| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 224 | 616 | 2.75 | 100 | 44.64% | 50 | 22.32% | 74 | 33.04% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 16 | 10 | 3 | 3 | 33 | 19 | +14 | 33 | WWXW | 10 | 7 | 2 | 1 | 21 | 9 | 6 | 3 | 1 | 2 | 12 | 10 | ||
| 2 | 1 | Pittsburgh Riverhounds | 16 | 9 | 3 | 4 | 23 | 16 | +7 | 30 | WWWX | 7 | 4 | 1 | 2 | 8 | 5 | 9 | 5 | 2 | 2 | 15 | 11 | |
| 3 | 1 | Tampa Bay Rowdies | 15 | 9 | 0 | 6 | 21 | 14 | +7 | 27 | LWLL | 9 | 7 | 0 | 2 | 17 | 7 | 6 | 2 | 0 | 4 | 4 | 7 | |
| 4 | Birmingham Legion | 14 | 8 | 2 | 4 | 15 | 12 | +3 | 26 | XWLW | 6 | 3 | 1 | 2 | 6 | 5 | 8 | 5 | 1 | 2 | 9 | 7 | ||
| 5 | Hartford Athletic | 13 | 7 | 2 | 4 | 25 | 16 | +9 | 23 | LWLW | 6 | 3 | 2 | 1 | 14 | 5 | 7 | 4 | 0 | 3 | 11 | 11 | ||
| 6 | Miami FC | 15 | 7 | 2 | 6 | 21 | 20 | +1 | 23 | LWWW | 8 | 5 | 0 | 3 | 12 | 11 | 7 | 2 | 2 | 3 | 9 | 9 | ||
| 7 | 1 | Charleston Battery | 13 | 6 | 3 | 4 | 21 | 18 | +3 | 21 | WWWL | 7 | 4 | 2 | 1 | 13 | 8 | 6 | 2 | 1 | 3 | 8 | 10 | |
| 8 | 2 | Charlotte Independence | 14 | 6 | 1 | 7 | 19 | 19 | +0 | 19 | WLXL | 6 | 4 | 1 | 1 | 12 | 6 | 8 | 2 | 0 | 6 | 7 | 13 | |
| 9 | 2 | FC Tulsa | 14 | 6 | 1 | 7 | 22 | 26 | -4 | 19 | LLLW | 5 | 3 | 0 | 2 | 12 | 10 | 9 | 3 | 1 | 5 | 10 | 16 | |
| 10 | 3 | Atlanta United 2 | 16 | 4 | 6 | 6 | 21 | 21 | +0 | 18 | XWLL | 10 | 3 | 4 | 3 | 16 | 12 | 6 | 1 | 2 | 3 | 5 | 9 | |
| 11 | 2 | OKC Energy | 16 | 4 | 6 | 6 | 14 | 18 | -4 | 18 | LOWL | 8 | 1 | 4 | 3 | 5 | 8 | 8 | 3 | 2 | 3 | 9 | 10 | |
| 12 | 1 | Memphis 901 | 12 | 4 | 4 | 4 | 12 | 14 | -2 | 16 | WXWX | 4 | 2 | 0 | 2 | 4 | 4 | 8 | 2 | 4 | 2 | 8 | 10 | |
| 13 | 1 | Indy Eleven | 14 | 4 | 4 | 6 | 15 | 18 | -3 | 16 | LXXL | 8 | 1 | 2 | 5 | 6 | 10 | 6 | 3 | 2 | 1 | 9 | 8 | |
| 14 | Sporting Kansas City 2 | 16 | 3 | 5 | 8 | 19 | 28 | -9 | 14 | LOWL | 7 | 1 | 2 | 4 | 9 | 14 | 9 | 2 | 3 | 4 | 10 | 14 | ||
| 15 | New York Red Bulls 2 | 15 | 3 | 4 | 8 | 19 | 33 | -14 | 13 | LLXW | 8 | 1 | 2 | 5 | 8 | 14 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 15 | 2 | 0 | 13 | 15 | 34 | -19 | 6 | LLLL | 8 | 1 | 0 | 7 | 10 | 21 | 7 | 1 | 0 | 6 | 5 | 13 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 14 | 10 | 2 | 2 | 35 | 11 | +24 | 32 | WWWX | 8 | 7 | 1 | 0 | 28 | 5 | 6 | 3 | 1 | 2 | 7 | 6 | ||
| 2 | El Paso Locomotive | 14 | 9 | 4 | 1 | 21 | 10 | +11 | 31 | WWOW | 7 | 5 | 2 | 0 | 11 | 4 | 7 | 4 | 2 | 1 | 10 | 6 | ||
| 3 | 1 | Orange County SC | 16 | 7 | 4 | 5 | 24 | 18 | +6 | 25 | WLXL | 7 | 2 | 3 | 2 | 8 | 9 | 9 | 5 | 1 | 3 | 16 | 9 | |
