| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 132 | 370 | 2.80 | 67 | 50.76% | 23 | 17.42% | 42 | 31.82% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 11 | 7 | 3 | 1 | 23 | 8 | +15 | 24 | LWWX | 4 | 3 | 1 | 0 | 6 | 1 | 7 | 4 | 2 | 1 | 17 | 7 | ||
| 2 | Pittsburgh Riverhounds | 10 | 7 | 1 | 2 | 18 | 8 | +10 | 22 | WWLW | 5 | 5 | 0 | 0 | 10 | 1 | 5 | 2 | 1 | 2 | 8 | 7 | ||
| 3 | Detroit City | 10 | 6 | 2 | 2 | 17 | 9 | +8 | 20 | WLWW | 6 | 4 | 2 | 0 | 10 | 4 | 4 | 2 | 0 | 2 | 7 | 5 | ||
| 4 | Memphis 901 | 9 | 6 | 1 | 2 | 14 | 10 | +4 | 19 | WWLW | 5 | 3 | 0 | 2 | 8 | 8 | 4 | 3 | 1 | 0 | 6 | 2 | ||
| 5 | Indy Eleven | 9 | 4 | 2 | 3 | 11 | 10 | +1 | 14 | LWWW | 4 | 3 | 1 | 0 | 7 | 3 | 5 | 1 | 1 | 3 | 4 | 7 | ||
| 6 | Miami FC | 10 | 4 | 2 | 4 | 9 | 9 | +0 | 14 | LOWL | 5 | 2 | 1 | 2 | 5 | 4 | 5 | 2 | 1 | 2 | 4 | 5 | ||
| 7 | Tampa Bay Rowdies | 10 | 3 | 4 | 3 | 14 | 11 | +3 | 13 | LLXW | 5 | 2 | 1 | 2 | 8 | 6 | 5 | 1 | 3 | 1 | 6 | 5 | ||
| 8 | 1 | Birmingham Legion | 10 | 3 | 3 | 4 | 8 | 11 | -3 | 12 | LOWW | 6 | 2 | 3 | 1 | 5 | 5 | 4 | 1 | 0 | 3 | 3 | 6 | |
| 9 | 1 | FC Tulsa | 11 | 4 | 0 | 7 | 17 | 24 | -7 | 12 | LWLL | 6 | 4 | 0 | 2 | 13 | 10 | 5 | 0 | 0 | 5 | 4 | 14 | |
| 10 | 2 | Hartford Athletic | 9 | 2 | 1 | 6 | 9 | 14 | -5 | 7 | WWLL | 4 | 2 | 0 | 2 | 6 | 6 | 5 | 0 | 1 | 4 | 3 | 8 | |
| 11 | 1 | Loudoun United | 10 | 2 | 1 | 7 | 9 | 18 | -9 | 7 | LLLL | 4 | 1 | 0 | 3 | 3 | 7 | 6 | 1 | 1 | 4 | 6 | 11 | |
| 12 | 1 | Atlanta United 2 | 9 | 2 | 0 | 7 | 7 | 21 | -14 | 6 | LLLL | 5 | 1 | 0 | 4 | 4 | 13 | 4 | 1 | 0 | 3 | 3 | 8 | |
| 13 | 1 | New York Red Bulls 2 | 10 | 1 | 1 | 8 | 6 | 18 | -12 | 4 | LLLX | 5 | 0 | 1 | 4 | 1 | 8 | 5 | 1 | 0 | 4 | 5 | 10 | |
| 14 | 1 | Charleston Battery | 9 | 1 | 1 | 7 | 6 | 18 | -12 | 4 | LLLX | 5 | 1 | 1 | 3 | 3 | 7 | 4 | 0 | 0 | 4 | 3 | 11 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Colorado Springs | 9 | 8 | 0 | 1 | 19 | 8 | +11 | 24 | WWWL | 4 | 3 | 0 | 1 | 7 | 5 | 5 | 5 | 0 | 0 | 12 | 3 | ||
| 2 | San Antonio | 10 | 8 | 0 | 2 | 16 | 7 | +9 | 24 | WLWW | 4 | 3 | 0 | 1 | 8 | 2 | 6 | 5 | 0 | 1 | 8 | 5 | ||
| 3 | San Diego Loyal | 10 | 6 | 2 | 2 | 22 | 17 | +5 | 20 | XWLX | 5 | 4 | 0 | 1 | 13 | 9 | 5 | 2 | 2 | 1 | 9 | 8 | ||
| 4 | Phoenix Rising | 9 | 6 | 0 | 3 | 18 | 12 | +6 | 18 | WLWW | 6 | 5 | 0 | 1 | 15 | 7 | 3 | 1 | 0 | 2 | 3 | 5 | ||
| 5 | 2 | Sacramento Republic | 9 | 4 | 3 | 2 | 11 | 9 | +2 | 15 | WOXL | 5 | 3 | 2 | 0 | 8 | 4 | 4 | 1 | 1 | 2 | 3 | 5 | |
| 6 | 1 | Las Vegas Lights | 11 | 4 | 3 | 4 | 15 | 16 | -1 | 15 | XLXX | 6 | 2 | 2 | 2 | 7 | 7 | 5 | 2 | 1 | 2 | 8 | 9 | |
| 7 | 1 | LA Galaxy 2 | 10 | 4 | 2 | 4 | 16 | 17 | -1 | 14 | WLWX | 5 | 4 | 0 | 1 | 12 | 6 | 5 | 0 | 2 | 3 | 4 | 11 | |
