| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 291 | 753 | 2.58 | 121 | 41.58% | 77 | 26.46% | 93 | 31.96% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 21 | 12 | 6 | 3 | 38 | 21 | +17 | 42 | LLWX | 10 | 4 | 4 | 2 | 18 | 11 | 11 | 8 | 2 | 1 | 20 | 10 | ||
| 2 | New York Red Bulls 2 | 20 | 12 | 5 | 3 | 34 | 17 | +17 | 41 | LLWW | 10 | 4 | 4 | 2 | 15 | 8 | 10 | 8 | 1 | 1 | 19 | 9 | ||
| 3 | FC Cincinnati | 20 | 11 | 5 | 4 | 29 | 19 | +10 | 38 | XWLW | 12 | 7 | 3 | 2 | 18 | 11 | 8 | 4 | 2 | 2 | 11 | 8 | ||
| 4 | Charleston Battery | 20 | 10 | 6 | 4 | 26 | 19 | +7 | 36 | XWOX | 9 | 5 | 2 | 2 | 10 | 6 | 11 | 5 | 4 | 2 | 16 | 13 | ||
| 5 | 1 | Richmond Kickers | 20 | 9 | 5 | 6 | 25 | 16 | +9 | 32 | WWWW | 10 | 7 | 2 | 1 | 15 | 5 | 10 | 2 | 3 | 5 | 10 | 11 | |
| 6 | 1 | Rochester Rhinos | 20 | 8 | 8 | 4 | 24 | 18 | +6 | 32 | XXXW | 10 | 6 | 3 | 1 | 16 | 10 | 10 | 2 | 5 | 3 | 8 | 8 | |
| 7 | Charlotte Independence | 19 | 9 | 4 | 6 | 27 | 20 | +7 | 31 | WWLL | 10 | 5 | 1 | 4 | 14 | 13 | 9 | 4 | 3 | 2 | 13 | 7 | ||
| 8 | Orlando City B | 20 | 7 | 7 | 6 | 28 | 29 | -1 | 28 | WXOO | 12 | 3 | 5 | 4 | 17 | 19 | 8 | 4 | 2 | 2 | 11 | 10 | ||
| 9 | Bethlehem Steel | 21 | 6 | 7 | 8 | 23 | 26 | -3 | 25 | LXLW | 11 | 4 | 3 | 4 | 13 | 10 | 10 | 2 | 4 | 4 | 10 | 16 | ||
| 10 | Wilmington Hammerheads | 20 | 6 | 6 | 8 | 25 | 32 | -7 | 24 | LXLL | 10 | 3 | 3 | 4 | 12 | 14 | 10 | 3 | 3 | 4 | 13 | 18 | ||
| 11 | 1 | Toronto FC 2 | 23 | 6 | 5 | 12 | 29 | 43 | -14 | 23 | WLXW | 10 | 3 | 3 | 4 | 12 | 15 | 13 | 3 | 2 | 8 | 17 | 28 | |
| 12 | 1 | Harrisburg City | 22 | 6 | 3 | 13 | 27 | 39 | -12 | 21 | XWWL | 11 | 3 | 2 | 6 | 18 | 24 | 11 | 3 | 1 | 7 | 9 | 15 | |
| 13 | Pittsburgh Riverhounds | 19 | 3 | 4 | 12 | 19 | 32 | -13 | 13 | WLLL | 10 | 2 | 1 | 7 | 8 | 17 | 9 | 1 | 3 | 5 | 11 | 15 | ||
| 14 | FC Montréal | 19 | 2 | 1 | 16 | 15 | 35 | -20 | 7 | LLLL | 7 | 0 | 0 | 7 | 4 | 14 | 12 | 2 | 1 | 9 | 11 | 21 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy 2 | 20 | 9 | 8 | 3 | 40 | 27 | +13 | 35 | LWWW | 11 | 6 | 4 | 1 | 20 | 10 | 9 | 3 | 4 | 2 | 20 | 17 | ||
| 2 | Colorado Springs | 20 | 9 | 5 | 6 | 25 | 17 | +8 | 32 | XLXW | 10 | 6 | 3 | 1 | 11 | 4 | 10 | 3 | 2 | 5 | 14 | 13 | ||
| 3 | OKC Energy | 18 | 8 | 8 | 2 | 23 | 13 | +10 | 32 | OWWW | 9 | 4 | 4 | 1 | 14 | 8 | 9 | 4 | 4 | 1 | 9 | 5 | ||
| 4 | Sacramento Republic | 20 | 8 | 6 | 6 | 24 | 20 | +4 | 30 | OLLX | 10 | 5 | 2 | 3 | 14 | 11 | 10 | 3 | 4 | 3 | 10 | 9 | ||
| 5 | RGV Toros | 20 | 7 | 8 | 5 | 26 | 21 | +5 | 29 | OWOO | 10 | 4 | 4 | 2 | 15 | 7 | 10 | 3 | 4 | 3 | 11 | 14 | ||
| 6 | Swope Park Rangers | 20 | 8 | 4 | 8 | 28 | 28 | +0 | 28 | WWXL | 9 | 6 | 0 | 3 | 16 | 10 | 11 | 2 | 4 | 5 | 12 | 18 | ||
| 7 | 1 | Seattle Sounders-2 | 21 | 7 | 5 | 9 | 25 | 32 | -7 | 26 | WWWW | 13 | 5 | 3 | 5 | 16 | 18 | 8 | 2 | 2 | 4 | 9 | 14 | |
| 8 | 2 | Orange County SC | 20 | 7 | 4 | 9 | 25 | 31 | -6 | 25 | WLLX | 10 | 5 | 2 | 3 | 15 | 13 | 10 | 2 | 2 | 6 | 10 | 18 | |
