| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 388 | 1,123 | 2.89 | 177 | 45.62% | 81 | 20.88% | 130 | 33.51% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 29 | 18 | 6 | 5 | 55 | 22 | +33 | 60 | OXWL | 13 | 10 | 2 | 1 | 29 | 8 | 16 | 8 | 4 | 4 | 26 | 14 | ||
| 2 | Memphis 901 | 28 | 17 | 4 | 7 | 53 | 28 | +25 | 55 | WXLL | 14 | 9 | 0 | 5 | 31 | 19 | 14 | 8 | 4 | 2 | 22 | 9 | ||
| 3 | Tampa Bay Rowdies | 28 | 16 | 6 | 6 | 58 | 29 | +29 | 54 | LWWL | 13 | 9 | 2 | 2 | 28 | 11 | 15 | 7 | 4 | 4 | 30 | 18 | ||
| 4 | Birmingham Legion | 30 | 16 | 6 | 8 | 50 | 31 | +19 | 54 | WLXW | 15 | 8 | 4 | 3 | 25 | 12 | 15 | 8 | 2 | 5 | 25 | 19 | ||
| 5 | Pittsburgh Riverhounds | 30 | 15 | 7 | 8 | 45 | 34 | +11 | 52 | LOWO | 14 | 8 | 4 | 2 | 21 | 12 | 16 | 7 | 3 | 6 | 24 | 22 | ||
| 6 | Miami FC | 29 | 13 | 8 | 8 | 41 | 27 | +14 | 47 | WXWW | 14 | 4 | 5 | 5 | 15 | 16 | 15 | 9 | 3 | 3 | 26 | 11 | ||
| 7 | Detroit City | 28 | 12 | 10 | 6 | 36 | 25 | +11 | 46 | WOWL | 14 | 5 | 7 | 2 | 18 | 13 | 14 | 7 | 3 | 4 | 18 | 12 | ||
| 8 | FC Tulsa | 30 | 10 | 5 | 15 | 40 | 51 | -11 | 35 | LXLW | 15 | 8 | 3 | 4 | 25 | 20 | 15 | 2 | 2 | 11 | 15 | 31 | ||
| 9 | Indy Eleven | 28 | 9 | 5 | 14 | 32 | 42 | -10 | 32 | WOWW | 14 | 7 | 2 | 5 | 19 | 17 | 14 | 2 | 3 | 9 | 13 | 25 | ||
| 10 | Hartford Athletic | 29 | 8 | 6 | 15 | 36 | 46 | -10 | 30 | WWXW | 14 | 5 | 1 | 8 | 18 | 22 | 15 | 3 | 5 | 7 | 18 | 24 | ||
| 11 | 1 | Charleston Battery | 29 | 6 | 6 | 17 | 36 | 58 | -22 | 24 | WWOL | 15 | 5 | 1 | 9 | 22 | 31 | 14 | 1 | 5 | 8 | 14 | 27 | |
| 12 | 1 | Loudoun United | 28 | 7 | 3 | 18 | 30 | 56 | -26 | 24 | LLWL | 15 | 5 | 2 | 8 | 19 | 26 | 13 | 2 | 1 | 10 | 11 | 30 | |
| 13 | Atlanta United 2 | 30 | 5 | 4 | 21 | 33 | 78 | -45 | 19 | LWLL | 16 | 3 | 4 | 9 | 18 | 35 | 14 | 2 | 0 | 12 | 15 | 43 | ||
| 14 | New York Red Bulls 2 | 29 | 3 | 5 | 21 | 22 | 67 | -45 | 14 | LLXL | 16 | 2 | 4 | 10 | 14 | 33 | 13 | 1 | 1 | 11 | 8 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 28 | 20 | 3 | 5 | 46 | 22 | +24 | 63 | WWLX | 13 | 9 | 3 | 1 | 26 | 8 | 15 | 11 | 0 | 4 | 20 | 14 | ||
| 2 | San Diego Loyal | 29 | 16 | 4 | 9 | 58 | 45 | +13 | 52 | LLLW | 15 | 11 | 0 | 4 | 34 | 21 | 14 | 5 | 4 | 5 | 24 | 24 | ||
| 3 | Colorado Springs | 29 | 16 | 3 | 10 | 54 | 47 | +7 | 51 | LWWW | 16 | 10 | 2 | 4 | 34 | 23 | 13 | 6 | 1 | 6 | 20 | 24 | ||
| 4 | Sacramento Republic | 28 | 13 | 7 | 8 | 39 | 29 | +10 | 46 | WLWL | 13 | 8 | 4 | 1 | 23 | 9 | 15 | 5 | 3 | 7 | 16 | 20 | ||
| 5 | New Mexico United | 29 | 11 | 9 | 9 | 40 | 34 | +6 | 42 | LLLW | 15 | 4 | 5 | 6 | 20 | 18 | 14 | 7 | 4 | 3 | 20 | 16 | ||
| 6 | El Paso Locomotive | 30 | 11 | 7 | 12 | 49 | 42 | +7 | 40 | LWWL | 15 | 7 | 2 | 6 | 30 | 18 | 15 | 4 | 5 | 6 | 19 | 24 | ||
| 7 | Las Vegas Lights | 28 | 10 | 7 | 11 | 31 | 42 | -11 | 37 | LLWX | 13 | 5 | 2 | 6 | 15 | 19 | 15 | 5 | 5 | 5 | 16 | 23 | ||
| 8 | 2 | RGV Toros | 28 | 10 | 6 | 12 | 39 | 35 | +4 | 36 | WWLW | 13 | 5 | 2 | 6 | 14 | 14 | 15 | 5 | 4 | 6 | 25 | 21 | |
| 9 | 2 | Oakland Roots | 29 | 8 | 12 | 9 | 43 | 40 | +3 | 36 | WLLW | 15 | 5 | 5 | 5 | 23 | 21 | 14 | 3 | 7 | 4 | 20 | 19 | |
