| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 334 | 957 | 2.86 | 149 | 44.61% | 77 | 23.05% | 108 | 32.34% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 22 | 15 | 1 | 6 | 32 | 15 | +17 | 46 | WWWW | 12 | 10 | 0 | 2 | 23 | 7 | 10 | 5 | 1 | 4 | 9 | 8 | ||
| 2 | Pittsburgh Riverhounds | 24 | 13 | 5 | 6 | 37 | 26 | +11 | 44 | XWWW | 11 | 6 | 2 | 3 | 15 | 9 | 13 | 7 | 3 | 3 | 22 | 17 | ||
| 3 | Louisville City | 22 | 13 | 4 | 5 | 44 | 26 | +18 | 43 | WLLO | 13 | 9 | 2 | 2 | 27 | 12 | 9 | 4 | 2 | 3 | 17 | 14 | ||
| 4 | Birmingham Legion | 22 | 12 | 3 | 7 | 30 | 25 | +5 | 39 | LWWL | 10 | 6 | 1 | 3 | 16 | 11 | 12 | 6 | 2 | 4 | 14 | 14 | ||
| 5 | Miami FC | 22 | 11 | 5 | 6 | 35 | 27 | +8 | 38 | XWWO | 11 | 8 | 0 | 3 | 20 | 13 | 11 | 3 | 5 | 3 | 15 | 14 | ||
| 6 | FC Tulsa | 22 | 12 | 1 | 9 | 36 | 35 | +1 | 37 | WWWW | 10 | 7 | 0 | 3 | 22 | 16 | 12 | 5 | 1 | 6 | 14 | 19 | ||
| 7 | 3 | Charlotte Independence | 21 | 9 | 4 | 8 | 33 | 28 | +5 | 31 | WXLX | 9 | 5 | 3 | 1 | 18 | 11 | 12 | 4 | 1 | 7 | 15 | 17 | |
| 8 | 1 | OKC Energy | 23 | 7 | 8 | 8 | 24 | 27 | -3 | 29 | LWWO | 11 | 3 | 5 | 3 | 11 | 10 | 12 | 4 | 3 | 5 | 13 | 17 | |
| 9 | 3 | Atlanta United 2 | 23 | 7 | 7 | 9 | 37 | 36 | +1 | 28 | WLLW | 12 | 4 | 5 | 3 | 24 | 16 | 11 | 3 | 2 | 6 | 13 | 20 | |
| 10 | 2 | Charleston Battery | 20 | 8 | 4 | 8 | 30 | 29 | +1 | 28 | LOWL | 11 | 5 | 3 | 3 | 16 | 12 | 9 | 3 | 1 | 5 | 14 | 17 | |
| 11 | 2 | Hartford Athletic | 21 | 8 | 3 | 10 | 34 | 34 | +0 | 27 | LLLL | 10 | 4 | 3 | 3 | 21 | 14 | 11 | 4 | 0 | 7 | 13 | 20 | |
| 12 | 1 | Indy Eleven | 22 | 7 | 5 | 10 | 26 | 33 | -7 | 26 | LLWX | 11 | 3 | 2 | 6 | 10 | 12 | 11 | 4 | 3 | 4 | 16 | 21 | |
| 13 | Memphis 901 | 20 | 6 | 7 | 7 | 21 | 26 | -5 | 25 | WLOL | 8 | 3 | 2 | 3 | 9 | 9 | 12 | 3 | 5 | 4 | 12 | 17 | ||
| 14 | Sporting Kansas City 2 | 24 | 4 | 7 | 13 | 28 | 44 | -16 | 19 | WLOX | 13 | 2 | 4 | 7 | 15 | 22 | 11 | 2 | 3 | 6 | 13 | 22 | ||
| 15 | New York Red Bulls 2 | 21 | 4 | 4 | 13 | 26 | 45 | -19 | 16 | WLLL | 12 | 2 | 2 | 8 | 15 | 22 | 9 | 2 | 2 | 5 | 11 | 23 | ||
| 16 | Loudoun United | 21 | 3 | 2 | 16 | 20 | 44 | -24 | 11 | LXLW | 12 | 2 | 1 | 9 | 14 | 29 | 9 | 1 | 1 | 7 | 6 | 15 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Phoenix Rising | 21 | 13 | 5 | 3 | 46 | 20 | +26 | 44 | WWLO | 11 | 8 | 3 | 0 | 32 | 8 | 10 | 5 | 2 | 3 | 14 | 12 | |
| 2 | 1 | El Paso Locomotive | 20 | 12 | 6 | 2 | 33 | 16 | +17 | 42 | XLWX | 10 | 8 | 2 | 0 | 19 | 5 | 10 | 4 | 4 | 2 | 14 | 11 | |
