| ROUND | R1 | QF | SF | F | ||||
| l1 | l2 | l1 | l2 | l1 | l2 | l1 | l2 | |
| Season archive |
| Tuesday, 8 March 2022 | ||||||
| qfl1 |  Seattle Sounders | 3-0 | León | |||
| qfl1 | New York City | 3-1 | Comunicaciones | |||
| Wednesday, 9 March 2022 | ||||||
| qfl1 | Cruz Azul | 1-0 | CF Montréal | |||
| qfl1 | New England Revolution | 3-0 | UNAM | |||
| Tuesday, 15 March 2022 | ||||||
| qfl2 | Comunicaciones | 4-2 | New York City | 5-5 | ||
| Wednesday, 16 March 2022 | ||||||
| qfl2 | UNAM | 3-0 | New England Revolution | 3-3, p4-3 | ||
| qfl2 | CF Montréal | 1-1 | Cruz Azul | 1-2 | ||
| Thursday, 17 March 2022 | ||||||
| qfl2 | León | 1-1 | Seattle Sounders | 1-4 | ||
| 5 | +2 | Juan DINENNO (UNAM) |
| 4 | +2 | Valentín CASTELLANOS (New York City, 1p) |
| 3 | +1 | TALLES MAGNO Bacelar (New York City) |
| +3 | Fredy MONTERO (Seattle Sounders, 2p) | |
| 2 | +2 | Uriel ANTUNA (Cruz Azul) |
| +2 | Adam BUKSA (New England Revolution) | |
| Cristian BOLAÑOS (Saprissa, 1p) | ||
| +1 | Jordan MORRIS (Seattle Sounders) | |
| Elías HERNÁNDEZ (León) |
