| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 159 | 431 | 2.71 | 71 | 44.65% | 35 | 22.01% | 53 | 33.33% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 10 | 8 | 0 | 2 | 16 | 6 | +10 | 24 | WWLW | 7 | 6 | 0 | 1 | 14 | 5 | 3 | 2 | 0 | 1 | 2 | 1 | ||
| 2 | Birmingham Legion | 11 | 7 | 1 | 3 | 11 | 8 | +3 | 22 | WWLW | 4 | 3 | 0 | 1 | 4 | 2 | 7 | 4 | 1 | 2 | 7 | 6 | ||
| 3 | Louisville City | 10 | 6 | 2 | 2 | 21 | 12 | +9 | 20 | WXWW | 7 | 4 | 2 | 1 | 14 | 7 | 3 | 2 | 0 | 1 | 7 | 5 | ||
| 4 | Pittsburgh Riverhounds | 12 | 6 | 2 | 4 | 15 | 13 | +2 | 20 | WLWW | 5 | 2 | 1 | 2 | 4 | 4 | 7 | 4 | 1 | 2 | 11 | 9 | ||
| 5 | 3 | Hartford Athletic | 8 | 5 | 1 | 2 | 18 | 8 | +10 | 16 | WLWL | 4 | 2 | 1 | 1 | 10 | 3 | 4 | 3 | 0 | 1 | 8 | 5 | |
| 6 | FC Tulsa | 10 | 5 | 1 | 4 | 17 | 19 | -2 | 16 | OWLW | 3 | 2 | 0 | 1 | 8 | 6 | 7 | 3 | 1 | 3 | 9 | 13 | ||
| 7 | 2 | Charlotte Independence | 10 | 5 | 0 | 5 | 14 | 13 | +1 | 15 | LLWL | 3 | 3 | 0 | 0 | 7 | 2 | 7 | 2 | 0 | 5 | 7 | 11 | |
| 8 | 1 | Miami FC | 11 | 4 | 2 | 5 | 13 | 15 | -2 | 14 | XWLL | 6 | 3 | 0 | 3 | 8 | 9 | 5 | 1 | 2 | 2 | 5 | 6 | |
| 9 | 2 | Indy Eleven | 11 | 4 | 2 | 5 | 12 | 14 | -2 | 14 | LXWL | 6 | 1 | 1 | 4 | 4 | 7 | 5 | 3 | 1 | 1 | 8 | 7 | |
| 10 | OKC Energy | 12 | 3 | 5 | 4 | 10 | 12 | -2 | 14 | OWWW | 7 | 1 | 3 | 3 | 5 | 8 | 5 | 2 | 2 | 1 | 5 | 4 | ||
| 11 | Atlanta United 2 | 11 | 3 | 4 | 4 | 16 | 14 | +2 | 13 | XLLX | 7 | 2 | 3 | 2 | 13 | 9 | 4 | 1 | 1 | 2 | 3 | 5 | ||
| 12 | Charleston Battery | 8 | 3 | 2 | 3 | 9 | 11 | -2 | 11 | LWLW | 4 | 2 | 1 | 1 | 7 | 6 | 4 | 1 | 1 | 2 | 2 | 5 | ||
| 13 | Sporting Kansas City 2 | 13 | 2 | 4 | 7 | 17 | 26 | -9 | 10 | LWLL | 6 | 1 | 2 | 3 | 8 | 12 | 7 | 1 | 2 | 4 | 9 | 14 | ||
| 14 | Memphis 901 | 9 | 2 | 3 | 4 | 9 | 13 | -4 | 9 | XLLW | 3 | 1 | 0 | 2 | 3 | 4 | 6 | 1 | 3 | 2 | 6 | 9 | ||
| 15 | New York Red Bulls 2 | 11 | 2 | 3 | 6 | 12 | 23 | -11 | 9 | XLWL | 7 | 1 | 2 | 4 | 7 | 11 | 4 | 1 | 1 | 2 | 5 | 12 | ||
| 16 | Loudoun United | 10 | 2 | 0 | 8 | 9 | 18 | -9 | 6 | LWLL | 5 | 1 | 0 | 4 | 5 | 9 | 5 | 1 | 0 | 4 | 4 | 9 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Phoenix Rising | 10 | 7 | 1 | 2 | 25 | 9 | +16 | 22 | WWLW | 6 | 5 | 1 | 0 | 20 | 4 | 4 | 2 | 0 | 2 | 5 | 5 | |
