| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 235 | 643 | 2.73 | 104 | 44.26% | 52 | 22.13% | 79 | 33.62% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 16 | 10 | 3 | 3 | 33 | 19 | +14 | 33 | WWXW | 10 | 7 | 2 | 1 | 21 | 9 | 6 | 3 | 1 | 2 | 12 | 10 | ||
| 2 | Pittsburgh Riverhounds | 16 | 9 | 3 | 4 | 23 | 16 | +7 | 30 | WWWX | 7 | 4 | 1 | 2 | 8 | 5 | 9 | 5 | 2 | 2 | 15 | 11 | ||
| 3 | 1 | Birmingham Legion | 15 | 9 | 2 | 4 | 18 | 13 | +5 | 29 | WXWL | 7 | 4 | 1 | 2 | 9 | 6 | 8 | 5 | 1 | 2 | 9 | 7 | |
| 4 | 1 | Tampa Bay Rowdies | 15 | 9 | 0 | 6 | 21 | 14 | +7 | 27 | LWLL | 9 | 7 | 0 | 2 | 17 | 7 | 6 | 2 | 0 | 4 | 4 | 7 | |
| 5 | 1 | Miami FC | 17 | 8 | 3 | 6 | 25 | 23 | +2 | 27 | XWLW | 9 | 6 | 0 | 3 | 15 | 13 | 8 | 2 | 3 | 3 | 10 | 10 | |
| 6 | 1 | Hartford Athletic | 14 | 7 | 3 | 4 | 26 | 17 | +9 | 24 | XLWL | 7 | 3 | 3 | 1 | 15 | 6 | 7 | 4 | 0 | 3 | 11 | 11 | |
| 7 | Charleston Battery | 14 | 6 | 3 | 5 | 23 | 21 | +2 | 21 | LWWW | 7 | 4 | 2 | 1 | 13 | 8 | 7 | 2 | 1 | 4 | 10 | 13 | ||
| 8 | Charlotte Independence | 14 | 6 | 1 | 7 | 19 | 19 | +0 | 19 | WLXL | 6 | 4 | 1 | 1 | 12 | 6 | 8 | 2 | 0 | 6 | 7 | 13 | ||
| 9 | 4 | Indy Eleven | 15 | 5 | 4 | 6 | 17 | 18 | -1 | 19 | WLXX | 8 | 1 | 2 | 5 | 6 | 10 | 7 | 4 | 2 | 1 | 11 | 8 | |
| 10 | 2 | Memphis 901 | 13 | 5 | 4 | 4 | 14 | 15 | -1 | 19 | WWXW | 4 | 2 | 0 | 2 | 4 | 4 | 9 | 3 | 4 | 2 | 10 | 11 | |
| 11 | 2 | FC Tulsa | 15 | 6 | 1 | 8 | 22 | 28 | -6 | 19 | LLLL | 6 | 3 | 0 | 3 | 12 | 12 | 9 | 3 | 1 | 5 | 10 | 16 | |
| 12 | 2 | Atlanta United 2 | 17 | 4 | 6 | 7 | 22 | 24 | -2 | 18 | LXWL | 10 | 3 | 4 | 3 | 16 | 12 | 7 | 1 | 2 | 4 | 6 | 12 | |
| 13 | 2 | OKC Energy | 16 | 4 | 6 | 6 | 14 | 18 | -4 | 18 | LOWL | 8 | 1 | 4 | 3 | 5 | 8 | 8 | 3 | 2 | 3 | 9 | 10 | |
| 14 | Sporting Kansas City 2 | 17 | 3 | 5 | 9 | 20 | 30 | -10 | 14 | LLOW | 8 | 1 | 2 | 5 | 10 | 16 | 9 | 2 | 3 | 4 | 10 | 14 | ||
| 15 | New York Red Bulls 2 | 15 | 3 | 4 | 8 | 19 | 33 | -14 | 13 | LLXW | 8 | 1 | 2 | 5 | 8 | 14 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 15 | 2 | 0 | 13 | 15 | 34 | -19 | 6 | LLLL | 8 | 1 | 0 | 7 | 10 | 21 | 7 | 1 | 0 | 6 | 5 | 13 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 15 | 11 | 2 | 2 | 36 | 11 | +25 | 35 | WWWW | 8 | 7 | 1 | 0 | 28 | 5 | 7 | 4 | 1 | 2 | 8 | 6 | ||
| 2 | El Paso Locomotive | 15 | 10 | 4 | 1 | 23 | 10 | +13 | 34 | WWWO | 8 | 6 | 2 | 0 | 13 | 4 | 7 | 4 | 2 | 1 | 10 | 6 | ||
| 3 | 1 | RGV Toros | 16 | 8 | 4 | 4 | 24 | 17 | +7 | 28 | WLXW | 8 | 5 | 1 | 2 | 11 | 8 | 8 | 3 | 3 | 2 | 13 | 9 | |
| 4 | 1 | Orange County SC | 16 | 7 | 4 | 5 | 24 | 18 | +6 | 25 | WLXL | 7 | 2 | 3 | 2 | 8 | 9 | 9 | 5 | 1 | 3 | 16 | 9 | |
| 5 | 3 | San Diego Loyal | 16 | 7 | 3 | 6 | 21 | 22 | -1 | 24 | WLLW | 7 | 5 | 1 | 1 | 10 | 6 | 9 | 2 | 2 | 5 | 11 | 16 | |
| 6 | 3 | Austin Bold | 15 | 6 | 5 | 4 | 15 | 15 | +0 | 23 | WLXW | 7 | 3 | 1 | 3 | 8 | 9 | 8 | 3 | 4 | 1 | 7 | 6 | |
| 7 | New Mexico United | 16 | 6 | 4 | 6 | 19 | 18 | +1 | 22 | OOLW | 7 | 4 | 2 | 1 | 10 | 4 | 9 | 2 | 2 | 5 | 9 | 14 | ||
| 8 | 3 | San Antonio | 16 | 5 | 6 | 5 | 23 | 19 | +4 | 21 | LWLW | 8 | 3 | 3 | 2 | 13 | 8 | 8 | 2 | 3 | 3 | 10 | 11 | |
