| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 202 | 566 | 2.80 | 103 | 50.99% | 54 | 26.73% | 45 | 22.28% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 29 | 16 | 6 | 7 | 49 | 36 | +13 | 54 | LXWW | 14 | 10 | 2 | 2 | 29 | 15 | 15 | 6 | 4 | 5 | 20 | 21 | ||
| 2 | Chicago Fire | 29 | 12 | 7 | 10 | 39 | 31 | +8 | 43 | LXXW | 14 | 6 | 3 | 5 | 18 | 15 | 15 | 6 | 4 | 5 | 21 | 16 | ||
| 3 | New England Revolution | 29 | 12 | 7 | 10 | 39 | 40 | -1 | 43 | LLXL | 14 | 6 | 4 | 4 | 23 | 17 | 15 | 6 | 3 | 6 | 16 | 23 | ||
| 4 | New York Red Bulls | 29 | 10 | 9 | 10 | 40 | 43 | -3 | 39 | WXLL | 15 | 9 | 3 | 3 | 30 | 20 | 14 | 1 | 6 | 7 | 10 | 23 | ||
| 5 | Kansas City Wizards | 29 | 10 | 9 | 10 | 34 | 38 | -4 | 39 | WWXL | 15 | 9 | 4 | 2 | 22 | 15 | 14 | 1 | 5 | 8 | 12 | 23 | ||
| 6 | D.C. United | 29 | 11 | 4 | 14 | 43 | 50 | -7 | 37 | WOLL | 15 | 9 | 2 | 4 | 32 | 19 | 14 | 2 | 2 | 10 | 11 | 31 | ||
| 7 | Toronto FC | 29 | 9 | 8 | 12 | 34 | 41 | -7 | 35 | WXWX | 15 | 6 | 7 | 2 | 17 | 12 | 14 | 3 | 1 | 10 | 17 | 29 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Houston Dynamo | 29 | 13 | 11 | 5 | 44 | 31 | +13 | 50 | WWOW | 15 | 10 | 4 | 1 | 30 | 14 | 14 | 3 | 7 | 4 | 14 | 17 | ||
| 2 | Chivas USA | 28 | 12 | 6 | 10 | 38 | 38 | +0 | 42 | WWWW | 13 | 7 | 3 | 3 | 19 | 12 | 15 | 5 | 3 | 7 | 19 | 26 | ||
| 3 | Real Salt Lake | 29 | 10 | 9 | 10 | 39 | 38 | +1 | 39 | WXXW | 15 | 8 | 6 | 1 | 24 | 10 | 14 | 2 | 3 | 9 | 15 | 28 | ||
| 4 | FC Dallas | 29 | 8 | 11 | 10 | 43 | 39 | +4 | 35 | LXXW | 15 | 5 | 6 | 4 | 23 | 19 | 14 | 3 | 5 | 6 | 20 | 20 | ||
| 5 | Colorado Rapids | 28 | 10 | 4 | 14 | 41 | 43 | -2 | 34 | LLWX | 14 | 7 | 2 | 5 | 21 | 13 | 14 | 3 | 2 | 9 | 20 | 30 | ||
| 6 | LA Galaxy | 29 | 8 | 8 | 13 | 53 | 60 | -7 | 32 | LWLL | 14 | 6 | 4 | 4 | 33 | 25 | 15 | 2 | 4 | 9 | 20 | 35 | ||
| 7 | San Jose Earthquakes | 29 | 7 | 9 | 13 | 30 | 38 | -8 | 30 | LLLX | 14 | 5 | 4 | 5 | 20 | 19 | 15 | 2 | 5 | 8 | 10 | 19 | ||
| 19 | Landon DONOVAN (LA Galaxy, 3p) | |
| 18 | Kenny COOPER (FC Dallas, 4p) | |
| 14 | Edson BUDDLE (LA Galaxy) | |
| 13 | +1 | Brian CHING (Houston Dynamo) |
| +2 | Juan Pablo ÁNGEL (New York Red Bulls, 1p) | |
| 11 | Luciano EMILIO (D.C. United) | |
| 10 | Jaime MORENO (D.C. United, 4p) | |
| 9 | Alejandro MORENO (Columbus Crew) | |
| Chad BARRETT (Toronto FC) | ||
| Conor CASEY (Colorado Rapids, 1p) | ||
| 8 | +1 | Taylor TWELLMAN (New England Revolution) |
| Steve RALSTON (New England Revolution, 1p) | ||
| Jeff CUNNINGHAM (FC Dallas) | ||
| 7 | +1 | Cuauhtémoc BLANCO (Chicago Fire, 3p) |
| Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | ||
| Dave VAN DEN BERGH (New York Red Bulls) | ||
| 6 | Robbie ROGERS (Columbus Crew) | |
| Chris ROLFE (Chicago Fire) | ||
| Jimmy CONRAD (Kansas City Wizards) | ||
| Arturo ÁLVAREZ (San Jose Earthquakes) | ||
| +1 | Dwayne DE ROSARIO (Houston Dynamo, 1p) | |
| Adam CRISTMAN (New England Revolution) | ||
| Omar CUMMINGS (Colorado Rapids) | ||
| Darren HUCKERBY (San Jose Earthquakes) | ||
| +1 | Davy ARNAUD (Kansas City Wizards) | |
| +1 | Yura MOVSISYAN (Real Salt Lake) | |
| +1 | Robbie FINDLEY (Real Salt Lake) | |
| Javier MORALES (Real Salt Lake) |
| Wednesday, 15 October 2008 | |||||
| Houston Dynamo | 2-1 | San Jose Earthquakes | |||
| 6 | Holden | 68 | Sealy | ||
| 90 | Holden | ||||
| Thursday, 16 October 2008 | |||||
| D.C. United | 2-1 | New England Revolution | |||
| 63 | Doe | 58 | Twellman | ||
| 80 | Doe | ||||
| Saturday, 18 October 2008 | |||||
| Toronto FC | 3-2 | Chicago Fire | |||
| 12 | Guevara | 25 | Mapp | ||
| 18 | Ricketts | 59 | Blanco | ||
| 47 | Ricketts | ||||
| Houston Dynamo | 3-0 | LA Galaxy | |||
| 14(og) | Jordan | ||||
| 20 | De Rosario | ||||
| 23 | Ching | ||||
| Kansas City Wizards | 3-2 | San Jose Earthquakes | |||
| 18 | López | 20 | Sealy | ||
| 27 | Arnaud | 71 | Salinas | ||
| 90 | Gomez | ||||
| Real Salt Lake | 3-1 | FC Dallas | |||
| 35 | Movsisyan | 7 | Gallo | ||
| 54 | Johnson | ||||
| 86 | Findley | ||||
| New York Red Bulls | 3-1 | Columbus Crew | |||
| 48 | Ángel | 62 | Lenhart | ||
| 76 | Ángel | ||||
| 83 | Cepero | ||||