| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 431 | 1,239 | 2.87 | 194 | 45.01% | 101 | 23.43% | 136 | 31.55% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 28 | 20 | 1 | 7 | 48 | 21 | +27 | 61 | LWWW | 14 | 12 | 0 | 2 | 33 | 9 | 14 | 8 | 1 | 5 | 15 | 12 | ||
| 2 | Louisville City | 28 | 16 | 7 | 5 | 56 | 33 | +23 | 55 | WWXX | 15 | 11 | 2 | 2 | 34 | 16 | 13 | 5 | 5 | 3 | 22 | 17 | ||
| 3 | Birmingham Legion | 28 | 16 | 5 | 7 | 42 | 29 | +13 | 53 | WWWW | 13 | 8 | 2 | 3 | 22 | 14 | 15 | 8 | 3 | 4 | 20 | 15 | ||
| 4 | 1 | Pittsburgh Riverhounds | 29 | 15 | 6 | 8 | 49 | 33 | +16 | 51 | WLXL | 14 | 8 | 3 | 3 | 25 | 12 | 15 | 7 | 3 | 5 | 24 | 21 | |
| 5 | 1 | Charlotte Independence | 28 | 15 | 4 | 9 | 48 | 33 | +15 | 49 | WWWL | 14 | 10 | 3 | 1 | 30 | 13 | 14 | 5 | 1 | 8 | 18 | 20 | |
| 6 | 2 | Miami FC | 28 | 14 | 6 | 8 | 49 | 36 | +13 | 48 | LWWL | 14 | 10 | 1 | 3 | 30 | 17 | 14 | 4 | 5 | 5 | 19 | 19 | |
| 7 | FC Tulsa | 27 | 12 | 3 | 12 | 39 | 43 | -4 | 39 | LLXL | 14 | 7 | 1 | 6 | 24 | 23 | 13 | 5 | 2 | 6 | 15 | 20 | ||
| 8 | Memphis 901 | 27 | 10 | 8 | 9 | 34 | 34 | +0 | 38 | LWWX | 12 | 5 | 3 | 4 | 14 | 13 | 15 | 5 | 5 | 5 | 20 | 21 | ||
| 9 | OKC Energy | 29 | 8 | 12 | 9 | 30 | 32 | -2 | 36 | XLXW | 15 | 4 | 7 | 4 | 15 | 13 | 14 | 4 | 5 | 5 | 15 | 19 | ||
| 10 | Charleston Battery | 27 | 9 | 7 | 11 | 44 | 46 | -2 | 34 | WLLX | 14 | 6 | 3 | 5 | 23 | 20 | 13 | 3 | 4 | 6 | 21 | 26 | ||
| 11 | Hartford Athletic | 27 | 9 | 4 | 14 | 43 | 46 | -3 | 31 | LXLL | 13 | 5 | 3 | 5 | 25 | 18 | 14 | 4 | 1 | 9 | 18 | 28 | ||
| 12 | Atlanta United 2 | 29 | 7 | 10 | 12 | 42 | 48 | -6 | 31 | XXLL | 16 | 4 | 7 | 5 | 26 | 24 | 13 | 3 | 3 | 7 | 16 | 24 | ||
| 13 | Indy Eleven | 29 | 8 | 7 | 14 | 30 | 43 | -13 | 31 | LXXL | 14 | 4 | 3 | 7 | 12 | 15 | 15 | 4 | 4 | 7 | 18 | 28 | ||
| 14 | New York Red Bulls 2 | 28 | 5 | 6 | 17 | 34 | 63 | -29 | 21 | LXOW | 15 | 2 | 3 | 10 | 19 | 30 | 13 | 3 | 3 | 7 | 15 | 33 | ||
| 15 | Sporting Kansas City 2 | 29 | 4 | 8 | 17 | 33 | 54 | -21 | 20 | LLLX | 15 | 2 | 5 | 8 | 16 | 24 | 14 | 2 | 3 | 9 | 17 | 30 | ||
| 16 | Loudoun United | 26 | 4 | 3 | 19 | 28 | 65 | -37 | 15 | WLXL | 13 | 3 | 1 | 9 | 17 | 31 | 13 | 1 | 2 | 10 | 11 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 28 | 19 | 5 | 4 | 60 | 29 | +31 | 62 | WWLW | 14 | 11 | 3 | 0 | 39 | 10 | 14 | 8 | 2 | 4 | 21 | 19 | ||
| 2 | El Paso Locomotive | 27 | 15 | 10 | 2 | 44 | 23 | +21 | 55 | WXXW | 13 | 10 | 3 | 0 | 25 | 8 | 14 | 5 | 7 | 2 | 19 | 15 | ||
