| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 304 | 867 | 2.85 | 135 | 44.41% | 71 | 23.36% | 98 | 32.24% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 20 | 12 | 4 | 4 | 40 | 23 | +17 | 40 | LOWW | 12 | 9 | 2 | 1 | 27 | 11 | 8 | 3 | 2 | 3 | 13 | 12 | ||
| 2 | Tampa Bay Rowdies | 20 | 13 | 1 | 6 | 28 | 15 | +13 | 40 | WWOW | 11 | 9 | 0 | 2 | 20 | 7 | 9 | 4 | 1 | 4 | 8 | 8 | ||
| 3 | Pittsburgh Riverhounds | 22 | 12 | 4 | 6 | 35 | 25 | +10 | 40 | WWOL | 10 | 5 | 2 | 3 | 14 | 9 | 12 | 7 | 2 | 3 | 21 | 16 | ||
| 4 | 1 | Birmingham Legion | 20 | 11 | 3 | 6 | 27 | 22 | +5 | 36 | WLXW | 10 | 6 | 1 | 3 | 16 | 11 | 10 | 5 | 2 | 3 | 11 | 11 | |
| 5 | 1 | Miami FC | 20 | 10 | 4 | 6 | 30 | 25 | +5 | 34 | WOWX | 10 | 7 | 0 | 3 | 17 | 13 | 10 | 3 | 4 | 3 | 13 | 12 | |
| 6 | 4 | FC Tulsa | 20 | 10 | 1 | 9 | 33 | 34 | -1 | 31 | WWWL | 9 | 6 | 0 | 3 | 20 | 15 | 11 | 4 | 1 | 6 | 13 | 19 | |
| 7 | Charleston Battery | 19 | 8 | 4 | 7 | 30 | 28 | +2 | 28 | OWLW | 10 | 5 | 3 | 2 | 16 | 11 | 9 | 3 | 1 | 5 | 14 | 17 | ||
| 8 | 2 | Hartford Athletic | 19 | 8 | 3 | 8 | 32 | 28 | +4 | 27 | LLWL | 9 | 4 | 3 | 2 | 19 | 10 | 10 | 4 | 0 | 6 | 13 | 18 | |
| 9 | 1 | Charlotte Independence | 19 | 8 | 3 | 8 | 26 | 26 | +0 | 27 | LXWW | 8 | 5 | 2 | 1 | 16 | 9 | 11 | 3 | 1 | 7 | 10 | 17 | |
| 10 | 2 | Indy Eleven | 20 | 7 | 5 | 8 | 25 | 30 | -5 | 26 | WXLW | 10 | 3 | 2 | 5 | 10 | 11 | 10 | 4 | 3 | 3 | 15 | 19 | |
| 11 | 2 | Atlanta United 2 | 22 | 6 | 7 | 9 | 36 | 36 | +0 | 25 | LLWX | 12 | 4 | 5 | 3 | 24 | 16 | 10 | 2 | 2 | 6 | 12 | 20 | |
| 12 | 1 | OKC Energy | 20 | 5 | 8 | 7 | 21 | 23 | -2 | 23 | OLXW | 10 | 2 | 5 | 3 | 9 | 9 | 10 | 3 | 3 | 4 | 12 | 14 | |
| 13 | Memphis 901 | 17 | 5 | 6 | 6 | 18 | 23 | -5 | 21 | LXXL | 6 | 2 | 2 | 2 | 6 | 6 | 11 | 3 | 4 | 4 | 12 | 17 | ||
| 14 | Sporting Kansas City 2 | 21 | 3 | 6 | 12 | 25 | 43 | -18 | 15 | XLLL | 10 | 1 | 3 | 6 | 12 | 21 | 11 | 2 | 3 | 6 | 13 | 22 | ||
| 15 | New York Red Bulls 2 | 18 | 3 | 4 | 11 | 24 | 41 | -17 | 13 | LLLL | 11 | 1 | 2 | 8 | 13 | 22 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 19 | 3 | 1 | 15 | 19 | 38 | -19 | 10 | LWLO | 11 | 2 | 1 | 8 | 14 | 24 | 8 | 1 | 0 | 7 | 5 | 14 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Phoenix Rising | 20 | 12 | 5 | 3 | 43 | 19 | +24 | 41 | WLOX | 11 | 8 | 3 | 0 | 32 | 8 | 9 | 4 | 2 | 3 | 11 | 11 | |