| 4 | 1 | RGV Toros | 15 | 7 | 4 | 4 | 21 | 17 | +4 | 25 | LXWX | 8 | 5 | 1 | 2 | 11 | 8 | 7 | 2 | 3 | 2 | 10 | 9 | |
| 5 | 3 | San Antonio | 15 | 5 | 6 | 4 | 23 | 17 | +6 | 21 | WLWW | 8 | 3 | 3 | 2 | 13 | 8 | 7 | 2 | 3 | 2 | 10 | 9 | |
| 6 | 3 | Colorado Springs | 14 | 6 | 3 | 5 | 27 | 24 | +3 | 21 | WXLL | 8 | 3 | 2 | 3 | 15 | 14 | 6 | 3 | 1 | 2 | 12 | 10 | |
| 7 | 2 | New Mexico United | 15 | 6 | 3 | 6 | 19 | 18 | +1 | 21 | OLWW | 7 | 4 | 2 | 1 | 10 | 4 | 8 | 2 | 1 | 5 | 9 | 14 | |
| 8 | 2 | San Diego Loyal | 15 | 6 | 3 | 6 | 19 | 22 | -3 | 21 | LLWX | 7 | 5 | 1 | 1 | 10 | 6 | 8 | 1 | 2 | 5 | 9 | 16 | |
| 9 | 2 | Austin Bold | 14 | 5 | 5 | 4 | 13 | 14 | -1 | 20 | LXWX | 6 | 2 | 1 | 3 | 6 | 8 | 8 | 3 | 4 | 1 | 7 | 6 | |
| 10 | Tacoma Defiance | 12 | 4 | 4 | 4 | 13 | 15 | -2 | 16 | WXOL | 5 | 4 | 1 | 0 | 9 | 3 | 7 | 0 | 3 | 4 | 4 | 12 | ||
| 11 | 1 | LA Galaxy 2 | 15 | 4 | 4 | 7 | 24 | 27 | -3 | 16 | WLXL | 9 | 2 | 4 | 3 | 17 | 12 | 6 | 2 | 0 | 4 | 7 | 15 | |
| 12 | 1 | Sacramento Republic | 14 | 4 | 4 | 6 | 17 | 20 | -3 | 16 | WXWL | 8 | 2 | 2 | 4 | 11 | 13 | 6 | 2 | 2 | 2 | 6 | 7 | |
| 13 | 1 | Las Vegas Lights | 15 | 5 | 1 | 9 | 21 | 32 | -11 | 16 | WLLL | 7 | 3 | 1 | 3 | 10 | 9 | 8 | 2 | 0 | 6 | 11 | 23 | |
| 14 | 1 | Real Monarchs | 16 | 3 | 4 | 9 | 17 | 27 | -10 | 13 | LWLL | 9 | 3 | 2 | 4 | 12 | 14 | 7 | 0 | 2 | 5 | 5 | 13 | |
| 15 | Oakland Roots | 10 | 1 | 3 | 6 | 7 | 18 | -11 | 6 | LLLO | 3 | 0 | 1 | 2 | 1 | 5 | 7 | 1 | 2 | 4 | 6 | 13 | ||
| 14 | +1 | Hadji BARRY (Colorado Springs, 3p) |
| 9 | +1 | Neco BRETT (Birmingham Legion, 3p) |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| 8 | +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) |
| +1 | Ronaldo DAMUS (Orange County SC) | |
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| +1 | Cameron LANCASTER (Louisville City, 4p) | |
| 7 | SANTI Moar (Phoenix Rising) | |
| Russell CICERONE (Pittsburgh Riverhounds, 1p) | ||
| +1 | Dane KELLY (Charlotte Independence, 1p) | |
| Preston JUDD (LA Galaxy 2) | ||
| +1 | Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | |
| 6 | +1 | Villyan BIJEV (OKC Energy, 2p) |
| Kyle MURPHY (Memphis 901) | ||
| +3 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| +1 | Aiden McFADDEN (Atlanta United 2) | |
| +2 | Cal JENNINGS (Las Vegas Lights, 1p) | |
| 5 | +1 | NATHAN Uilian (San Antonio, 2p) |
| Tucker BONE (Sacramento Republic) | ||
| Joaquín RIVAS (FC Tulsa, 1p) | ||