| 3 | 1 | San Antonio | 28 | 13 | 8 | 7 | 44 | 33 | +11 | 47 | WXWL | 13 | 6 | 4 | 3 | 23 | 15 | 15 | 7 | 4 | 4 | 21 | 18 | |
| 4 | 1 | San Diego Loyal | 28 | 14 | 4 | 10 | 46 | 36 | +10 | 46 | WWWL | 14 | 9 | 1 | 4 | 24 | 15 | 14 | 5 | 3 | 6 | 22 | 21 | |
| 5 | 2 | Colorado Springs | 28 | 12 | 9 | 7 | 56 | 42 | +14 | 45 | OXWW | 15 | 7 | 5 | 3 | 30 | 20 | 13 | 5 | 4 | 4 | 26 | 22 | |
| 6 | Austin Bold | 27 | 10 | 10 | 7 | 27 | 31 | -4 | 40 | XWLX | 15 | 6 | 6 | 3 | 17 | 15 | 12 | 4 | 4 | 4 | 10 | 16 | ||
| 7 | New Mexico United | 28 | 10 | 9 | 9 | 36 | 34 | +2 | 39 | XXLW | 14 | 7 | 6 | 1 | 22 | 12 | 14 | 3 | 3 | 8 | 14 | 22 | ||
| 8 | 1 | RGV Toros | 28 | 10 | 8 | 10 | 40 | 39 | +1 | 38 | XWLW | 14 | 7 | 2 | 5 | 22 | 20 | 14 | 3 | 6 | 5 | 18 | 19 | |
| 9 | 1 | Orange County SC | 27 | 10 | 7 | 10 | 38 | 36 | +2 | 37 | LLWL | 13 | 4 | 4 | 5 | 17 | 19 | 14 | 6 | 3 | 5 | 21 | 17 | |
| 10 | 1 | LA Galaxy 2 | 27 | 10 | 5 | 12 | 46 | 49 | -3 | 35 | WLWW | 14 | 3 | 5 | 6 | 26 | 24 | 13 | 7 | 0 | 6 | 20 | 25 | |
| 11 | 1 | Oakland Roots | 28 | 9 | 7 | 12 | 31 | 39 | -8 | 34 | LWXL | 14 | 6 | 4 | 4 | 18 | 15 | 14 | 3 | 3 | 8 | 13 | 24 | |
| 12 | 1 | Tacoma Defiance | 27 | 9 | 6 | 12 | 33 | 37 | -4 | 33 | WLLL | 13 | 7 | 3 | 3 | 21 | 13 | 14 | 2 | 3 | 9 | 12 | 24 | |
| 13 | 1 | Sacramento Republic | 28 | 8 | 8 | 12 | 33 | 39 | -6 | 32 | LLWL | 13 | 4 | 2 | 7 | 17 | 21 | 15 | 4 | 6 | 5 | 16 | 18 | |
| 14 | 1 | Real Monarchs | 28 | 4 | 6 | 18 | 21 | 46 | -25 | 18 | OLLO | 13 | 3 | 4 | 6 | 12 | 18 | 15 | 1 | 2 | 12 | 9 | 28 | |
| 15 | 1 | Las Vegas Lights | 28 | 5 | 3 | 20 | 35 | 67 | -32 | 18 | LXLL | 14 | 3 | 2 | 9 | 18 | 26 | 14 | 2 | 1 | 11 | 17 | 41 | |
| 24 | Hadji BARRY (Colorado Springs, 6p) | |
| 19 | +2 | Sebastián GUENZATTI (Tampa Bay Rowdies, 5p) |
| 17 | Kyle MURPHY (Memphis 901, 3p) | |
| +2 | Cameron LANCASTER (Louisville City, 5p) | |
| 16 | +1 | Neco BRETT (Birmingham Legion, 4p) |
| 15 | +1 | Russell CICERONE (Pittsburgh Riverhounds, 4p) |
| 14 | SANTI Moar (Phoenix Rising, 2p) | |
| 13 | Ronaldo DAMUS (Orange County SC) | |
| 12 | +1 | Villyan BIJEV (OKC Energy, 3p) |
| Preston JUDD (LA Galaxy 2) | ||
| +1 | Jorge HERNÁNDEZ (LA Galaxy 2, 3p) | |
| 11 | +1 | Irvin PARRA (Charlotte Independence, 1p) |
| +1 | Elvis AMOH (RGV Toros, 1p) | |
| 10 | +1 | Chris WEHAN (New Mexico United) |
| Tumi MOSHOBANE (San Diego Loyal) | ||
| +2 | NATHAN Uilian (San Antonio, 3p) | |
