| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Wednesday, 27 April 2022 | ||||||
| fl1 |  UNAM | 2-2 | Seattle Sounders | |||
| Wednesday, 4 May 2022 | ||||||
| fl2 | Seattle Sounders | 3-0 | UNAM | 5-2 | ||
| 9 | +2 | Juan DINENNO (UNAM, 1p) |
| 5 | +3 | Nicolás LODEIRO (Seattle Sounders, 3p) |
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| 3 | Jordan MORRIS (Seattle Sounders) | |
| +2 | Raúl RUIDÍAZ (Seattle Sounders) | |
| TALLES MAGNO Bacelar (New York City) | ||
| Fredy MONTERO (Seattle Sounders, 2p) | ||
| 2 | Adam BUKSA (New England Revolution) | |
| Uriel ANTUNA (Cruz Azul) | ||
| Santiago RODRÍGUEZ (New York City) | ||
| Cristian BOLAÑOS (Saprissa, 1p) | ||
| Elías HERNÁNDEZ (León) |
