| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 374 | 1,054 | 2.81 | 166 | 44.39% | 86 | 22.99% | 122 | 32.62% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Tampa Bay Rowdies | 24 | 17 | 1 | 6 | 40 | 15 | +25 | 52 | WWWW | 13 | 11 | 0 | 2 | 29 | 7 | 11 | 6 | 1 | 4 | 11 | 8 | ||
| 2 | 1 | Louisville City | 24 | 14 | 5 | 5 | 47 | 27 | +20 | 47 | WXWL | 13 | 9 | 2 | 2 | 27 | 12 | 11 | 5 | 3 | 3 | 20 | 15 | |
| 3 | 1 | Pittsburgh Riverhounds | 26 | 14 | 5 | 7 | 42 | 27 | +15 | 47 | LWXW | 12 | 7 | 2 | 3 | 20 | 9 | 14 | 7 | 3 | 4 | 22 | 18 | |
| 4 | 1 | Birmingham Legion | 25 | 13 | 5 | 7 | 36 | 27 | +9 | 44 | WXXL | 11 | 6 | 2 | 3 | 17 | 12 | 14 | 7 | 3 | 4 | 19 | 15 | |
| 5 | 1 | Miami FC | 25 | 12 | 6 | 7 | 38 | 30 | +8 | 42 | LXWX | 12 | 8 | 1 | 3 | 21 | 14 | 13 | 4 | 5 | 4 | 17 | 16 | |
| 6 | 1 | Charlotte Independence | 24 | 12 | 4 | 8 | 38 | 28 | +10 | 40 | WWWW | 12 | 8 | 3 | 1 | 23 | 11 | 12 | 4 | 1 | 7 | 15 | 17 | |
| 7 | 1 | FC Tulsa | 24 | 12 | 2 | 10 | 37 | 37 | +0 | 38 | LXWW | 12 | 7 | 1 | 4 | 23 | 18 | 12 | 5 | 1 | 6 | 14 | 19 | |
| 8 | 1 | OKC Energy | 25 | 7 | 10 | 8 | 26 | 29 | -3 | 31 | XXLW | 12 | 3 | 6 | 3 | 12 | 11 | 13 | 4 | 4 | 5 | 14 | 18 | |
| 9 | 4 | Memphis 901 | 23 | 8 | 7 | 8 | 25 | 28 | -3 | 31 | WWLW | 10 | 4 | 2 | 4 | 10 | 11 | 13 | 4 | 5 | 4 | 15 | 17 | |
| 10 | 2 | Hartford Athletic | 23 | 9 | 3 | 11 | 36 | 36 | +0 | 30 | WLLL | 11 | 5 | 3 | 3 | 23 | 14 | 12 | 4 | 0 | 8 | 13 | 22 | |
| 11 | Charleston Battery | 23 | 8 | 6 | 9 | 34 | 34 | +0 | 30 | LXXL | 12 | 5 | 3 | 4 | 18 | 15 | 11 | 3 | 3 | 5 | 16 | 19 | ||
| 12 | 2 | Atlanta United 2 | 26 | 7 | 8 | 11 | 38 | 43 | -5 | 29 | LLXW | 15 | 4 | 6 | 5 | 25 | 23 | 11 | 3 | 2 | 6 | 13 | 20 | |
| 13 | 1 | Indy Eleven | 25 | 8 | 5 | 12 | 27 | 36 | -9 | 29 | LLWL | 13 | 4 | 2 | 7 | 11 | 14 | 12 | 4 | 3 | 5 | 16 | 22 | |
| 14 | Sporting Kansas City 2 | 25 | 4 | 7 | 14 | 28 | 45 | -17 | 19 | LWLO | 13 | 2 | 4 | 7 | 15 | 22 | 12 | 2 | 3 | 7 | 13 | 23 | ||
| 15 | New York Red Bulls 2 | 25 | 5 | 4 | 16 | 30 | 58 | -28 | 19 | WLLL | 14 | 2 | 2 | 10 | 16 | 27 | 11 | 3 | 2 | 6 | 14 | 31 | ||
| 16 | Loudoun United | 22 | 3 | 2 | 17 | 20 | 49 | -29 | 11 | LLXL | 12 | 2 | 1 | 9 | 14 | 29 | 10 | 1 | 1 | 8 | 6 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Phoenix Rising | 24 | 16 | 5 | 3 | 56 | 25 | +31 | 53 | WWWW | 13 | 10 | 3 | 0 | 38 | 10 | 11 | 6 | 2 | 3 | 18 | 15 | ||
| 2 | El Paso Locomotive | 23 | 13 | 8 | 2 | 37 | 18 | +19 | 47 | XOWX | 11 | 9 | 2 | 0 | 21 | 5 | 12 | 4 | 6 | 2 | 16 | 13 | ||
