| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 82 | 225 | 2.74 | 42 | 51.22% | 13 | 15.85% | 27 | 32.93% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Louisville City | 7 | 5 | 2 | 0 | 13 | 3 | +10 | 17 | WWOX | 3 | 2 | 1 | 0 | 4 | 1 | 4 | 3 | 1 | 0 | 9 | 2 | |
| 2 | 1 | Pittsburgh Riverhounds | 6 | 4 | 1 | 1 | 12 | 6 | +6 | 13 | LWWX | 2 | 2 | 0 | 0 | 4 | 1 | 4 | 2 | 1 | 1 | 8 | 5 | |
| 3 | Tampa Bay Rowdies | 7 | 3 | 3 | 1 | 10 | 4 | +6 | 12 | WLOX | 4 | 2 | 1 | 1 | 6 | 3 | 3 | 1 | 2 | 0 | 4 | 1 | ||
| 4 | 1 | Detroit City | 6 | 3 | 2 | 1 | 8 | 3 | +5 | 11 | WWXX | 4 | 2 | 2 | 0 | 4 | 2 | 2 | 1 | 0 | 1 | 4 | 1 | |
| 5 | 2 | Miami FC | 6 | 3 | 1 | 2 | 6 | 4 | +2 | 10 | WWLO | 4 | 2 | 1 | 1 | 5 | 2 | 2 | 1 | 0 | 1 | 1 | 2 | |
| 6 | 2 | Memphis 901 | 5 | 3 | 1 | 1 | 6 | 6 | +0 | 10 | WXWW | 2 | 1 | 0 | 1 | 2 | 4 | 3 | 2 | 1 | 0 | 4 | 2 | |
| 7 | 3 | FC Tulsa | 7 | 3 | 0 | 4 | 12 | 13 | -1 | 9 | LLWL | 4 | 3 | 0 | 1 | 10 | 7 | 3 | 0 | 0 | 3 | 2 | 6 | |
| 8 | 2 | Indy Eleven | 6 | 2 | 2 | 2 | 6 | 7 | -1 | 8 | WWXX | 2 | 1 | 1 | 0 | 3 | 2 | 4 | 1 | 1 | 2 | 3 | 5 | |
| 9 | 3 | Loudoun United | 6 | 2 | 1 | 3 | 5 | 8 | -3 | 7 | LLLO | 2 | 1 | 0 | 1 | 1 | 2 | 4 | 1 | 1 | 2 | 4 | 6 | |
| 10 | 1 | Atlanta United 2 | 7 | 2 | 0 | 5 | 7 | 13 | -6 | 6 | LLWW | 4 | 1 | 0 | 3 | 4 | 9 | 3 | 1 | 0 | 2 | 3 | 4 | |
| 11 | 2 | Birmingham Legion | 6 | 1 | 2 | 3 | 4 | 8 | -4 | 5 | LWOL | 4 | 1 | 2 | 1 | 3 | 4 | 2 | 0 | 0 | 2 | 1 | 4 | |
| 12 | 1 | Charleston Battery | 5 | 1 | 0 | 4 | 4 | 11 | -7 | 3 | LLLL | 2 | 1 | 0 | 1 | 2 | 2 | 3 | 0 | 0 | 3 | 2 | 9 | |
| 13 | 1 | New York Red Bulls 2 | 6 | 1 | 0 | 5 | 3 | 11 | -8 | 3 | LLLL | 3 | 0 | 0 | 3 | 0 | 6 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 14 | Hartford Athletic | 5 | 0 | 1 | 4 | 4 | 9 | -5 | 1 | LLLX | 1 | 0 | 0 | 1 | 1 | 2 | 4 | 0 | 1 | 3 | 3 | 7 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Diego Loyal | 8 | 5 | 1 | 2 | 18 | 14 | +4 | 16 | LXWW | 5 | 4 | 0 | 1 | 13 | 9 | 3 | 1 | 1 | 1 | 5 | 5 | ||
| 2 | Colorado Springs | 6 | 5 | 0 | 1 | 11 | 6 | +5 | 15 | LWWW | 3 | 2 | 0 | 1 | 4 | 3 | 3 | 3 | 0 | 0 | 7 | 3 | ||
| 3 | San Antonio | 6 | 5 | 0 | 1 | 7 | 4 | +3 | 15 | WWLW | 3 | 2 | 0 | 1 | 2 | 2 | 3 | 3 | 0 | 0 | 5 | 2 | ||
| 4 | Phoenix Rising | 6 | 4 | 0 | 2 | 13 | 8 | +5 | 12 | WWWL | 4 | 3 | 0 | 1 | 10 | 6 | 2 | 1 | 0 | 1 | 3 | 2 | ||
| 5 | 1 | Las Vegas Lights | 7 | 4 | 0 | 3 | 12 | 12 | +0 | 12 | WLWL | 4 | 2 | 0 | 2 | 5 | 5 | 3 | 2 | 0 | 1 | 7 | 7 | |
| 6 | 1 | Sacramento Republic | 5 | 3 | 1 | 1 | 8 | 6 | +2 | 10 | XWWL | 3 | 3 | 0 | 0 | 7 | 3 | 2 | 0 | 1 | 1 | 1 | 3 | |
| 7 | New Mexico United | 5 | 2 | 2 | 1 | 7 | 5 | +2 | 8 | LXXW | 3 | 1 | 2 | 0 | 5 | 3 | 2 | 1 | 0 | 1 | 2 | 2 | ||
| 8 | 1 | LA Galaxy 2 | 6 | 2 | 1 | 3 | 8 | 9 | -1 | 7 | WLXW | 3 | 2 | 0 | 1 | 5 | 3 | 3 | 0 | 1 | 2 | 3 | 6 | |
| 9 | 4 | Oakland Roots | 7 | 1 | 3 | 3 | 11 | 11 | +0 | 6 | WXOX | 4 | 1 | 2 | 1 | 8 | 6 | 3 | 0 | 1 | 2 | 3 | 5 | |
| 10 | 1 | RGV Toros | 6 | 2 | 0 | 4 | 5 | 7 | -2 | 6 | WLLL | 3 | 1 | 0 | 2 | 3 | 4 | 3 | 1 | 0 | 2 | 2 | 3 | |
