| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 439 | 1,284 | 2.92 | 202 | 46.01% | 93 | 21.18% | 144 | 32.80% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 33 | 21 | 6 | 6 | 63 | 27 | +36 | 69 | WWLW | 16 | 12 | 2 | 2 | 36 | 13 | 17 | 9 | 4 | 4 | 27 | 14 | ||
| 2 | Memphis 901 | 32 | 19 | 5 | 8 | 62 | 32 | +30 | 62 | XLWW | 16 | 10 | 1 | 5 | 38 | 21 | 16 | 9 | 4 | 3 | 24 | 11 | ||
| 3 | Tampa Bay Rowdies | 32 | 18 | 7 | 7 | 69 | 32 | +37 | 61 | WWXL | 15 | 10 | 3 | 2 | 37 | 12 | 17 | 8 | 4 | 5 | 32 | 20 | ||
| 4 | Birmingham Legion | 32 | 16 | 7 | 9 | 52 | 34 | +18 | 55 | LXWL | 15 | 8 | 4 | 3 | 25 | 12 | 17 | 8 | 3 | 6 | 27 | 22 | ||
| 5 | Detroit City | 33 | 14 | 12 | 7 | 44 | 29 | +15 | 54 | LWXO | 16 | 6 | 8 | 2 | 21 | 15 | 17 | 8 | 4 | 5 | 23 | 14 | ||
| 6 | Pittsburgh Riverhounds | 32 | 15 | 8 | 9 | 46 | 36 | +10 | 53 | LXLO | 16 | 8 | 5 | 3 | 22 | 14 | 16 | 7 | 3 | 6 | 24 | 22 | ||
| 7 | Miami FC | 33 | 14 | 10 | 9 | 46 | 32 | +14 | 52 | LWOX | 17 | 5 | 7 | 5 | 18 | 18 | 16 | 9 | 3 | 4 | 28 | 14 | ||
| 8 | 1 | Indy Eleven | 33 | 12 | 5 | 16 | 40 | 52 | -12 | 41 | WLWW | 17 | 9 | 2 | 6 | 26 | 22 | 16 | 3 | 3 | 10 | 14 | 30 | |
| 9 | 1 | FC Tulsa | 32 | 11 | 6 | 15 | 46 | 55 | -9 | 39 | WXLX | 15 | 8 | 3 | 4 | 25 | 20 | 17 | 3 | 3 | 11 | 21 | 35 | |
| 10 | Hartford Athletic | 33 | 10 | 6 | 17 | 46 | 55 | -9 | 36 | LWLW | 17 | 7 | 1 | 9 | 28 | 28 | 16 | 3 | 5 | 8 | 18 | 27 | ||
| 11 | Loudoun United | 33 | 8 | 3 | 22 | 35 | 73 | -38 | 27 | LLLW | 17 | 6 | 2 | 9 | 22 | 30 | 16 | 2 | 1 | 13 | 13 | 43 | ||
| 12 | Charleston Battery | 33 | 6 | 6 | 21 | 40 | 76 | -36 | 24 | LLLL | 16 | 5 | 1 | 10 | 22 | 34 | 17 | 1 | 5 | 11 | 18 | 42 | ||
| 13 | Atlanta United 2 | 33 | 6 | 5 | 22 | 38 | 82 | -44 | 23 | WLXL | 17 | 3 | 4 | 10 | 18 | 36 | 16 | 3 | 1 | 12 | 20 | 46 | ||
| 14 | New York Red Bulls 2 | 32 | 3 | 6 | 23 | 23 | 73 | -50 | 15 | LOLL | 17 | 2 | 5 | 10 | 14 | 33 | 15 | 1 | 1 | 13 | 9 | 40 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 32 | 23 | 4 | 5 | 50 | 23 | +27 | 73 | WWWX | 16 | 11 | 4 | 1 | 29 | 9 | 16 | 12 | 0 | 4 | 21 | 14 | ||
| 2 | San Diego Loyal | 32 | 18 | 5 | 9 | 65 | 48 | +17 | 59 | XWWL | 16 | 12 | 0 | 4 | 37 | 21 | 16 | 6 | 5 | 5 | 28 | 27 | ||
| 3 | Colorado Springs | 33 | 17 | 4 | 12 | 59 | 51 | +8 | 55 | WXLL | 17 | 10 | 3 | 4 | 35 | 24 | 16 | 7 | 1 | 8 | 24 | 27 | ||
| 4 | Sacramento Republic | 32 | 14 | 7 | 11 | 43 | 33 | +10 | 49 | LLLW | 15 | 9 | 4 | 2 | 27 | 10 | 17 | 5 | 3 | 9 | 16 | 23 | ||
| 5 | 3 | RGV Toros | 33 | 13 | 7 | 13 | 47 | 39 | +8 | 46 | WXLW | 16 | 7 | 2 | 7 | 17 | 16 | 17 | 6 | 5 | 6 | 30 | 23 | |
| 6 | 1 | Oakland Roots | 33 | 11 | 13 | 9 | 50 | 43 | +7 | 46 | WWXW | 17 | 7 | 5 | 5 | 26 | 22 | 16 | 4 | 8 | 4 | 24 | 21 | |
| 7 | 1 | El Paso Locomotive | 33 | 13 | 7 | 13 | 55 | 49 | +6 | 46 | WLWL | 17 | 8 | 2 | 7 | 33 | 23 | 16 | 5 | 5 | 6 | 22 | 26 | |
| 8 | 3 | New Mexico United | 31 | 11 | 11 | 9 | 41 | 35 | +6 | 44 | OXLL | 15 | 4 | 5 | 6 | 20 | 18 | 16 | 7 | 6 | 3 | 21 | 17 | |
| 9 | Las Vegas Lights | 33 | 12 | 8 | 13 | 39 | 49 | -10 | 44 | WOWL | 17 | 7 | 3 | 7 | 23 | 23 | 16 | 5 | 5 | 6 | 16 | 26 | ||
