| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 140 | 382 | 2.72 | 72 | 51.43% | 36 | 25.71% | 32 | 22.86% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 20 | 11 | 3 | 6 | 28 | 26 | +2 | 36 | WLLW | 10 | 5 | 2 | 3 | 15 | 12 | 10 | 6 | 1 | 3 | 13 | 14 | ||
| 2 | 1 | Columbus Crew | 20 | 10 | 4 | 6 | 31 | 28 | +3 | 34 | WLWX | 10 | 6 | 2 | 2 | 18 | 14 | 10 | 4 | 2 | 4 | 13 | 14 | |
| 3 | 1 | Chicago Fire | 20 | 9 | 5 | 6 | 27 | 16 | +11 | 32 | LWWO | 10 | 4 | 2 | 4 | 11 | 8 | 10 | 5 | 3 | 2 | 16 | 8 | |
| 4 | D.C. United | 20 | 9 | 1 | 10 | 33 | 34 | -1 | 28 | LWLW | 10 | 7 | 0 | 3 | 25 | 13 | 10 | 2 | 1 | 7 | 8 | 21 | ||
| 5 | 1 | New York Red Bulls | 20 | 7 | 7 | 6 | 25 | 28 | -3 | 28 | WWXX | 10 | 6 | 3 | 1 | 17 | 10 | 10 | 1 | 4 | 5 | 8 | 18 | |
| 6 | 1 | Toronto FC | 20 | 7 | 4 | 9 | 21 | 26 | -5 | 25 | LWLL | 10 | 5 | 4 | 1 | 10 | 4 | 10 | 2 | 0 | 8 | 11 | 22 | |
| 7 | Kansas City Wizards | 20 | 6 | 7 | 7 | 21 | 27 | -6 | 25 | LWLO | 9 | 5 | 2 | 2 | 12 | 11 | 11 | 1 | 5 | 5 | 9 | 16 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Houston Dynamo | 20 | 8 | 8 | 4 | 29 | 22 | +7 | 32 | WWWW | 10 | 6 | 3 | 1 | 20 | 11 | 10 | 2 | 5 | 3 | 9 | 11 | |
| 2 | 1 | Real Salt Lake | 20 | 7 | 6 | 7 | 25 | 24 | +1 | 27 | LWOW | 11 | 6 | 5 | 0 | 18 | 7 | 9 | 1 | 1 | 7 | 7 | 17 | |
| 3 | FC Dallas | 20 | 6 | 7 | 7 | 28 | 26 | +2 | 25 | LWWX | 10 | 4 | 4 | 2 | 16 | 13 | 10 | 2 | 3 | 5 | 12 | 13 | ||
| 4 | 2 | Colorado Rapids | 20 | 7 | 3 | 10 | 29 | 27 | +2 | 24 | WLLX | 11 | 6 | 1 | 4 | 17 | 9 | 9 | 1 | 2 | 6 | 12 | 18 | |
| 5 | 1 | LA Galaxy | 20 | 6 | 6 | 8 | 40 | 42 | -2 | 24 | XLLX | 10 | 4 | 3 | 3 | 23 | 18 | 10 | 2 | 3 | 5 | 17 | 24 | |
| 6 | 1 | Chivas USA | 20 | 6 | 5 | 9 | 26 | 31 | -5 | 23 | LXLL | 10 | 5 | 2 | 3 | 15 | 10 | 10 | 1 | 3 | 6 | 11 | 21 | |
| 7 | San Jose Earthquakes | 20 | 5 | 6 | 9 | 19 | 25 | -6 | 21 | WWXO | 9 | 3 | 3 | 3 | 13 | 12 | 11 | 2 | 3 | 6 | 6 | 13 | ||
| 14 | Landon DONOVAN (LA Galaxy, 3p) | |
| 13 | Kenny COOPER (FC Dallas, 2p) | |
| 12 | Edson BUDDLE (LA Galaxy) | |
| 11 | Luciano EMILIO (D.C. United) | |
| 9 | +1 | Brian CHING (Houston Dynamo) |
| +1 | Jaime MORENO (D.C. United, 4p) | |
| 7 | Alejandro MORENO (Columbus Crew) | |
| +1 | Juan Pablo ÁNGEL (New York Red Bulls) | |
| 6 | Adam CRISTMAN (New England Revolution) | |
| Chad BARRETT (Toronto FC) | ||
| Steve RALSTON (New England Revolution, 1p) | ||
| 5 | Robbie ROGERS (Columbus Crew) | |
| Danny DICHIO (Toronto FC) | ||
| Dave VAN DEN BERGH (New York Red Bulls) | ||
| Sacha KLJESTAN (Chivas USA) | ||
| Robbie FINDLEY (Real Salt Lake) | ||
| David BECKHAM (LA Galaxy) | ||
| Dominic ODURO (FC Dallas) | ||
| +2 | Conor CASEY (Colorado Rapids) |
| Saturday, 16 August 2008 | |||||
| San Jose Earthquakes | 4-0 | New England Revolution | |||
| 11 | O'Brien | ||||
| 71 | Johnson | ||||
| 76 | Sealy | ||||
| 87 | O'Brien | ||||
| Columbus Crew | 2-1 | FC Dallas | |||
| 62 | Carroll | 35 | Cunningham | ||
| 65 | Evans | ||||
| Chicago Fire | 0-1 | D.C. United | |||
| 27 | Fred | ||||
| Houston Dynamo | 4-3 | Real Salt Lake | |||
| 16 | Mullan | 3 | Movsisyan | ||
| 29 | Ching | 25 | Morales | ||
| 35 | Clark | 80 | Deuchar | ||
| 42 | Jaqua | ||||
| Colorado Rapids | 2-1 | Kansas City Wizards | |||
| 11 | Casey | 44 | Harrington | ||
| 47 | Casey | ||||
| Sunday, 17 August 2008 | |||||
| New York Red Bulls | 2-0 | Toronto FC | |||
| 37 | Magee | ||||
| 90 | Ángel | ||||
| Wednesday, 20 August 2008 | |||||
| New England Revolution | 2-1 | D.C. United | |||
| 24 | Twellman | 69 | Moreno | ||
| 49 | Larentowicz | ||||
| Houston Dynamo | 4-0 | Chivas USA | |||
| 11 | Holden | ||||
| 22 | Kamara | ||||
| 28 | Jaqua | ||||
| 35 | Kamara | ||||