| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 216 | 630 | 2.91 | 102 | 47.22% | 43 | 19.91% | 71 | 32.87% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Memphis 901 | 16 | 11 | 2 | 3 | 32 | 14 | +18 | 35 | WWXL | 9 | 7 | 0 | 2 | 22 | 10 | 7 | 4 | 2 | 1 | 10 | 4 | |
| 2 | 1 | Louisville City | 16 | 10 | 3 | 3 | 32 | 13 | +19 | 33 | WWLW | 7 | 5 | 1 | 1 | 13 | 5 | 9 | 5 | 2 | 2 | 19 | 8 | |
| 3 | Tampa Bay Rowdies | 17 | 8 | 6 | 3 | 32 | 18 | +14 | 30 | WXWW | 8 | 4 | 2 | 2 | 13 | 8 | 9 | 4 | 4 | 1 | 19 | 10 | ||
| 4 | Detroit City | 16 | 7 | 5 | 4 | 23 | 17 | +6 | 26 | LXLX | 9 | 5 | 3 | 1 | 14 | 8 | 7 | 2 | 2 | 3 | 9 | 9 | ||
| 5 | 1 | Birmingham Legion | 15 | 7 | 4 | 4 | 14 | 12 | +2 | 25 | WWWW | 8 | 3 | 4 | 1 | 6 | 5 | 7 | 4 | 0 | 3 | 8 | 7 | |
| 6 | 1 | Pittsburgh Riverhounds | 16 | 7 | 3 | 6 | 24 | 23 | +1 | 24 | LLLX | 7 | 5 | 1 | 1 | 13 | 7 | 9 | 2 | 2 | 5 | 11 | 16 | |
| 7 | Miami FC | 17 | 5 | 6 | 6 | 19 | 18 | +1 | 21 | LLXO | 10 | 2 | 4 | 4 | 11 | 13 | 7 | 3 | 2 | 2 | 8 | 5 | ||
| 8 | Indy Eleven | 15 | 6 | 3 | 6 | 22 | 25 | -3 | 21 | LLXW | 6 | 4 | 1 | 1 | 10 | 5 | 9 | 2 | 2 | 5 | 12 | 20 | ||
| 9 | FC Tulsa | 17 | 5 | 3 | 9 | 21 | 32 | -11 | 18 | WLOO | 9 | 5 | 2 | 2 | 16 | 12 | 8 | 0 | 1 | 7 | 5 | 20 | ||
| 10 | Loudoun United | 16 | 4 | 2 | 10 | 16 | 30 | -14 | 14 | LWLW | 8 | 3 | 1 | 4 | 9 | 14 | 8 | 1 | 1 | 6 | 7 | 16 | ||
| 11 | Hartford Athletic | 15 | 3 | 3 | 9 | 15 | 23 | -8 | 12 | LWXL | 7 | 2 | 1 | 4 | 8 | 11 | 8 | 1 | 2 | 5 | 7 | 12 | ||
| 12 | Atlanta United 2 | 16 | 3 | 1 | 12 | 16 | 39 | -23 | 10 | LLWL | 9 | 2 | 1 | 6 | 9 | 20 | 7 | 1 | 0 | 6 | 7 | 19 | ||
| 13 | Charleston Battery | 15 | 2 | 3 | 10 | 15 | 30 | -15 | 9 | LXWL | 8 | 2 | 1 | 5 | 9 | 15 | 7 | 0 | 2 | 5 | 6 | 15 | ||
| 14 | New York Red Bulls 2 | 16 | 1 | 3 | 12 | 9 | 30 | -21 | 6 | LOLX | 8 | 0 | 3 | 5 | 4 | 12 | 8 | 1 | 0 | 7 | 5 | 18 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | San Antonio | 15 | 11 | 1 | 3 | 24 | 13 | +11 | 34 | WXWL | 5 | 3 | 1 | 1 | 9 | 3 | 10 | 8 | 0 | 2 | 15 | 10 | |
| 2 | 1 | Colorado Springs | 14 | 11 | 0 | 3 | 31 | 17 | +14 | 33 | LWWW | 7 | 5 | 0 | 2 | 14 | 9 | 7 | 6 | 0 | 1 | 17 | 8 | |
| 3 | 1 | El Paso Locomotive | 18 | 8 | 4 | 6 | 36 | 22 | +14 | 28 | WXWX | 9 | 5 | 2 | 2 | 25 | 10 | 9 | 3 | 2 | 4 | 11 | 12 | |
| 4 | 1 | San Diego Loyal | 16 | 8 | 4 | 4 | 36 | 25 | +11 | 28 | WLWX | 8 | 6 | 0 | 2 | 22 | 11 | 8 | 2 | 4 | 2 | 14 | 14 | |
| 5 | 1 | Sacramento Republic | 15 | 8 | 4 | 3 | 19 | 12 | +7 | 28 | WWWW | 7 | 5 | 2 | 0 | 11 | 4 | 8 | 3 | 2 | 3 | 8 | 8 | |
| 6 | 3 | New Mexico United | 14 | 7 | 4 | 3 | 23 | 12 | +11 | 25 | LWWW | 7 | 2 | 3 | 2 | 13 | 7 | 7 | 5 | 1 | 1 | 10 | 5 | |
| 7 | 4 | Las Vegas Lights | 17 | 7 | 4 | 6 | 23 | 23 | +0 | 25 | WWWL | 9 | 4 | 2 | 3 | 13 | 10 | 8 | 3 | 2 | 3 | 10 | 13 | |
| 8 | Oakland Roots | 19 | 5 | 9 | 5 | 29 | 27 | +2 | 24 | WXLX | 11 | 4 | 4 | 3 | 19 | 17 | 8 | 1 | 5 | 2 | 10 | 10 | ||
| 9 | 1 | LA Galaxy 2 | 18 | 7 | 3 | 8 | 26 | 33 | -7 | 24 | WLWL | 8 | 5 | 1 | 2 | 18 | 13 | 10 | 2 | 2 | 6 | 8 | 20 | |
| 10 | 3 | RGV Toros | 16 | 7 | 1 | 8 | 23 | 24 | -1 | 22 | WXLW | 9 | 4 | 0 | 5 | 11 | 12 | 7 | 3 | 1 | 3 | 12 | 12 | |