| 3 | Colorado Springs | 22 | 10 | 5 | 7 | 49 | 38 | +11 | 35 | WLWX | 11 | 6 | 2 | 3 | 25 | 17 | 11 | 4 | 3 | 4 | 24 | 21 | ||
| 4 | 3 | San Diego Loyal | 22 | 10 | 3 | 9 | 35 | 31 | +4 | 33 | WWLW | 12 | 7 | 1 | 4 | 21 | 14 | 10 | 3 | 2 | 5 | 14 | 17 | |
| 5 | San Antonio | 21 | 8 | 7 | 6 | 32 | 26 | +6 | 31 | LXWW | 11 | 5 | 4 | 2 | 19 | 12 | 10 | 3 | 3 | 4 | 13 | 14 | ||
| 6 | 2 | Orange County SC | 22 | 8 | 7 | 7 | 31 | 28 | +3 | 31 | XOWL | 10 | 2 | 4 | 4 | 12 | 17 | 12 | 6 | 3 | 3 | 19 | 11 | |
| 7 | 1 | Tacoma Defiance | 20 | 8 | 6 | 6 | 26 | 25 | +1 | 30 | LWLW | 10 | 6 | 3 | 1 | 16 | 9 | 10 | 2 | 3 | 5 | 10 | 16 | |
| 8 | RGV Toros | 22 | 8 | 6 | 8 | 31 | 31 | +0 | 30 | XLLX | 11 | 5 | 2 | 4 | 15 | 16 | 11 | 3 | 4 | 4 | 16 | 15 | ||
| 9 | Austin Bold | 21 | 7 | 8 | 6 | 20 | 25 | -5 | 29 | WLXX | 11 | 4 | 4 | 3 | 12 | 12 | 10 | 3 | 4 | 3 | 8 | 13 | ||
| 10 | New Mexico United | 21 | 7 | 7 | 7 | 27 | 26 | +1 | 28 | WLXX | 10 | 5 | 4 | 1 | 15 | 8 | 11 | 2 | 3 | 6 | 12 | 18 | ||
| 11 | 1 | Sacramento Republic | 21 | 6 | 8 | 7 | 27 | 29 | -2 | 26 | WXLO | 10 | 3 | 2 | 5 | 14 | 17 | 11 | 3 | 6 | 2 | 13 | 12 | |
| 12 | 1 | LA Galaxy 2 | 21 | 6 | 5 | 10 | 36 | 42 | -6 | 23 | LXWL | 11 | 2 | 5 | 4 | 20 | 17 | 10 | 4 | 0 | 6 | 16 | 25 | |
| 13 | Oakland Roots | 20 | 6 | 5 | 9 | 21 | 30 | -9 | 23 | WLWW | 8 | 3 | 2 | 3 | 9 | 9 | 12 | 3 | 3 | 6 | 12 | 21 | ||
| 14 | Las Vegas Lights | 23 | 5 | 2 | 16 | 30 | 53 | -23 | 17 | LLLL | 12 | 3 | 2 | 7 | 16 | 21 | 11 | 2 | 0 | 9 | 14 | 32 | ||
| 15 | Real Monarchs | 21 | 4 | 4 | 13 | 20 | 37 | -17 | 16 | LLLW | 10 | 3 | 2 | 5 | 12 | 17 | 11 | 1 | 2 | 8 | 8 | 20 | ||
| 21 | +1 | Hadji BARRY (Colorado Springs, 6p) |
| 13 | Russell CICERONE (Pittsburgh Riverhounds, 3p) | |
| 12 | +1 | Cameron LANCASTER (Louisville City, 4p) |
| Neco BRETT (Birmingham Legion, 4p) | ||
| 11 | Kyle MURPHY (Memphis 901, 1p) | |
| Ronaldo DAMUS (Orange County SC) | ||
| Preston JUDD (LA Galaxy 2) | ||
| 10 | Villyan BIJEV (OKC Energy, 3p) | |
| +1 | SANTI Moar (Phoenix Rising, 2p) | |
| Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | ||
| Jorge HERNÁNDEZ (LA Galaxy 2, 3p) | ||
| 9 | +3 | Irvin PARRA (Charlotte Independence, 1p) |
| 8 | +1 | Tumi MOSHOBANE (San Diego Loyal) |
| +1 | NATHAN Uilian (San Antonio, 3p) | |
| Michee NGALINA (Colorado Springs, 1p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| +1 | Elvis AMOH (RGV Toros, 1p) | |
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| +1 | Alex DIXON (Pittsburgh Riverhounds) | |
