| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 306 | 875 | 2.85 | 132 | 43.14% | 64 | 20.92% | 110 | 35.95% |
| 2021/22 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Ajax | 34 | 26 | 5 | 3 | 98 | 19 | +79 | 83 | XWXW | 17 | 14 | 1 | 2 | 62 | 8 | 17 | 12 | 4 | 1 | 36 | 11 | ||
| 2 | PSV | 34 | 26 | 3 | 5 | 86 | 42 | +44 | 81 | WWXW | 17 | 14 | 0 | 3 | 49 | 22 | 17 | 12 | 3 | 2 | 37 | 20 | ||
| 3 | Feyenoord | 34 | 22 | 5 | 7 | 76 | 34 | +42 | 71 | LWXW | 17 | 11 | 3 | 3 | 39 | 17 | 17 | 11 | 2 | 4 | 37 | 17 | ||
| 4 | FC Twente | 34 | 20 | 8 | 6 | 55 | 37 | +18 | 68 | WWLX | 17 | 10 | 5 | 2 | 28 | 13 | 17 | 10 | 3 | 4 | 27 | 24 | ||
| 5 | AZ | 34 | 18 | 7 | 9 | 64 | 44 | +20 | 61 | LXXX | 17 | 11 | 3 | 3 | 36 | 20 | 17 | 7 | 4 | 6 | 28 | 24 | ||
| 6 | Vitesse | 34 | 15 | 6 | 13 | 42 | 51 | -9 | 51 | XWLW | 17 | 6 | 3 | 8 | 20 | 29 | 17 | 9 | 3 | 5 | 22 | 22 | ||
| 7 | FC Utrecht | 34 | 12 | 11 | 11 | 51 | 46 | +5 | 47 | LXXW | 17 | 8 | 6 | 3 | 32 | 20 | 17 | 4 | 5 | 8 | 19 | 26 | ||
| 8 | 1 | SC Heerenveen | 34 | 11 | 8 | 15 | 37 | 50 | -13 | 41 | WLWX | 17 | 6 | 3 | 8 | 23 | 26 | 17 | 5 | 5 | 7 | 14 | 24 | |
| 9 | 3 | Cambuur | 34 | 11 | 6 | 17 | 53 | 70 | -17 | 39 | WXXX | 17 | 5 | 3 | 9 | 29 | 35 | 17 | 6 | 3 | 8 | 24 | 35 | |
| 10 | 3 | RKC Waalwijk | 34 | 9 | 11 | 14 | 40 | 51 | -11 | 38 | WWXW | 17 | 6 | 3 | 8 | 17 | 25 | 17 | 3 | 8 | 6 | 23 | 26 | |
| 11 | 3 | NEC | 34 | 10 | 8 | 16 | 38 | 52 | -14 | 38 | LLWL | 17 | 3 | 5 | 9 | 13 | 22 | 17 | 7 | 3 | 7 | 25 | 30 | |
| 12 | 1 | FC Groningen | 34 | 9 | 9 | 16 | 41 | 55 | -14 | 36 | LLLL | 17 | 4 | 6 | 7 | 18 | 21 | 17 | 5 | 3 | 9 | 23 | 34 | |
| 13 | 3 | Go Ahead Eagles | 34 | 10 | 6 | 18 | 37 | 51 | -14 | 36 | LLLL | 17 | 7 | 1 | 9 | 25 | 24 | 17 | 3 | 5 | 9 | 12 | 27 | |
| 14 | 1 | Sparta | 34 | 8 | 11 | 15 | 30 | 48 | -18 | 35 | WWWX | 17 | 4 | 7 | 6 | 16 | 21 | 17 | 4 | 4 | 9 | 14 | 27 | |
| 15 | 1 | Fortuna Sittard | 34 | 10 | 5 | 19 | 36 | 67 | -31 | 35 | WLWL | 17 | 6 | 2 | 9 | 20 | 31 | 17 | 4 | 3 | 10 | 16 | 36 | |
