| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 15 February 2022 | ||||||
| r1l1 |  Santos Laguna | 1-0 | CF Montréal | |||
| r1l1 |  Santos | 0-2 | New York City | |||
| Wednesday, 16 February 2022 | ||||||
| r1l1 | Saprissa | 2-2 | UNAM | |||
| r1l1 |  Guastatoya | 0-2 | León | |||
| r1l1 |  Forge | 0-1 | Cruz Azul | |||
| Thursday, 17 February 2022 | ||||||
| r1l1 |  Motagua | 0-0 | Seattle Sounders | |||
| r1l1 | Comunicaciones | 1-0 | Colorado Rapids | |||
| Tuesday, 22 February 2022 | ||||||
| r1l2 | León | 1-0 | Guastatoya | 3-0 | ||
| r1l2 | New England Revolution | - | Cavaly AS | 0-0p?-? | ||
| Wednesday, 23 February 2022 | ||||||
| r1l2 | UNAM | 4-1 | Saprissa | 6-3 | ||
| r1l2 | Colorado Rapids | 1-0 | Comunicaciones | 1-1p?-? | ||
| r1l2 | CF Montréal | 3-0 | Santos Laguna | 3-1 | ||
| r1l2 | New York City | 4-0 | Santos | 6-0 | ||
| Thursday, 24 February 2022 | ||||||
| r1l2 | Cruz Azul | 3-1 | Forge | 4-1 | ||
| r1l2 | Seattle Sounders | 5-0 | Motagua | 5-0 | ||
| Tuesday, 15 February 2022 | ||||||
| r1l1 | Cavaly AS | 0-3 | New England Revolution | |||
| 3 | +3 | Juan DINENNO (UNAM) |
| 2 | +2 | Valentín CASTELLANOS (New York City, 1p) |
| +2 | Cristian BOLAÑOS (Saprissa, 1p) | |
| +2 | TALLES MAGNO Bacelar (New York City) | |
| +2 | Elías HERNÁNDEZ (León) | |
| 1 | +1 | Karel ESPINO (Comunicaciones) |
| +1 | Omar FERNÁNDEZ (León) | |
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| +1 | MAX Alves (Colorado Rapids) | |
| +1 | Alfredo MORALES (New York City) | |
| +1 | Ángel ROMERO (Cruz Azul) | |
| +1 | Kelyn ROWE (Seattle Sounders) | |
| +1 | Ryan BOLAÑOS (Saprissa) | |
| +1 | Ismaël KONÉ (CF Montréal) | |
| +1 | Arturo ORTIZ (UNAM) | |
| +1 | Nicolás LODEIRO (Seattle Sounders) | |
| +1 | Jordan MORRIS (Seattle Sounders) | |
| +1 | Rommel QUIOTO (CF Montréal) | |
| +1 | Juan ESCOBAR (Cruz Azul) | |
| +1 | Jesús OCEJO (Santos Laguna) | |
| +1 | Cristian ROLDAN (Seattle Sounders) | |
| +1 | David CHOINIÈRE (Forge) | |
| +1 | Rafael BACA (Cruz Azul) | |
| +1 | Rómulo OTERO (Cruz Azul) | |
| +1 | Washington COROZO (UNAM) | |
| +1 | LÉO CHÚ (Seattle Sounders) | |
| +1 | Maxime CHANOT (New York City) | |
| +1 | José ROGÉRIO (UNAM) |
