| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 268 | 690 | 2.57 | 116 | 43.28% | 97 | 36.19% | 55 | 20.52% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 3 | Houston Dynamo | 31 | 10 | 12 | 9 | 39 | 39 | +0 | 42 | WWXL | 15 | 9 | 3 | 3 | 28 | 18 | 16 | 1 | 9 | 6 | 11 | 21 | |
| 2 | Sporting Kansas City | 30 | 10 | 11 | 9 | 44 | 38 | +6 | 41 | XLWX | 15 | 7 | 6 | 2 | 25 | 15 | 15 | 3 | 5 | 7 | 19 | 23 | ||
| 3 | 2 | Columbus Crew | 30 | 11 | 8 | 11 | 35 | 38 | -3 | 41 | LLXL | 16 | 8 | 5 | 3 | 25 | 17 | 14 | 3 | 3 | 8 | 10 | 21 | |
| 4 | 1 | Philadelphia Union | 29 | 9 | 13 | 7 | 37 | 31 | +6 | 40 | XWOX | 15 | 6 | 8 | 1 | 20 | 15 | 14 | 3 | 5 | 6 | 17 | 16 | |
| 5 | New York Red Bulls | 30 | 8 | 15 | 7 | 46 | 41 | +5 | 39 | WLWX | 15 | 6 | 6 | 3 | 26 | 17 | 15 | 2 | 9 | 4 | 20 | 24 | ||
| 6 | D.C. United | 28 | 9 | 11 | 8 | 43 | 41 | +2 | 38 | WXLW | 14 | 4 | 7 | 3 | 26 | 23 | 14 | 5 | 4 | 5 | 17 | 18 | ||
| 7 | Chicago Fire | 28 | 5 | 15 | 8 | 33 | 37 | -4 | 30 | WLWW | 14 | 4 | 8 | 2 | 17 | 13 | 14 | 1 | 7 | 6 | 16 | 24 | ||
| 8 | Toronto FC | 31 | 6 | 12 | 13 | 32 | 55 | -23 | 30 | LWWX | 15 | 5 | 6 | 4 | 15 | 18 | 16 | 1 | 6 | 9 | 17 | 37 | ||
| 9 | New England Revolution | 29 | 5 | 12 | 12 | 32 | 46 | -14 | 27 | LWXX | 14 | 4 | 6 | 4 | 15 | 17 | 15 | 1 | 6 | 8 | 17 | 29 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 30 | 17 | 10 | 3 | 44 | 22 | +22 | 61 | WWWX | 15 | 10 | 5 | 0 | 25 | 7 | 15 | 7 | 5 | 3 | 19 | 15 | ||
| 2 | Seattle Sounders | 30 | 15 | 9 | 6 | 49 | 32 | +17 | 54 | WWLW | 15 | 8 | 4 | 3 | 30 | 17 | 15 | 7 | 5 | 3 | 19 | 15 | ||
| 3 | Real Salt Lake | 29 | 15 | 6 | 8 | 42 | 27 | +15 | 51 | LWWW | 15 | 10 | 3 | 2 | 28 | 11 | 14 | 5 | 3 | 6 | 14 | 16 | ||
| 4 | FC Dallas | 30 | 13 | 7 | 10 | 36 | 33 | +3 | 46 | LLLW | 16 | 8 | 3 | 5 | 18 | 11 | 14 | 5 | 4 | 5 | 18 | 22 | ||
| 5 | Colorado Rapids | 31 | 10 | 12 | 9 | 41 | 40 | +1 | 42 | XLLL | 15 | 5 | 8 | 2 | 24 | 16 | 16 | 5 | 4 | 7 | 17 | 24 | ||
| 6 | Portland Timbers | 30 | 10 | 7 | 13 | 37 | 44 | -7 | 37 | LXWO | 16 | 9 | 3 | 4 | 30 | 20 | 14 | 1 | 4 | 9 | 7 | 24 | ||
| 7 | Chivas USA | 31 | 8 | 11 | 12 | 39 | 38 | +1 | 35 | WXLL | 15 | 5 | 4 | 6 | 17 | 13 | 16 | 3 | 7 | 6 | 22 | 25 | ||
| 8 | San Jose Earthquakes | 30 | 6 | 13 | 11 | 32 | 39 | -7 | 31 | XXLW | 15 | 4 | 7 | 4 | 19 | 16 | 15 | 2 | 6 | 7 | 13 | 23 | ||
