| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 405 | 1,055 | 2.60 | 169 | 41.73% | 108 | 26.67% | 128 | 31.60% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls 2 | 28 | 19 | 6 | 3 | 55 | 20 | +35 | 63 | XWWW | 13 | 7 | 4 | 2 | 23 | 9 | 15 | 12 | 2 | 1 | 32 | 11 | ||
| 2 | Louisville City | 28 | 16 | 8 | 4 | 46 | 25 | +21 | 56 | WWWL | 14 | 6 | 6 | 2 | 23 | 13 | 14 | 10 | 2 | 2 | 23 | 12 | ||
| 3 | FC Cincinnati | 28 | 14 | 8 | 6 | 39 | 27 | +12 | 50 | OWWL | 14 | 8 | 4 | 2 | 21 | 13 | 14 | 6 | 4 | 4 | 18 | 14 | ||
| 4 | Charlotte Independence | 28 | 14 | 7 | 7 | 47 | 27 | +20 | 49 | OWWW | 14 | 9 | 1 | 4 | 26 | 15 | 14 | 5 | 6 | 3 | 21 | 12 | ||
| 5 | Richmond Kickers | 28 | 12 | 9 | 7 | 32 | 22 | +10 | 45 | OLXW | 14 | 8 | 5 | 1 | 18 | 7 | 14 | 4 | 4 | 6 | 14 | 15 | ||
| 6 | 1 | Charleston Battery | 28 | 12 | 9 | 7 | 35 | 30 | +5 | 45 | WLLX | 14 | 7 | 3 | 4 | 16 | 13 | 14 | 5 | 6 | 3 | 19 | 17 | |
| 7 | 1 | Rochester Rhinos | 28 | 11 | 12 | 5 | 36 | 25 | +11 | 45 | XWXX | 14 | 8 | 4 | 2 | 22 | 12 | 14 | 3 | 8 | 3 | 14 | 13 | |
| 8 | Orlando City B | 28 | 8 | 8 | 12 | 33 | 48 | -15 | 32 | LLLL | 15 | 4 | 6 | 5 | 20 | 23 | 13 | 4 | 2 | 7 | 13 | 25 | ||
| 9 | Wilmington Hammerheads | 28 | 7 | 9 | 12 | 34 | 46 | -12 | 30 | LWXX | 14 | 4 | 5 | 5 | 18 | 19 | 14 | 3 | 4 | 7 | 16 | 27 | ||
| 10 | Harrisburg City | 28 | 7 | 6 | 15 | 33 | 52 | -19 | 27 | LXXW | 15 | 3 | 4 | 8 | 22 | 36 | 13 | 4 | 2 | 7 | 11 | 16 | ||
| 11 | Bethlehem Steel | 28 | 6 | 9 | 13 | 31 | 40 | -9 | 27 | LLXL | 13 | 4 | 4 | 5 | 15 | 14 | 15 | 2 | 5 | 8 | 16 | 26 | ||
| 12 | 2 | Toronto FC 2 | 29 | 7 | 5 | 17 | 36 | 57 | -21 | 26 | WLLL | 15 | 4 | 3 | 8 | 18 | 27 | 14 | 3 | 2 | 9 | 18 | 30 | |
| 13 | Pittsburgh Riverhounds | 28 | 6 | 6 | 16 | 30 | 48 | -18 | 24 | OLWX | 14 | 4 | 2 | 8 | 15 | 21 | 14 | 2 | 4 | 8 | 15 | 27 | ||
| 14 | 2 | FC Montréal | 28 | 7 | 2 | 19 | 34 | 50 | -16 | 23 | WLXW | 14 | 3 | 1 | 10 | 16 | 25 | 14 | 4 | 1 | 9 | 18 | 25 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sacramento Republic | 28 | 13 | 9 | 6 | 38 | 26 | +12 | 48 | XWOW | 14 | 7 | 4 | 3 | 21 | 13 | 14 | 6 | 5 | 3 | 17 | 13 | ||
