| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 290 | 818 | 2.82 | 125 | 43.10% | 70 | 24.14% | 95 | 32.76% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 19 | 12 | 4 | 3 | 39 | 21 | +18 | 40 | OWWW | 12 | 9 | 2 | 1 | 27 | 11 | 7 | 3 | 2 | 2 | 12 | 10 | ||
| 2 | Tampa Bay Rowdies | 19 | 12 | 1 | 6 | 26 | 15 | +11 | 37 | WOWW | 10 | 8 | 0 | 2 | 18 | 7 | 9 | 4 | 1 | 4 | 8 | 8 | ||
| 3 | Pittsburgh Riverhounds | 21 | 11 | 4 | 6 | 32 | 23 | +9 | 37 | WOLL | 10 | 5 | 2 | 3 | 14 | 9 | 11 | 6 | 2 | 3 | 18 | 14 | ||
| 4 | 1 | Miami FC | 20 | 10 | 4 | 6 | 30 | 25 | +5 | 34 | WOWX | 10 | 7 | 0 | 3 | 17 | 13 | 10 | 3 | 4 | 3 | 13 | 12 | |
| 5 | 1 | Birmingham Legion | 19 | 10 | 3 | 6 | 25 | 21 | +4 | 33 | LXWL | 9 | 5 | 1 | 3 | 14 | 10 | 10 | 5 | 2 | 3 | 11 | 11 | |
| 6 | Hartford Athletic | 18 | 8 | 3 | 7 | 30 | 25 | +5 | 27 | LWLL | 8 | 4 | 3 | 1 | 17 | 7 | 10 | 4 | 0 | 6 | 13 | 18 | ||
| 7 | 2 | Charleston Battery | 18 | 8 | 3 | 7 | 30 | 28 | +2 | 27 | WLWL | 9 | 5 | 2 | 2 | 16 | 11 | 9 | 3 | 1 | 5 | 14 | 17 | |
| 8 | 1 | Charlotte Independence | 18 | 8 | 3 | 7 | 26 | 24 | +2 | 27 | XWWO | 8 | 5 | 2 | 1 | 16 | 9 | 10 | 3 | 1 | 6 | 10 | 15 | |
| 9 | 1 | Atlanta United 2 | 21 | 6 | 7 | 8 | 35 | 33 | +2 | 25 | LWXW | 12 | 4 | 5 | 3 | 24 | 16 | 9 | 2 | 2 | 5 | 11 | 17 | |
| 10 | 1 | FC Tulsa | 18 | 8 | 1 | 9 | 28 | 32 | -4 | 25 | WLWL | 7 | 4 | 0 | 3 | 15 | 13 | 11 | 4 | 1 | 6 | 13 | 19 | |
| 11 | 1 | OKC Energy | 20 | 5 | 8 | 7 | 21 | 23 | -2 | 23 | OLXW | 10 | 2 | 5 | 3 | 9 | 9 | 10 | 3 | 3 | 4 | 12 | 14 | |
| 12 | Indy Eleven | 19 | 6 | 5 | 8 | 23 | 30 | -7 | 23 | XLWL | 9 | 2 | 2 | 5 | 8 | 11 | 10 | 4 | 3 | 3 | 15 | 19 | ||
| 13 | Memphis 901 | 16 | 5 | 6 | 5 | 17 | 21 | -4 | 21 | XXLW | 6 | 2 | 2 | 2 | 6 | 6 | 10 | 3 | 4 | 3 | 11 | 15 | ||
| 14 | Sporting Kansas City 2 | 21 | 3 | 6 | 12 | 25 | 43 | -18 | 15 | XLLL | 10 | 1 | 3 | 6 | 12 | 21 | 11 | 2 | 3 | 6 | 13 | 22 | ||
| 15 | New York Red Bulls 2 | 18 | 3 | 4 | 11 | 24 | 41 | -17 | 13 | LLLL | 11 | 1 | 2 | 8 | 13 | 22 | 7 | 2 | 2 | 3 | 11 | 19 | ||
| 16 | Loudoun United | 19 | 3 | 1 | 15 | 19 | 38 | -19 | 10 | LWLO | 11 | 2 | 1 | 8 | 14 | 24 | 8 | 1 | 0 | 7 | 5 | 14 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | El Paso Locomotive | 18 | 12 | 5 | 1 | 30 | 12 | +18 | 41 | WXWW | 10 | 8 | 2 | 0 | 19 | 5 | 8 | 4 | 3 | 1 | 11 | 7 | ||
