| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 159 | 456 | 2.86 | 77 | 48.43% | 31 | 19.50% | 51 | 32.08% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 13 | 8 | 3 | 2 | 27 | 11 | +16 | 27 | WLLW | 6 | 4 | 1 | 1 | 10 | 4 | 7 | 4 | 2 | 1 | 17 | 7 | ||
| 2 | 1 | Memphis 901 | 11 | 8 | 1 | 2 | 22 | 10 | +12 | 25 | WWWW | 6 | 4 | 0 | 2 | 13 | 8 | 5 | 4 | 1 | 0 | 9 | 2 | |
| 3 | 1 | Detroit City | 12 | 7 | 3 | 2 | 21 | 11 | +10 | 24 | WXWL | 7 | 5 | 2 | 0 | 13 | 5 | 5 | 2 | 1 | 2 | 8 | 6 | |
| 4 | Pittsburgh Riverhounds | 12 | 7 | 2 | 3 | 21 | 13 | +8 | 23 | XLWW | 5 | 5 | 0 | 0 | 10 | 1 | 7 | 2 | 2 | 3 | 11 | 12 | ||
| 5 | Tampa Bay Rowdies | 12 | 5 | 4 | 3 | 22 | 13 | +9 | 19 | WWLL | 6 | 3 | 1 | 2 | 11 | 7 | 6 | 2 | 3 | 1 | 11 | 6 | ||
| 6 | Miami FC | 13 | 5 | 4 | 4 | 16 | 12 | +4 | 19 | XWXL | 7 | 2 | 3 | 2 | 8 | 7 | 6 | 3 | 1 | 2 | 8 | 5 | ||
| 7 | Indy Eleven | 11 | 5 | 2 | 4 | 14 | 12 | +2 | 17 | LWLW | 6 | 4 | 1 | 1 | 10 | 5 | 5 | 1 | 1 | 3 | 4 | 7 | ||
| 8 | Birmingham Legion | 12 | 4 | 4 | 4 | 10 | 12 | -2 | 16 | WOLO | 7 | 2 | 4 | 1 | 5 | 5 | 5 | 2 | 0 | 3 | 5 | 7 | ||
| 9 | FC Tulsa | 12 | 4 | 0 | 8 | 18 | 28 | -10 | 12 | LLWL | 6 | 4 | 0 | 2 | 13 | 10 | 6 | 0 | 0 | 6 | 5 | 18 | ||
| 10 | 1 | Loudoun United | 12 | 2 | 2 | 8 | 10 | 22 | -12 | 8 | XLLL | 6 | 1 | 1 | 4 | 4 | 11 | 6 | 1 | 1 | 4 | 6 | 11 | |
| 11 | 1 | Hartford Athletic | 10 | 2 | 1 | 7 | 10 | 16 | -6 | 7 | LWWL | 5 | 2 | 0 | 3 | 7 | 8 | 5 | 0 | 1 | 4 | 3 | 8 | |
| 12 | Atlanta United 2 | 11 | 2 | 1 | 8 | 8 | 24 | -16 | 7 | OLLL | 6 | 1 | 1 | 4 | 4 | 13 | 5 | 1 | 0 | 4 | 4 | 11 | ||
| 13 | 1 | Charleston Battery | 11 | 1 | 2 | 8 | 7 | 23 | -16 | 5 | XLLL | 6 | 1 | 1 | 4 | 3 | 11 | 5 | 0 | 1 | 4 | 4 | 12 | |
| 14 | 1 | New York Red Bulls 2 | 12 | 1 | 1 | 10 | 7 | 22 | -15 | 4 | LLLL | 6 | 0 | 1 | 5 | 2 | 10 | 6 | 1 | 0 | 5 | 5 | 12 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | San Antonio | 11 | 9 | 0 | 2 | 19 | 9 | +10 | 27 | WWLW | 4 | 3 | 0 | 1 | 8 | 2 | 7 | 6 | 0 | 1 | 11 | 7 | |
| 2 | 1 | Colorado Springs | 10 | 8 | 0 | 2 | 21 | 12 | +9 | 24 | LWWW | 4 | 3 | 0 | 1 | 7 | 5 | 6 | 5 | 0 | 1 | 14 | 7 | |
| 3 | San Diego Loyal | 12 | 6 | 3 | 3 | 25 | 21 | +4 | 21 | XLXW | 5 | 4 | 0 | 1 | 13 | 9 | 7 | 2 | 3 | 2 | 12 | 12 | ||
| 4 | Phoenix Rising | 12 | 7 | 0 | 5 | 21 | 25 | -4 | 21 | WLLW | 7 | 5 | 0 | 2 | 16 | 12 | 5 | 2 | 0 | 3 | 5 | 13 | ||
| 5 | El Paso Locomotive | 14 | 6 | 2 | 6 | 28 | 20 | +8 | 20 | WXWL | 7 | 4 | 1 | 2 | 19 | 9 | 7 | 2 | 1 | 4 | 9 | 11 | ||
| 6 | 4 | New Mexico United | 11 | 5 | 4 | 2 | 19 | 8 | +11 | 19 | WWWX | 6 | 2 | 3 | 1 | 13 | 5 | 5 | 3 | 1 | 1 | 6 | 3 | |
| 7 | Sacramento Republic | 11 | 4 | 4 | 3 | 12 | 11 | +1 | 16 | XLWO | 5 | 3 | 2 | 0 | 8 | 4 | 6 | 1 | 2 | 3 | 4 | 7 | ||
| 8 | 2 | Las Vegas Lights | 13 | 4 | 4 | 5 | 15 | 17 | -2 | 16 | LOXL | 7 | 2 | 2 | 3 | 7 | 8 | 6 | 2 | 2 | 2 | 8 | 9 | |
| 9 | 1 | RGV Toros | 12 | 5 | 0 | 7 | 16 | 18 | -2 | 15 | LWWL | 7 | 3 | 0 | 4 | 10 | 11 | 5 | 2 | 0 | 3 | 6 | 7 | |