| 9 | 3 | Colorado Springs | 15 | 6 | 3 | 6 | 28 | 26 | +2 | 21 | LWXL | 8 | 3 | 2 | 3 | 15 | 14 | 7 | 3 | 1 | 3 | 13 | 12 | |
| 10 | Tacoma Defiance | 13 | 4 | 5 | 4 | 13 | 15 | -2 | 17 | OWXO | 6 | 4 | 2 | 0 | 9 | 3 | 7 | 0 | 3 | 4 | 4 | 12 | ||
| 11 | 1 | Sacramento Republic | 14 | 4 | 4 | 6 | 17 | 20 | -3 | 16 | WXWL | 8 | 2 | 2 | 4 | 11 | 13 | 6 | 2 | 2 | 2 | 6 | 7 | |
| 12 | 1 | LA Galaxy 2 | 16 | 4 | 4 | 8 | 24 | 29 | -5 | 16 | LWLX | 10 | 2 | 4 | 4 | 17 | 14 | 6 | 2 | 0 | 4 | 7 | 15 | |
| 13 | Las Vegas Lights | 15 | 5 | 1 | 9 | 21 | 32 | -11 | 16 | WLLL | 7 | 3 | 1 | 3 | 10 | 9 | 8 | 2 | 0 | 6 | 11 | 23 | ||
| 14 | Real Monarchs | 17 | 3 | 4 | 10 | 17 | 30 | -13 | 13 | LLWL | 10 | 3 | 2 | 5 | 12 | 17 | 7 | 0 | 2 | 5 | 5 | 13 | ||
| 15 | Oakland Roots | 11 | 1 | 3 | 7 | 7 | 19 | -12 | 6 | LLLL | 4 | 0 | 1 | 3 | 1 | 6 | 7 | 1 | 2 | 4 | 6 | 13 | ||
| 14 | Hadji BARRY (Colorado Springs, 3p) | |
| 9 | Neco BRETT (Birmingham Legion, 3p) | |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| 8 | RODRIGO BANDEIRA da Costa (FC Tulsa) | |
| Ronaldo DAMUS (Orange County SC) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| Cameron LANCASTER (Louisville City, 4p) | ||
| 7 | SANTI Moar (Phoenix Rising) | |
| Russell CICERONE (Pittsburgh Riverhounds, 1p) | ||
| +1 | Kyle MURPHY (Memphis 901) | |
| Dane KELLY (Charlotte Independence, 1p) | ||
| Preston JUDD (LA Galaxy 2) | ||
| Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | ||
| 6 | Villyan BIJEV (OKC Energy, 2p) | |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Aiden McFADDEN (Atlanta United 2) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) | ||
| 5 | NATHAN Uilian (San Antonio, 2p) | |
| Tucker BONE (Sacramento Republic) | ||
| Joaquín RIVAS (FC Tulsa, 1p) | ||
| Irvin PARRA (Charlotte Independence, 1p) | ||
| +1 | Nicque DALEY (Charleston Battery) | |
| +1 | Diego LUNA (El Paso Locomotive) | |
| Kyle GREIG (Louisville City) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Santiago PATIÑO (San Antonio) | ||
| Preston TABORTETAKA (Hartford Athletic) |
| Sunday, 1 August 2021 | |||||
| LA Galaxy 2 | 0-2 | San Diego Loyal | |||
| 9 | Hertzog | ||||
| 23 | Moshobane | ||||
| Tacoma Defiance | 0-0 | New Mexico United | |||
| Sporting Kansas City 2 | 1-2 | Memphis 901 | |||
| 25(p) | Harris | 12 | Murphy | ||
| 48 | Salazar | ||||
| Miami FC | 3-2 | Charleston Battery | |||
| 45 | Martínez | 11 | Daley | ||
| 61 | François | 30 | Lewis | ||
| 78 | Forbes | ||||
| Wednesday, 4 August 2021 | |||||
| FC Tulsa | 0-2 | Indy Eleven | |||
| 79 | Wild | ||||
| 85 | Vassell | ||||
| Real Monarchs | 0-3 | RGV Toros | |||
| 19 | Quero | ||||
| 54 | Sánchez | ||||
| 83 | Sorto | ||||
| El Paso Locomotive | 2-0 | San Antonio | |||
| 29 | Luna | ||||
| 45 | Aguinaga | ||||
| Birmingham Legion | 3-1 | Atlanta United 2 | |||
| 11 | Williams | 9 | Goodrum | ||
| 49 | Lopez | ||||
| 51 | Flemmings | ||||
| Austin Bold | 2-1 | Colorado Springs | |||
| 12 | Torres | 31 | Yapi | ||
| 81 | Fernandez | ||||
| Hartford Athletic | 1-1 | Miami FC | |||
| 14(p) | Jamieson | 25 | Bah | ||
| Oakland Roots | 0-1 | Phoenix Rising | |||
| 64 | Quinn | ||||