| 2 | Phoenix Rising | 18 | 11 | 5 | 2 | 39 | 14 | +25 | 38 | OXXW | 10 | 7 | 3 | 0 | 29 | 6 | 8 | 4 | 2 | 2 | 10 | 8 | ||
| 3 | 1 | Colorado Springs | 19 | 8 | 5 | 6 | 41 | 34 | +7 | 29 | XWXW | 9 | 4 | 2 | 3 | 19 | 16 | 10 | 4 | 3 | 3 | 22 | 18 | |
| 4 | 3 | Orange County SC | 20 | 8 | 5 | 7 | 29 | 26 | +3 | 29 | WLXL | 9 | 2 | 3 | 4 | 10 | 15 | 11 | 6 | 2 | 3 | 19 | 11 | |
| 5 | 2 | RGV Toros | 20 | 8 | 5 | 7 | 29 | 28 | +1 | 29 | LXLL | 10 | 5 | 1 | 4 | 14 | 15 | 10 | 3 | 4 | 3 | 15 | 13 | |
| 6 | 1 | Tacoma Defiance | 17 | 7 | 6 | 4 | 22 | 18 | +4 | 27 | WWWX | 8 | 5 | 3 | 0 | 13 | 5 | 9 | 2 | 3 | 4 | 9 | 13 | |
| 7 | 1 | San Diego Loyal | 20 | 8 | 3 | 9 | 28 | 28 | +0 | 27 | LWLL | 11 | 6 | 1 | 4 | 17 | 12 | 9 | 2 | 2 | 5 | 11 | 16 | |
| 8 | Austin Bold | 19 | 6 | 8 | 5 | 17 | 20 | -3 | 26 | XXOL | 10 | 3 | 4 | 3 | 10 | 11 | 9 | 3 | 4 | 2 | 7 | 9 | ||
| 9 | 1 | New Mexico United | 19 | 6 | 7 | 6 | 22 | 21 | +1 | 25 | XXXO | 9 | 4 | 4 | 1 | 12 | 6 | 10 | 2 | 3 | 5 | 10 | 15 | |
| 10 | 1 | San Antonio | 17 | 6 | 6 | 5 | 25 | 20 | +5 | 24 | WLWL | 8 | 3 | 3 | 2 | 13 | 8 | 9 | 3 | 3 | 3 | 12 | 12 | |
| 11 | Sacramento Republic | 18 | 5 | 7 | 6 | 20 | 22 | -2 | 22 | OWOX | 9 | 3 | 2 | 4 | 13 | 14 | 9 | 2 | 5 | 2 | 7 | 8 | ||
| 12 | LA Galaxy 2 | 18 | 5 | 4 | 9 | 28 | 33 | -5 | 19 | LWLW | 10 | 2 | 4 | 4 | 17 | 14 | 8 | 3 | 0 | 5 | 11 | 19 | ||
| 13 | Las Vegas Lights | 19 | 5 | 2 | 12 | 26 | 44 | -18 | 17 | LLLX | 9 | 3 | 2 | 4 | 13 | 14 | 10 | 2 | 0 | 8 | 13 | 30 | ||
| 14 | Real Monarchs | 18 | 4 | 4 | 10 | 18 | 30 | -12 | 16 | WLLW | 10 | 3 | 2 | 5 | 12 | 17 | 8 | 1 | 2 | 5 | 6 | 13 | ||
| 15 | Oakland Roots | 16 | 3 | 5 | 8 | 14 | 25 | -11 | 14 | WXWO | 6 | 1 | 2 | 3 | 3 | 7 | 10 | 2 | 3 | 5 | 11 | 18 | ||
| 19 | +1 | Hadji BARRY (Colorado Springs, 5p) |
| 11 | +3 | Russell CICERONE (Pittsburgh Riverhounds, 2p) |
| Cameron LANCASTER (Louisville City, 4p) | ||
| Neco BRETT (Birmingham Legion, 4p) | ||
| 10 | Kyle MURPHY (Memphis 901, 1p) | |
| +1 | Ronaldo DAMUS (Orange County SC) | |
| 9 | Villyan BIJEV (OKC Energy, 3p) | |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| 8 | SANTI Moar (Phoenix Rising, 1p) | |