| 10 | 2 | LA Galaxy 2 | 29 | 10 | 6 | 13 | 45 | 53 | -8 | 36 | LLWX | 13 | 6 | 3 | 4 | 27 | 25 | 16 | 4 | 3 | 9 | 18 | 28 | |
| 11 | 2 | Monterey Bay | 27 | 11 | 2 | 14 | 32 | 44 | -12 | 35 | WWLL | 14 | 7 | 2 | 5 | 18 | 15 | 13 | 4 | 0 | 9 | 14 | 29 | |
| 12 | Phoenix Rising | 28 | 9 | 5 | 14 | 37 | 48 | -11 | 32 | LLWL | 15 | 7 | 3 | 5 | 24 | 19 | 13 | 2 | 2 | 9 | 13 | 29 | ||
| 13 | Orange County SC | 29 | 7 | 10 | 12 | 43 | 48 | -5 | 31 | WLXL | 16 | 5 | 7 | 4 | 26 | 22 | 13 | 2 | 3 | 8 | 17 | 26 | ||
| 20 | +1 | Milan ILOSKI (Orange County SC) |
| 17 | Phillip GOODRUM (Memphis 901) | |
| 16 | Hadji BARRY (Colorado Springs, 3p) | |
| 15 | Leonardo FERNANDES (Tampa Bay Rowdies, 5p) | |
| Óttar KARLSSON (Oakland Roots, 6p) | ||
| 14 | Augustine WILLIAMS (Charleston Battery, 2p) | |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| 13 | +2 | Enzo MARTÍNEZ (Birmingham Legion) |
| 12 | Kyle VASSELL (San Diego Loyal, 1p) | |
| Russell CICERONE (Pittsburgh Riverhounds) | ||
| Elvis AMOH (Colorado Springs) | ||
| Preston JUDD (LA Galaxy 2) | ||
| 11 | Jerome 'J.J.' WILLIAMS (Phoenix Rising) | |
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Wilson HARRIS (Louisville City, 1p) | ||
| 10 | +1 | STÉFANO Souza (Indy Eleven, 1p) |
| Jackson CONWAY (Atlanta United 2) | ||
| +1 | Albert DIKWA (Pittsburgh Riverhounds) | |
| Danny TREJO (Las Vegas Lights) | ||
| 9 | Erick TORRES (Orange County SC, 2p) | |
| Thomas AMANG (San Diego Loyal) | ||
| Michee NGALINA (Colorado Springs) | ||
| Dylan MARES (El Paso Locomotive) | ||
| Kyle MURPHY (Miami FC, 2p) | ||
| Cameron DUNBAR (LA Galaxy 2, 2p) | ||
| +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) | |
| Samuel ADENIRAN (San Antonio) | ||
| Enoch MUSHAGALUSA (Louisville City) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Saturday, 10 September 2022 | |||||
| Charleston Battery | 2-1 | Tampa Bay Rowdies | |||
| 21 | Booth | 3 | Guenzatti | ||
| 67 | Booth | ||||
| Pittsburgh Riverhounds | 0-0 | Louisville City | |||
| Orange County SC | 1-0 | LA Galaxy 2 | |||
| 68 | Iloski | ||||
| San Antonio | 1-0 | San Diego Loyal | |||
| 30 | Bailone | ||||
| Phoenix Rising | 0-2 | Oakland Roots | |||
| 5 | Mfeka | ||||
| 27 | Mfeka | ||||
| Indy Eleven | 4-3 | Birmingham Legion | |||
| 11 | Hackshaw | 35 | Martínez | ||
| 16 | Hackshaw | 62 | Marlon | ||
| 31 | Tejada | 71 | Marlon | ||
| 78 | Stéfano | ||||
| Sacramento Republic | 4-0 | Loudoun United | |||
| 48 | Brown | ||||
| 56 | Gurr | ||||
| 65 | Casey | ||||
| 83 | Archimède | ||||
| Colorado Springs | 1-2 | Detroit City | |||
| 90 | Wheeler | 42 | Rodriguez | ||
| 59 | Wynne | ||||
| RGV Toros | 3-1 | New Mexico United | |||
| 15 | Ycaza | 8 | Moreno | ||
| 22 | Pinzón | ||||
| 67 | Fjeldberg | ||||
| Hartford Athletic | 3-2 | FC Tulsa | |||
| 9 | Yacoubou | 90 | Suárez | ||
| 16(og) | Wormell | 90 | Rodrigo Bandeira | ||
| 24 | Saydee | ||||
| Wednesday, 14 September 2022 | |||||
| Birmingham Legion | 2-1 | Pittsburgh Riverhounds | |||
| 50 | Martínez | 38 | Dikwa | ||
| 66 | Balarabe | ||||