| +1 | Christiano FRANÇOIS (Miami FC, 1p) | |
| +3 | Samuel ADENIRAN (Tacoma Defiance, 1p) | |
| 9 | +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) |
| +1 | Juan OBREGÓN (Hartford Athletic) | |
| Manuel ARTEAGA (Indy Eleven, 1p) | ||
| Alex DIXON (Pittsburgh Riverhounds) | ||
| Dane KELLY (Charlotte Independence, 1p) | ||
| Darío SUÁREZ (FC Tulsa, 4p) | ||
| Claudio REPETTO (Charleston Battery, 1p) |
| Thursday, 7 October 2021 | |||||
| Tampa Bay Rowdies | 4-2 | Charleston Battery | |||
| 27 | Guenzatti | 36(og) | Scarlett | ||
| 34 | Guenzatti | 90 | Bunting | ||
| 57 | Fernandes | ||||
| 90 | Duba | ||||
| Friday, 8 October 2021 | |||||
| Real Monarchs | 0-0 | Colorado Springs | |||
| Las Vegas Lights | 0-1 | LA Galaxy 2 | |||
| 8 | Hernández | ||||
| Saturday, 9 October 2021 | |||||
| Phoenix Rising | 1-0 | Oakland Roots | |||
| 11 | Mattocks | ||||
| FC Tulsa | 1-2 | El Paso Locomotive | |||
| 45 | Rodrigo Bandeira | 7 | Gómez | ||
| 14 | Solignac | ||||
| Charlotte Independence | 2-1 | New York Red Bulls 2 | |||
| 66 | Martínez | 3(og) | Roberts | ||
| 67 | Parra | ||||
| Louisville City | 4-3 | Sporting Kansas City 2 | |||
| 8 | Delpiccolo | 45 | Davis | ||
| 30(p) | Lancaster | 84 | Davis | ||
| 88 | Jimenez | 85 | Roberts | ||
| 90 | Lancaster | ||||
| Tacoma Defiance | 4-1 | Orange County SC | |||
| 46 | Adeniran | 60 | Mines | ||
| 52 | Adeniran | ||||
| 90 | Diaz | ||||
| 90 | Adeniran | ||||
| New Mexico United | 1-1 | RGV Toros | |||
| 24 | Wehan | 5 | Amoh | ||
| San Diego Loyal | 2-1 | Sacramento Republic | |||
| 54 | Guido | 30 | Formella | ||
| 57 | Martínez | ||||
| Sunday, 10 October 2021 | |||||
| Charleston Battery | 4-3 | Hartford Athletic | |||
| 2(og) | Janjigian | 45(og) | Piggott | ||
| 10 | Daley | 81 | Obregón | ||
| 43 | Daley | 88 | Hot | ||
| 61 | Fahling | ||||
| Pittsburgh Riverhounds | 2-0 | Tampa Bay Rowdies | |||
| 42 | Williamson | ||||
| 74(p) | Cicerone | ||||
| San Antonio | 4-2 | Memphis 901 | |||
| 30 | Gallegos | 22 | Salazar | ||
| 54 | Dhillon | 90(p) | Dacres | ||
| 66 | Nathan | ||||
| 86 | Nathan | ||||
| Birmingham Legion | 3-1 | Indy Eleven | |||
| 8 | Brett | 42 | Law | ||
| 74 | Crognale | ||||
| 90 | Rufe | ||||
| Austin Bold | 1-1 | OKC Energy | |||
| 90(p) | Báez | 83 | Bijev | ||
| Loudoun United | 3-2 | Miami FC | |||
| 20 | Greene | 13(p) | François | ||
| 77(p) | Ku-Dipietro | 74 | Cortez | ||
| 86 | Bolívar | ||||