| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 285 | 735 | 2.57 | 124 | 43.51% | 101 | 35.44% | 60 | 21.05% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Philadelphia Union | 32 | 11 | 14 | 7 | 43 | 34 | +9 | 47 | WXWX | 16 | 7 | 8 | 1 | 23 | 17 | 16 | 4 | 6 | 6 | 20 | 17 | |
| 2 | 1 | Sporting Kansas City | 32 | 11 | 12 | 9 | 47 | 40 | +7 | 45 | XWXL | 16 | 8 | 6 | 2 | 27 | 16 | 16 | 3 | 6 | 7 | 20 | 24 | |
| 3 | 1 | Columbus Crew | 32 | 12 | 8 | 12 | 38 | 41 | -3 | 44 | WLLL | 17 | 9 | 5 | 3 | 27 | 18 | 15 | 3 | 3 | 9 | 11 | 23 | |
| 4 | 1 | New York Red Bulls | 32 | 9 | 16 | 7 | 49 | 42 | +7 | 43 | WXWL | 16 | 7 | 6 | 3 | 28 | 17 | 16 | 2 | 10 | 4 | 21 | 25 | |
| 5 | 2 | Houston Dynamo | 32 | 10 | 13 | 9 | 40 | 40 | +0 | 43 | XWWX | 16 | 9 | 4 | 3 | 29 | 19 | 16 | 1 | 9 | 6 | 11 | 21 | |
| 6 | D.C. United | 30 | 9 | 11 | 10 | 46 | 46 | +0 | 38 | LLWX | 14 | 4 | 7 | 3 | 26 | 23 | 16 | 5 | 4 | 7 | 20 | 23 | ||
| 7 | Chicago Fire | 31 | 7 | 16 | 8 | 40 | 40 | +0 | 37 | XWWW | 15 | 5 | 8 | 2 | 20 | 15 | 16 | 2 | 8 | 6 | 20 | 25 | ||
| 8 | Toronto FC | 32 | 6 | 13 | 13 | 33 | 56 | -23 | 31 | XLWW | 16 | 5 | 7 | 4 | 16 | 19 | 16 | 1 | 6 | 9 | 17 | 37 | ||
| 9 | New England Revolution | 32 | 5 | 12 | 15 | 36 | 53 | -17 | 27 | LLLL | 16 | 4 | 6 | 6 | 17 | 21 | 16 | 1 | 6 | 9 | 19 | 32 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 32 | 18 | 10 | 4 | 46 | 25 | +21 | 64 | LWWW | 16 | 11 | 5 | 0 | 27 | 8 | 16 | 7 | 5 | 4 | 19 | 17 | ||
| 2 | Seattle Sounders | 32 | 16 | 9 | 7 | 51 | 35 | +16 | 57 | LWWW | 16 | 8 | 4 | 4 | 30 | 19 | 16 | 8 | 5 | 3 | 21 | 16 | ||
| 3 | Real Salt Lake | 32 | 15 | 6 | 11 | 43 | 35 | +8 | 51 | LLLL | 16 | 10 | 3 | 3 | 28 | 14 | 16 | 5 | 3 | 8 | 15 | 21 | ||
| 4 | FC Dallas | 31 | 13 | 7 | 11 | 36 | 34 | +2 | 46 | LLLL | 16 | 8 | 3 | 5 | 18 | 11 | 15 | 5 | 4 | 6 | 18 | 23 | ||
| 5 | Colorado Rapids | 32 | 11 | 12 | 9 | 42 | 40 | +2 | 45 | WXLL | 16 | 6 | 8 | 2 | 25 | 16 | 16 | 5 | 4 | 7 | 17 | 24 | ||
| 6 | Portland Timbers | 31 | 11 | 7 | 13 | 38 | 44 | -6 | 40 | WLXW | 16 | 9 | 3 | 4 | 30 | 20 | 15 | 2 | 4 | 9 | 8 | 24 | ||
| 7 | Chivas USA | 32 | 8 | 12 | 12 | 40 | 39 | +1 | 36 | XWXL | 16 | 5 | 5 | 6 | 18 | 14 | 16 | 3 | 7 | 6 | 22 | 25 | ||
| 8 | San Jose Earthquakes | 32 | 7 | 14 | 11 | 35 | 41 | -6 | 35 | WXXX | 16 | 4 | 8 | 4 | 20 | 17 | 16 | 3 | 6 | 7 | 15 | 24 | ||
| 14 | +2 | Chris WONDOLOWSKI (San Jose Earthquakes) |
| Dwayne DE ROSARIO (D.C. United, 3p) | ||
| +1 | Thierry HENRY (New York Red Bulls) | |
| 12 | Landon DONOVAN (LA Galaxy, 4p) | |
| Dominic ODURO (Chicago Fire) | ||
| 11 | Andrés MENDOZA (Columbus Crew, 5p) | |
| Charlie DAVIES (D.C. United, 4p) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| +2 | CAMILO da Silva (Vancouver Whitecaps, 2p) | |
| 10 | Brek SHEA (FC Dallas) | |
| Álvaro SABORIO (Real Salt Lake, 3p) | ||
| Edgar ESPÍNDOLA (Real Salt Lake, 1p) | ||
| Eric HASSLI (Vancouver Whitecaps, 3p) | ||
| Sébastien LE TOUX (Philadelphia Union, 4p) | ||
| +1 | Juan Pablo ÁNGEL (Chivas USA) | |
| 9 | Kei KAMARA (Sporting Kansas City, 1p) | |
| +1 | Luke RODGERS (New York Red Bulls, 1p) | |
| Omar BRAVO (Sporting Kansas City, 1p) | ||
| 8 | Teal BUNBURY (Sporting Kansas City) | |
| Nick LABROCCA (Chivas USA) | ||
| Justin BRAUN (Chivas USA) | ||
| Álvaro FERNÁNDEZ (Seattle Sounders, 1p) | ||
| Marco PAPPA (Chicago Fire) | ||
| MAICON CARIOCA (FC Dallas) | ||
| Shalrie JOSEPH (New England Revolution, 4p) |
| Sunday, 2 October 2011 | |||||
| Columbus Crew | 2-1 | D.C. United | |||
| 48(og) | Woolard | 37 | Woolard | ||
| 60 | Gaven | ||||
| Vancouver Whitecaps | 0-1 | Portland Timbers | |||
| 25 | Cooper | ||||
| Chivas USA | 1-1 | Philadelphia Union | |||
| 90 | Ángel | 59 | Mapp | ||
| Tuesday, 4 October 2011 | |||||
| New York Red Bulls | 2-0 | LA Galaxy | |||
| 32 | Rodgers | ||||
| 59 | Henry | ||||
| Thursday, 6 October 2011 | |||||
| Vancouver Whitecaps | 3-0 | Real Salt Lake | |||
| 44(p) | Camilo | ||||
| 53(p) | Camilo | ||||
| 88 | Khalfan | ||||
| Saturday, 8 October 2011 | |||||
| Seattle Sounders | 0-2 | Philadelphia Union | |||
| 60 | Adu | ||||
| 70 | Carroll | ||||
| New England Revolution | 1-2 | San Jose Earthquakes | |||
| 55 | Feilhaber | 8 | Wondolowski | ||
| 82 | Wondolowski | ||||