| 9 | 2 | San Antonio | 19 | 6 | 6 | 7 | 24 | 21 | +3 | 24 | LLWO | 10 | 4 | 3 | 3 | 15 | 12 | 9 | 2 | 3 | 4 | 9 | 9 | |
| 10 | 1 | Real Monarchs | 21 | 6 | 4 | 11 | 21 | 31 | -10 | 22 | LLWL | 9 | 2 | 2 | 5 | 9 | 13 | 12 | 4 | 2 | 6 | 12 | 18 | |
| 11 | Arizona United | 19 | 5 | 6 | 8 | 22 | 26 | -4 | 21 | LWLX | 9 | 2 | 4 | 3 | 11 | 12 | 10 | 3 | 2 | 5 | 11 | 14 | ||
| 12 | Portland Timbers 2 | 19 | 5 | 3 | 11 | 17 | 26 | -9 | 18 | LLXL | 11 | 4 | 2 | 5 | 13 | 18 | 8 | 1 | 1 | 6 | 4 | 8 | ||
| 13 | Tulsa Roughnecks | 20 | 5 | 3 | 12 | 22 | 40 | -18 | 18 | WLWO | 10 | 3 | 1 | 6 | 13 | 18 | 10 | 2 | 2 | 6 | 9 | 22 | ||
| 15 | Jack McBEAN (LA Galaxy 2, 4p) | |
| 14 | Chandler HOFFMAN (Louisville City, 3p) | |
| 10 | Kyle GREIG (Vancouver Whitecaps 2, 3p) | |
| Irvin HERRERA (Saint Louis, 1p) | ||
| 9 | Samuel OCHOA (Tulsa Roughnecks, 1p) | |
| +1 | Brandon ALLEN (New York Red Bulls 2, 1p) | |
| Sean OKOLI (FC Cincinnati, 4p) | ||
| 8 | Romario WILLIAMS (Charleston Battery) | |
| 7 | Cameron IWASA (Sacramento Republic) | |
| +1 | Yudai IMURA (Richmond Kickers, 3p) | |
| +1 | Mark GONZALEZ (Swope Park Rangers) | |
| Ricárdo VELAZCO (Real Monarchs, 1p) | ||
| Didier CRETTENAND (Orange County SC, 4p) | ||
| Christian VOLESKY (Rochester Rhinos, 1p) | ||
| Michael COX (Orlando City B, 1p) | ||
| 6 | Raheem EDWARDS (Toronto FC 2, 1p) | |
| TAN Long (Arizona United, 2p) | ||
| +2 | Trevin CAESAR (Orange County SC) | |
| Martin MAYBIN (Colorado Springs) | ||
| José VILLARREAL (LA Galaxy 2, 1p) |
| Friday, 29 July 2016 | |||||
| Harrisburg City | 1-1 | Rochester Rhinos | |||
| 90 | Jankouskas | 88 | Totsch | ||
| Colorado Springs | 1-1 | Vancouver Whitecaps 2 | |||
| 47 | Gonzalez | 55 | Levis | ||
| Saturday, 30 July 2016 | |||||
| Richmond Kickers | 2-1 | New York Red Bulls 2 | |||
| 11(p) | Imura | 10 | Allen | ||
| 90 | Eskay | ||||
| Wilmington Hammerheads | 1-4 | Pittsburgh Riverhounds | |||
| 62 | Lynch | 45 | Kerr | ||
| 45 | Hertzog | ||||
| 69 | Okai | ||||
| 90 | Thompson | ||||
| Orange County SC | 2-0 | LA Galaxy 2 | |||
| 19 | Caesar | ||||
| 61 | Caesar | ||||
| Arizona United | 1-2 | Tulsa Roughnecks | |||
| 62(og) | Schafer | 3 | Mata | ||
| 90 | Mata | ||||
| Louisville City | 1-2 | Orlando City B | |||
| 13 | Abend | 90(p) | Turner | ||
| 90 | Smith | ||||
| FC Montréal | 0-1 | Charlotte Independence | |||
| 49 | Martínez | ||||
| Saint Louis | 0-0 | OKC Energy | |||
| Swope Park Rangers | 2-1 | San Antonio | |||
| 71 | Kelly | 30 | Reed | ||
| 84 | Gonzalez | ||||
| RGV Toros | 0-0 | Sacramento Republic | |||
| FC Cincinnati | 1-1 | Charleston Battery | |||
| 51 | Cummings | 70 | Cordovés | ||
| Sunday, 31 July 2016 | |||||
| Bethlehem Steel | 2-3 | Toronto FC 2 | |||
| 48 | Bibbs | 17 | Hundal | ||
| 81 | Richter | 58 | Hundal | ||
| 78 | Uccello | ||||
| Monday, 1 August 2016 | |||||
| Seattle Sounders-2 | 4-1 | Real Monarchs | |||
| 35(p) | Samuel | 23 | Brody | ||
| 60 | Jones | ||||
| 86 | Samuel | ||||
| 90 | Jones | ||||