| 10 | 1 | LA Galaxy 2 | 13 | 4 | 3 | 6 | 18 | 25 | -7 | 15 | XLLW | 6 | 4 | 1 | 1 | 14 | 8 | 7 | 0 | 2 | 5 | 4 | 17 | |
| 11 | Orange County SC | 11 | 3 | 5 | 3 | 17 | 15 | +2 | 14 | OXWX | 6 | 2 | 3 | 1 | 12 | 8 | 5 | 1 | 2 | 2 | 5 | 7 | ||
| 12 | Oakland Roots | 13 | 2 | 7 | 4 | 17 | 19 | -2 | 13 | XWXX | 7 | 2 | 3 | 2 | 10 | 10 | 6 | 0 | 4 | 2 | 7 | 9 | ||
| 13 | Monterey Bay | 11 | 4 | 0 | 7 | 15 | 27 | -12 | 12 | WWLW | 3 | 2 | 0 | 1 | 6 | 4 | 8 | 2 | 0 | 6 | 9 | 23 | ||
| 8 | +1 | Kyle VASSELL (San Diego Loyal, 1p) |
| +1 | Óttar KARLSSON (Oakland Roots, 4p) | |
| 7 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| +1 | Wilson HARRIS (Louisville City) | |
| 6 | Milan ILOSKI (Orange County SC) | |
| Danny TREJO (Las Vegas Lights) | ||
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Dane KELLY (Pittsburgh Riverhounds) | ||
| 5 | +1 | STÉFANO Souza (Indy Eleven) |
| Erick TORRES (Orange County SC, 1p) | ||
| +1 | Dylan MARES (El Paso Locomotive) | |
| Jerome 'J.J.' WILLIAMS (FC Tulsa) | ||
| +1 | Phillip GOODRUM (Memphis 901) | |
| Luis SEIJAS (Phoenix Rising) | ||
| Antoine HOPPENOT (Detroit City) | ||
| +1 | Greg HURST (Phoenix Rising) |
| Sunday, 22 May 2022 | |||||
| Loudoun United | 0-3 | Memphis 901 | |||
| 5 | Kissiedou | ||||
| 29 | Kelly | ||||
| 55 | Goodrum | ||||
| Tuesday, 24 May 2022 | |||||
| New Mexico United | 7-0 | Phoenix Rising | |||
| 6 | Wehan | ||||
| 10(p) | Portillo | ||||
| 18 | Swartz | ||||
| 30(p) | Portillo | ||||
| 75(og) | King | ||||
| 78 | Nava | ||||
| 82 | Bruce | ||||
| Friday, 27 May 2022 | |||||
| New York Red Bulls 2 | 1-2 | Birmingham Legion | |||
| 25 | Adebayo-Smith | 12 | Martínez | ||
| 81 | Marlon | ||||
| Las Vegas Lights | 0-1 | El Paso Locomotive | |||
| 62 | Mares | ||||
| Atlanta United 2 | 0-0 | Orange County SC | |||
| Saturday, 28 May 2022 | |||||
| Indy Eleven | 1-2 | New Mexico United | |||
| 80 | Stéfano | 38 | Portillo | ||
| 63(og) | Jérôme | ||||
| LA Galaxy 2 | 2-2 | San Diego Loyal | |||
| 90(p) | Davila | 16 | Adams | ||
| 90 | Judd | 30 | Vassell | ||
| Louisville City | 4-1 | FC Tulsa | |||
| 45(p) | Lancaster | 34 | Brown | ||
| 53 | Lancaster | ||||
| 65(og) | Obinwa | ||||
| 90 | Harris | ||||
| RGV Toros | 2-3 | San Antonio | |||
| 41 | Cabezas | 26 | Dhillon | ||
| 90 | Herrera | 62 | Taintor | ||
| 87 | Dhillon | ||||
| Miami FC | 2-2 | Pittsburgh Riverhounds | |||
| 24 | Palacios | 38 | Cicerone | ||
| 45 | Reid | 54 | Dixon | ||
| Hartford Athletic | 1-2 | Phoenix Rising | |||
| 20 | Saydee | 35 | Lambert | ||
| 37 | Hurst | ||||
| Loudoun United | 1-1 | Charleston Battery | |||
| 76 | Dexter | 90 | Kuzminsky | ||
| Oakland Roots | 1-1 | Sacramento Republic | |||
| 81(p) | Karlsson | 42 | Luis Felipe | ||
| Monterey Bay | 4-2 | Colorado Springs | |||
| 44 | Roberts | 54 | Barry | ||
| 51 | Gleadle | 90 | Amoh | ||
| 73 | Rebollar | ||||
| 90 | Boone | ||||