| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 308 | 894 | 2.90 | 137 | 44.48% | 67 | 21.75% | 104 | 33.77% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 22 | 15 | 4 | 3 | 47 | 16 | +31 | 49 | WWOW | 11 | 8 | 2 | 1 | 25 | 7 | 11 | 7 | 2 | 2 | 22 | 9 | ||
| 2 | Tampa Bay Rowdies | 23 | 14 | 6 | 3 | 48 | 23 | +25 | 48 | WWWW | 11 | 7 | 2 | 2 | 19 | 9 | 12 | 7 | 4 | 1 | 29 | 14 | ||
| 3 | 1 | Memphis 901 | 22 | 14 | 3 | 5 | 42 | 22 | +20 | 45 | WWXL | 12 | 9 | 0 | 3 | 29 | 14 | 10 | 5 | 3 | 2 | 13 | 8 | |
| 4 | 1 | Pittsburgh Riverhounds | 23 | 13 | 4 | 6 | 38 | 26 | +12 | 43 | WWWX | 10 | 8 | 1 | 1 | 19 | 8 | 13 | 5 | 3 | 5 | 19 | 18 | |
| 5 | Birmingham Legion | 23 | 12 | 5 | 6 | 35 | 20 | +15 | 41 | WWWL | 11 | 5 | 4 | 2 | 18 | 8 | 12 | 7 | 1 | 4 | 17 | 12 | ||
| 6 | Detroit City | 22 | 9 | 8 | 5 | 28 | 21 | +7 | 35 | LXOW | 11 | 5 | 5 | 1 | 17 | 11 | 11 | 4 | 3 | 4 | 11 | 10 | ||
| 7 | Miami FC | 23 | 9 | 7 | 7 | 27 | 23 | +4 | 34 | WWOW | 11 | 3 | 4 | 4 | 12 | 13 | 12 | 6 | 3 | 3 | 15 | 10 | ||
| 8 | FC Tulsa | 23 | 7 | 4 | 12 | 29 | 40 | -11 | 25 | LWLW | 11 | 6 | 2 | 3 | 19 | 15 | 12 | 1 | 2 | 9 | 10 | 25 | ||
| 9 | Indy Eleven | 22 | 6 | 4 | 12 | 24 | 35 | -11 | 22 | LLXL | 11 | 4 | 2 | 5 | 12 | 13 | 11 | 2 | 2 | 7 | 12 | 22 | ||
| 10 | 2 | Loudoun United | 22 | 5 | 3 | 14 | 23 | 45 | -22 | 18 | WLLL | 13 | 4 | 2 | 7 | 15 | 23 | 9 | 1 | 1 | 7 | 8 | 22 | |
| 11 | 1 | Hartford Athletic | 23 | 4 | 5 | 14 | 23 | 36 | -13 | 17 | LLOL | 11 | 3 | 1 | 7 | 13 | 17 | 12 | 1 | 4 | 7 | 10 | 19 | |
| 12 | 1 | Atlanta United 2 | 24 | 4 | 4 | 16 | 28 | 64 | -36 | 16 | LXLL | 12 | 2 | 4 | 6 | 15 | 26 | 12 | 2 | 0 | 10 | 13 | 38 | |
| 13 | Charleston Battery | 23 | 3 | 4 | 16 | 27 | 52 | -25 | 13 | LLXW | 12 | 3 | 1 | 8 | 17 | 27 | 11 | 0 | 3 | 8 | 10 | 25 | ||
| 14 | New York Red Bulls 2 | 22 | 2 | 3 | 17 | 12 | 45 | -33 | 9 | LLLW | 12 | 1 | 3 | 8 | 7 | 19 | 10 | 1 | 0 | 9 | 5 | 26 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 22 | 16 | 2 | 4 | 37 | 18 | +19 | 50 | LXWW | 9 | 6 | 2 | 1 | 19 | 5 | 13 | 10 | 0 | 3 | 18 | 13 | ||
| 2 | San Diego Loyal | 23 | 14 | 4 | 5 | 52 | 36 | +16 | 46 | WWWW | 13 | 10 | 0 | 3 | 32 | 18 | 10 | 4 | 4 | 2 | 20 | 18 | ||
| 3 | Colorado Springs | 23 | 13 | 2 | 8 | 46 | 38 | +8 | 41 | XLXL | 11 | 7 | 1 | 3 | 26 | 17 | 12 | 6 | 1 | 5 | 20 | 21 | ||
| 4 | New Mexico United | 23 | 10 | 8 | 5 | 34 | 24 | +10 | 38 | LLWX | 12 | 3 | 5 | 4 | 17 | 14 | 11 | 7 | 3 | 1 | 17 | 10 | ||
| 5 | 1 | Sacramento Republic | 22 | 10 | 7 | 5 | 29 | 23 | +6 | 37 | XWWO | 10 | 5 | 4 | 1 | 15 | 9 | 12 | 5 | 3 | 4 | 14 | 14 | |
| 6 | 1 | El Paso Locomotive | 25 | 9 | 6 | 10 | 39 | 31 | +8 | 33 | LLLL | 12 | 6 | 2 | 4 | 26 | 12 | 13 | 3 | 4 | 6 | 13 | 19 | |
| 7 | Las Vegas Lights | 23 | 9 | 6 | 8 | 27 | 27 | +0 | 33 | OXLW | 11 | 4 | 2 | 5 | 13 | 13 | 12 | 5 | 4 | 3 | 14 | 14 | ||
| 8 | LA Galaxy 2 | 24 | 9 | 4 | 11 | 39 | 46 | -7 | 31 | LXLL | 10 | 6 | 1 | 3 | 23 | 19 | 14 | 3 | 3 | 8 | 16 | 27 | ||
| 9 | Oakland Roots | 24 | 6 | 11 | 7 | 37 | 35 | +2 | 29 | OLWX | 14 | 5 | 5 | 4 | 23 | 19 | 10 | 1 | 6 | 3 | 14 | 16 | ||
| 10 | Phoenix Rising | 23 | 8 | 5 | 10 | 33 | 39 | -6 | 29 | OWOO | 13 | 6 | 3 | 4 | 22 | 16 | 10 | 2 | 2 | 6 | 11 | 23 | ||
| 11 | RGV Toros | 23 | 7 | 5 | 11 | 26 | 30 | -4 | 26 | XOLL | 12 | 4 | 2 | 6 | 11 | 13 | 11 | 3 | 3 | 5 | 15 | 17 | ||