| 2 | 1 | El Paso Locomotive | 19 | 12 | 5 | 2 | 31 | 14 | +17 | 41 | LWXW | 10 | 8 | 2 | 0 | 19 | 5 | 9 | 4 | 3 | 2 | 12 | 9 | |
| 3 | Colorado Springs | 20 | 9 | 5 | 6 | 45 | 35 | +10 | 32 | WXWX | 10 | 5 | 2 | 3 | 23 | 17 | 10 | 4 | 3 | 3 | 22 | 18 | ||
| 4 | Orange County SC | 21 | 8 | 6 | 7 | 29 | 26 | +3 | 30 | OWLX | 9 | 2 | 3 | 4 | 10 | 15 | 12 | 6 | 3 | 3 | 19 | 11 | ||
| 5 | 2 | San Diego Loyal | 21 | 9 | 3 | 9 | 31 | 29 | +2 | 30 | WLWL | 11 | 6 | 1 | 4 | 17 | 12 | 10 | 3 | 2 | 5 | 14 | 17 | |
| 6 | 1 | RGV Toros | 20 | 8 | 5 | 7 | 29 | 28 | +1 | 29 | LXLL | 10 | 5 | 1 | 4 | 14 | 15 | 10 | 3 | 4 | 3 | 15 | 13 | |
| 7 | 3 | San Antonio | 18 | 7 | 6 | 5 | 27 | 21 | +6 | 27 | WWLW | 9 | 4 | 3 | 2 | 15 | 9 | 9 | 3 | 3 | 3 | 12 | 12 | |
| 8 | 2 | Tacoma Defiance | 18 | 7 | 6 | 5 | 23 | 21 | +2 | 27 | LWWW | 8 | 5 | 3 | 0 | 13 | 5 | 10 | 2 | 3 | 5 | 10 | 16 | |
| 9 | 1 | Austin Bold | 20 | 6 | 8 | 6 | 18 | 24 | -6 | 26 | LXXO | 10 | 3 | 4 | 3 | 10 | 11 | 10 | 3 | 4 | 3 | 8 | 13 | |
| 10 | 1 | New Mexico United | 20 | 6 | 7 | 7 | 24 | 24 | +0 | 25 | LXXX | 9 | 4 | 4 | 1 | 12 | 6 | 11 | 2 | 3 | 6 | 12 | 18 | |
| 11 | 1 | LA Galaxy 2 | 19 | 6 | 4 | 9 | 31 | 35 | -4 | 22 | WLWL | 10 | 2 | 4 | 4 | 17 | 14 | 9 | 4 | 0 | 5 | 14 | 21 | |
| 12 | 1 | Sacramento Republic | 19 | 5 | 7 | 7 | 21 | 25 | -4 | 22 | LOWO | 10 | 3 | 2 | 5 | 14 | 17 | 9 | 2 | 5 | 2 | 7 | 8 | |
| 13 | 2 | Oakland Roots | 18 | 5 | 5 | 8 | 20 | 27 | -7 | 20 | WWWX | 8 | 3 | 2 | 3 | 9 | 9 | 10 | 2 | 3 | 5 | 11 | 18 | |
| 14 | 1 | Las Vegas Lights | 20 | 5 | 2 | 13 | 28 | 47 | -19 | 17 | LLLL | 10 | 3 | 2 | 5 | 15 | 17 | 10 | 2 | 0 | 8 | 13 | 30 | |
| 15 | 1 | Real Monarchs | 19 | 4 | 4 | 11 | 18 | 32 | -14 | 16 | LWLL | 10 | 3 | 2 | 5 | 12 | 17 | 9 | 1 | 2 | 6 | 6 | 15 | |
| 20 | +1 | Hadji BARRY (Colorado Springs, 6p) |
| 13 | +2 | Russell CICERONE (Pittsburgh Riverhounds, 3p) |
| 12 | +1 | Neco BRETT (Birmingham Legion, 4p) |
| 11 | +1 | Kyle MURPHY (Memphis 901, 1p) |
| Cameron LANCASTER (Louisville City, 4p) | ||
| 10 | Ronaldo DAMUS (Orange County SC) | |
| 9 | Villyan BIJEV (OKC Energy, 3p) | |
| +1 | SANTI Moar (Phoenix Rising, 1p) | |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| +1 | Preston JUDD (LA Galaxy 2) | |
| +1 | Jorge HERNÁNDEZ (LA Galaxy 2, 2p) | |
| 8 | +1 | Michee NGALINA (Colorado Springs, 1p) |
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| 7 | Tumi MOSHOBANE (San Diego Loyal) | |