| 11 | 3 | Orange County SC | 5 | 1 | 2 | 2 | 5 | 6 | -1 | 5 | XLXW | 3 | 1 | 1 | 1 | 3 | 3 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 12 | 2 | El Paso Locomotive | 6 | 1 | 0 | 5 | 13 | 14 | -1 | 3 | LWLL | 3 | 1 | 0 | 2 | 10 | 7 | 3 | 0 | 0 | 3 | 3 | 7 | |
| 13 | 1 | Monterey Bay | 6 | 1 | 0 | 5 | 7 | 17 | -10 | 3 | LLLW | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 5 | 7 | 17 | |
| 6 | +1 | Danny TREJO (Las Vegas Lights) |
| 5 | +1 | Kyle VASSELL (San Diego Loyal) |
| 4 | +1 | Jackson CONWAY (Atlanta United 2) |
| +1 | Jerome 'J.J.' WILLIAMS (FC Tulsa) | |
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| Dane KELLY (Pittsburgh Riverhounds) | ||
| +1 | Frank LÓPEZ (RGV Toros) | |
| +2 | Wilson HARRIS (Louisville City) | |
| +2 | Óttar KARLSSON (Oakland Roots, 2p) | |
| 3 | STÉFANO Souza (Indy Eleven) | |
| Michee NGALINA (Colorado Springs) | ||
| Aarón GÓMEZ (El Paso Locomotive, 1p) | ||
| Dylan MARES (El Paso Locomotive) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Chase BOONE (Monterey Bay) | ||
| Luis SEIJAS (Phoenix Rising) | ||
| +1 | Antoine HOPPENOT (Detroit City) | |
| Neco BRETT (New Mexico United) | ||
| +2 | Brian OWNBY (Louisville City) | |
| Cal JENNINGS (Las Vegas Lights) | ||
| +1 | Elliot COLLIER (San Antonio) |
| Sunday, 10 April 2022 | |||||
| Birmingham Legion | 2-1 | Hartford Athletic | |||
| 37(p) | Agudelo | 43 | Apollon | ||
| 90 | Asiedu | ||||
| Loudoun United | 0-2 | Louisville City | |||
| 4 | Harris | ||||
| 53 | Ownby | ||||
| Wednesday, 13 April 2022 | |||||
| Oakland Roots | 2-2 | San Diego Loyal | |||
| 86 | Azocár | 52 | Martin | ||
| 90 | Karlsson | 90 | Stoneman | ||
| Friday, 15 April 2022 | |||||
| New York Red Bulls 2 | 0-1 | RGV Toros | |||
| 66 | López | ||||
| Detroit City | 1-0 | Birmingham Legion | |||
| 63 | Hoppenot | ||||
| Saturday, 16 April 2022 | |||||
| Tampa Bay Rowdies | 3-1 | FC Tulsa | |||
| 3 | Hilton | 85 | Williams | ||
| 37 | Greig | ||||
| 87 | Harris | ||||
| Orange County SC | 1-1 | Sacramento Republic | |||
| 26(p) | Torres | 2 | Dami | ||
| San Antonio | 1-0 | El Paso Locomotive | |||
| 11 | Collier | ||||
| Phoenix Rising | 1-0 | New Mexico United | |||
| 14 | Hurst | ||||
| Indy Eleven | 2-1 | Atlanta United 2 | |||
| 12 | Law | 68 | Conway | ||
| 90 | Briggs | ||||
| LA Galaxy 2 | 3-1 | Monterey Bay | |||
| 40 | Salazar | 68 | Conneh | ||
| 57 | Williams | ||||
| 86 | Judd | ||||
| Colorado Springs | 1-2 | Memphis 901 | |||
| 90 | Mahoney | 43 | Molloy | ||
| 59 | Goodrum | ||||
| Miami FC | 2-0 | Hartford Athletic | |||
| 16 | Murphy | ||||
| 87 | Parkes | ||||
| Las Vegas Lights | 1-0 | Pittsburgh Riverhounds | |||
| 27 | Trejo | ||||
| San Diego Loyal | 2-5 | Louisville City | |||
| 14(p) | Carleton | 4 | Harris | ||
| 52 | Vassell | 45 | Charpie | ||
| 51(p) | Totsch | ||||
| 83(p) | McCabe | ||||
| 90 | Ownby | ||||
| Oakland Roots | 4-1 | Loudoun United | |||
| 26 | Klimenta | 81 | Aboukoura | ||
| 53(p) | Karlsson | ||||
| 67 | Azocár | ||||
| 76 | Rito | ||||