| 7 | +1 | Manuel ARTEAGA (Indy Eleven, 1p) |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| +1 | Aiden McFADDEN (Atlanta United 2) | |
| +1 | MARLON dos Santos (FC Tulsa) | |
| +1 | Enoch MUSHAGALUSA (Sporting Kansas City 2) | |
| Dane KELLY (Charlotte Independence, 1p) | ||
| +1 | Darío SUÁREZ (FC Tulsa, 2p) | |
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Saturday, 4 September 2021 | |||||
| San Antonio | 1-1 | Pittsburgh Riverhounds | |||
| 64 | Nathan | 90 | Dixon | ||
| Indy Eleven | 0-1 | Atlanta United 2 | |||
| 26 | McFadden | ||||
| Charlotte Independence | 2-2 | Miami FC | |||
| 19 | Parra | 63 | Craig | ||
| 44 | Martínez | 88 | François | ||
| New York Red Bulls 2 | 2-0 | Hartford Athletic | |||
| 12 | Lacava | ||||
| 90 | Ngoma | ||||
| Sporting Kansas City 2 | 3-0 | OKC Energy | |||
| 20 | Cisneros | ||||
| 72 | Smith | ||||
| 79 | Mushagalusa | ||||
| RGV Toros | 1-1 | Loudoun United | |||
| 14(p) | Amoh | 20(p) | Ku-Dipietro | ||
| Memphis 901 | 3-2 | Birmingham Legion | |||
| 45 | Kissiedou | 42 | Kasim | ||
| 90 | Lamah | 79 | Crognale | ||
| 90 | González | ||||
| New Mexico United | 3-2 | Colorado Springs | |||
| 3 | Wehan | 23(og) | Tetteh | ||
| 42 | Suggs | 88 | Touré | ||
| 47(p) | Sandoval | ||||
| Sunday, 5 September 2021 | |||||
| Tacoma Defiance | 1-3 | Phoenix Rising | |||
| 35 | Adeniran | 4 | Mattocks | ||
| 32 | Mattocks | ||||
| 90(p) | Santi | ||||
| Las Vegas Lights | 1-3 | Sacramento Republic | |||
| 12 | Jaime | 56(og) | Daroma | ||
| 73 | Luis Felipe | ||||
| 88 | Chavez | ||||
| San Diego Loyal | 4-2 | LA Galaxy 2 | |||
| 11 | Williams | 63 | Koreniuk | ||
| 41 | Hertzog | 87 | Cabral | ||
| 65 | Hertzog | ||||
| 79 | Moshobane | ||||
| Tuesday, 7 September 2021 | |||||
| Charleston Battery | 0-1 | Tampa Bay Rowdies | |||
| 63 | Hilton | ||||
| Austin Bold | 2-1 | San Antonio | |||
| 40 | Fernandez | 42 | Dhillon | ||
| 45 | Garcia | ||||
| Hartford Athletic | 2-4 | Louisville City | |||
| 31 | Obregón | 7 | Lancaster | ||
| 44 | Dodson | 29 | González | ||
| 56 | Ownby | ||||
| 59 | Hoppenot | ||||
| Wednesday, 8 September 2021 | |||||
| FC Tulsa | 2-1 | Indy Eleven | |||
| 9 | Marlon | 34 | Arteaga | ||
| 89(p) | Suárez | ||||
| Colorado Springs | 2-0 | Real Monarchs | |||
| 57 | Barry | ||||
| 65 | Torres | ||||
| Las Vegas Lights | 0-1 | Oakland Roots | |||
| 63 | Rodriguez | ||||
| Loudoun United | 0-5 | Charlotte Independence | |||
| 28 | Parra | ||||
| 40 | Parra | ||||
| 49 | Roberts | ||||
| 74 | Palomino | ||||
| 81 | Sabella | ||||