| 3 | Colorado Springs | 25 | 11 | 7 | 7 | 52 | 40 | +12 | 40 | WOXW | 13 | 6 | 4 | 3 | 26 | 18 | 12 | 5 | 3 | 4 | 26 | 22 | ||
| 4 | San Antonio | 24 | 11 | 7 | 6 | 36 | 27 | +9 | 40 | WWWL | 11 | 5 | 4 | 2 | 19 | 12 | 13 | 6 | 3 | 4 | 17 | 15 | ||
| 5 | 1 | San Diego Loyal | 25 | 11 | 4 | 10 | 37 | 33 | +4 | 37 | LWOW | 13 | 8 | 1 | 4 | 22 | 14 | 12 | 3 | 3 | 6 | 15 | 19 | |
| 6 | 1 | Austin Bold | 24 | 9 | 9 | 6 | 24 | 27 | -3 | 36 | XWWW | 13 | 5 | 5 | 3 | 15 | 14 | 11 | 4 | 4 | 3 | 9 | 13 | |
| 7 | 2 | Orange County SC | 24 | 9 | 7 | 8 | 35 | 30 | +5 | 34 | LWXO | 11 | 3 | 4 | 4 | 15 | 17 | 13 | 6 | 3 | 4 | 20 | 13 | |
| 8 | 2 | New Mexico United | 23 | 8 | 7 | 8 | 29 | 28 | +1 | 31 | WLWL | 11 | 6 | 4 | 1 | 17 | 9 | 12 | 2 | 3 | 7 | 12 | 19 | |
| 9 | 1 | RGV Toros | 24 | 8 | 7 | 9 | 33 | 34 | -1 | 31 | LXXL | 12 | 5 | 2 | 5 | 16 | 18 | 12 | 3 | 5 | 4 | 17 | 16 | |
| 10 | 1 | Tacoma Defiance | 23 | 8 | 6 | 9 | 27 | 30 | -3 | 30 | LLLL | 11 | 6 | 3 | 2 | 16 | 10 | 12 | 2 | 3 | 7 | 11 | 20 | |
| 11 | Oakland Roots | 24 | 8 | 6 | 10 | 26 | 33 | -7 | 30 | WLWO | 12 | 5 | 3 | 4 | 14 | 12 | 12 | 3 | 3 | 6 | 12 | 21 | ||
| 12 | Sacramento Republic | 24 | 7 | 8 | 9 | 28 | 32 | -4 | 29 | WLLW | 11 | 3 | 2 | 6 | 14 | 18 | 13 | 4 | 6 | 3 | 14 | 14 | ||
| 13 | LA Galaxy 2 | 23 | 7 | 5 | 11 | 40 | 46 | -6 | 26 | WLLX | 12 | 2 | 5 | 5 | 23 | 21 | 11 | 5 | 0 | 6 | 17 | 25 | ||
| 14 | Las Vegas Lights | 25 | 5 | 2 | 18 | 31 | 60 | -29 | 17 | LLLL | 12 | 3 | 2 | 7 | 16 | 21 | 13 | 2 | 0 | 11 | 15 | 39 | ||
| 15 | Real Monarchs | 24 | 4 | 4 | 16 | 21 | 42 | -21 | 16 | LLLL | 11 | 3 | 2 | 6 | 12 | 18 | 13 | 1 | 2 | 10 | 9 | 24 | ||
| 23 | +2 | Hadji BARRY (Colorado Springs, 6p) |
| 14 | Russell CICERONE (Pittsburgh Riverhounds, 3p) | |
| +3 | Kyle MURPHY (Memphis 901, 2p) | |
| +2 | Neco BRETT (Birmingham Legion, 4p) | |
| +2 | Sebastián GUENZATTI (Tampa Bay Rowdies, 4p) | |
| 13 | +1 | SANTI Moar (Phoenix Rising, 2p) |
| +1 | Ronaldo DAMUS (Orange County SC) | |
| +1 | Cameron LANCASTER (Louisville City, 4p) | |
| 11 | +1 | Villyan BIJEV (OKC Energy, 3p) |
| Preston JUDD (LA Galaxy 2) | ||
| 10 | +1 | Irvin PARRA (Charlotte Independence, 1p) |
| Jorge HERNÁNDEZ (LA Galaxy 2, 3p) | ||
| 8 | Tumi MOSHOBANE (San Diego Loyal) | |
| NATHAN Uilian (San Antonio, 3p) | ||
| Michee NGALINA (Colorado Springs, 1p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Elvis AMOH (RGV Toros, 1p) | ||