| 11 | 2 | Phoenix Rising | 16 | 7 | 0 | 9 | 26 | 34 | -8 | 21 | LLLL | 9 | 5 | 0 | 4 | 16 | 14 | 7 | 2 | 0 | 5 | 10 | 20 | |
| 12 | Orange County SC | 16 | 4 | 5 | 7 | 24 | 27 | -3 | 17 | WLLL | 8 | 3 | 3 | 2 | 16 | 11 | 8 | 1 | 2 | 5 | 8 | 16 | ||
| 13 | Monterey Bay | 15 | 4 | 0 | 11 | 20 | 37 | -17 | 12 | LLLL | 6 | 2 | 0 | 4 | 9 | 11 | 9 | 2 | 0 | 7 | 11 | 26 | ||
| 11 | +1 | Óttar KARLSSON (Oakland Roots, 5p) |
| 10 | +2 | Kyle VASSELL (San Diego Loyal, 1p) |
| 9 | +2 | Milan ILOSKI (Orange County SC) |
| +2 | Danny TREJO (Las Vegas Lights) | |
| +1 | Phillip GOODRUM (Memphis 901) | |
| 8 | +1 | Erick TORRES (Orange County SC, 2p) |
| +1 | Preston JUDD (LA Galaxy 2) | |
| Wilson HARRIS (Louisville City, 1p) | ||
| 7 | STÉFANO Souza (Indy Eleven) | |
| Michee NGALINA (Colorado Springs) | ||
| +2 | Leonardo FERNANDES (Tampa Bay Rowdies, 2p) | |
| +2 | Jerome 'J.J.' WILLIAMS (FC Tulsa) | |
| +1 | Jake LACAVA (Tampa Bay Rowdies) | |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| 6 | +1 | Thomas AMANG (San Diego Loyal) |
| Augustine WILLIAMS (Charleston Battery, 1p) | ||
| Elvis AMOH (Colorado Springs) | ||
| Hadji BARRY (Colorado Springs, 1p) | ||
| Dane KELLY (Pittsburgh Riverhounds) | ||
| +2 | Cal JENNINGS (Las Vegas Lights, 1p) |
| Sunday, 19 June 2022 | |||||
| San Diego Loyal | 1-2 | Las Vegas Lights | |||
| 7 | Guido | 17 | Jennings | ||
| 68 | Trejo | ||||
| Wednesday, 22 June 2022 | |||||
| Memphis 901 | 2-0 | FC Tulsa | |||
| 14 | Smith | ||||
| 84 | Dodson | ||||
| Friday, 24 June 2022 | |||||
| Colorado Springs | 0-1 | San Antonio | |||
| 48(og) | Mahoney | ||||
| Las Vegas Lights | 3-2 | Phoenix Rising | |||
| 31 | Quezada | 55 | Santi | ||
| 41 | Jennings | 79 | Quinn | ||
| 75 | Trejo | ||||
| Saturday, 25 June 2022 | |||||
| Pittsburgh Riverhounds | 2-5 | Tampa Bay Rowdies | |||
| 13 | Arturo Osuna | 15 | Greig | ||
| 75 | Cicerone | 20 | Fernandes | ||
| 41 | Lacava | ||||
| 57 | Fernandes | ||||
| 64 | Mkosana | ||||
| Orange County SC | 3-1 | Loudoun United | |||
| 4 | Iloski | 2 | Lehland | ||
| 58 | Torres | ||||
| 90 | Iloski | ||||
| FC Tulsa | 2-1 | Charleston Battery | |||
| 17 | Williams | 45 | Piggott | ||
| 34 | Williams | ||||
| Miami FC | 1-3 | LA Galaxy 2 | |||
| 16 | Murphy | 6 | Drack | ||
| 9 | Salazar | ||||
| 70 | Judd | ||||
| El Paso Locomotive | 5-0 | New York Red Bulls 2 | |||
| 4 | François | ||||
| 12 | Calvillo | ||||
| 19 | Hinds | ||||
| 36 | Calvillo | ||||
| 74 | Gómez | ||||
| Memphis 901 | 2-0 | Detroit City | |||
| 38 | Smith | ||||
| 89 | Goodrum | ||||
| Hartford Athletic | 0-2 | Louisville City | |||
| 64 | Totsch | ||||
| 79 | Delpiccolo | ||||
| New Mexico United | 0-2 | Birmingham Legion | |||
| 21 | Agudelo | ||||
| 30 | Martínez | ||||
| San Diego Loyal | 5-0 | Indy Eleven | |||
| 29 | Amang | ||||
| 42 | Vassell | ||||
| 52 | Vassell | ||||
| 60(og) | Jérôme | ||||
| 85 | Moshobane | ||||
| Oakland Roots | 3-1 | Atlanta United 2 | |||
| 49 | Johnsen | 60 | Trager | ||
| 74(p) | Karlsson | ||||
| 87 | Rodriguez | ||||
| Monterey Bay | 1-2 | Sacramento Republic | |||
| 33(og) | Lacroix | 74 | Foster | ||
| 76 | Foster | ||||