| 2 | 1 | RGV Toros | 11 | 6 | 2 | 3 | 16 | 12 | +4 | 20 | WLXL | 7 | 5 | 0 | 2 | 10 | 7 | 4 | 1 | 2 | 1 | 6 | 5 | |
| 3 | 1 | El Paso Locomotive | 9 | 5 | 3 | 1 | 12 | 7 | +5 | 18 | WLWX | 5 | 3 | 2 | 0 | 7 | 3 | 4 | 2 | 1 | 1 | 5 | 4 | |
| 4 | 1 | San Diego Loyal | 12 | 5 | 3 | 4 | 16 | 18 | -2 | 18 | XWWW | 5 | 4 | 1 | 0 | 8 | 4 | 7 | 1 | 2 | 4 | 8 | 14 | |
| 5 | 1 | Orange County SC | 9 | 5 | 2 | 2 | 15 | 9 | +6 | 17 | WXWW | 4 | 2 | 1 | 1 | 6 | 5 | 5 | 3 | 1 | 1 | 9 | 4 | |
| 6 | 1 | Colorado Springs | 10 | 5 | 2 | 3 | 20 | 16 | +4 | 17 | WLWW | 6 | 3 | 1 | 2 | 12 | 10 | 4 | 2 | 1 | 1 | 8 | 6 | |
| 7 | 3 | Austin Bold | 10 | 4 | 3 | 3 | 10 | 9 | +1 | 15 | WOLW | 3 | 1 | 0 | 2 | 4 | 4 | 7 | 3 | 3 | 1 | 6 | 5 | |
| 8 | 1 | New Mexico United | 11 | 4 | 2 | 5 | 14 | 13 | +1 | 14 | LLLW | 4 | 2 | 1 | 1 | 5 | 2 | 7 | 2 | 1 | 4 | 9 | 11 | |
| 9 | San Antonio | 11 | 2 | 6 | 3 | 13 | 13 | +0 | 12 | LXXL | 6 | 2 | 3 | 1 | 9 | 6 | 5 | 0 | 3 | 2 | 4 | 7 | ||
| 10 | 2 | LA Galaxy 2 | 12 | 3 | 3 | 6 | 20 | 21 | -1 | 12 | LLXL | 7 | 1 | 3 | 3 | 13 | 11 | 5 | 2 | 0 | 3 | 7 | 10 | |
| 11 | Tacoma Defiance | 9 | 3 | 2 | 4 | 10 | 13 | -3 | 11 | LWXL | 4 | 3 | 1 | 0 | 7 | 2 | 5 | 0 | 1 | 4 | 3 | 11 | ||
| 12 | Real Monarchs | 12 | 2 | 4 | 6 | 12 | 18 | -6 | 10 | LWXX | 7 | 2 | 2 | 3 | 8 | 9 | 5 | 0 | 2 | 3 | 4 | 9 | ||
| 13 | 1 | Las Vegas Lights | 10 | 3 | 1 | 6 | 13 | 24 | -11 | 10 | WLLW | 5 | 2 | 1 | 2 | 6 | 6 | 5 | 1 | 0 | 4 | 7 | 18 | |
| 14 | 1 | Sacramento Republic | 9 | 2 | 2 | 5 | 10 | 14 | -4 | 8 | XLLL | 5 | 1 | 1 | 3 | 8 | 10 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 15 | Oakland Roots | 6 | 1 | 2 | 3 | 6 | 10 | -4 | 5 | LOLX | 1 | 0 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 3 | 6 | 10 | ||
| 11 | +1 | Hadji BARRY (Colorado Springs, 3p) |
| 8 | +1 | Neco BRETT (Birmingham Legion, 2p) |
| +1 | Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | |
| 7 | +1 | SANTI Moar (Phoenix Rising) |
| +1 | Solomon ASANTÉ (Phoenix Rising, 1p) | |
| Preston JUDD (LA Galaxy 2) | ||
| 6 | Ronaldo DAMUS (Orange County SC) | |
| Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | ||
