| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 305 | 787 | 2.58 | 132 | 43.28% | 106 | 34.75% | 67 | 21.97% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 34 | 13 | 12 | 9 | 50 | 40 | +10 | 51 | WWXW | 17 | 9 | 6 | 2 | 29 | 16 | 17 | 4 | 6 | 7 | 21 | 24 | ||
| 2 | Philadelphia Union | 34 | 11 | 15 | 8 | 44 | 36 | +8 | 48 | LXWX | 17 | 7 | 9 | 1 | 24 | 18 | 17 | 4 | 6 | 7 | 20 | 18 | ||
| 3 | Columbus Crew | 34 | 13 | 8 | 13 | 43 | 44 | -1 | 47 | LWWL | 17 | 9 | 5 | 3 | 27 | 18 | 17 | 4 | 3 | 10 | 16 | 26 | ||
| 4 | 1 | New York Red Bulls | 34 | 10 | 16 | 8 | 50 | 44 | +6 | 46 | WLWX | 17 | 8 | 6 | 3 | 29 | 17 | 17 | 2 | 10 | 5 | 21 | 27 | |
| 5 | 1 | Houston Dynamo | 33 | 11 | 13 | 9 | 42 | 40 | +2 | 46 | WXWW | 16 | 9 | 4 | 3 | 29 | 19 | 17 | 2 | 9 | 6 | 13 | 21 | |
| 6 | Chicago Fire | 34 | 9 | 16 | 9 | 46 | 45 | +1 | 43 | WWLX | 17 | 6 | 8 | 3 | 24 | 19 | 17 | 3 | 8 | 6 | 22 | 26 | ||
| 7 | D.C. United | 34 | 9 | 12 | 13 | 49 | 52 | -3 | 39 | LXLL | 17 | 4 | 8 | 5 | 28 | 27 | 17 | 5 | 4 | 8 | 21 | 25 | ||
| 8 | Toronto FC | 34 | 6 | 15 | 13 | 36 | 59 | -23 | 33 | XXXL | 17 | 5 | 8 | 4 | 18 | 21 | 17 | 1 | 7 | 9 | 18 | 38 | ||
| 9 | New England Revolution | 34 | 5 | 13 | 16 | 38 | 58 | -20 | 28 | XLLL | 17 | 4 | 6 | 7 | 17 | 24 | 17 | 1 | 7 | 9 | 21 | 34 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 33 | 19 | 10 | 4 | 47 | 25 | +22 | 67 | WLWW | 17 | 12 | 5 | 0 | 28 | 8 | 16 | 7 | 5 | 4 | 19 | 17 | ||
| 2 | Seattle Sounders | 34 | 18 | 9 | 7 | 56 | 37 | +19 | 63 | WWLW | 17 | 9 | 4 | 4 | 32 | 20 | 17 | 9 | 5 | 3 | 24 | 17 | ||
| 3 | Real Salt Lake | 34 | 15 | 8 | 11 | 44 | 36 | +8 | 53 | XOLL | 17 | 10 | 4 | 3 | 29 | 15 | 17 | 5 | 4 | 8 | 15 | 21 | ||
| 4 | FC Dallas | 34 | 15 | 7 | 12 | 42 | 39 | +3 | 52 | LWWL | 17 | 9 | 3 | 5 | 20 | 11 | 17 | 6 | 4 | 7 | 22 | 28 | ||
| 5 | Colorado Rapids | 34 | 12 | 13 | 9 | 44 | 41 | +3 | 49 | WOWX | 17 | 6 | 9 | 2 | 25 | 16 | 17 | 6 | 4 | 7 | 19 | 25 | ||
| 6 | Portland Timbers | 34 | 11 | 9 | 14 | 40 | 48 | -8 | 42 | XXLW | 17 | 9 | 3 | 5 | 30 | 22 | 17 | 2 | 6 | 9 | 10 | 26 | ||
| 7 | 1 | San Jose Earthquakes | 34 | 8 | 14 | 12 | 40 | 45 | -5 | 38 | WLWX | 17 | 5 | 8 | 4 | 24 | 19 | 17 | 3 | 6 | 8 | 16 | 26 | |
| 8 | 1 | Chivas USA | 34 | 8 | 12 | 14 | 41 | 43 | -2 | 36 | LLXW | 17 | 5 | 5 | 7 | 19 | 17 | 17 | 3 | 7 | 7 | 22 | 26 | |