| 16 | 2 | Heracles Almelo | 34 | 9 | 7 | 18 | 33 | 49 | -16 | 34 | LLLX | 17 | 7 | 5 | 5 | 22 | 21 | 17 | 2 | 2 | 13 | 11 | 28 | |
| 17 | Willem II | 34 | 9 | 6 | 19 | 32 | 57 | -25 | 33 | WXWL | 17 | 7 | 3 | 7 | 18 | 20 | 17 | 2 | 3 | 12 | 14 | 37 | ||
| 18 | PEC Zwolle | 34 | 7 | 6 | 21 | 26 | 52 | -26 | 27 | LLXL | 17 | 3 | 5 | 9 | 13 | 20 | 17 | 4 | 1 | 12 | 13 | 32 | ||
| Sunday, 15 May 2022 | ||||||
| Feyenoord | 1-2 | FC Twente | ||||
| SC Heerenveen | 3-1 | Go Ahead Eagles | ||||
| Willem II | 3-0 | FC Utrecht | ||||
| FC Groningen | 2-3 | Cambuur | ||||
| NEC | 0-1 | Fortuna Sittard | ||||
| AZ | 1-3 | RKC Waalwijk | ||||
| Heracles Almelo | 1-3 | Sparta | ||||
| PEC Zwolle | 1-2 | PSV | ||||
| Vitesse | 2-2 | Ajax | ||||
| Play-offs | ||||||
| Thursday, 19 May 2022 | ||||||
| sfl1 | SC Heerenveen | 3-2 | AZ | |||
| sfl1 | FC Utrecht | 3-1 | Vitesse | |||
| Sunday, 22 May 2022 | ||||||
| sfl2 | AZ | 2-0 | SC Heerenveen | 4-3 | ||
| sfl2 | Vitesse | 3-0 | FC Utrecht | 4-3, aet | ||
| Thursday, 26 May 2022 | ||||||
| fl1 | Vitesse | 2-1 | AZ | |||
| Sunday, 29 May 2022 | ||||||
| fl2 | AZ | 6-1 | Vitesse | 7-3 | ||
| 21 | Sébastien HALLER (Ajax, 2p) |
| 18 | Loïs OPENDA (Vitesse, 2p) |
| 16 | Vangelis PAVLIDIS (AZ) |
| Ricky VAN WOLFSWINKEL (FC Twente, 5p) | |
| 15 | Guus TIL (Feyenoord) |
| Jesper KARLSSON (AZ, 5p) | |
| 14 | Jørgen LARSEN (FC Groningen) |
| 13 | Dušan TADIĆ (Ajax, 4p) |
| Bryan LINSSEN (Feyenoord) | |
| 12 | Zian FLEMMING (Fortuna Sittard) |
| Cody GAKPO (PSV, 1p) | |
| Luis SINISTERRA (Feyenoord) | |
| 11 | Michiel KRAMER (RKC Waalwijk) |
| Eran ZEHAVI (PSV) | |
| 9 | Bart RAMSELAAR (FC Utrecht, 1p) |
| Anastasios DOUVIKAS (FC Utrecht, 2p) | |
| IÑIGO CÓRDOBA Querejeta (Go Ahead Eagles) | |
| Cyriel DESSERS (Feyenoord, 1p) | |
| Davy KLAASSEN (Ajax) | |
| Mats SEUNTJENS (Fortuna Sittard, 2p) | |
| 8 | Dani DE WIT (AZ) |
| Henk VEERMAN (FC Utrecht, 2p) | |
| Luuk BROUWERS (Go Ahead Eagles, 1p) | |
| Dimitris LIMNIOS (FC Twente) | |
| Ritsu DOAN (PSV) | |
| Steven BERGHUIS (Ajax) | |
| ANTONY Matheus (Ajax) | |
| Jens ODGAARD (RKC Waalwijk) |