| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 295 | 758 | 2.56 | 128 | 43.39% | 103 | 34.92% | 64 | 21.69% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Sporting Kansas City | 33 | 12 | 12 | 9 | 49 | 40 | +9 | 48 | WXWX | 17 | 9 | 6 | 2 | 29 | 16 | 16 | 3 | 6 | 7 | 20 | 24 | |
| 2 | 1 | Philadelphia Union | 33 | 11 | 15 | 7 | 44 | 35 | +9 | 48 | XWXW | 17 | 7 | 9 | 1 | 24 | 18 | 16 | 4 | 6 | 6 | 20 | 17 | |
| 3 | Columbus Crew | 33 | 13 | 8 | 12 | 41 | 41 | +0 | 47 | WWLL | 17 | 9 | 5 | 3 | 27 | 18 | 16 | 4 | 3 | 9 | 14 | 23 | ||
| 4 | 1 | Houston Dynamo | 33 | 11 | 13 | 9 | 42 | 40 | +2 | 46 | WXWW | 16 | 9 | 4 | 3 | 29 | 19 | 17 | 2 | 9 | 6 | 13 | 21 | |
| 5 | 1 | New York Red Bulls | 33 | 9 | 16 | 8 | 49 | 44 | +5 | 43 | LWXW | 16 | 7 | 6 | 3 | 28 | 17 | 17 | 2 | 10 | 5 | 21 | 27 | |
| 6 | 1 | Chicago Fire | 33 | 8 | 16 | 9 | 43 | 43 | +0 | 40 | WLXW | 16 | 5 | 8 | 3 | 21 | 17 | 17 | 3 | 8 | 6 | 22 | 26 | |
| 7 | 1 | D.C. United | 32 | 9 | 11 | 12 | 48 | 50 | -2 | 38 | LLLL | 15 | 4 | 7 | 4 | 27 | 25 | 17 | 5 | 4 | 8 | 21 | 25 | |
| 8 | Toronto FC | 33 | 6 | 14 | 13 | 34 | 57 | -23 | 32 | XXLW | 16 | 5 | 7 | 4 | 16 | 19 | 17 | 1 | 7 | 9 | 18 | 38 | ||
| 9 | New England Revolution | 33 | 5 | 12 | 16 | 36 | 56 | -20 | 27 | LLLL | 17 | 4 | 6 | 7 | 17 | 24 | 16 | 1 | 6 | 9 | 19 | 32 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 32 | 18 | 10 | 4 | 46 | 25 | +21 | 64 | LWWW | 16 | 11 | 5 | 0 | 27 | 8 | 16 | 7 | 5 | 4 | 19 | 17 | ||
| 2 | Seattle Sounders | 33 | 17 | 9 | 7 | 53 | 36 | +17 | 60 | WLWW | 17 | 9 | 4 | 4 | 32 | 20 | 16 | 8 | 5 | 3 | 21 | 16 | ||
| 3 | Real Salt Lake | 33 | 15 | 7 | 11 | 43 | 35 | +8 | 52 | OLLL | 16 | 10 | 3 | 3 | 28 | 14 | 17 | 5 | 4 | 8 | 15 | 21 | ||
| 4 | FC Dallas | 33 | 15 | 7 | 11 | 40 | 35 | +5 | 52 | WWLL | 17 | 9 | 3 | 5 | 20 | 11 | 16 | 6 | 4 | 6 | 20 | 24 | ||
| 5 | Colorado Rapids | 33 | 11 | 13 | 9 | 42 | 40 | +2 | 46 | OWXL | 17 | 6 | 9 | 2 | 25 | 16 | 16 | 5 | 4 | 7 | 17 | 24 | ||
| 6 | Portland Timbers | 32 | 11 | 7 | 14 | 38 | 46 | -8 | 40 | LWLX | 17 | 9 | 3 | 5 | 30 | 22 | 15 | 2 | 4 | 9 | 8 | 24 | ||
| 7 | Chivas USA | 32 | 8 | 12 | 12 | 40 | 39 | +1 | 36 | XWXL | 16 | 5 | 5 | 6 | 18 | 14 | 16 | 3 | 7 | 6 | 22 | 25 | ||
