| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 387 | 1,015 | 2.62 | 162 | 41.86% | 103 | 26.61% | 122 | 31.52% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls 2 | 27 | 19 | 5 | 3 | 54 | 19 | +35 | 62 | WWWW | 13 | 7 | 4 | 2 | 23 | 9 | 14 | 12 | 1 | 1 | 31 | 10 | ||
| 2 | Louisville City | 27 | 15 | 8 | 4 | 44 | 25 | +19 | 53 | WWLX | 13 | 5 | 6 | 2 | 21 | 13 | 14 | 10 | 2 | 2 | 23 | 12 | ||
| 3 | 1 | FC Cincinnati | 26 | 13 | 7 | 6 | 37 | 27 | +10 | 46 | WLLX | 14 | 8 | 4 | 2 | 21 | 13 | 12 | 5 | 3 | 4 | 16 | 14 | |
| 4 | 1 | Charlotte Independence | 26 | 13 | 6 | 7 | 43 | 27 | +16 | 45 | WWLW | 13 | 8 | 1 | 4 | 22 | 15 | 13 | 5 | 5 | 3 | 21 | 12 | |
| 5 | 2 | Richmond Kickers | 26 | 12 | 8 | 6 | 32 | 20 | +12 | 44 | XWXX | 13 | 8 | 4 | 1 | 18 | 7 | 13 | 4 | 4 | 5 | 14 | 13 | |
| 6 | 1 | Rochester Rhinos | 27 | 11 | 11 | 5 | 35 | 24 | +11 | 44 | WXXW | 13 | 8 | 3 | 2 | 21 | 11 | 14 | 3 | 8 | 3 | 14 | 13 | |
| 7 | 1 | Charleston Battery | 27 | 11 | 9 | 7 | 33 | 29 | +4 | 42 | LLXW | 13 | 6 | 3 | 4 | 14 | 12 | 14 | 5 | 6 | 3 | 19 | 17 | |
| 8 | Orlando City B | 27 | 8 | 8 | 11 | 32 | 46 | -14 | 32 | LLLX | 15 | 4 | 6 | 5 | 20 | 23 | 12 | 4 | 2 | 6 | 12 | 23 | ||
| 9 | 2 | Wilmington Hammerheads | 27 | 7 | 9 | 11 | 34 | 44 | -10 | 30 | WXXL | 13 | 4 | 5 | 4 | 18 | 17 | 14 | 3 | 4 | 7 | 16 | 27 | |
| 10 | 1 | Harrisburg City | 28 | 7 | 6 | 15 | 33 | 52 | -19 | 27 | LXXW | 15 | 3 | 4 | 8 | 22 | 36 | 13 | 4 | 2 | 7 | 11 | 16 | |
| 11 | 1 | Bethlehem Steel | 27 | 6 | 9 | 12 | 30 | 38 | -8 | 27 | LXLL | 13 | 4 | 4 | 5 | 15 | 14 | 14 | 2 | 5 | 7 | 15 | 24 | |
| 12 | 1 | FC Montréal | 28 | 7 | 2 | 19 | 34 | 50 | -16 | 23 | WLXW | 14 | 3 | 1 | 10 | 16 | 25 | 14 | 4 | 1 | 9 | 18 | 25 | |
| 13 | 1 | Pittsburgh Riverhounds | 26 | 6 | 5 | 15 | 30 | 44 | -14 | 23 | WXWL | 13 | 4 | 1 | 8 | 15 | 21 | 13 | 2 | 4 | 7 | 15 | 23 | |
| 14 | 2 | Toronto FC 2 | 28 | 6 | 5 | 17 | 34 | 56 | -22 | 23 | LLLL | 14 | 3 | 3 | 8 | 16 | 26 | 14 | 3 | 2 | 9 | 18 | 30 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sacramento Republic | 27 | 13 | 8 | 6 | 37 | 25 | +12 | 47 | WOWW | 14 | 7 | 4 | 3 | 21 | 13 | 13 | 6 | 4 | 3 | 16 | 12 | ||
| 2 | RGV Toros | 26 | 12 | 9 | 5 | 43 | 22 | +21 | 45 | WWWW | 13 | 6 | 5 | 2 | 23 | 8 | 13 | 6 | 4 | 3 | 20 | 14 | ||