| Solomon ASANTÉ (Phoenix Rising, 1p) | ||
| Alex DIXON (Pittsburgh Riverhounds) | ||
| Darío SUÁREZ (FC Tulsa, 3p) | ||
| 7 | +1 | Chris WEHAN (New Mexico United) |
| Christiano FRANÇOIS (Miami FC) | ||
| Juan OBREGÓN (Hartford Athletic) | ||
| Manuel ARTEAGA (Indy Eleven, 1p) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Aiden McFADDEN (Atlanta United 2) | ||
| MARLON dos Santos (FC Tulsa) | ||
| Enoch MUSHAGALUSA (Sporting Kansas City 2) | ||
| Dane KELLY (Charlotte Independence, 1p) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Saturday, 18 September 2021 | |||||
| Phoenix Rising | 2-1 | Orange County SC | |||
| 9 | Santi | 47 | Damus | ||
| 86 | Mattocks | ||||
| Indy Eleven | 0-2 | Louisville City | |||
| 41 | Hoppenot | ||||
| 69 | Lancaster | ||||
| Sacramento Republic | 0-1 | San Antonio | |||
| 74 | Ford | ||||
| FC Tulsa | 0-1 | Austin Bold | |||
| 11 | Garcia | ||||
| Charlotte Independence | 1-0 | Pittsburgh Riverhounds | |||
| 81 | Parra | ||||
| RGV Toros | 1-2 | Colorado Springs | |||
| 26 | Ycaza | 49 | Barry | ||
| 81 | Barry | ||||
| Miami FC | 1-1 | Charleston Battery | |||
| 67 | Walker | 14 | Hogan | ||
| Atlanta United 2 | 0-2 | Tampa Bay Rowdies | |||
| 2 | Guenzatti | ||||
| 45 | Guenzatti | ||||
| Birmingham Legion | 1-1 | OKC Energy | |||
| 55 | Lopez | 39 | Bijev | ||
| New Mexico United | 2-1 | Real Monarchs | |||
| 48 | Moreno | 50 | Wehan | ||
| 80 | Wehan | ||||
| Oakland Roots | 0-1 | LA Galaxy 2 | |||
| 75(p) | Davila | ||||
| Sunday, 19 September 2021 | |||||
| New York Red Bulls 2 | 0-3 | Memphis 901 | |||
| 21(p) | Murphy | ||||
| 26 | Thomas | ||||
| 79 | Murphy | ||||
| San Diego Loyal | 1-0 | Tacoma Defiance | |||
| 31 | Yaro | ||||
| Wednesday, 22 September 2021 | |||||
| Charleston Battery | 2-3 | New York Red Bulls 2 | |||
| 34 | Bunting | 14 | Ngoma | ||
| 80 | Archer | 20 | Lacava | ||
| 47 | Rafanello | ||||
| Charlotte Independence | 2-0 | Miami FC | |||
| 12 | Obertan | ||||
| 64(og) | Palacios | ||||
| Tacoma Defiance | 0-1 | Sacramento Republic | |||
| 78 | Formella | ||||
| Atlanta United 2 | 0-4 | Birmingham Legion | |||
| 17 | Vancaeyezeele | ||||
| 78 | Brett | ||||
| 82 | Kasim | ||||
| 90 | Brett | ||||
| Austin Bold | 2-2 | El Paso Locomotive | |||
| 31 | Stéfano | 70 | Luna | ||
| 90 | Guadarrama | 83 | Gómez | ||
| Memphis 901 | 1-0 | Indy Eleven | |||
| 31 | Murphy | ||||
| Oakland Roots | 2-1 | San Diego Loyal | |||
| 6 | Rodriguez | 45 | Martin | ||
| 63(p) | Hernández | ||||