| NATHAN Uilian (San Antonio, 3p) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| +1 | Alex DIXON (Pittsburgh Riverhounds) | |
| Dane KELLY (Charlotte Independence, 1p) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) | ||
| 6 | Omar SOWE (New York Red Bulls 2) | |
| Irvin PARRA (Charlotte Independence, 1p) | ||
| Tyler WOLFF (Atlanta United 2) | ||
| Elvis AMOH (RGV Toros) | ||
| +2 | Manuel ARTEAGA (Indy Eleven, 1p) | |
| Aiden McFADDEN (Atlanta United 2) | ||
| +2 | MARLON dos Santos (FC Tulsa) | |
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Juan AZOCÁR (RGV Toros) | ||
| Claudio REPETTO (Charleston Battery) |
| Wednesday, 25 August 2021 | |||||
| FC Tulsa | 2-1 | Memphis 901 | |||
| 80 | Marlon | 87 | Murphy | ||
| 90 | Marlon | ||||
| Oakland Roots | 3-1 | Phoenix Rising | |||
| 43 | Fall | 53 | King | ||
| 51 | Hernández | ||||
| 61 | Mbumba | ||||
| Friday, 27 August 2021 | |||||
| Las Vegas Lights | 2-3 | LA Galaxy 2 | |||
| 36 | Musovski | 39 | Judd | ||
| 89 | Sepulveda | 70(p) | Hernández | ||
| 90 | Cabral | ||||
| Saturday, 28 August 2021 | |||||
| Charleston Battery | 0-0 | Orange County SC | |||
| Tampa Bay Rowdies | 2-0 | Charlotte Independence | |||
| 73 | Duba | ||||
| 76 | Duba | ||||
| San Antonio | 2-1 | El Paso Locomotive | |||
| 32 | Epps | 54 | Velásquez | ||
| 90 | Dhillon | ||||
| Phoenix Rising | 3-2 | New Mexico United | |||
| 59 | Calistri | 11 | Rivas | ||
| 66 | Calistri | 80(og) | Musa | ||
| 90 | Santi | ||||
| Indy Eleven | 2-0 | Real Monarchs | |||
| 26 | Arteaga | ||||
| 45(p) | Arteaga | ||||
| Sacramento Republic | 1-3 | San Diego Loyal | |||
| 39(p) | Iwasa | 3 | Larraz | ||
| 23 | Williams | ||||
| 29 | Williams | ||||
| FC Tulsa | 3-1 | Atlanta United 2 | |||
| 14 | Sheldon | 17 | Chol | ||
| 30 | Moloto | ||||
| 34 | Moloto | ||||
| Colorado Springs | 4-1 | Austin Bold | |||
| 22(p) | Barry | 15 | Báez | ||
| 38 | Hodge | ||||
| 40 | Amang | ||||
| 90 | Ngalina | ||||
| Birmingham Legion | 2-1 | Louisville City | |||
| 51 | Brett | 62 | Delpiccolo | ||
| 78 | Williams | ||||
| Hartford Athletic | 2-3 | Pittsburgh Riverhounds | |||
| 18 | Obregón | 2(p) | Cicerone | ||
| 51(p) | Barrera | 57 | Dixon | ||
| 90 | Cicerone | ||||
| Oakland Roots | 3-1 | Tacoma Defiance | |||
| 13 | Greene | 45 | Brewitt | ||
| 57 | Mbumba | ||||
| 82 | Bokila | ||||