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| Preston JUDD (LA Galaxy 2) | ||
| Jorge HERNÁNDEZ (LA Galaxy 2, 1p) | ||
| 7 | +1 | Tumi MOSHOBANE (San Diego Loyal) |
| NATHAN Uilian (San Antonio, 3p) | ||
| +1 | Michee NGALINA (Colorado Springs, 1p) | |
| +1 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| Dane KELLY (Charlotte Independence, 1p) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) | ||
| 6 | Omar SOWE (New York Red Bulls 2) | |
| +1 | Irvin PARRA (Charlotte Independence, 1p) | |
| Tyler WOLFF (Atlanta United 2) | ||
| +1 | Elvis AMOH (RGV Toros) | |
| Aiden McFADDEN (Atlanta United 2) | ||
| Alex DIXON (Pittsburgh Riverhounds) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Juan AZOCÁR (RGV Toros) | ||
| +1 | Claudio REPETTO (Charleston Battery) |
| Friday, 20 August 2021 | |||||
| New York Red Bulls 2 | 2-3 | Charleston Battery | |||
| 5 | Jørgensen | 2 | Harmon | ||
| 90 | Ngoma | 10 | Penn | ||
| 44 | Repetto | ||||
| Saturday, 21 August 2021 | |||||
| Phoenix Rising | 0-0 | Sacramento Republic | |||
| Charlotte Independence | 3-3 | Colorado Springs | |||
| 12 | Marveaux | 18 | Barry | ||
| 55 | Palomino | 22 | Lewis | ||
| 71 | Parra | 84 | Ngalina | ||
| Las Vegas Lights | 1-3 | Oakland Roots | |||
| 48 | Musovski | 52 | Hernández | ||
| 60 | Enríquez | ||||
| 82 | Bokila | ||||
| El Paso Locomotive | 3-1 | RGV Toros | |||
| 67 | Solignac | 38 | Amoh | ||
| 89 | Velásquez | ||||
| 90 | Mares | ||||
| San Diego Loyal | 1-2 | Orange County SC | |||
| 56 | Moshobane | 64 | Damus | ||
| 66(og) | Chavez | ||||
| Sunday, 22 August 2021 | |||||
| Pittsburgh Riverhounds | 4-1 | Atlanta United 2 | |||
| 4 | Cicerone | 15 | Matheus | ||
| 26 | Williamson | ||||
| 31 | Cicerone | ||||
| 66 | Cicerone | ||||
| OKC Energy | 0-0 | Louisville City | |||
| Sporting Kansas City 2 | 1-1 | Indy Eleven | |||
| 40 | Harris | 51 | Hamilton | ||
| Miami FC | 2-0 | Hartford Athletic | |||
| 48 | Forbes | ||||
| 90 | Forbes | ||||
| Birmingham Legion | 1-2 | FC Tulsa | |||
| 68 | Flemmings | 8 | Johnson | ||
| 56 | Suárez | ||||
| Monday, 23 August 2021 | |||||
| Austin Bold | 1-1 | New Mexico United | |||
| 55 | Avila | 37 | Wehan | ||
| Loudoun United | 0-2 | Tampa Bay Rowdies | |||
| 23 | Hilton | ||||
| 45 | Lasso | ||||