| 2 | 1 | Colorado Springs | 28 | 13 | 7 | 8 | 35 | 22 | +13 | 46 | WWLW | 14 | 9 | 3 | 2 | 17 | 6 | 14 | 4 | 4 | 6 | 18 | 16 | |
| 3 | 1 | RGV Toros | 28 | 12 | 9 | 7 | 43 | 24 | +19 | 45 | LLWW | 14 | 6 | 5 | 3 | 23 | 9 | 14 | 6 | 4 | 4 | 20 | 15 | |
| 4 | 1 | LA Galaxy 2 | 28 | 11 | 10 | 7 | 48 | 40 | +8 | 43 | WXLW | 14 | 7 | 5 | 2 | 25 | 15 | 14 | 4 | 5 | 5 | 23 | 25 | |
| 5 | 1 | OKC Energy | 27 | 10 | 12 | 5 | 29 | 23 | +6 | 42 | XLXW | 13 | 5 | 6 | 2 | 17 | 11 | 14 | 5 | 6 | 3 | 12 | 12 | |
| 6 | Swope Park Rangers | 27 | 11 | 6 | 10 | 37 | 35 | +2 | 39 | WLWW | 14 | 9 | 1 | 4 | 24 | 15 | 13 | 2 | 5 | 6 | 13 | 20 | ||
| 7 | 1 | Orange County SC | 28 | 11 | 4 | 13 | 35 | 40 | -5 | 37 | WLLW | 13 | 6 | 2 | 5 | 18 | 17 | 15 | 5 | 2 | 8 | 17 | 23 | |
| 8 | 2 | Real Monarchs | 28 | 10 | 6 | 12 | 28 | 35 | -7 | 36 | WLXW | 15 | 5 | 4 | 6 | 15 | 17 | 13 | 5 | 2 | 6 | 13 | 18 | |
| 9 | 2 | San Antonio | 28 | 9 | 8 | 11 | 34 | 33 | +1 | 35 | LLXL | 14 | 6 | 4 | 4 | 21 | 18 | 14 | 3 | 4 | 7 | 13 | 15 | |
| 10 | 1 | Seattle Sounders-2 | 28 | 9 | 8 | 11 | 34 | 46 | -12 | 35 | XXWW | 15 | 7 | 3 | 5 | 20 | 20 | 13 | 2 | 5 | 6 | 14 | 26 | |
| 11 | 1 | Portland Timbers 2 | 28 | 10 | 4 | 14 | 33 | 40 | -7 | 34 | WWWL | 14 | 6 | 3 | 5 | 20 | 20 | 14 | 4 | 1 | 9 | 13 | 20 | |
| 12 | 1 | Arizona United | 28 | 8 | 7 | 13 | 35 | 41 | -6 | 31 | LXLL | 14 | 4 | 4 | 6 | 17 | 19 | 14 | 4 | 3 | 7 | 18 | 22 | |
| 13 | Tulsa Roughnecks | 27 | 5 | 4 | 18 | 24 | 55 | -31 | 19 | LXLL | 13 | 3 | 1 | 9 | 14 | 27 | 14 | 2 | 3 | 9 | 10 | 28 | ||
| 15 | Jack McBEAN (LA Galaxy 2, 4p) | |
| +1 | Sean OKOLI (FC Cincinnati, 5p) | |
| 14 | Chandler HOFFMAN (Louisville City, 3p) | |
| +3 | Irvin HERRERA (Saint Louis, 2p) | |
| 13 | Brandon ALLEN (New York Red Bulls 2, 5p) | |
| 11 | Corey HERTZOG (Pittsburgh Riverhounds, 2p) | |
| Cameron IWASA (Sacramento Republic) | ||
| Kyle GREIG (Vancouver Whitecaps 2, 3p) | ||
| Christian VOLESKY (Rochester Rhinos, 1p) | ||
| +1 | Michael COX (Orlando City B, 1p) | |
| 10 | Samuel OCHOA (Tulsa Roughnecks, 1p) | |
| 9 | Romario WILLIAMS (Charleston Battery) | |
| Anthony JACKSON-HAMEL (FC Montréal) | ||
| Yudai IMURA (Richmond Kickers, 3p) | ||
| Enzo MARTÍNEZ (Charlotte Independence, 2p) | ||
