev | ||||
| 90 | Stephenson | ||||
| FC Tulsa | 3-1 | Birmingham Legion | |||
| 25 | Sheldon | 66(p) | Brett | ||
| 88 | Marlon | ||||
| 90 | Kibato | ||||
| Colorado Springs | 4-2 | Hartford Athletic | |||
| 19(p) | Barry | 24 | McGlynn | ||
| 38 | Ngalina | 58 | Ashitey | ||
| 51 | Lewis | ||||
| 63 | Lewis | ||||
| Louisville City | 4-1 | Sporting Kansas City 2 | |||
| 45 | González | 68 | Mushagalusa | ||
| 71 | Ownby | ||||
| 75 | Lancaster | ||||
| 90 | McLaughlin | ||||
| Las Vegas Lights | 2-2 | Phoenix Rising | |||
| 12 | Molina | 29(p) | Santi | ||
| 84 | Traore | 45 | Quinn | ||
| El Paso Locomotive | 3-0 | Austin Bold | |||
| 59 | Fox | ||||
| 72 | Mares | ||||
| 90 | Leandro Carrijo | ||||
| San Diego Loyal | 0-1 | Real Monarchs | |||
| 1 | Martínez | ||||