| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 257 | 660 | 2.56 | 113 | 43.97% | 93 | 36.19% | 51 | 19.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Columbus Crew | 29 | 11 | 8 | 10 | 35 | 37 | -2 | 41 | LXLL | 15 | 8 | 5 | 2 | 25 | 16 | 14 | 3 | 3 | 8 | 10 | 21 | |
| 2 | 1 | Sporting Kansas City | 29 | 10 | 10 | 9 | 43 | 37 | +6 | 40 | LWXL | 14 | 7 | 5 | 2 | 24 | 14 | 15 | 3 | 5 | 7 | 19 | 23 | |
| 3 | Philadelphia Union | 28 | 9 | 12 | 7 | 36 | 30 | +6 | 39 | WOXL | 15 | 6 | 8 | 1 | 20 | 15 | 13 | 3 | 4 | 6 | 16 | 15 | ||
| 4 | Houston Dynamo | 30 | 9 | 12 | 9 | 38 | 39 | -1 | 39 | WXLL | 15 | 9 | 3 | 3 | 28 | 18 | 15 | 0 | 9 | 6 | 10 | 21 | ||
| 5 | 1 | New York Red Bulls | 28 | 7 | 15 | 6 | 43 | 38 | +5 | 36 | WXXX | 13 | 5 | 6 | 2 | 23 | 14 | 15 | 2 | 9 | 4 | 20 | 24 | |
| 6 | 1 | D.C. United | 26 | 8 | 10 | 8 | 37 | 38 | -1 | 34 | LWLX | 12 | 3 | 6 | 3 | 20 | 20 | 14 | 5 | 4 | 5 | 17 | 18 | |
| 7 | Chicago Fire | 28 | 5 | 15 | 8 | 33 | 37 | -4 | 30 | WLWW | 14 | 4 | 8 | 2 | 17 | 13 | 14 | 1 | 7 | 6 | 16 | 24 | ||
| 8 | 1 | Toronto FC | 30 | 6 | 12 | 12 | 32 | 52 | -20 | 30 | WWXL | 15 | 5 | 6 | 4 | 15 | 18 | 15 | 1 | 6 | 8 | 17 | 34 | |
| 9 | 1 | New England Revolution | 29 | 5 | 12 | 12 | 32 | 46 | -14 | 27 | LWXX | 14 | 4 | 6 | 4 | 15 | 17 | 15 | 1 | 6 | 8 | 17 | 29 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 29 | 16 | 10 | 3 | 43 | 22 | +21 | 58 | WWXW | 15 | 10 | 5 | 0 | 25 | 7 | 14 | 6 | 5 | 3 | 18 | 15 | ||
| 2 | Seattle Sounders | 29 | 14 | 9 | 6 | 46 | 31 | +15 | 51 | WLWW | 15 | 8 | 4 | 3 | 30 | 17 | 14 | 6 | 5 | 3 | 16 | 14 | ||
| 3 | 1 | Real Salt Lake | 27 | 14 | 6 | 7 | 38 | 22 | +16 | 48 | WWWW | 15 | 10 | 3 | 2 | 28 | 11 | 12 | 4 | 3 | 5 | 10 | 11 | |
| 4 | 1 | FC Dallas | 29 | 13 | 7 | 9 | 36 | 32 | +4 | 46 | LLWL | 15 | 8 | 3 | 4 | 18 | 10 | 14 | 5 | 4 | 5 | 18 | 22 | |
| 5 | Colorado Rapids | 30 | 10 | 11 | 9 | 40 | 39 | +1 | 41 | LLLX | 14 | 5 | 7 | 2 | 23 | 15 | 16 | 5 | 4 | 7 | 17 | 24 | ||
| 6 | Portland Timbers | 28 | 10 | 6 | 12 | 36 | 41 | -5 | 36 | WOWW | 15 | 9 | 2 | 4 | 29 | 19 | 13 | 1 | 4 | 8 | 7 | 22 | ||
| 7 | Chivas USA | 29 | 7 | 10 | 12 | 34 | 36 | -2 | 31 | LLLL | 14 | 4 | 4 | 6 | 14 | 13 | 15 | 3 | 6 | 6 | 20 | 23 | ||