| 13 | +4 | Dwayne DE ROSARIO (D.C. United, 3p) |
| 12 | Landon DONOVAN (LA Galaxy, 4p) | |
| Thierry HENRY (New York Red Bulls) | ||
| 11 | Andrés MENDOZA (Columbus Crew, 5p) | |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes) | |
| Charlie DAVIES (D.C. United, 4p) | ||
| 10 | Brek SHEA (FC Dallas) | |
| +2 | Álvaro SABORIO (Real Salt Lake, 3p) | |
| Eric HASSLI (Vancouver Whitecaps, 3p) | ||
| Dominic ODURO (Chicago Fire) | ||
| 9 | +2 | Edgar ESPÍNDOLA (Real Salt Lake, 1p) |
| +1 | Omar BRAVO (Sporting Kansas City, 1p) | |
| +2 | Fredy MONTERO (Seattle Sounders) | |
| +1 | CAMILO da Silva (Vancouver Whitecaps) | |
| +4 | Juan Pablo ÁNGEL (Chivas USA) | |
| 8 | Kei KAMARA (Sporting Kansas City) | |
| +1 | Luke RODGERS (New York Red Bulls, 1p) | |
| Nick LABROCCA (Chivas USA) | ||
| +1 | Justin BRAUN (Chivas USA) | |
| Álvaro FERNÁNDEZ (Seattle Sounders, 1p) | ||
| +1 | Sébastien LE TOUX (Philadelphia Union, 4p) | |
| MAICON CARIOCA (FC Dallas) | ||
| Shalrie JOSEPH (New England Revolution, 4p) |
| Wednesday, 21 September 2011 | |||||
| New York Red Bulls | 1-3 | Real Salt Lake | |||
| 69 | Lindpere | 7 | Saborio | ||
| 11 | Espíndola | ||||
| 21 | Espíndola | ||||
| D.C. United | 2-2 | Chivas USA | |||
| 39 | De Rosario | 57 | Ángel | ||
| 47 | White | 69 | Ángel | ||
| Portland Timbers | 1-1 | San Jose Earthquakes | |||
| 9 | Cooper | 70 | Stephenson | ||
| Friday, 23 September 2011 | |||||
| Sporting Kansas City | 1-1 | Philadelphia Union | |||
| 56 | Bravo | 63 | Le Toux | ||
| Saturday, 24 September 2011 | |||||
| D.C. United | 4-1 | Real Salt Lake | |||
| 13 | Najar | 86 | Saborio | ||
| 22 | De Rosario | ||||
| 27 | De Rosario | ||||
| 31 | De Rosario | ||||
| Vancouver Whitecaps | 1-3 | Seattle Sounders | |||
| 22 | Camilo | 33(p) | Evans | ||
| 64 | Montero | ||||
| 67 | Montero | ||||
| Chivas USA | 3-0 | Toronto FC | |||
| 12 | Ángel | ||||
| 71 | Braun | ||||
| 77 | Ángel | ||||
| Colorado Rapids | 1-1 | San Jose Earthquakes | |||
| 71 | Moor | 19 | Wondolowski | ||
| FC Dallas | 0-1 | Houston Dynamo | |||
| 87 | Cameron | ||||
| New York Red Bulls | 2-0 | Portland Timbers | |||
| 21 | Richards | ||||
| 66(p) | Rodgers | ||||
| Columbus Crew | 0-1 | LA Galaxy | |||
| 90 | Barrett | ||||