| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 370 | 1,064 | 2.87 | 168 | 45.41% | 79 | 21.35% | 123 | 33.24% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 27 | 18 | 4 | 5 | 53 | 20 | +33 | 58 | WLLW | 13 | 10 | 2 | 1 | 29 | 8 | 14 | 8 | 2 | 4 | 24 | 12 | ||
| 2 | Tampa Bay Rowdies | 27 | 16 | 6 | 5 | 57 | 27 | +30 | 54 | WWLL | 13 | 9 | 2 | 2 | 28 | 11 | 14 | 7 | 4 | 3 | 29 | 16 | ||
| 3 | Memphis 901 | 27 | 16 | 4 | 7 | 49 | 28 | +21 | 52 | XLLW | 14 | 9 | 0 | 5 | 31 | 19 | 13 | 7 | 4 | 2 | 18 | 9 | ||
| 4 | Birmingham Legion | 28 | 15 | 6 | 7 | 45 | 26 | +19 | 51 | XWWL | 14 | 7 | 4 | 3 | 23 | 11 | 14 | 8 | 2 | 4 | 22 | 15 | ||
| 5 | Pittsburgh Riverhounds | 27 | 14 | 6 | 7 | 42 | 31 | +11 | 48 | OWXL | 13 | 8 | 3 | 2 | 21 | 12 | 14 | 6 | 3 | 5 | 21 | 19 | ||
| 6 | Miami FC | 28 | 12 | 8 | 8 | 34 | 26 | +8 | 44 | XWWW | 14 | 4 | 5 | 5 | 15 | 16 | 14 | 8 | 3 | 3 | 19 | 10 | ||
| 7 | Detroit City | 27 | 11 | 10 | 6 | 34 | 24 | +10 | 43 | OWLW | 14 | 5 | 7 | 2 | 18 | 13 | 13 | 6 | 3 | 4 | 16 | 11 | ||
| 8 | FC Tulsa | 28 | 10 | 4 | 14 | 36 | 46 | -10 | 34 | LWLW | 14 | 8 | 2 | 4 | 23 | 18 | 14 | 2 | 2 | 10 | 13 | 28 | ||
| 9 | Indy Eleven | 27 | 8 | 5 | 14 | 28 | 39 | -11 | 29 | OWWL | 13 | 6 | 2 | 5 | 15 | 14 | 14 | 2 | 3 | 9 | 13 | 25 | ||
| 10 | Hartford Athletic | 27 | 6 | 6 | 15 | 30 | 43 | -13 | 24 | XWLW | 13 | 4 | 1 | 8 | 15 | 20 | 14 | 2 | 5 | 7 | 15 | 23 | ||
| 11 | Loudoun United | 26 | 7 | 3 | 16 | 29 | 50 | -21 | 24 | WLWL | 14 | 5 | 2 | 7 | 18 | 24 | 12 | 2 | 1 | 9 | 11 | 26 | ||
| 12 | Charleston Battery | 28 | 5 | 6 | 17 | 34 | 57 | -23 | 21 | WOLX | 14 | 4 | 1 | 9 | 20 | 30 | 14 | 1 | 5 | 8 | 14 | 27 | ||
| 13 | Atlanta United 2 | 29 | 5 | 4 | 20 | 33 | 74 | -41 | 19 | WLLL | 15 | 3 | 4 | 8 | 18 | 31 | 14 | 2 | 0 | 12 | 15 | 43 | ||
| 14 | New York Red Bulls 2 | 28 | 3 | 5 | 20 | 21 | 60 | -39 | 14 | LXLX | 15 | 2 | 4 | 9 | 13 | 26 | 13 | 1 | 1 | 11 | 8 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 27 | 19 | 3 | 5 | 45 | 22 | +23 | 60 | WLXW | 12 | 8 | 3 | 1 | 25 | 8 | 15 | 11 | 0 | 4 | 20 | 14 | ||
| 2 | San Diego Loyal | 28 | 16 | 4 | 8 | 58 | 44 | +14 | 52 | LLWL | 15 | 11 | 0 | 4 | 34 | 21 | 13 | 5 | 4 | 4 | 24 | 23 | ||
| 3 | Colorado Springs | 28 | 16 | 3 | 9 | 53 | 45 | +8 | 51 | WWWL | 15 | 10 | 2 | 3 | 33 | 21 | 13 | 6 | 1 | 6 | 20 | 24 | ||
| 4 | Sacramento Republic | 27 | 12 | 7 | 8 | 35 | 29 | +6 | 43 | LWLW | 12 | 7 | 4 | 1 | 19 | 9 | 15 | 5 | 3 | 7 | 16 | 20 | ||
| 5 | New Mexico United | 28 | 11 | 9 | 8 | 39 | 31 | +8 | 42 | LLWL | 15 | 4 | 5 | 6 | 20 | 18 | 13 | 7 | 4 | 2 | 19 | 13 | ||
| 6 | El Paso Locomotive | 29 | 11 | 7 | 11 | 49 | 40 | +9 | 40 | WWLX | 14 | 7 | 2 | 5 | 30 | 16 | 15 | 4 | 5 | 6 | 19 | 24 | ||
| 7 | Las Vegas Lights | 28 | 10 | 7 | 11 | 31 | 42 | -11 | 37 | LLWX | 13 | 5 | 2 | 6 | 15 | 19 | 15 | 5 | 5 | 5 | 16 | 23 | ||
| 8 | LA Galaxy 2 | 27 | 10 | 6 | 11 | 44 | 49 | -5 | 36 | WXXL | 12 | 6 | 3 | 3 | 26 | 22 | 15 | 4 | 3 | 8 | 18 | 27 | ||
| 9 | Oakland Roots | 28 | 7 | 12 | 9 | 41 | 40 | +1 | 33 | LLWX | 15 | 5 | 5 | 5 | 23 | 21 | 13 | 2 | 7 | 4 | 18 | 19 | ||
| 10 | 1 | Phoenix Rising | 27 | 9 | 5 | 13 | 37 | 46 | -9 | 32 | LWLL | 14 | 7 | 3 | 4 | 24 | 17 | 13 | 2 | 2 | 9 | 13 | 29 | |
| 11 | 1 | Monterey Bay | 26 | 10 | 2 | 14 | 31 | 44 | -13 | 32 | WLLW | 13 | 6 | 2 | 5 | 17 | 15 | 13 | 4 | 0 | 9 | 14 | 29 | |