| 8 | 2 | El Paso Locomotive | 11 | 4 | 1 | 6 | 24 | 18 | +6 | 13 | LWWW | 6 | 3 | 1 | 2 | 18 | 9 | 5 | 1 | 0 | 4 | 6 | 9 | |
| 9 | New Mexico United | 9 | 3 | 4 | 2 | 10 | 7 | +3 | 13 | WXOL | 5 | 1 | 3 | 1 | 6 | 5 | 4 | 2 | 1 | 1 | 4 | 2 | ||
| 10 | Orange County SC | 9 | 3 | 3 | 3 | 15 | 13 | +2 | 12 | WXWL | 5 | 2 | 2 | 1 | 10 | 6 | 4 | 1 | 1 | 2 | 5 | 7 | ||
| 11 | RGV Toros | 10 | 4 | 0 | 6 | 12 | 14 | -2 | 12 | WLLW | 5 | 2 | 0 | 3 | 6 | 7 | 5 | 2 | 0 | 3 | 6 | 7 | ||
| 12 | Oakland Roots | 11 | 1 | 6 | 4 | 15 | 18 | -3 | 9 | XXLX | 5 | 1 | 2 | 2 | 8 | 9 | 6 | 0 | 4 | 2 | 7 | 9 | ||
| 13 | Monterey Bay | 9 | 2 | 0 | 7 | 9 | 25 | -16 | 6 | LWLL | 2 | 1 | 0 | 1 | 2 | 2 | 7 | 1 | 0 | 6 | 7 | 23 | ||
| 6 | Kyle VASSELL (San Diego Loyal) | |
| Danny TREJO (Las Vegas Lights) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Dane KELLY (Pittsburgh Riverhounds) | ||
| +1 | Wilson HARRIS (Louisville City) | |
| +1 | Óttar KARLSSON (Oakland Roots, 2p) | |
| 5 | +3 | Milan ILOSKI (Orange County SC) |
| Jerome 'J.J.' WILLIAMS (FC Tulsa) | ||
| 4 | STÉFANO Souza (Indy Eleven) | |
| +1 | Erick TORRES (Orange County SC, 1p) | |
| Michee NGALINA (Colorado Springs) | ||
| Jackson CONWAY (Atlanta United 2) | ||
| Dylan MARES (El Paso Locomotive) | ||
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Luis SEIJAS (Phoenix Rising) | ||
| +1 | Neco BRETT (New Mexico United) | |
| Greg HURST (Phoenix Rising) | ||
| Frank LÓPEZ (RGV Toros) | ||
| Elliot COLLIER (San Antonio) |
| Sunday, 8 May 2022 | |||||
| New York Red Bulls 2 | 0-1 | Sacramento Republic | |||
| 88 | Foster | ||||
| Friday, 13 May 2022 | |||||
| Orange County SC | 5-1 | FC Tulsa | |||
| 5 | Torres | 90 | Brown | ||
| 9 | Iloski | ||||
| 20 | Iloski | ||||
| 30(p) | Pedersen | ||||
| 45 | Iloski | ||||
| LA Galaxy 2 | 4-3 | Louisville City | |||
| 19 | Dunbar | 2 | Serrano | ||
| 60 | Dunbar | 51 | McCabe | ||
| 63(p) | Davila | 78 | Harris | ||
| 76 | Salazar | ||||
| Saturday, 14 May 2022 | |||||
| Charleston Battery | 0-2 | New Mexico United | |||
| 5 | Brett | ||||
| 46 | Wehan | ||||
| Pittsburgh Riverhounds | 1-0 | El Paso Locomotive | |||
| 46 | Cicerone | ||||
| Miami FC | 0-2 | San Antonio | |||
| 41 | Beckford | ||||
| 90(p) | Taintor | ||||
| Las Vegas Lights | 1-1 | Oakland Roots | |||
| 24 | Lara | 3 | Karlsson | ||
| Memphis 901 | 2-1 | Indy Eleven | |||
| 34 | Carroll | 66 | Fjeldberg | ||
| 58 | Kissiedou | ||||
| Hartford Athletic | 3-2 | New York Red Bulls 2 | |||
| 36 | Prpa | 45 | Adebayo-Smith | ||
| 54 | Johnson | 70 | Tyrkus | ||
| 90 | Hertzog | ||||
| Detroit City | 4-2 | Loudoun United | |||
| 35(og) | Lillard | 68 | Lehland | ||
| 39 | Botello | 90 | Lillard | ||
| 45 | Bryant | ||||
| 53 | Rodriguez | ||||
| Monterey Bay | 1-2 | RGV Toros | |||
| 20 | Roberts | 42 | Ycaza | ||
| 45 | Coronado | ||||