| 8 | San Jose Earthquakes | 28 | 6 | 11 | 11 | 30 | 37 | -7 | 29 | LWXL | 15 | 4 | 7 | 4 | 19 | 16 | 13 | 2 | 4 | 7 | 11 | 21 | ||
| 12 | Landon DONOVAN (LA Galaxy, 4p) | |
| Thierry HENRY (New York Red Bulls) | ||
| 11 | +2 | Andrés MENDOZA (Columbus Crew, 5p) |
| Charlie DAVIES (D.C. United, 4p) | ||
| 10 | Brek SHEA (FC Dallas) | |
| Chris WONDOLOWSKI (San Jose Earthquakes) | ||
| Eric HASSLI (Vancouver Whitecaps, 3p) | ||
| +1 | Dominic ODURO (Chicago Fire) | |
| 9 | Dwayne DE ROSARIO (D.C. United, 3p) | |
| 8 | Kei KAMARA (Sporting Kansas City) | |
| Álvaro SABORIO (Real Salt Lake, 3p) | ||
| Omar BRAVO (Sporting Kansas City, 1p) | ||
| +1 | Nick LABROCCA (Chivas USA) | |
| +2 | Álvaro FERNÁNDEZ (Seattle Sounders, 1p) | |
| CAMILO da Silva (Vancouver Whitecaps) | ||
| MAICON CARIOCA (FC Dallas) | ||
| Shalrie JOSEPH (New England Revolution, 4p) | ||
| 7 | Chris PONTIUS (D.C. United, 1p) | |
| Teal BUNBURY (Sporting Kansas City) | ||
| Edgar ESPÍNDOLA (Real Salt Lake, 1p) | ||
| Jack JEWSBURY (Portland Timbers, 3p) | ||
| +1 | Luke RODGERS (New York Red Bulls) | |
| Fredy MONTERO (Seattle Sounders) | ||
| Justin BRAUN (Chivas USA) | ||
| +1 | Sébastien LE TOUX (Philadelphia Union, 4p) |
| Wednesday, 14 September 2011 | |||||
| Columbus Crew | 2-2 | Houston Dynamo | |||
| 64(p) | Mendoza | 34 | Watson | ||
| 76(p) | Mendoza | 86 | Carr | ||
| Friday, 16 September 2011 | |||||
| Portland Timbers | 3-0 | New England Revolution | |||
| 9 | Chará | ||||
| 32 | Cooper | ||||
| 66 | Nagbe | ||||
| Saturday, 17 September 2011 | |||||
| Toronto FC | 2-1 | Colorado Rapids | |||
| 52 | Koevermans | 70 | Nyassi | ||
| 60 | Koevermans | ||||
| Philadelphia Union | 1-0 | Columbus Crew | |||
| 32 | Le Toux | ||||
| FC Dallas | 0-1 | New York Red Bulls | |||
| 36 | Rodgers | ||||
| Houston Dynamo | 2-1 | San Jose Earthquakes | |||
| 48(p) | Davis | 40 | Stephenson | ||
| 80 | Bruin | ||||
| Real Salt Lake | 1-0 | Sporting Kansas City | |||
| 54 | Borchers | ||||
| Seattle Sounders | 3-0 | D.C. United | |||
| 35 | Fucito | ||||
| 45 | Fernández | ||||
| 60 | Fernández | ||||
| LA Galaxy | 3-0 | Vancouver Whitecaps | |||
| 40 | Magee | ||||
| 64 | Keane | ||||
| 75 | Magee | ||||
| Chicago Fire | 3-2 | Chivas USA | |||
| 2 | Gibbs | 61 | Ángel | ||
| 26(og) | Ángel | 63 | Labrocca | ||
| 85 | Oduro | ||||