| 12 | 2 | RGV Toros | 26 | 8 | 6 | 12 | 34 | 34 | +0 | 30 | LWXX | 12 | 4 | 2 | 6 | 11 | 13 | 14 | 4 | 4 | 6 | 23 | 21 | |
| 13 | Orange County SC | 27 | 6 | 10 | 11 | 42 | 47 | -5 | 28 | XLXW | 15 | 4 | 7 | 4 | 25 | 22 | 12 | 2 | 3 | 7 | 17 | 25 | ||
| 19 | Milan ILOSKI (Orange County SC) | |
| 16 | Hadji BARRY (Colorado Springs, 3p) | |
| 15 | +2 | Leonardo FERNANDES (Tampa Bay Rowdies, 5p) |
| Óttar KARLSSON (Oakland Roots, 6p) | ||
| 14 | +1 | Augustine WILLIAMS (Charleston Battery, 2p) |
| Phillip GOODRUM (Memphis 901) | ||
| +2 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| 12 | Kyle VASSELL (San Diego Loyal, 1p) | |
| Elvis AMOH (Colorado Springs) | ||
| Preston JUDD (LA Galaxy 2) | ||
| 11 | Jerome 'J.J.' WILLIAMS (Phoenix Rising) | |
| Russell CICERONE (Pittsburgh Riverhounds) | ||
| +1 | Jake LACAVA (Tampa Bay Rowdies) | |
| +1 | Enzo MARTÍNEZ (Birmingham Legion) | |
| +1 | Wilson HARRIS (Louisville City, 1p) | |
| 10 | +2 | Jackson CONWAY (Atlanta United 2) |
| Danny TREJO (Las Vegas Lights) | ||
| 9 | +2 | STÉFANO Souza (Indy Eleven, 1p) |
| Erick TORRES (Orange County SC, 2p) | ||
| Thomas AMANG (San Diego Loyal) | ||
| Michee NGALINA (Colorado Springs) | ||
| Dylan MARES (El Paso Locomotive) | ||
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| +2 | Samuel ADENIRAN (San Antonio) | |
| +1 | Cal JENNINGS (Las Vegas Lights, 1p) |
| Sunday, 28 August 2022 | |||||
| Birmingham Legion | 3-1 | New York Red Bulls 2 | |||
| 38 | Dean | 25(p) | Adebayo-Smith | ||
| 49(p) | Agudelo | ||||
| 74 | Martínez | ||||
| Wednesday, 31 August 2022 | |||||
| Pittsburgh Riverhounds | 0-0 | Charleston Battery | |||
| Phoenix Rising | 2-1 | RGV Toros | |||
| 15 | Seijas | 41 | Pinzón | ||
| 67 | Seijas | ||||
| Indy Eleven | 2-1 | Louisville City | |||
| 28 | Stéfano | 8 | Serrano | ||
| 78(p) | Stéfano | ||||
| New York Red Bulls 2 | 3-3 | Hartford Athletic | |||
| 1 | Castellano | 50 | Brewitt | ||
| 3 | Filipe | 90 | Obregón | ||
| 71 | Filipe | 90 | Dally | ||
| Memphis 901 | 0-1 | Loudoun United | |||
| 56 | Greene | ||||
| Friday, 2 September 2022 | |||||
| New Mexico United | 1-2 | El Paso Locomotive | |||
| 22 | Frater | 18 | Solignac | ||
| 71 | Solignac | ||||
| Saturday, 3 September 2022 | |||||
| Charleston Battery | 3-0 | New York Red Bulls 2 | |||
| 17 | Apodaca | ||||
| 27(p) | Piggott | ||||
| 90 | Williams | ||||
| Tampa Bay Rowdies | 6-1 | Las Vegas Lights | |||
| 24 | Scarlett | 60 | Jennings | ||
| 37 | Fernandes | ||||
| 51 | Lacava | ||||
| 66 | Fernandes | ||||
| 87 | Duba | ||||
| 90 | Mkosana | ||||
| Orange County SC | 1-1 | Memphis 901 | |||
| 43 | Iloski | 85 | Kelly | ||
| Colorado Springs | 1-0 | Phoenix Rising | |||
| 55 | Henríquez | ||||
| Louisville City | 3-1 | Sacramento Republic | |||
| 9 | Harris | 29 | Cuello | ||
| 45 | Totsch | ||||
| 87 | Wynder | ||||
| Miami FC | 1-1 | Birmingham Legion | |||
| 32 | Walker | 69 | Bruno Lapa | ||
| Atlanta United 2 | 2-1 | FC Tulsa | |||
| 64 | Conway | 69 | Suárez | ||
| 89 | Conway | ||||
| Detroit City | 0-0 | Indy Eleven | |||
| Oakland Roots | 0-2 | San Antonio | |||
| 5 | Adeniran | ||||
| 85 | Adeniran | ||||
| Monterey Bay | 3-1 | San Diego Loyal | |||
| 45 | Gleadle | 19 | Moon | ||
| 60 | Volesky | ||||
| 88 | Gleadle | ||||