| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 92 | 252 | 2.73 | 47 | 51.09% | 20 | 21.74% | 25 | 27.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 15 | 8 | 3 | 4 | 21 | 17 | +4 | 27 | LXWW | 7 | 3 | 2 | 2 | 10 | 8 | 8 | 5 | 1 | 2 | 11 | 9 | ||
| 2 | Columbus Crew | 13 | 7 | 2 | 4 | 20 | 17 | +3 | 23 | XWLL | 6 | 4 | 0 | 2 | 9 | 7 | 7 | 3 | 2 | 2 | 11 | 10 | ||
| 3 | Toronto FC | 13 | 6 | 3 | 4 | 17 | 16 | +1 | 21 | OWLW | 8 | 5 | 3 | 0 | 10 | 2 | 5 | 1 | 0 | 4 | 7 | 14 | ||
| 4 | Chicago Fire | 12 | 6 | 1 | 5 | 20 | 11 | +9 | 19 | LLLW | 5 | 2 | 0 | 3 | 8 | 6 | 7 | 4 | 1 | 2 | 12 | 5 | ||
| 5 | 1 | New York Red Bulls | 13 | 5 | 4 | 4 | 14 | 17 | -3 | 19 | WXLW | 7 | 4 | 2 | 1 | 9 | 7 | 6 | 1 | 2 | 3 | 5 | 10 | |
| 6 | 1 | D.C. United | 13 | 5 | 1 | 7 | 21 | 24 | -3 | 16 | WWXW | 6 | 4 | 0 | 2 | 16 | 9 | 7 | 1 | 1 | 5 | 5 | 15 | |
| 7 | Kansas City Wizards | 12 | 3 | 4 | 5 | 10 | 16 | -6 | 13 | OLOL | 5 | 2 | 1 | 2 | 6 | 8 | 7 | 1 | 3 | 3 | 4 | 8 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 13 | 6 | 3 | 4 | 31 | 24 | +7 | 21 | XWWL | 8 | 4 | 2 | 2 | 21 | 15 | 5 | 2 | 1 | 2 | 10 | 9 | ||
| 2 | 2 | Real Salt Lake | 14 | 5 | 4 | 5 | 18 | 18 | +0 | 19 | WOWO | 8 | 4 | 4 | 0 | 14 | 6 | 6 | 1 | 0 | 5 | 4 | 12 | |
| 3 | 1 | Houston Dynamo | 14 | 4 | 6 | 4 | 16 | 18 | -2 | 18 | OLWW | 6 | 3 | 2 | 1 | 9 | 7 | 8 | 1 | 4 | 3 | 7 | 11 | |
| 4 | 1 | Chivas USA | 13 | 5 | 2 | 6 | 19 | 19 | +0 | 17 | WLLW | 7 | 4 | 0 | 3 | 11 | 7 | 6 | 1 | 2 | 3 | 8 | 12 | |
| 5 | 2 | Colorado Rapids | 13 | 5 | 1 | 7 | 19 | 18 | +1 | 16 | OLLW | 7 | 4 | 1 | 2 | 11 | 5 | 6 | 1 | 0 | 5 | 8 | 13 | |
| 6 | FC Dallas | 14 | 4 | 4 | 6 | 17 | 20 | -3 | 16 | LWLL | 7 | 3 | 2 | 2 | 9 | 10 | 7 | 1 | 2 | 4 | 8 | 10 | ||
| 7 | San Jose Earthquakes | 12 | 3 | 2 | 7 | 9 | 17 | -8 | 11 | OLWL | 5 | 1 | 1 | 3 | 4 | 8 | 7 | 2 | 1 | 4 | 5 | 9 | ||
| 11 | +2 | Landon DONOVAN (LA Galaxy, 3p) |
| 9 | +1 | Edson BUDDLE (LA Galaxy) |
| 7 | +1 | Kenny COOPER (FC Dallas) |
| Luciano EMILIO (D.C. United) | ||
| 6 | Alejandro MORENO (Columbus Crew) | |
| 5 | Robbie ROGERS (Columbus Crew) | |
| Danny DICHIO (Toronto FC) | ||
| Chad BARRETT (Chicago Fire) | ||
| Brian CHING (Houston Dynamo) | ||
| +1 | Sacha KLJESTAN (Chivas USA) | |
| Jaime MORENO (D.C. United, 3p) | ||
| 4 | Kheli DUBE (New England Revolution) | |
| Cuauhtémoc BLANCO (Chicago Fire, 2p) | ||
| Dwayne DE ROSARIO (Houston Dynamo, 1p) | ||
| +1 | Adam CRISTMAN (New England Revolution) | |
| Jesse MARSCH (Chivas USA) | ||
| +1 | Steve RALSTON (New England Revolution, 1p) | |
| David BECKHAM (LA Galaxy) | ||
| Dominic ODURO (FC Dallas) |
| Sunday, 15 June 2008 | |||||
| FC Dallas | 1-0 | Chicago Fire | |||
| 17 | Cooper | ||||
| Wednesday, 18 June 2008 | |||||
| Real Salt Lake | 0-0 | San Jose Earthquakes | |||
| New England Revolution | 1-1 | New York Red Bulls | |||
| 79 | Ralston | 37 | Stammler | ||
| Thursday, 19 June 2008 | |||||
| Chivas USA | 2-0 | Chicago Fire | |||
| 26 | Kljestan | ||||
| 32 | Braun | ||||
| Saturday, 21 June 2008 | |||||
| Toronto FC | 0-0 | Kansas City Wizards | |||
| Colorado Rapids | 0-0 | Houston Dynamo | |||
| New York Red Bulls | 1-0 | FC Dallas | |||
| 16 | Goldthwaite | ||||
| LA Galaxy | 3-3 | Columbus Crew | |||
| 4 | Donovan | 67 | Evans | ||
| 47 | Buddle | 71(p) | Barros Schelotto | ||
| 83(p) | Donovan | 88 | Lenhart | ||
| Real Salt Lake | 2-1 | New England Revolution | |||
| 11(og) | Heaps | 8 | Cristman | ||
| 60 | Nunez | ||||