| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 5 April 2022 | ||||||
| sfl1 |  UNAM | 2-1 | Cruz Azul | |||
| Wednesday, 6 April 2022 | ||||||
| sfl1 |  Seattle Sounders | 3-1 | New York City | |||
| Tuesday, 12 April 2022 | ||||||
| sfl2 | Cruz Azul | 0-0 | UNAM | 1-2 | ||
| Wednesday, 13 April 2022 | ||||||
| sfl2 | New York City | 1-1 | Seattle Sounders | 2-4 | ||
| 7 | +2 | Juan DINENNO (UNAM) |
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| 3 | TALLES MAGNO Bacelar (New York City) | |
| +1 | Jordan MORRIS (Seattle Sounders) | |
| Fredy MONTERO (Seattle Sounders, 2p) | ||
| 2 | Uriel ANTUNA (Cruz Azul) | |
| Adam BUKSA (New England Revolution) | ||
| +1 | Santiago RODRÍGUEZ (New York City) | |
| Cristian BOLAÑOS (Saprissa, 1p) | ||
| +1 | Nicolás LODEIRO (Seattle Sounders, 1p) | |
| Elías HERNÁNDEZ (León) |