| 16 | +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 1p) |
| +1 | Dwayne DE ROSARIO (D.C. United, 4p) | |
| 14 | Thierry HENRY (New York Red Bulls) | |
| 13 | Andrés MENDOZA (Columbus Crew, 5p) | |
| 12 | Landon DONOVAN (LA Galaxy, 4p) | |
| Fredy MONTERO (Seattle Sounders) | ||
| CAMILO da Silva (Vancouver Whitecaps, 2p) | ||
| Dominic ODURO (Chicago Fire) | ||
| 11 | Brek SHEA (FC Dallas) | |
| +1 | Álvaro SABORIO (Real Salt Lake, 3p) | |
| Charlie DAVIES (D.C. United, 4p) | ||
| Sébastien LE TOUX (Philadelphia Union, 4p) | ||
| 10 | Edgar ESPÍNDOLA (Real Salt Lake, 1p) | |
| Eric HASSLI (Vancouver Whitecaps, 3p) | ||
| Juan Pablo ÁNGEL (Chivas USA) | ||
| 9 | Kei KAMARA (Sporting Kansas City, 1p) | |
| Teal BUNBURY (Sporting Kansas City) | ||
| Luke RODGERS (New York Red Bulls, 1p) | ||
| Omar BRAVO (Sporting Kansas City, 1p) | ||
| +1 | Álvaro FERNÁNDEZ (Seattle Sounders, 1p) | |
| 8 | +1 | Kenny COOPER (Portland Timbers) |
| Nick LABROCCA (Chivas USA) | ||
| +1 | Danny KOEVERMANS (Toronto FC) | |
| Justin BRAUN (Chivas USA) | ||
| Marco PAPPA (Chicago Fire) | ||
| MAICON CARIOCA (FC Dallas) | ||
| +1 | Emilio RENTERÍA (Columbus Crew, 2p) | |
| Shalrie JOSEPH (New England Revolution, 4p) |
| Sunday, 16 October 2011 | |||||
| LA Galaxy | 1-0 | Chivas USA | |||
| 53 | Barrett | ||||
| Wednesday, 19 October 2011 | |||||
| D.C. United | 1-1 | Portland Timbers | |||
| 73 | De Rosario | 24 | Cooper | ||
| Thursday, 20 October 2011 | |||||
| New York Red Bulls | 1-0 | Philadelphia Union | |||
| 8(og) | Mondragón | ||||
| Saturday, 22 October 2011 | |||||
| Toronto FC | 2-2 | New England Revolution | |||
| 20 | Soolsma | 41 | Zerka | ||
| 83 | Koevermans | 46 | Caraglio | ||
| D.C. United | 0-1 | Sporting Kansas City | |||
| 54 | Besler | ||||
| Chicago Fire | 3-2 | Columbus Crew | |||
| 11 | Anibaba | 73 | Rentería | ||
| 30 | Anibaba | 79 | Duka | ||
| 80 | Chávez | ||||
| Real Salt Lake | 1-1 | Portland Timbers | |||
| 45 | Saborio | 90 | Danso | ||
| Chivas USA | 1-3 | Seattle Sounders | |||
| 83 | Estupiñán | 53(og) | Boyens | ||
| 68 | Fernández | ||||
| 73 | Ochoa | ||||
| Vancouver Whitecaps | 1-2 | Colorado Rapids | |||
| 49 | Rochat | 59 | Larentowicz | ||
| 84 | Thompson | ||||
| San Jose Earthquakes | 4-2 | FC Dallas | |||
| 26 | Dawkins | 45 | John | ||
| 27 | Baca | 90 | Luna | ||
| 34(p) | Wondolowski | ||||
| 38 | Dawkins | ||||