| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 147 | 396 | 2.69 | 75 | 51.02% | 39 | 26.53% | 33 | 22.45% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Columbus Crew | 21 | 11 | 4 | 6 | 34 | 28 | +6 | 37 | WWLW | 11 | 7 | 2 | 2 | 21 | 14 | 10 | 4 | 2 | 4 | 13 | 14 | |
| 2 | 1 | New England Revolution | 21 | 11 | 4 | 6 | 29 | 27 | +2 | 37 | XWLL | 10 | 5 | 2 | 3 | 15 | 12 | 11 | 6 | 2 | 3 | 14 | 15 | |
| 3 | Chicago Fire | 21 | 10 | 5 | 6 | 28 | 16 | +12 | 35 | WLWW | 10 | 4 | 2 | 4 | 11 | 8 | 11 | 6 | 3 | 2 | 17 | 8 | ||
| 4 | D.C. United | 21 | 10 | 1 | 10 | 36 | 34 | +2 | 31 | WLWL | 11 | 8 | 0 | 3 | 28 | 13 | 10 | 2 | 1 | 7 | 8 | 21 | ||
| 5 | New York Red Bulls | 21 | 8 | 7 | 6 | 28 | 28 | +0 | 31 | WWWX | 11 | 7 | 3 | 1 | 20 | 10 | 10 | 1 | 4 | 5 | 8 | 18 | ||
| 6 | Toronto FC | 21 | 7 | 5 | 9 | 22 | 27 | -5 | 26 | XLWL | 11 | 5 | 5 | 1 | 11 | 5 | 10 | 2 | 0 | 8 | 11 | 22 | ||
| 7 | Kansas City Wizards | 21 | 6 | 8 | 7 | 22 | 28 | -6 | 26 | XLWL | 10 | 5 | 3 | 2 | 13 | 12 | 11 | 1 | 5 | 5 | 9 | 16 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Houston Dynamo | 21 | 8 | 8 | 5 | 29 | 25 | +4 | 32 | LWWW | 10 | 6 | 3 | 1 | 20 | 11 | 11 | 2 | 5 | 4 | 9 | 14 | ||
| 2 | Real Salt Lake | 21 | 7 | 6 | 8 | 25 | 27 | -2 | 27 | LLWO | 11 | 6 | 5 | 0 | 18 | 7 | 10 | 1 | 1 | 8 | 7 | 20 | ||
| 3 | FC Dallas | 21 | 6 | 8 | 7 | 29 | 27 | +2 | 26 | XLWW | 10 | 4 | 4 | 2 | 16 | 13 | 11 | 2 | 4 | 5 | 13 | 14 | ||
| 4 | Colorado Rapids | 21 | 7 | 3 | 11 | 29 | 30 | -1 | 24 | LWLL | 11 | 6 | 1 | 4 | 17 | 9 | 10 | 1 | 2 | 7 | 12 | 21 | ||
| 5 | LA Galaxy | 21 | 6 | 6 | 9 | 40 | 43 | -3 | 24 | LXLL | 11 | 4 | 3 | 4 | 23 | 19 | 10 | 2 | 3 | 5 | 17 | 24 | ||
| 6 | Chivas USA | 21 | 6 | 6 | 9 | 26 | 31 | -5 | 24 | OLXL | 11 | 5 | 3 | 3 | 15 | 10 | 10 | 1 | 3 | 6 | 11 | 21 | ||
| 7 | San Jose Earthquakes | 21 | 5 | 7 | 9 | 19 | 25 | -6 | 22 | OWWX | 9 | 3 | 3 | 3 | 13 | 12 | 12 | 2 | 4 | 6 | 6 | 13 | ||
| 14 | Landon DONOVAN (LA Galaxy, 3p) | |
| 13 | Kenny COOPER (FC Dallas, 2p) | |
| 12 | Edson BUDDLE (LA Galaxy) | |
| 11 | Luciano EMILIO (D.C. United) | |
| 9 | Brian CHING (Houston Dynamo) | |
| Jaime MORENO (D.C. United, 4p) | ||
| 8 | +1 | Juan Pablo ÁNGEL (New York Red Bulls) |
| 7 | Alejandro MORENO (Columbus Crew) | |
| +1 | Chad BARRETT (Toronto FC) | |
| 6 | Adam CRISTMAN (New England Revolution) | |
| Steve RALSTON (New England Revolution, 1p) | ||
| 5 | Robbie ROGERS (Columbus Crew) | |
| +1 | Jimmy CONRAD (Kansas City Wizards) | |
| +1 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | |
| +1 | John THORRINGTON (Chicago Fire) | |
| Danny DICHIO (Toronto FC) | ||
| Dave VAN DEN BERGH (New York Red Bulls) | ||
| Sacha KLJESTAN (Chivas USA) | ||
| Robbie FINDLEY (Real Salt Lake) | ||
| David BECKHAM (LA Galaxy) | ||
| Dominic ODURO (FC Dallas) | ||
| Conor CASEY (Colorado Rapids) |
| Thursday, 21 August 2008 | |||||
| LA Galaxy | 0-1 | Chicago Fire | |||
| 65 | Thorrington | ||||
| Saturday, 23 August 2008 | |||||
| D.C. United | 3-0 | Colorado Rapids | |||
| 45 | Vide | ||||
| 82 | Quaranta | ||||
| 87 | Kirk | ||||
| Columbus Crew | 3-0 | Real Salt Lake | |||
| 15 | Marshall | ||||
| 25(p) | Barros Schelotto | ||||
| 55 | Evans | ||||
| Toronto FC | 1-1 | New England Revolution | |||
| 66 | Barrett | 35 | Twellman | ||
| Kansas City Wizards | 1-1 | FC Dallas | |||
| 90 | Conrad | 7 | André Rocha | ||
| Chivas USA | 0-0 | San Jose Earthquakes | |||
| Sunday, 24 August 2008 | |||||
| New York Red Bulls | 3-0 | Houston Dynamo | |||
| 8 | Ángel | ||||
| 26 | Richards | ||||
| 60 | Magee | ||||