| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 5 April 2022 | |||||
| sfl1 |  UNAM | 2-1 | Cruz Azul | ||
| 37 | Dinenno | 83 | Tabó | ||
| 45 | Dinenno | ||||
| Wednesday, 6 April 2022 | |||||
| sfl1 |  Seattle Sounders | 3-1 | New York City | ||
| 16 | Rusnák | 27 | Thiago Andrade | ||
| 35 | Morris | ||||
| 68(p) | Lodeiro | ||||
| 7 | +2 | Juan DINENNO (UNAM) |
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| 3 | TALLES MAGNO Bacelar (New York City) | |
| +1 | Jordan MORRIS (Seattle Sounders) | |
| Fredy MONTERO (Seattle Sounders, 2p) | ||
| 2 | Uriel ANTUNA (Cruz Azul) | |
| Adam BUKSA (New England Revolution) | ||
| Cristian BOLAÑOS (Saprissa, 1p) | ||
| +1 | Nicolás LODEIRO (Seattle Sounders, 1p) | |
| Elías HERNÁNDEZ (León) |