| 3 | 1 | Colorado Springs | 27 | 12 | 7 | 8 | 33 | 22 | +11 | 43 | WLWL | 14 | 9 | 3 | 2 | 17 | 6 | 13 | 3 | 4 | 6 | 16 | 16 | |
| 4 | 1 | OKC Energy | 26 | 10 | 11 | 5 | 27 | 21 | +6 | 41 | LXWL | 12 | 5 | 5 | 2 | 15 | 9 | 14 | 5 | 6 | 3 | 12 | 12 | |
| 5 | LA Galaxy 2 | 26 | 10 | 9 | 7 | 46 | 39 | +7 | 39 | LWLL | 12 | 6 | 4 | 2 | 23 | 14 | 14 | 4 | 5 | 5 | 23 | 25 | ||
| 6 | Swope Park Rangers | 26 | 10 | 6 | 10 | 34 | 35 | -1 | 36 | LWWX | 13 | 8 | 1 | 4 | 21 | 15 | 13 | 2 | 5 | 6 | 13 | 20 | ||
| 7 | 1 | San Antonio | 26 | 9 | 8 | 9 | 33 | 28 | +5 | 35 | XLWW | 13 | 6 | 4 | 3 | 20 | 15 | 13 | 3 | 4 | 6 | 13 | 13 | |
| 8 | 1 | Orange County SC | 27 | 10 | 4 | 13 | 33 | 40 | -7 | 34 | LLWL | 13 | 6 | 2 | 5 | 18 | 17 | 14 | 4 | 2 | 8 | 15 | 23 | |
| 9 | 2 | Seattle Sounders-2 | 27 | 9 | 7 | 11 | 32 | 44 | -12 | 34 | XWWL | 15 | 7 | 3 | 5 | 20 | 20 | 12 | 2 | 4 | 6 | 12 | 24 | |
| 10 | 1 | Real Monarchs | 26 | 9 | 6 | 11 | 26 | 33 | -7 | 33 | XWWW | 13 | 4 | 4 | 5 | 13 | 15 | 13 | 5 | 2 | 6 | 13 | 18 | |
| 11 | 1 | Arizona United | 27 | 8 | 7 | 12 | 34 | 39 | -5 | 31 | XLLL | 13 | 4 | 4 | 5 | 16 | 17 | 14 | 4 | 3 | 7 | 18 | 22 | |
| 12 | Portland Timbers 2 | 26 | 8 | 4 | 14 | 30 | 39 | -9 | 28 | WLLL | 14 | 6 | 3 | 5 | 20 | 20 | 12 | 2 | 1 | 9 | 10 | 19 | ||
| 13 | Tulsa Roughnecks | 26 | 5 | 4 | 17 | 24 | 52 | -28 | 19 | XLLL | 13 | 3 | 1 | 9 | 14 | 27 | 13 | 2 | 3 | 8 | 10 | 25 | ||
| 15 | Jack McBEAN (LA Galaxy 2, 4p) | |
| 14 | Chandler HOFFMAN (Louisville City, 3p) | |
| +2 | Sean OKOLI (FC Cincinnati, 5p) | |
| 13 | +1 | Brandon ALLEN (New York Red Bulls 2, 5p) |
| 11 | +1 | Corey HERTZOG (Pittsburgh Riverhounds, 2p) |
| Cameron IWASA (Sacramento Republic) | ||
| +1 | Kyle GREIG (Vancouver Whitecaps 2, 3p) | |
| Irvin HERRERA (Saint Louis, 2p) | ||
| +1 | Christian VOLESKY (Rochester Rhinos, 1p) | |
| 10 | Samuel OCHOA (Tulsa Roughnecks, 1p) | |
| Michael COX (Orlando City B, 1p) | ||
| 9 | Romario WILLIAMS (Charleston Battery) | |
| +1 | Anthony JACKSON-HAMEL (FC Montréal) | |
| Yudai IMURA (Richmond Kickers, 3p) | ||
| Enzo MARTÍNEZ (Charlotte Independence, 2p) | ||
| 8 | +2 | BRUNO Caldini PERONE (Wilmington Hammerheads, 3p) |
| +1 | TAN Long (Arizona United, 2p) | |