| 12 | Monterey Bay | 21 | 8 | 2 | 11 | 27 | 38 | -11 | 26 | WWWO | 10 | 4 | 2 | 4 | 13 | 12 | 11 | 4 | 0 | 7 | 14 | 26 | ||
| 13 | Orange County SC | 23 | 5 | 8 | 10 | 37 | 41 | -4 | 23 | XLWO | 12 | 3 | 5 | 4 | 21 | 19 | 11 | 2 | 3 | 6 | 16 | 22 | ||
| 16 | Milan ILOSKI (Orange County SC) | |
| 15 | Óttar KARLSSON (Oakland Roots, 6p) | |
| 13 | +1 | Phillip GOODRUM (Memphis 901) |
| +1 | Hadji BARRY (Colorado Springs, 3p) | |
| 12 | +1 | Augustine WILLIAMS (Charleston Battery, 1p) |
| Leonardo FERNANDES (Tampa Bay Rowdies, 5p) | ||
| Preston JUDD (LA Galaxy 2) | ||
| 11 | +1 | Kyle VASSELL (San Diego Loyal, 1p) |
| +2 | Russell CICERONE (Pittsburgh Riverhounds) | |
| +1 | Elvis AMOH (Colorado Springs) | |
| 10 | Jerome 'J.J.' WILLIAMS (Phoenix Rising) | |
| Danny TREJO (Las Vegas Lights) | ||
| Jake LACAVA (Tampa Bay Rowdies) | ||
| 9 | Erick TORRES (Orange County SC, 2p) | |
| +1 | Michee NGALINA (Colorado Springs) | |
| +2 | Enzo MARTÍNEZ (Birmingham Legion) | |
| +1 | Wilson HARRIS (Louisville City, 1p) | |
| 8 | Thomas AMANG (San Diego Loyal) | |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| +1 | Brian OWNBY (Louisville City) | |
| 7 | STÉFANO Souza (Indy Eleven) | |
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| Cameron DUNBAR (LA Galaxy 2, 2p) | ||
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| +1 | Neco BRETT (New Mexico United) | |
| +1 | Enoch MUSHAGALUSA (Louisville City) | |
| Dane KELLY (Pittsburgh Riverhounds) | ||
| Cal JENNINGS (Las Vegas Lights, 1p) |
| Sunday, 31 July 2022 | |||||
| New York Red Bulls 2 | 1-2 | New Mexico United | |||
| 55 | Sserwadda | 9 | Brett | ||
| 90 | Seymore | ||||
| Wednesday, 3 August 2022 | |||||
| New York Red Bulls 2 | 1-2 | Memphis 901 | |||
| 87 | Adebayo-Smith | 17 | Kelly | ||
| 70 | Goodrum | ||||
| New Mexico United | 1-2 | Sacramento Republic | |||
| 54 | Tabortetaka | 57 | Keko | ||
| 61 | Martínez | ||||
| Saturday, 6 August 2022 | |||||
| Tampa Bay Rowdies | 1-0 | Detroit City | |||
| 64 | Duba | ||||
| Orange County SC | 3-3 | Colorado Springs | |||
| 45(p) | Okoli | 35 | Ngalina | ||
| 46 | McCabe | 80 | Amoh | ||
| 74 | Powers | 90(p) | Barry | ||
| Phoenix Rising | 0-0 | Las Vegas Lights | |||
| Indy Eleven | 0-2 | Pittsburgh Riverhounds | |||
| 13 | Cicerone | ||||
| 52 | Cicerone | ||||
| Sacramento Republic | 1-1 | RGV Toros | |||
| 90 | López | 53 | Ricketts | ||
| Louisville City | 4-1 | Charleston Battery | |||
| 30 | Ownby | 26 | Williams | ||
| 52 | Mushagalusa | ||||
| 67 | Harris | ||||
| 89 | Totsch | ||||
| Birmingham Legion | 6-0 | Atlanta United 2 | |||
| 2 | Martínez | ||||
| 37(p) | Kasim | ||||
| 39 | Marlon | ||||
| 43 | Agudelo | ||||
| 74 | Martínez | ||||
| 87 | Balarabe | ||||
| Memphis 901 | 3-1 | Hartford Athletic | |||
| 41 | Molloy | 37 | Saydee | ||
| 44 | Carroll | ||||
| 87 | Pickering | ||||
| New Mexico United | 0-3 | Miami FC | |||
| 45 | Murphy | ||||
| 49 | Murphy | ||||
| 79 | Parkes | ||||
| Loudoun United | 2-0 | LA Galaxy 2 | |||
| 63 | Fletcher | ||||
| 85 | Fletcher | ||||
| San Diego Loyal | 3-0 | San Antonio | |||
| 65 | Conway | ||||
| 72 | Stoneman | ||||
| 77 | Vassell | ||||
| Monterey Bay | 1-0 | El Paso Locomotive | |||
| 88 | Rebollar | ||||