| 8 | BRUNO Caldini PERONE (Wilmington Hammerheads, 3p) | |
| TAN Long (Arizona United, 2p) | ||
| Mark GONZALEZ (Swope Park Rangers) | ||
| Tyler BLACKWOOD (Arizona United) | ||
| +1 | Trevin CAESAR (Orange County SC) | |
| +2 | Ariel LASSITER (LA Galaxy 2, 1p) | |
| Ricárdo VELAZCO (Real Monarchs, 1p) | ||
| Didier CRETTENAND (Orange County SC, 4p) |
| Friday, 9 September 2016 | |||||
| Real Monarchs | 0-2 | Orange County SC | |||
| 63 | Caesar | ||||
| 79 | Rauhofer | ||||
| Saturday, 10 September 2016 | |||||
| Rochester Rhinos | 1-1 | New York Red Bulls 2 | |||
| 58 | Samuels | 89 | Bezecourt | ||
| Charleston Battery | 2-1 | Bethlehem Steel | |||
| 10 | Chang | 35(p) | Jones | ||
| 39 | Guerra | ||||
| San Antonio | 1-3 | Saint Louis | |||
| 32 | Alvarez | 12 | Herrera | ||
| 16 | Herrera | ||||
| 54 | Herrera | ||||
| LA Galaxy 2 | 1-1 | Sacramento Republic | |||
| 39 | Lassiter | 83 | Kneeshaw | ||
| Charlotte Independence | 4-0 | Pittsburgh Riverhounds | |||
| 37 | Brown | ||||
| 45 | Estrada | ||||
| 54 | Estrada | ||||
| 90 | Herrera | ||||
| Louisville City | 2-0 | Richmond Kickers | |||
| 19 | Lancaster | ||||
| 55 | Rasmussen | ||||
| Swope Park Rangers | 3-0 | Tulsa Roughnecks | |||
| 2 | Duke | ||||
| 32 | Tyrpak | ||||
| 43 | Kelly | ||||
| RGV Toros | 0-1 | Portland Timbers 2 | |||
| 60 | Richards | ||||
| Sunday, 11 September 2016 | |||||
| Wilmington Hammerheads | 0-2 | FC Cincinnati | |||
| 30 | Okoli | ||||
| 64 | Wiedeman | ||||
| OKC Energy | 2-2 | Seattle Sounders-2 | |||
| 10 | Hyland | 53 | Mansaray | ||
| 58 | Olsson | 90 | Alfaro | ||
| Vancouver Whitecaps 2 | 0-2 | Colorado Springs | |||
| 59 | Vercollone | ||||
| 86 | Vercollone | ||||
| Toronto FC 2 | 2-1 | Orlando City B | |||
| 28 | Hundal | 5 | Cox | ||
| 71 | John | ||||
| Tuesday, 13 September 2016 | |||||
| Arizona United | 1-2 | Portland Timbers 2 | |||
| 23 | Cascio | 59 | Williams | ||
| 90 | Brett | ||||
| Wednesday, 14 September 2016 | |||||
| Richmond Kickers | 0-0 | Charlotte Independence | |||
| Pittsburgh Riverhounds | 0-0 | FC Cincinnati | |||
| LA Galaxy 2 | 1-0 | RGV Toros | |||
| 61 | Lassiter | ||||
| Real Monarchs | 2-0 | San Antonio | |||
| 74 | Adams | ||||
| 82 | Báez | ||||