| Mark GONZALEZ (Swope Park Rangers) | ||
| Tyler BLACKWOOD (Arizona United) | ||
| +1 | Ricárdo VELAZCO (Real Monarchs, 1p) | |
| +1 | Didier CRETTENAND (Orange County SC, 4p) |
| Friday, 2 September 2016 | |||||
| Seattle Sounders-2 | 2-1 | Vancouver Whitecaps 2 | |||
| 67 | Parra | 64 | Greig | ||
| 90 | Jones | ||||
| Saturday, 3 September 2016 | |||||
| Charleston Battery | 1-2 | Rochester Rhinos | |||
| 15(p) | Portillo | 25 | Volesky | ||
| 80 | Bakayoko | ||||
| Sacramento Republic | 2-1 | Orange County SC | |||
| 48 | Lagrassa | 45 | Crettenand | ||
| 85 | Williams | ||||
| Colorado Springs | 3-0 | LA Galaxy 2 | |||
| 10 | Seth | ||||
| 45 | Seth | ||||
| 58 | Vercollone | ||||
| FC Montréal | 0-1 | Louisville City | |||
| 49 | Quinn | ||||
| Real Monarchs | 1-1 | Tulsa Roughnecks | |||
| 37 | Velazco | 9 | Mata | ||
| Swope Park Rangers | 0-2 | RGV Toros | |||
| 8 | Luna | ||||
| 67 | Casner | ||||
| Orlando City B | 0-2 | Pittsburgh Riverhounds | |||
| 24 | Walsh | ||||
| 90 | Hertzog | ||||
| Sunday, 4 September 2016 | |||||
| San Antonio | 1-1 | Arizona United | |||
| 43 | Alvarez | 9 | Tan | ||
| Portland Timbers 2 | 4-0 | OKC Energy | |||
| 35(p) | Bijev | ||||
| 46 | Bijev | ||||
| 70 | Bodily | ||||
| 73(p) | Williams | ||||
| Toronto FC 2 | 1-5 | Charlotte Independence | |||
| 58 | James | 4 | Slogic | ||
| 40 | Martinez | ||||
| 53 | Estrada | ||||
| 89 | Hassan | ||||
| 90 | Ochoa | ||||
| Bethlehem Steel | 0-2 | New York Red Bulls 2 | |||
| 32(p) | Allen | ||||
| 90 | Etienne | ||||
| Monday, 5 September 2016 | |||||
| Vancouver Whitecaps 2 | 2-2 | Seattle Sounders-2 | |||
| 3 | Bustos | 21 | Schweitzer | ||
| 50(p) | Bustos | 80 | Schweitzer | ||
| FC Cincinnati | 2-1 | Saint Louis | |||
| 84 | Okoli | 86 | Doody | ||
| 90(p) | Okoli | ||||
| Wednesday, 7 September 2016 | |||||
| Harrisburg City | 1-4 | New York Red Bulls 2 | |||
| 46 | Benbow | 23 | Bezecourt | ||
| 62 | Powder | ||||
| 73 | Bezecourt | ||||
| 78 | Powder | ||||
| Wilmington Hammerheads | 3-0 | Orlando City B | |||
| 49 | Michaud | ||||
| 71(p) | Bruno Perone | ||||
| 78 | Bruno Perone | ||||
| FC Montréal | 2-1 | Charleston Battery | |||
| 14 | Jackson-Hamel | 40 | Ebobisse | ||
| 80 | Sanon | ||||