| 5 | Joaquín RIVAS (FC Tulsa, 1p) | |
| Russell CICERONE (Pittsburgh Riverhounds, 1p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Cameron LANCASTER (Louisville City, 3p) | ||
| Aiden McFADDEN (Atlanta United 2) | ||
| Santiago PATIÑO (San Antonio) | ||
| +1 | Preston TABORTETAKA (Hartford Athletic) | |
| 4 | Jack BLAKE (San Diego Loyal) | |
| +1 | Rojay SMITH (Sporting Kansas City 2) | |
| Villyan BIJEV (OKC Energy, 1p) | ||
| Jovanny BOLÍVAR (Loudoun United, 1p) | ||
| +2 | Kyle MURPHY (Memphis 901) | |
| Elvis AMOH (RGV Toros) | ||
| Juan OBREGÓN (Hartford Athletic) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Dane KELLY (Charlotte Independence, 1p) | ||
| Darío SUÁREZ (FC Tulsa, 1p) |
| Thursday, 1 July 2021 | |||||
| Colorado Springs | 0-2 | Orange County SC | |||
| 18 | Markkanen | ||||
| 90 | Calvillo | ||||
| Friday, 2 July 2021 | |||||
| Tampa Bay Rowdies | 1-0 | Charleston Battery | |||
| 68(p) | Guenzatti | ||||
| OKC Energy | 0-0 | FC Tulsa | |||
| New York Red Bulls 2 | 1-1 | Miami FC | |||
| 7 | Lacava | 24 | Bah | ||
| Sporting Kansas City 2 | 2-4 | Louisville City | |||
| 13 | Smith | 5 | Greig | ||
| 80 | Jones | 57 | Ownby | ||
| 59 | Souahy | ||||
| 67 | Greig | ||||
| Saturday, 3 July 2021 | |||||
| Pittsburgh Riverhounds | 1-0 | Charlotte Independence | |||
| 45 | Velarde | ||||
| San Antonio | 0-1 | Austin Bold | |||
| 2 | Diouf | ||||
| Phoenix Rising | 3-0 | LA Galaxy 2 | |||
| 19 | Schmitt | ||||
| 46 | Asanté | ||||
| 66 | Santi | ||||
| Indy Eleven | 0-1 | Birmingham Legion | |||
| 8(p) | Brett | ||||
| Las Vegas Lights | 1-0 | Tacoma Defiance | |||
| 5 | Musovski | ||||
| Atlanta United 2 | 2-2 | Memphis 901 | |||
| 54 | Sabhatu | 21 | Murphy | ||
| 90(p) | Matheus | 27 | Murphy | ||
| El Paso Locomotive | 2-1 | New Mexico United | |||
| 56 | Mares | 41 | Brown | ||
| 57 | Mares | ||||
| San Diego Loyal | 1-1 | Sacramento Republic | |||
| 62 | Hertzog | 90 | Taintor | ||
| Sunday, 4 July 2021 | |||||
| Colorado Springs | 3-1 | Real Monarchs | |||
| 16 | Beckford | 28 | Briggs | ||
| 22 | Barry | ||||
| 32 | Edwards | ||||
| Loudoun United | 0-2 | Hartford Athletic | |||
| 64 | Rogers | ||||
| 73 | Tabortetaka | ||||