| +1 | Irvin PARRA (Charlotte Independence, 1p) | |
| +1 | Kyle GREIG (Louisville City) | |
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Santiago PATIÑO (San Antonio) | ||
| Preston TABORTETAKA (Hartford Athletic) |
| Sunday, 25 July 2021 | |||||
| LA Galaxy 2 | 3-0 | Oakland Roots | |||
| 33 | Drack | ||||
| 78 | Harvey | ||||
| 85 | Hernández | ||||
| Tuesday, 27 July 2021 | |||||
| Las Vegas Lights | 3-1 | Orange County SC | |||
| 18 | Jennings | 39 | Iloski | ||
| 80 | Jennings | ||||
| 90 | Iloski | ||||
| Loudoun United | 3-5 | Charleston Battery | |||
| 22 | Ku-Dipietro | 4 | Repetto | ||
| 41 | Amoustapha | 9 | Zarokostas | ||
| 45(og) | Hogan | 32 | Repetto | ||
| 56 | Harmon | ||||
| 90(p) | Lewis | ||||
| Wednesday, 28 July 2021 | |||||
| San Antonio | 1-2 | El Paso Locomotive | |||
| 74 | Sjöberg | 18(p) | Solignac | ||
| 71 | Luna | ||||
| Sporting Kansas City 2 | 1-2 | Louisville City | |||
| 89 | Cisneros | 46 | González | ||
| 56 | Greig | ||||
| Atlanta United 2 | 2-1 | FC Tulsa | |||
| 25(p) | Diop | 55 | Rodrigo Bandeira | ||
| 49 | Fortune | ||||
| Thursday, 29 July 2021 | |||||
| Tacoma Defiance | 2-1 | San Diego Loyal | |||
| 50 | Gonzalez | 55 | Moshobane | ||
| 65 | Anguiano | ||||
| Saturday, 31 July 2021 | |||||
| Pittsburgh Riverhounds | 3-1 | Hartford Athletic | |||
| 49 | Dixon | 26 | Dodson | ||
| 83 | Dixon | ||||
| 88 | Perez | ||||
| Phoenix Rising | 3-1 | RGV Toros | |||
| 14 | King | 55 | Azocár | ||
| 19 | Quinn | ||||
| 27 | Dadashov | ||||
| Sacramento Republic | 3-1 | New York Red Bulls 2 | |||
| 17 | Luis Felipe | 62 | Rafanello | ||
| 22 | Luis Felipe | ||||
| 41 | Formella | ||||
| Charlotte Independence | 2-0 | Tampa Bay Rowdies | |||
| 47 | Kelly | ||||
| 62 | Parra | ||||
| Louisville City | 2-1 | OKC Energy | |||
| 37(og) | Donovan | 87(p) | Bijev | ||
| 76(p) | Lancaster | ||||
| El Paso Locomotive | 3-1 | Real Monarchs | |||
| 24 | Gómez | 17 | Wehan | ||
| 68 | Solignac | ||||
| 81 | Solignac | ||||
| Birmingham Legion | 2-2 | Atlanta United 2 | |||
| 66(p) | Brett | 35 | McFadden | ||
| 69 | Flemmings | 90 | Matheus | ||
| Austin Bold | 0-3 | San Antonio | |||
| 30(p) | Cuello | ||||
| 69(p) | Nathan | ||||
| 74 | Gallegos | ||||
| Loudoun United | 1-3 | Colorado Springs | |||
| 70 | Smith | 63 | Edwards | ||
| 65 | Touré | ||||
| 90 | Barry | ||||
| Oakland Roots | 0-3 | Orange County SC | |||
| 31 | Henry | ||||
| 36 | Damus | ||||
| 76 | Apodaca | ||||