| 8 | San Jose Earthquakes | 33 | 7 | 14 | 12 | 36 | 43 | -7 | 35 | LWXX | 16 | 4 | 8 | 4 | 20 | 17 | 17 | 3 | 6 | 8 | 16 | 26 | ||
| 15 | +1 | Chris WONDOLOWSKI (San Jose Earthquakes) |
| +1 | Dwayne DE ROSARIO (D.C. United, 4p) | |
| 14 | Thierry HENRY (New York Red Bulls) | |
| 13 | +2 | Andrés MENDOZA (Columbus Crew, 5p) |
| 12 | Landon DONOVAN (LA Galaxy, 4p) | |
| +1 | Fredy MONTERO (Seattle Sounders) | |
| +1 | CAMILO da Silva (Vancouver Whitecaps, 2p) | |
| Dominic ODURO (Chicago Fire) | ||
| 11 | +1 | Brek SHEA (FC Dallas) |
| Charlie DAVIES (D.C. United, 4p) | ||
| +1 | Sébastien LE TOUX (Philadelphia Union, 4p) | |
| 10 | Álvaro SABORIO (Real Salt Lake, 3p) | |
| Edgar ESPÍNDOLA (Real Salt Lake, 1p) | ||
| Eric HASSLI (Vancouver Whitecaps, 3p) | ||
| Juan Pablo ÁNGEL (Chivas USA) | ||
| 9 | Kei KAMARA (Sporting Kansas City, 1p) | |
| +1 | Teal BUNBURY (Sporting Kansas City) | |
| Luke RODGERS (New York Red Bulls, 1p) | ||
| Omar BRAVO (Sporting Kansas City, 1p) | ||
| 8 | Nick LABROCCA (Chivas USA) | |
| Justin BRAUN (Chivas USA) | ||
| Álvaro FERNÁNDEZ (Seattle Sounders, 1p) | ||
| Marco PAPPA (Chicago Fire) | ||
| MAICON CARIOCA (FC Dallas) | ||
| Shalrie JOSEPH (New England Revolution, 4p) |
| Wednesday, 12 October 2011 | |||||
| Vancouver Whitecaps | 2-1 | D.C. United | |||
| 1 | Camilo | 58 | McDonald | ||
| 46 | Tan | ||||
| Chicago Fire | 1-2 | FC Dallas | |||
| 85 | Grazzini | 41 | Jackson | ||
| 52 | Cruz | ||||
| Friday, 14 October 2011 | |||||
| Colorado Rapids | 0-0 | Real Salt Lake | |||
| Portland Timbers | 0-2 | Houston Dynamo | |||
| 36 | Hainault | ||||
| 59 | Cruz | ||||
| Saturday, 15 October 2011 | |||||
| Sporting Kansas City | 2-0 | New York Red Bulls | |||
| 57 | Bunbury | ||||
| 74 | Sapong | ||||
| Philadelphia Union | 1-1 | Toronto FC | |||
| 42 | Le Toux | 57 | Johnson | ||
| New England Revolution | 0-3 | Columbus Crew | |||
| 31 | Mendoza | ||||
| 59 | Duka | ||||
| 63 | Mendoza | ||||
| D.C. United | 1-2 | Chicago Fire | |||
| 90(p) | De Rosario | 90 | Grazzini | ||
| 90 | Chávez | ||||
| FC Dallas | 2-0 | Vancouver Whitecaps | |||
| 35 | Chávez | ||||
| 54 | Shea | ||||
| Seattle Sounders | 2-1 | San Jose Earthquakes | |||
| 82 | Ochoa | 24 | Wondolowski | ||
| 87 | Montero | ||||