| 10 | Monterey Bay | 32 | 12 | 4 | 16 | 41 | 53 | -12 | 40 | LLOX | 17 | 8 | 3 | 6 | 27 | 20 | 15 | 4 | 1 | 10 | 14 | 33 | ||
| 11 | 1 | LA Galaxy 2 | 32 | 11 | 6 | 15 | 50 | 59 | -9 | 39 | LWLL | 16 | 7 | 3 | 6 | 32 | 31 | 16 | 4 | 3 | 9 | 18 | 28 | |
| 12 | 1 | Phoenix Rising | 33 | 11 | 6 | 16 | 47 | 57 | -10 | 39 | LWWX | 16 | 8 | 3 | 5 | 29 | 20 | 17 | 3 | 3 | 11 | 18 | 37 | |
| 13 | Orange County SC | 33 | 7 | 12 | 14 | 47 | 57 | -10 | 33 | LXXL | 17 | 5 | 8 | 4 | 28 | 24 | 16 | 2 | 4 | 10 | 19 | 33 | ||
| 22 | Milan ILOSKI (Orange County SC) | |
| 19 | Phillip GOODRUM (Memphis 901) | |
| +1 | Óttar KARLSSON (Oakland Roots, 7p) | |
| 17 | +2 | Luis SOLIGNAC (El Paso Locomotive, 1p) |
| 16 | +1 | Augustine WILLIAMS (Charleston Battery, 2p) |
| Leonardo FERNANDES (Tampa Bay Rowdies, 5p) | ||
| Hadji BARRY (Colorado Springs, 3p) | ||
| 15 | +1 | Wilson HARRIS (Louisville City, 1p) |
| 14 | Kyle VASSELL (San Diego Loyal, 1p) | |
| Enzo MARTÍNEZ (Birmingham Legion) | ||
| 13 | Danny TREJO (Las Vegas Lights) | |
| Elvis AMOH (Colorado Springs) | ||
| +1 | Preston JUDD (LA Galaxy 2) | |
| 12 | +2 | STÉFANO Souza (Indy Eleven, 1p) |
| +3 | Michee NGALINA (Colorado Springs, 1p) | |
| Jerome 'J.J.' WILLIAMS (Phoenix Rising) | ||
| Russell CICERONE (Pittsburgh Riverhounds) | ||
| +1 | Jake LACAVA (Tampa Bay Rowdies) | |
| 11 | Albert DIKWA (Pittsburgh Riverhounds) | |
| +1 | Cameron DUNBAR (LA Galaxy 2, 3p) | |
| +1 | Cal JENNINGS (Las Vegas Lights, 1p) |
| Sunday, 2 October 2022 | |||||
| LA Galaxy 2 | 2-0 | Sacramento Republic | |||
| 7 | Judd | ||||
| 61(og) | Bauer | ||||
| Monterey Bay | 1-2 | Tampa Bay Rowdies | |||
| 22 | Gleadle | 49 | Law | ||
| 67 | Wyke | ||||
| Wednesday, 5 October 2022 | |||||
| Louisville City | 2-1 | Detroit City | |||
| 61 | Harris | 42 | Hoppenot | ||
| 64 | Wynder | ||||
| El Paso Locomotive | 1-4 | Colorado Springs | |||
| 27 | Solignac | 22 | Ngalina | ||
| 54 | Zandi | ||||
| 59(p) | Ngalina | ||||
| 69 | Ngalina | ||||
| Memphis 901 | 2-2 | RGV Toros | |||
| 2 | Kelly | 73 | Torres | ||
| 55 | Kissiedou | 80(og) | Smith | ||
| Saturday, 8 October 2022 | |||||
| Tampa Bay Rowdies | 8-0 | Loudoun United | |||
| 19(p) | Guenzatti | ||||
| 23 | Castellanos | ||||
| 45 | Lacava | ||||
| 61 | Guenzatti | ||||
| 64 | Dalgaard | ||||
| 83 | Mkosana | ||||
| 87 | Harris | ||||
| 90 | Harris | ||||
| Indy Eleven | 4-1 | Charleston Battery | |||
| 40 | Cochran | 18 | Williams | ||
| 48 | Stéfano | ||||
| 64 | Stéfano | ||||
| 71(og) | Asensio | ||||
| LA Galaxy 2 | 1-3 | Atlanta United 2 | |||
| 8 | Dunbar | 75 | Trager | ||
| 87 | Trager | ||||
| 90 | Villal | ||||
| RGV Toros | 2-1 | Phoenix Rising | |||
| 39 | Fjeldberg | 48 | Torres | ||
| 55 | Fjeldberg | ||||
| Las Vegas Lights | 3-2 | Miami FC | |||
| 31(og) | Antonelli | 69 | Rivas | ||
| 66 | Crisostomo | 84 | Valot | ||
| 78 | Jennings | ||||
| El Paso Locomotive | 2-1 | Orange County SC | |||
| 37 | Solignac | 83 | Jamison | ||
| 54 | Fox | ||||
| Hartford Athletic | 1-3 | Oakland Roots | |||
| 48 | Yacoubou | 4 | Azocár | ||
| 59 | Karlsson | ||||
| 90 | Rodriguez | ||||