| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 22 February 2022 | ||||||
| r1l2 |  León | 1-0 | Guastatoya | 3-0 | ||
| 11 | Hernández | |||||
| r1l2 |  New England Revolution | - | Cavaly AS | 0-0p?-? | ||
| Wednesday, 23 February 2022 | ||||||
| r1l2 | UNAM | 4-1 | Saprissa | 6-3 | ||
| 12 | Ortiz | 51 | Bolaños | |||
| 75 | Dinenno | |||||
| 82 | Dinenno | |||||
| 90 | Rogério | |||||
| r1l2 | Colorado Rapids | 1-0 | Comunicaciones | 1-1p?-? | ||
| 29 | Max | |||||
| r1l2 | CF Montréal | 3-0 | Santos Laguna | 3-1 | ||
| 10 | Quioto | |||||
| 22 | Mihailovic | |||||
| 61 | Koné | |||||
| r1l2 | New York City | 4-0 | Santos | 6-0 | ||
| 32 | Morales | |||||
| 36 | Chanot | |||||
| 80 | Talles Magno | |||||
| 86 | Talles Magno | |||||
| Thursday, 24 February 2022 | ||||||
| r1l2 | Cruz Azul | 3-1 | Forge | 4-1 | ||
| 5 | Romero | 26 | Choinière | |||
| 21 | Baca | |||||
| 44 | Escobar | |||||
| r1l2 | Seattle Sounders | 5-0 | Motagua | 5-0 | ||
| 33 | Lodeiro | |||||
| 47 | Roldan | |||||
| 56 | Morris | |||||
| 62 | Rowe | |||||
| 74 | Léo Chú | |||||
| 3 | +2 | Juan DINENNO (UNAM) |
| 2 | +2 | TALLES MAGNO Bacelar (New York City) |
| Valentín CASTELLANOS (New York City, 1p) | ||
| Cristian BOLAÑOS (Saprissa, 1p) | ||
| +1 | Elías HERNÁNDEZ (León) | |
| 1 | Omar FERNÁNDEZ (León) | |
| +1 | Ryan BOLAÑOS (Saprissa) | |
| +1 | Arturo ORTIZ (UNAM) | |
| +1 | Nicolás LODEIRO (Seattle Sounders) | |
| +1 | Jordan MORRIS (Seattle Sounders) | |
| +1 | LÉO CHÚ (Seattle Sounders) | |
| +1 | Maxime CHANOT (New York City) | |
| +1 | Ismaël KONÉ (CF Montréal) | |
| +1 | Kelyn ROWE (Seattle Sounders) | |
| +1 | Rommel QUIOTO (CF Montréal) | |
| Jesús OCEJO (Santos Laguna) | ||
| +1 | David CHOINIÈRE (Forge) | |
| +1 | Rafael BACA (Cruz Azul) | |
| Rómulo OTERO (Cruz Azul) | ||
| Karel ESPINO (Comunicaciones) | ||
| +1 | Ángel ROMERO (Cruz Azul) | |
| Washington COROZO (UNAM) | ||
| +1 | Juan ESCOBAR (Cruz Azul) | |
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| +1 | MAX Alves (Colorado Rapids) | |
| +1 | Alfredo MORALES (New York City) | |
| +1 | Cristian ROLDAN (Seattle Sounders) | |
| +1 | José ROGÉRIO (UNAM) |
